2 Works

Data from: Functional confirmation of PLAG1 as the candidate causative gene underlying major pleiotropic effects on body weight and milk characteristics

Tania Fink, Kathryn Tiplady, Thomas Lopdell, Thomas Johnson, Russell G. Snell, Richard J. Spelman, Stephen R. Davis & Mathew D. Littlejohn
A major pleiotropic quantitative trait locus (QTL) located at ~25Mbp on bovine chromosome 14 affects a myriad of growth and developmental traits in Bos taurus and indicus breeds. These QTL have been attributed to two functional variants in the bidirectional promoter of PLAG1 and CHCHD7, and although PLAG1 is a good candidate for mediating these effects, its role remains uncertain given these variants are also associated with expression of five additional genes at the broader...

Data from: DNA and RNA-sequence based GWAS highlights membrane-transport genes as key modulators of milk lactose content

Thomas J. Lopdell, Kathryn Tiplady, Maksim Struchalin, Thomas J.J. Johnson, Michael Keehan, Ric Sherlock, Christine Couldrey, Stephen R. Davis, Russell G. Snell, Richard J. Spelman & Mathew D. Littlejohn
Lactose provides an easily-digested energy source for neonate mammals, and is the primary carbohydrate in milk. Lactose is also a key component of many human food products, though compared to analyses of other milk components, the genetic control of lactose has been little studied. Here we present the first GWAS of milk lactose concentration and yield, investigated in a population of 12,000 taurine dairy cattle. We detail 27 QTL spanning these traits, and subsequently validate...

Registration Year

  • 2017
    2

Resource Types

  • Dataset
    2

Affiliations

  • Livestock Improvement Corporation
    2
  • University of Auckland
    2