MicroRNA-451a (miR-451a) has been implicated in the initiation and progression of multiple cancers. However, the regulatory mechanisms underlying its function in nasopharyngeal carcinoma (NPC) are poorly understood. Thus, we investigated in detail the role of the microRNA-451a/chromosome segregation 1-like (miR-45a/CSE1L) axis and its regulatory mechanism in NPC. We examined the levels of miR-451a and CSE1L in NPC, and assessed the effects of miR-451a and CSE1L on NPC by cell functional experiments. Furthermore, we elucidated the...

MicroRNA-451a (miR-451a) has been implicated in the initiation and progression of multiple cancers. However, the regulatory mechanisms underlying its function in nasopharyngeal carcinoma (NPC) are poorly understood. Thus, we investigated in detail the role of the microRNA-451a/chromosome segregation 1-like (miR-45a/CSE1L) axis and its regulatory mechanism in NPC. We examined the levels of miR-451a and CSE1L in NPC, and assessed the effects of miR-451a and CSE1L on NPC by cell functional experiments. Furthermore, we elucidated the...

Long non-coding RNAs (LncRNAs) participate in the regulation of chronic kidney disease (CKD), and acute kidney injury (AKI) is identified as an important risk factor for CKD. This study investigated the involvement of a novel LncRNA MALAT1 in regulating lipopolysaccharide (LPS)-induced cell pyroptosis and inflammation in the human renal tubular epithelial HK-2 cells. Here, the HK-2 cells were subjected to LPS (2 μg/mL) treatment to establish cellular AKI models in vitro, and we validated that...

Long non-coding RNAs (LncRNAs) participate in the regulation of chronic kidney disease (CKD), and acute kidney injury (AKI) is identified as an important risk factor for CKD. This study investigated the involvement of a novel LncRNA MALAT1 in regulating lipopolysaccharide (LPS)-induced cell pyroptosis and inflammation in the human renal tubular epithelial HK-2 cells. Here, the HK-2 cells were subjected to LPS (2 μg/mL) treatment to establish cellular AKI models in vitro, and we validated that...

There is growing evidence that circular RNAs (circRNAs) play a vital role in many kinds of diseases, including erectile dysfunction (ED). Nevertheless, the role of circRNAs in cavernous nerve-damaging ED (CNI-ED) is unknown. Here, we aimed to discover novel circRNAs, probed their potential role in the CNI-ED, and construct a ceRNA network of circRNAs. Twelve male Sprague Dawley rats were randomly divided into 2 groups by us: bilateral cavernous nerve crush (BCNC) and control groups....

Additional file 1.

Additional file 1: Supplemental Table 1. Interaction and stratified analysis results for the association between marijuana use and GrimAge acceleration at examination years 15 and 20 by tobacco smoking status. Supplemental Table 2. Interaction and stratified analysis results for the association between marijuana use and GrimAge acceleration at examination years 15 and 20 by race. Supplemental Table 3. Interaction and stratified analysis results for the association between marijuana use and GrimAge acceleration at examination years...

Additional file 1.

Additional file 1.

Calculation results of various MOF/gas systems

Background:Pain is the most common cancer-related symptom, but it is often undertreated. Telemedicine is widely used in cancer treatment, but its effectiveness is uncertain.Objective:We aimed to evaluate the impact of telemedicine intervention on pain in patients with cancer.Design:Methodological quality and risk-of-bias evaluation were conducted, and the sources of heterogeneity were explored through subgroup analysis and sensitivity analysis.Data Sources and Methods:PubMed, Embase, Web of Science, Cochrane Library, and clinical trial databases were searched up to 16...

Previous studies have shown that the increased prevalent ST764 clone in China, Japan, and other Asian areas. However, the knowledge of the genetic features and virulence characteristics of methicillin-resistant Staphylococcus aureus (MRSA) ST764 in China is still limited. In this study, we identified 52 ST764-SCCmec type II isolates collected from five cities in China between 2014 and 2021. Whole genome sequencing showed that the most common staphylococcal protein A (spa) types of ST764 in China...

Calculations of adsorption-dependent refractive indices of metal-organic frameworks for gas sensing applications

Calculation results of various gas/MOF systems

Calculation results of various gas/MOF systems

Background:Pain is the most common cancer-related symptom, but it is often undertreated. Telemedicine is widely used in cancer treatment, but its effectiveness is uncertain.Objective:We aimed to evaluate the impact of telemedicine intervention on pain in patients with cancer.Design:Methodological quality and risk-of-bias evaluation were conducted, and the sources of heterogeneity were explored through subgroup analysis and sensitivity analysis.Data Sources and Methods:PubMed, Embase, Web of Science, Cochrane Library, and clinical trial databases were searched up to 16...

Abstract Background Histologically, cytoplasmic deposits of lipids and glycogen are common in clear cell renal cell carcinoma (ccRCC). Owing to the significance of lipid deposition in ccRCC, numerous trials targeting lipid metabolism have shown certain therapeutic potential. The agonism of peroxisome proliferator-activated receptor-α (PPARα) via ligands, including WY-14,643, has been considered a promising intervention for cancers. Methods First, the effects of WY-14,643 on malignant behaviors were investigated in ccRCC in vitro. After RNA sequencing, the...

Additional file 2: Figure S2. (A) Quantifications of Colony formation assays. (B) Flow cytometry analysis was utilized in the control or WZ35-treated HCCLM3 cells to measure the possible arrest in the cell cycle. Representative fitting curve of the cell cycle qualitatively illustrated the percentage of cells in G1, S and G2/M phase. (C) Apoptosis was assessed via flow cytometry in HCCLM3 cells with or without the treatment of WZ35 (10 μg/mL) for 18h using Annexin...

Additional file 4: Figure S4. (A) KEGG pathways involved by YAP expression related genes.

Additional file 4: Figure S4. (A) KEGG pathways involved by YAP expression related genes.

Additional file 6: Figure S6. (A) Heatmap visualizing DEGs' in liver cancer samples from TCGA datasets. (B) Heatmap visualizing glucose metabolism genes' expression levels exposed to different YAP1 expression in liver cancer samples from TCGA datasets.

Additional file 7: Figure S7. (A) Volcano plot of RNA-seq data from GEO database with SLC2A1 being marked out. (B) Box plot exhibits the distinct expression of SLC2A1 in the normal and the tumor samples, with the blue box being the representative of the tumor samples and the red box of the normal samples. (C) Kaplan–Meier analysis displaying survival for liver cancer patients stratified by expression levels of SLC2A1 (P = 3.7×10-6). (D) Western blotting...

Additional file 9: Figure S9. (A and C) Time-dependent ROC curves analyzing the potential value of expression levels of SLC2A1 (A) and combination of SLC2A1 and YAP1 (C) in diagnosis of liver cancer. (B and D) Kaplan–Meier analysis displaying survival rate for liver cancer samples from GEO datasets according to the expression levels of single factor of SLC2A1 (B) (P = 0.00035) and multi factors of YAP1 and SLC2A1 (D) (P < 0.0001). High integrated...

Abstract Introduction Telemedicine is increasingly relied upon for care delivery in primary care, but the impact of visit type on clinical ordering behavior is uncertain. Methods Within Kaiser Permanente Northern California, we identified patients who self-scheduled and completed telemedicine encounters with their personal primary care provider or another available primary care provider in the same medical group, between April 1st, 2020, and October 31st, 2020, while physical distancing restrictions for COVID-19 were in place. We...

Additional file 1. Correlation of parameters with SUVmax.