Additional file 1: Table S1. Associations of liver biomarkers with blood glucose values in OGTT. Table S2. Joint associations of higher liver enzymes with risk of GDM. Table S3. Association of HSI with risk of GDM stratified by pre-pregnancy BMI and alcohol drinking status. Table S4. Associations of liver biomarkers with GDM after excluding participants with a history of GDM, current smokers, or current drinkers. Table S5. Associations of liver biomarkers with GDM among participants...

Abstract Background The cholinergic anti-inflammatory pathway (CAP) has been widely studied to modulate the immune response. Current stimulating strategies are invasive or imprecise. Noninvasive low-intensity pulsed ultrasound (LIPUS) has become increasingly appreciated for targeted neuronal modulation. However, its mechanisms and physiological role on myocarditis remain poorly defined. Methods The mouse model of experimental autoimmune myocarditis was established. Low-intensity pulsed ultrasound was targeted at the spleen to stimulate the spleen nerve. Under different ultrasound parameters, histological...

Additional file 7. The effect of splenic denervation on vessels of EAM mice. A. HE staining for spleen histological signs of EAM mice and EAM+SDN mice. B. Representative images of whole spleen sections of EAM mice and EAM+SDN mice. Blue, nuclear staining. Green, CD31 is a sensitive and specific marker for vascular endothelial injury (especially white arrow). EAM: Experimental Autoimmune Myocarditis; SDN: Splenic Denervation; HE: hematoxylin and eosin.

Additional file 3: Table S3. 461 m7G-related lncRNAs.

Abstract Background Ovarian aging is a process of decline in its reserve leading to ovary dysfunction and even reduced health quality in offspring. However, aging-related molecular pathways in the ovary remain obscure. Lysine succinylation (Ksuc), a newly post-translational modification (PTM), has been found to be broadly conserved in both eukaryotic and prokaryotic cells, and associated with multiple pathophysiological processes. There are no relevant reports revealing a link between the molecular mechanisms of ovarian aging and...

Additional file 1: Figure S1. Validation of successful mouse POI model construction. (A) and (B) Histopathological examination and follicle counts of ovaries. Scale bar: 200 μm. (C) and (D) Ovary weight (mg) and ovary index (ovary weight / body weight, mg/g). (E) and (F) Levels of serum AMH and E2 concentrations. * P < 0.05, ** P < 0.01.

Additional file 2: Figure S2. (A) The negative control of IHC-Ksuc and -Cleaved Caspase 3 in mouse ovary administered in vivo sections. Scale bar: 100 μm (B) The negative control of IF-Ksuc (green) and -DAPI (blue) in mouse ovarian sections. Scale bar: 100 μm.

Additional file 4: Table S4. Premier sequences for qRT‒PCR Analysis.

Abstract Purpose Hepatocellular carcinoma (HCC) is a kind of primary liver cancer. It is a common malignant tumor of digestive system that is difficult to predict the prognosis of patients. As an important epigenetic modification, N7 methyl guanosine (m7G) is indispensable in gene regulation. This regulation may affect the development and occurrence of cancer. However, the prognosis of long non coding RNAs (lncRNAs) in HCC is limited, especially how m7G-related lncRNAs regulate the development of...

Additional file 7.

Supplementary Material 1

Abstract Background There are debates in acupuncture related systematic reviews and meta-analyses on whether searching Chinese databases to get more Chinese-language studies may increase the risk of bias and overestimate the effect size, and whether the treatment effects of acupuncture differ between Chinese and non-Chinese populations. Methods In this meta-epidemiological study, we searched the Cochrane library from its inception until December 2021, and identified systematic reviews and meta-analyses with acupuncture as one of the interventions....

Additional file 1.

