2 Works

Heterochromatin-dependent transcription of satellite DNAs in the Drosophila melanogaster female germline

Xiaolu Wei, Danna G. Eickbush, Iain Speece & Amanda M. Larracuente
Large blocks of tandemly repeated DNAs—satellite DNAs (satDNAs)—play important roles in heterochromatin formation and chromosome segregation. We know little about how satDNAs are regulated, however their misregulation is associated with genomic instability and human diseases. We use the Drosophila melanogaster germline as a model to study the regulation of satDNA transcription and chromatin. Here we show that complex satDNAs (>100-bp repeat units) are transcribed into long noncoding RNAs and processed into piRNAs (PIWI interacting RNAs)....

Optimizing parameters for using the parallel auditory brainstem response (pABR) to quickly estimate hearing thresholds

Melissa Polonenko & Ross Maddox
Objectives: Timely assessments are critical to providing early intervention and better hearing and spoken language outcomes for children with hearing loss. To facilitate faster diagnostic hearing assessments in infants, the authors developed the parallel auditory brainstem response (pABR), which presents randomly timed trains of tone pips at five frequencies to each ear simultaneously. The pABR yields high-quality waveforms that are similar to the standard, single-frequency serial ABR but in a fraction of the recording time....

Registration Year

  • 2021
    2

Resource Types

  • Dataset
    2

Affiliations

  • University of Rochester Medical Center
    2
  • University of Rochester
    2