3 Works
A new mechanism for a familiar mutation – bovine DGAT1 K232A modulates gene expression through multi-junction exon splice enhancement
Thomas Lopdell, Tania Fink, Kathryn Tiplady, Renee Handley, Thomas Johnson, Richard Spelman, Stephen Davis, Russell Snell & Mathew Littlejohn
The DGAT1 gene encodes an enzyme responsible for catalysing the terminal reaction in mammary triglyceride synthesis, and underpins a well-known pleiotropic quantitative trait locus (QTL) with a large influence on milk composition phenotypes. Since first described over 15 years ago, a protein-coding variant K232A has been assumed as the causative variant underlying these effects, following in-vitro studies that demonstrated differing levels of triglyceride synthesis between the two protein isoforms. In the current study, we used...
Photoelectrochemical Immunosensor Based on ZnIn2S4/Bi2Se3 Nanocomposite for the Determination of Cardiac Troponin I
Wanxin Dong, Xinxin Mo, Yu Wang, Qin Lei & He Li
In this work, a novel flexible photoelectrochemical immunosensor is developed to determine cardiac troponin I (cTnI) in serum. The flower-like ZnIn2S4 nanospheres (ZIS), as signal amplification material, were successfully synthesized by a solvothermal method. The ZIS and Bi2Se3 were modified on the indium tin oxide- polyethylene terephthalate (ITO-PET) electrode, which effectively accelerates the electronic transition and improved the photocurrent conversion efficiency (signal on). However, the binding of antigen–antibody proteins blocks the electron transfer, resulting in...
Photoelectrochemical Immunosensor Based on ZnIn2S4/Bi2Se3 Nanocomposite for the Determination of Cardiac Troponin I
Wanxin Dong, Xinxin Mo, Yu Wang, Qin Lei & He Li
In this work, a novel flexible photoelectrochemical immunosensor is developed to determine cardiac troponin I (cTnI) in serum. The flower-like ZnIn2S4 nanospheres (ZIS), as signal amplification material, were successfully synthesized by a solvothermal method. The ZIS and Bi2Se3 were modified on the indium tin oxide- polyethylene terephthalate (ITO-PET) electrode, which effectively accelerates the electronic transition and improved the photocurrent conversion efficiency (signal on). However, the binding of antigen–antibody proteins blocks the electron transfer, resulting in...
Affiliations
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Livestock Improvement Corporation3
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Tianjin Agricultural University2
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Hainan Medical University2
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West China Hospital of Sichuan University2
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Zhejiang University2
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Central South University2
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Xuan Wu Hospital of the Capital Medical University2
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Fudan University Shanghai Cancer Center2
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Tianjin Huanhu Hospital2
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Wenzhou Medical University2