28 Works

sj-docx-1-msj-10.1177_13524585221124043 – Supplemental material for The mSteps pilot study: Analysis of the distance walked using a novel smartphone application in multiple sclerosis

Sarah Alexander, Marie Braisher, Carmen Tur & Jeremy Chataway
Supplemental material, sj-docx-1-msj-10.1177_13524585221124043 for The mSteps pilot study: Analysis of the distance walked using a novel smartphone application in multiple sclerosis by Sarah Alexander, Marie Braisher, Carmen Tur and Jeremy Chataway in Multiple Sclerosis Journal

sj-docx-1-jiv-10.1177_08862605221141865 – Supplemental material for Intimate Partner Violence During COVID-19 Restrictions: A Study of 30 Countries From the I-SHARE Consortium

Linda Campbell, Rayner K. J. Tan, Maximiliane Uhlich, Joel M. Francis, Kristen Mark, Naomi Miall, Stefano Eleuteri, Amanda Gabster, Simukai Shamu, Leona Plášilová, Elizabeth Kemigisha, Adesola Olumide, Priya Kosana, Felipe Hurtado-Murillo, Elin C. Larsson, Amanda Cleeve, Soraya Calvo González, Gabriela Perrotta, Victoria Fernández Albamonte, Lucía Blanco, Johanna Schröder, Adedamola Adebayo, Jacqueline Hendriks, Hanna Saltis, Michael Marks … & Joseph D Tucker
Supplemental material, sj-docx-1-jiv-10.1177_08862605221141865 for Intimate Partner Violence During COVID-19 Restrictions: A Study of 30 Countries From the I-SHARE Consortium by Linda Campbell, Rayner K. J. Tan, Maximiliane Uhlich, Joel M. Francis, Kristen Mark, Naomi Miall, Stefano Eleuteri, Amanda Gabster, Simukai Shamu, Leona Plášilová, Elizabeth Kemigisha, Adesola Olumide, Priya Kosana, Felipe Hurtado-Murillo, Elin C. Larsson, Amanda Cleeve, Soraya Calvo González, Gabriela Perrotta, Victoria Fernández Albamonte, Lucía Blanco, Johanna Schröder, Adedamola Adebayo, Jacqueline Hendriks, Hanna Saltis, Michael...

Additional file 1 of MEDICC2: whole-genome doubling aware copy-number phylogenies for cancer evolution

Tom L. Kaufmann, Marina Petkovic, Thomas B. K. Watkins, Emma C. Colliver, Sofya Laskina, Nisha Thapa, Darlan C. Minussi, Nicholas Navin, Charles Swanton, Peter Van Loo, Kerstin Haase, Maxime Tarabichi & Roland F. Schwarz
Additional file 1: Supplementary Figures S1-S23 and Supplementary Tables S1-S3.

Additional file 2 of MEDICC2: whole-genome doubling aware copy-number phylogenies for cancer evolution

Tom L. Kaufmann, Marina Petkovic, Thomas B. K. Watkins, Emma C. Colliver, Sofya Laskina, Nisha Thapa, Darlan C. Minussi, Nicholas Navin, Charles Swanton, Peter Van Loo, Kerstin Haase, Maxime Tarabichi & Roland F. Schwarz
Additional file 2. Peer review history.

MEDICC2: whole-genome doubling aware copy-number phylogenies for cancer evolution

Tom L. Kaufmann, Marina Petkovic, Thomas B. K. Watkins, Emma C. Colliver, Sofya Laskina, Nisha Thapa, Darlan C. Minussi, Nicholas Navin, Charles Swanton, Peter Van Loo, Kerstin Haase, Maxime Tarabichi & Roland F. Schwarz
Abstract Aneuploidy, chromosomal instability, somatic copy-number alterations, and whole-genome doubling (WGD) play key roles in cancer evolution and provide information for the complex task of phylogenetic inference. We present MEDICC2, a method for inferring evolutionary trees and WGD using haplotype-specific somatic copy-number alterations from single-cell or bulk data. MEDICC2 eschews simplifications such as the infinite sites assumption, allowing multiple mutations and parallel evolution, and does not treat adjacent loci as independent, allowing overlapping copy-number events....

Longitudinal profile of circulating endothelial cells in post-acute coronary syndrome patients

Marie de Bakker, Jaco Kraan, K. Martijn Akkerhuis, Rohit Oemrawsingh, Folkert W. Asselbergs, Imo Hoefer, Isabella Kardys & Eric Boersma
Patients who have experienced an acute coronary syndrome (ACS) are at risk of a recurrent event, but their level of risk varies. Because of their close temporal relationship with vascular injury, longitudinal measurements of circulating endothelial cells (CECs) carry potential to improve individual risk assessment. We conducted an explorative nested case-control study within our multicenter, prospective, observational biomarker study (BIOMArCS) of 844 ACS patients. Following an index ACS, high-frequency blood sampling was performed during 1-year...

Intimate Partner Violence During COVID-19 Restrictions: A Study of 30 Countries From the I-SHARE Consortium

Linda Campbell, Rayner K. J. Tan, Maximiliane Uhlich, Joel M. Francis, Kristen Mark, Naomi Miall, Stefano Eleuteri, Amanda Gabster, Simukai Shamu, Leona Plášilová, Elizabeth Kemigisha, Adesola Olumide, Priya Kosana, Felipe Hurtado-Murillo, Elin C. Larsson, Amanda Cleeve, Soraya Calvo González, Gabriela Perrotta, Victoria Fernández Albamonte, Lucía Blanco, Johanna Schröder, Adedamola Adebayo, Jacqueline Hendriks, Hanna Saltis, Michael Marks … & Joseph D Tucker
Intimate partner violence (IPV) causes substantial physical and psychological trauma. Restrictions introduced in response to the COVID-19 pandemic, including lockdowns and movement restrictions, may exacerbate IPV risk and reduce access to IPV support services. This cross-sectional study examines IPV during COVID-19 restrictions in 30 countries from the International Sexual HeAlth and REproductive Health (I-SHARE) study conducted from July 20th, 2020, to February, 15th, 2021. IPV was a primary outcome measure adapted from a World Health...

The mSteps pilot study: Analysis of the distance walked using a novel smartphone application in multiple sclerosis

Sarah Alexander, Marie Braisher, Carmen Tur & Jeremy Chataway
Background:Clinical studies in multiple sclerosis (MS) often require accurate measurement of walking distance. Utilisation of electronic devices could theoretically improve this. Mobile devices have the potential to continuously monitor health by collecting movement data. Popular fitness trackers record steps taken and distance travelled, typically using a fixed-stride length. However, applications using fixed-stride length may be less accurate in those with altered gait patterns. While useful for everyday purposes, medical monitoring requires greater accuracy.Objective:Our aim was...

MEDICC2: whole-genome doubling aware copy-number phylogenies for cancer evolution

Tom L. Kaufmann, Marina Petkovic, Thomas B. K. Watkins, Emma C. Colliver, Sofya Laskina, Nisha Thapa, Darlan C. Minussi, Nicholas Navin, Charles Swanton, Peter Van Loo, Kerstin Haase, Maxime Tarabichi & Roland F. Schwarz
Abstract Aneuploidy, chromosomal instability, somatic copy-number alterations, and whole-genome doubling (WGD) play key roles in cancer evolution and provide information for the complex task of phylogenetic inference. We present MEDICC2, a method for inferring evolutionary trees and WGD using haplotype-specific somatic copy-number alterations from single-cell or bulk data. MEDICC2 eschews simplifications such as the infinite sites assumption, allowing multiple mutations and parallel evolution, and does not treat adjacent loci as independent, allowing overlapping copy-number events....

Using national electronic health records for pandemic preparedness: validation of a parsimonious model for predicting excess deaths among those with COVID-19–a data-driven retrospective cohort study

Mehrdad A Mizani, Ashkan Dashtban, Laura Pasea, Alvina G Lai, Johan Thygesen, Chris Tomlinson, Alex Handy, Jil B Mamza, Tamsin Morris, Sara Khalid, Francesco Zaccardi, Mary Joan Macleod, Fatemeh Torabi, Dexter Canoy, Ashley Akbari, Colin Berry, Thomas Bolton, John Nolan, Kamlesh Khunti, Spiros Denaxas, Harry Hemingway, Cathie Sudlow & Amitava Banerjee
ObjectivesTo use national, pre- and post-pandemic electronic health records (EHR) to develop and validate a scenario-based model incorporating baseline mortality risk, infection rate (IR) and relative risk (RR) of death for prediction of excess deaths.DesignAn EHR-based, retrospective cohort study.SettingLinked EHR in Clinical Practice Research Datalink (CPRD); and linked EHR and COVID-19 data in England provided in NHS Digital Trusted Research Environment (TRE).ParticipantsIn the development (CPRD) and validation (TRE) cohorts, we included 3.8 million and 35.1...

Hepatitis B virus: Infection, liver disease, carcinogen or syndemic threat? Remodelling the clinical and public health response

Philippa C Matthews, Tongai Maponga, Indrajit Ghosh, Maud Lemoine, Ponsiano Ocama, Ibrahim Abubakar, Alistair Story & Stuart Flanagan
No description supplied

Longitudinal profile of circulating endothelial cells in post-acute coronary syndrome patients

Marie de Bakker, Jaco Kraan, K. Martijn Akkerhuis, Rohit Oemrawsingh, Folkert W. Asselbergs, Imo Hoefer, Isabella Kardys & Eric Boersma
Patients who have experienced an acute coronary syndrome (ACS) are at risk of a recurrent event, but their level of risk varies. Because of their close temporal relationship with vascular injury, longitudinal measurements of circulating endothelial cells (CECs) carry potential to improve individual risk assessment. We conducted an explorative nested case-control study within our multicenter, prospective, observational biomarker study (BIOMArCS) of 844 ACS patients. Following an index ACS, high-frequency blood sampling was performed during 1-year...

Emotional experiences of women who access early pregnancy assessment units: a qualitative investigation

Sergio A. Silverio, Maria Memtsa, Geraldine Barrett, Venetia Goodhart, Judith Stephenson, Davor Jurković & Jennifer A. Hall
Purpose: Early pregnancy complications are common and often result in pregnancy loss, which can be emotionally challenging for women. Research on the emotional experiences of those attending Early Pregnancy Assessment Units [EPAUs] is scarce. This analysis explored the emotions which women spontaneously reported when being interviewed about their experiences of using EPAU services. Materials and methods: Semi-structured telephone interviews were conducted with a purposive sample of 38 women. Using Thematic Framework Analysis, we identified six...

sj-pdf-1-jrs-10.1177_01410768221131897 - Supplemental material for Using national electronic health records for pandemic preparedness: validation of a parsimonious model for predicting excess deaths among those with COVID-19–a data-driven retrospective cohort study

Mehrdad A Mizani, Ashkan Dashtban, Laura Pasea, Alvina G Lai, Johan Thygesen, Chris Tomlinson, Alex Handy, Jil B Mamza, Tamsin Morris, Sara Khalid, Francesco Zaccardi, Mary Joan Macleod, Fatemeh Torabi, Dexter Canoy, Ashley Akbari, Colin Berry, Thomas Bolton, John Nolan, Kamlesh Khunti, Spiros Denaxas, Harry Hemingway, Cathie Sudlow & Amitava Banerjee
Supplemental material, sj-pdf-1-jrs-10.1177_01410768221131897 for Using national electronic health records for pandemic preparedness: validation of a parsimonious model for predicting excess deaths among those with COVID-19–a data-driven retrospective cohort study by Mehrdad A Mizani, Ashkan Dashtban, Laura Pasea, Alvina G Lai, Johan Thygesen, Chris Tomlinson, Alex Handy, Jil B Mamza, Tamsin Morris, Sara Khalid, Francesco Zaccardi, Mary Joan Macleod, Fatemeh Torabi, Dexter Canoy, Ashley Akbari, Colin Berry, Thomas Bolton, John Nolan, Kamlesh Khunti, Spiros Denaxas, Harry...

Additional file 2 of MEDICC2: whole-genome doubling aware copy-number phylogenies for cancer evolution

Tom L. Kaufmann, Marina Petkovic, Thomas B. K. Watkins, Emma C. Colliver, