3 Works

Data from: Comparative dynamics of microglialand glioma cell motility at the infiltrative margin of brain tumours

Joseph Juliano, Orlando Gil, Andrea Hawkins-Daarud, Sonal Noticewala, Russell C. Rockne, Jill Gallaher, Susan C. Massey, Peter A. Sims, Alexander R. A. Anderson, Kristin R. Swanson & Peter Canoll
Microglia are a major cellular component of gliomas, and abundant in the centre of the tumour and at the infiltrative margins. While glioma is a notoriously infiltrative disease, the dynamics of microglia and glioma migratory patterns have not been well characterized. To investigate the migratory behaviour of microglia and glioma cells at the infiltrative edge, we performed two-colour time-lapse fluorescence microscopy of brain slices generated from a platelet-derived growth factor-B (PDGFB)-driven rat model of glioma,...

Bayesian network analysis of immune signaling networks FACS data

Andrei Rodin & Grigoriy Gogoshin
Cancer immunotherapy, specifically immune checkpoint blockade therapy, has been found to be effective in the treatment of metastatic cancers. However, many patients do not show marked clinical response. Consequently, elucidating immune system-related pre-treatment biomarkers that are predictive with respect to sustained clinical response is a major research priority. Another research priority is evaluating changes in immune signaling networks before and after treatment in responders and non-responders. High-dimensional flow cytometry data (FACS, Fluorescence-activated cell sorting) characterizing...

Data from: Aspirin reduces long term stroke risk in women with prior hypertensive disorders of pregnancy

Eliza C. Miller, Amelia K. Boehme, Nadia T. Chung, James V. Lacey, Sophia Wang, Kamakshi Lakshminarayan, Charlie Zhong, Daniel Woo, Natalie A. Bello, Ronald Wapner, Mitchell S. V. Elkind & Joshua Zebadiah Willey
OBJECTIVE: To determine if hypertensive disorders of pregnancy (HDP) increased long-term stroke risk in women in the California Teachers Study (CTS), a prospective cohort study, and if aspirin or statin use modified this risk. METHODS: CTS participants aged ≤60 years at time of enrollment in 1995 were followed prospectively for validated stroke outcomes obtained via linkage with California hospital records through 12/31/2015. We calculated unadjusted and adjusted hazard ratios (HR) and 95% confidence intervals (95%CI)...

Registration Year

  • 2020
    1
  • 2018
    2

Resource Types

  • Dataset
    3

Affiliations

  • City Of Hope National Medical Center
    3
  • Columbia University
    2
  • University of California, San Diego
    1
  • Moffitt Cancer Center
    1
  • University of Cincinnati Medical Center
    1
  • University of Minnesota Medical Center
    1
  • University of Southern California
    1
  • Mayo Clinic
    1