13 Works

Consuming disaster data: is IT ethical?

Sung-Yueh Perng, Monika Büscher & Luke Moffat
Most people use disaster apps infrequently, primarily only in situations of turmoil, when they are physically or emotionally vulnerable. Personal data may be necessary to help them, data protections may be waived. In some circumstances, free movement and liberties may be curtailed for public protection, as was seen in the current COVID pandemic. Consuming and producing disaster data can deepen problems arising at the confluence of surveillance and disaster capitalism, where data has become a...

Additional file 1 of Identification of cell states using super-enhancer RNA

Yueh-Hua Tu, Hsueh-Fen Juan & Hsuan-Cheng Huang
Additional file 1: Figure S1. Definition of super-enhancer RNA. Figure S2. Heat map of the cell type correlation matrix. Figure S3. NMF decomposition of the time-coursed macrophages response to the LPS experiment.

β-arrestin-2 alleviates rheumatoid arthritis injury by suppressing NLRP3 inflammasome activation and NF- κB pathway in macrophages

Feng Cao, Cheng Huang, Jiwei Cheng & Zhaochun He
Rheumatoid arthritis (RA) is a chronic inflammatory joint disorder that inflicts damage to the joints of the hands and wrist. The aim of this study was to investigate the protective effect of β-Arrestin-2 (βArr2) on RA in vivo and in vitro. The βArr2 adenovirus (βArr2-Ad) or the control (Con-Ad) was injected into the ankle joint cavity of collagen-induced arthritis (CIA) mice. According to the results, an improvement was shown in the symptoms and pathological injury...

β-arrestin-2 alleviates rheumatoid arthritis injury by suppressing NLRP3 inflammasome activation and NF- κB pathway in macrophages

Feng Cao, Cheng Huang, Jiwei Cheng & Zhaochun He
Rheumatoid arthritis (RA) is a chronic inflammatory joint disorder that inflicts damage to the joints of the hands and wrist. The aim of this study was to investigate the protective effect of β-Arrestin-2 (βArr2) on RA in vivo and in vitro. The βArr2 adenovirus (βArr2-Ad) or the control (Con-Ad) was injected into the ankle joint cavity of collagen-induced arthritis (CIA) mice. According to the results, an improvement was shown in the symptoms and pathological injury...

Exact properties of some heteroscedastic TOST alternatives for bioequivalence

Gwowen Shieh, Show-Li Jan & Cheng-Shiun Leu
The two one-sided tests (TOST) procedure is the common method for assessing bioequivalence between two different drugs or formulations of the same drug. Several solutions to Behrens-Fisher Problem have been extended to establish statistical equivalence under variance heterogeneity. Unlike other existing studies that rely exclusively on simulation results, the analytical formulas of power and Type I error rate are derived. Exact numerical investigations were conducted to evaluate the behavior of the Welch-Satterthwaite, Cochran-Cox, and Banerjee-McCullough...

Additional file 1 of Identification of cell states using super-enhancer RNA

Yueh-Hua Tu, Hsueh-Fen Juan & Hsuan-Cheng Huang
Additional file 1: Figure S1. Definition of super-enhancer RNA. Figure S2. Heat map of the cell type correlation matrix. Figure S3. NMF decomposition of the time-coursed macrophages response to the LPS experiment.

Prediction of intrahepatic cholestasis of pregnancy in the first 20 weeks of pregnancy

Xinyuan Zhang, Yu Chen, Stephen Salerno, Yi Li, Libin Zhou, Xiaoxi Zeng & Huafeng Li
Intrahepatic cholestasis of pregnancy (ICP) is a pregnancy-specific liver disease associated with a significant risk of fetal complications including pre-term delivery and fetal death. Typically, it was diagnosed in the third trimester of pregnancy. This study utilized characteristics from routine maternal examinations in the first 20 weeks’ gestation to predict ICP in pregnant women. This is a retrospective case-control study. 13,329 medical records were collected on pregnant women presenting to the West China Second University...

Identification of cell states using super-enhancer RNA

Yueh-Hua Tu, Hsueh-Fen Juan & Hsuan-Cheng Huang
Abstract Background A new class of regulatory elements called super-enhancers, comprised of multiple neighboring enhancers, have recently been reported to be the key transcriptional drivers of cellular, developmental, and disease states. Results Here, we defined super-enhancer RNAs as highly expressed enhancer RNAs that are transcribed from a cluster of localized genomic regions. Using the cap analysis of gene expression sequencing data from FANTOM5, we systematically explored the enhancer and messenger RNA landscapes in hundreds of...

Identification of cell states using super-enhancer RNA

Yueh-Hua Tu, Hsueh-Fen Juan & Hsuan-Cheng Huang
Abstract Background A new class of regulatory elements called super-enhancers, comprised of multiple neighboring enhancers, have recently been reported to be the key transcriptional drivers of cellular, developmental, and disease states. Results Here, we defined super-enhancer RNAs as highly expressed enhancer RNAs that are transcribed from a cluster of localized genomic regions. Using the cap analysis of gene expression sequencing data from FANTOM5, we systematically explored the enhancer and messenger RNA landscapes in hundreds of...

Exact Properties of Some Heteroscedastic TOST Alternatives for Bioequivalence

Gwowen Shieh, Show-Li Jan & Cheng-Shiun Leu
The two one-sided tests (TOST) procedure is the common method for assessing bioequivalence between two different drugs or formulations of the same drug. Several solutions to Behrens-Fisher problem have been extended to establish statistical equivalence under variance heterogeneity. Unlike other existing studies that rely exclusively on simulation results, the analytical formulas of power and Type I error rate are derived. Exact numerical investigations were conducted to evaluate the behavior of the Welch–Satterthwaite, Cochran–Cox, and Banerjee–McCullough...

Prediction of intrahepatic cholestasis of pregnancy in the first 20 weeks of pregnancy

Xinyuan Zhang, Yu Chen, Stephen Salerno, Yi Li, Libin Zhou, Xiaoxi Zeng & Huafeng Li
Intrahepatic cholestasis of pregnancy (ICP) is a pregnancy-specific liver disease associated with a significant risk of fetal complications including pre-term delivery and fetal death. Typically, it was diagnosed in the third trimester of pregnancy. This study utilized characteristics from routine maternal examinations in the first 20 weeks’ gestation to predict ICP in pregnant women. This is a retrospective case-control study. 13,329 medical records were collected on pregnant women presenting to the West China Second University...

Genomic basis for skin phenotype and cold adaptation in the extinct Steller's sea cow

Diana Le Duc, Akhil Velluva, Molly Cassatt-Johnstone, Remi-Andre Olsen, Sina Baleka, Chen-Ching Lin, Johannes R. Lemke, John R. Southon, Alexander Burdin, Ming-Shan Wang, Sonja Grunewald, Wilfried Rosendahl, Ulrich Joger, Sereina Rutschmann, Thomas B. Hildebrandt, Guido Fritsch, James A. Estes, Janet Kelso, Love Dalén, Michael Hofreiter, Beth Shapiro & Torsten Schöneberg
Steller’s sea cow, an extinct sirenian and one of the largest Quaternary mammals, was described by Georg Steller in 1741 and eradicated by humans within 27 years. Here, we complement Steller’s descriptions with paleogenomic data from 12 individuals. We identified convergent evolution between Steller’s sea cow and cetaceans but not extant sirenians, suggesting a role of several genes in adaptation to cold environments. Among these are inactivations of lipoxygenase genes, which in humans and mouse...

Exact Properties of Some Heteroscedastic TOST Alternatives for Bioequivalence

Gwowen Shieh, Show-Li Jan & Cheng-Shiun Leu
The two one-sided tests (TOST) procedure is the common method for assessing bioequivalence between two different drugs or formulations of the same drug. Several solutions to Behrens-Fisher problem have been extended to establish statistical equivalence under variance heterogeneity. Unlike other existing studies that rely exclusively on simulation results, the analytical formulas of power and Type I error rate are derived. Exact numerical investigations were conducted to evaluate the behavior of the Welch–Satterthwaite, Cochran–Cox, and Banerjee–McCullough...

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