Additional file 1. The details of the methods, including study design, treatment protocol, haematologic response criteria, and statistical analysis. The predicting factors for haematologic response for IST plus hetrombopag. Table S1 showed haematologic response according to severity of aplastic anemia.

Abstract Hetrombopag, a small molecular thrombopoietin-receptor agonist, has shown encouraging efficiency in immunosuppressive therapy refractory or relapsed severe aplastic anaemia. To investigate the response rate of hetrombopag combined with IST as first-line treatment, we designed a prospective pilot study including 32 patients with SAA treated with anti-human T lymphocyte porcine immunoglobulin (p-ATG), cyclosporine, and hetrombopag. In addition, 96 patients with SAA treated with p-ATG and cyclosporine alone were matched as controls. In total, 21.9% of...

Additional file 1: Figure S1. A) The hydrodynamic size of FePt, MOFePt, pLMOFePt-TGO. B) Hydrodynamic size change of pLMOFePt-TGO pLMOFePt-TGO in a different medium. Figure S2.The particle size and polymer dispersity index (PDI) change of pLMOFePt-TGO in (A) distilled water, (B) PBS, and (C) DMEM with standing time. Figure S3. A-F) XPS high-resolution spectra of Fe2p, Pt4f, Si2p, S2p C1s, and full spectra in pLMOFePt-TGO. Figure S4. Zeta potential of FePt, MOFePt,pLMOFePt-TGO. Figure S5. A)...

Abstract Chemodynamic therapy of cancer is limited by insufficient endogenous H2O2 generation and acidity in the tumor microenvironment (TME). Herein, we developed a biodegradable theranostic platform (pLMOFePt-TGO) involving composite of dendritic organosilica and FePt alloy, loaded with tamoxifen (TAM) and glucose oxidase (GOx), and encapsulated by platelet-derived growth factor-B (PDGFB)-labeled liposomes, that effectively uses the synergy among chemotherapy, enhanced chemodynamic therapy (CDT), and anti-angiogenesis. The increased concentration of glutathione (GSH) present in the cancer cells...

Additional file 7: Table S6. The unigenes were successfully annotated to the seven databases

Additional file 9: Fig. S2. GO classification of DEGs. A GO functional classification of DEGs between GL vs. ML. B GO functional classification of DEGs between GL vs. PL. C GO functional classification of DEGs between ML vs. PL

Additional file 11: Table S9. FPKM of key anthocyanin biosynthesis-related genes in leaves of L. chinense var. rubrum

Additional file 12: Table S10. qRT-PCR data for structural and transcriptional factors

Additional file 14: Fig. S3. Correlation analysis of transcription factors and structural genes

Additional file 15: Table S12. List of primers used in this study

Additional file 2: Supplementary Figure 1. Subgroup analysis on the mediating effect of mediation adherence on symptoms and QOL of older adults with T2DM.

Additional file 1: Supplementary Table 1. The detailed information of MMAS-8. Supplementary Table 2. The detailed information of WHOQOL-BREF. Supplementary Table 3. The internal consistency of MMAS-8 and WHOQOL-BREF. Supplementary Table 4. Sensitivity analysis of variables before and after the missing values manipulated. Supplementary Table 5. Comparisons of characteristics of T2DM patients with MMAS-8<6 or ≥6. Supplementary Table 6. Subgroup analysis on the mediating effect of mediation adherence on symptoms and QOL of older adults...

Additional file 2. Funding, acknowledgements. Funding – Information on consortia funding. Acknowledgements – Information on consortia acknowledgements.

Abstract Background Previous studies have revealed that sodium-restricted diet intervention significantly decreased apnea frequency among patients with sleep apnea. However, the longitudinal association between the habit of adding salt to foods and sleep apnea in general populations is uncertain. Methods The UK Biobank cohort study includes more than 500,000 participants aged 40 to 69 across the United Kingdom from 2006 to 2010. The frequency of adding salt to foods was collected through a touch screen...