Supplemental Material for Atropine-eluting silicone contact lenses for myopia control by Yan Fu, Yang Luo, Xi Chen, Yao Tong, Yabin Zhu, and Lu Yang in Journal of Biomaterials Applications

Port wine stain (PWS) is a congenital cutaneous capillary malformation composed of ecstatic vessels, while the microstructure of these vessels remains largely unknown. Optical coherence tomography angiography (OCTA) serves as a non-invasive, label-free and high-resolution tool to visualize the 3D tissue microvasculature. However, even as the 3D vessel images become readily accessible, quantitative analysis algorithms for their organization have mainly remained limited to analysis of 2D images. In this study, we employed the inverse signal-to-noise...

Supplementary information

Genes with sex-biased expression are thought to underlie sexually dimorphic phenotypes and are therefore subject to different selection pressures in males and females. Many authors have proposed that sexual conflict leads to the evolution of sex-biased expression, which allows males and females to reach separate phenotypic and fitness optima. The selection pressures associated with domestication may cause changes in population architectures and mating systems, which in turn can alter their direction and strength. We compared...

Supplemental Document

This dataset contains rescaled estimates of inland water greenhouse gas emissions that were homogenised with regard to water surface area and effects of seasonal ice cover and ice out for the second phase of the REgional Carbon Cycle Assessment and Processes (RECCAP) initiative (RECCAP-2). Estimates were broken down over the 10 land regions use in RECCAP2. For more information in RECCAP-2, see https://gmd.copernicus.org/articles/15/1289/2022/.

Bipolar disorder (BD) is a common mental condition with a seasonal pattern (SP) of onset. In the spring, there is a higher incidence rate of mania or mixed onset and suicide. However, the underlying mechanism of this SP remains unclear. In this study, targeted metabolomics was used to understand metabolic changes in patients with BD before and after the spring equinox. Nine patients with BD and matched healthy controls were tested for serum metabolomics at...

As a valid metric of metric-measure spaces, Gromov-Wasserstein (GW) distance has shown the potential for matching problems of structured data like point clouds and graphs. However, its application in practice is limited due to the high computational complexity. To overcome this challenge, we propose a novel importance sparsification method, called Spar-GW, to approximate GW distance efficiently. In particular, instead of considering a dense coupling matrix, our method leverages a simple but effective sampling strategy to...

As a valid metric of metric-measure spaces, Gromov-Wasserstein (GW) distance has shown the potential for matching problems of structured data like point clouds and graphs. However, its application in practice is limited due to the high computational complexity. To overcome this challenge, we propose a novel importance sparsification method, called Spar-GW, to approximate GW distance efficiently. In particular, instead of considering a dense coupling matrix, our method leverages a simple but effective sampling strategy to...

To investigate the effects and mechanisms of 4-(1H-indol-1-yl)-4-oxobutanoic acid spliced podophyllotoxin derivatives (3a–3l) on tumor cells. The MTT method was adopted to evaluate (3a–3l) antitumor activity in vitro against A549 cells, A549/DDP cells, MCF-7 cells. The results showed that compound 3l had the most prominent inhibitory effect and high selectivity with IC50 18.53 ± 1.51 µM against A549/DDP cells. Meanwhile, the effects of compound 3l on the nuclear state, cell cycle and apoptosis of A549/DDP...

Supplemental material, sj-tiff-3-tah-10.1177_20406207221146031 for Antihuman T lymphocyte porcine immunoglobulin combined with cyclosporine as first-line immunosuppressive therapy for severe aplastic anemia in China: a large single-center, 10-year retrospective study by Wenrui Yang, Xu Liu, Xin Zhao, Li Zhang, Guangxin Peng, Lei Ye, Kang Zhou, Yuan Li, Jianping Li, Huihui Fan, Yang Yang, Youzhen Xiong, Liping Jing and Fengkui Zhang in Therapeutic Advances in Hematology

Supplemental material, sj-tif-3-cll-10.1177_09636897221149444 for CD27-Expressing Xenoantigen-Expanded Human Regulatory T Cells Are Efficient in Suppressing Xenogeneic Immune Response by Lu Cao, Xiaoqian Ma, Juan Zhang, Min Yang, Zhenhu He, Cejun Yang, Sang Li, Pengfei Rong and Wei Wang in Cell Transplantation