Additional file 1: Figure S1. The base peak chromatograms (BPCs) of positive ions and negative ions. A The BPCs of positive ions in the ND group. B The BPCs of negative ions in the ND group. C BPCs of positive ions in the HFD group. D The BPCs of negative ions in the HFD group. BPC, base peak chromatogram; ND, normal diet; HFD, high-fat diet.

Additional file 2: Figure S2. The multivariate statistical analysis. A PCA analysis. B OPLS-DA. PCA, principal component analysis; OPLS-DA, orthogonal partial least squares discriminant analysis.

Additional file 4: Figure S4. Chromatogram analysis of various lipid components. A A total of 131 differential lipids, including 53 TG (40.46%), 24 PE (18.32%), 10 PC (7.63%), 10 PS (7.63%), 7 SM (5.34%), 7 PA (5.34%) and 20 other lipids (15.27%), were identified. B TG, C PE, D PC, E PS, F PA, G SM, H Other lipids. TG, triglyceride; PE, phosphatidylethanolamine; PC, phosphatidylcholine; PS, phosphatidylserine; PA, phosphatidic acid; SM, sphingomyelin; LPE, lysophosphatidylethanolamine; LPC,...

Additional file 2: Table T1. Subject characteristics of replication set. Table T2. List od FDR (p<0.05) corrected DMP. Table T3. DMR list.

Additional file 1: Table S1. Detection Data of Various Physiological Characteristics of ML, PL, and GL Tricolor Leaves

Additional file 3: Table S3. Differential metabolites between GL, ML, and PL

Additional file 4: Fig. S1. KEGG annotation of putative proteins. The x-axis indicates the percentage of the number of genes annotated to the pathway out of the total number of genes annotated. The y-axis indicates the name of the KEGG metabolic pathway. A KEGG pathway analysis between GL and ML. B KEGG pathway analysis of between GL and PL. C KEGG pathway analysis between ML and PL

Bacterium-induced inflammatory responses cause bone nonunion. Although antibiotics suppress infection, bone loss after antibacterial treatment remains a critical challenge. Erxian herbal pair (EHP) has been proven effective in promoting bone formation. Our study aimed to investigate the effect of EHP on bone repair after anti-infection treatment, explore its effect on a lipopolysaccharide (LPS)-induced osteoblast. We evaluated effects of EHP on bone repair with Micro-CT, and morphology detecting. Chemical constituents of EHP and EHP-containing serum (EHP-CS)...

To clarify the clinicopathological importance of REG4 mRNA expression, we used GEO, TCGA, xiantao, UALCAN, and Kaplan-Meier plotter for a bioinformatics analysis in breast, cervical, endometrial and ovarian cancers. Compared to normal tissues, REG4 expression was found to be upregulated in breast, cervical, endometrial, and ovarian cancers (p < 0.05). Breast cancer had a higher level of REG4 methylation than normal tissues (p < 0.05), which was negatively correlated with its mRNA expression. REG4 expression...

Supplemental material, sj-docx-1-dhj-10.1177_20552076231176652 for Real-world integration of the protocol for responding to and assessing patients’ assets, risks, and experiences tool to assess social determinants of health in the electronic medical record at an academic medical center by Carrie R Howell, Heather Bradley, Li Zhang, John D Cleveland, Dustin Long, Trudi Horton, Olivia Krantz, Michael J Mugavero and Winter L Williams, Alesha Amerson, Andrea L Cherrington in DIGITAL HEALTH

ObjectiveTo describe the real-world deployment of a tool, the Protocol for Responding to and Assessing Patients’ Assets, Risks, and Experiences (PRAPARE), to assess social determinants of health (SDoH) in an electronic medical record (EMR).MethodsWe employed the collection of the PRAPARE tool in the EMR of a large academic health system in the ambulatory clinic and emergency department setting. After integration, we evaluated SDoH prevalence, levels of missingness, and data anomalies to inform ongoing collection. We...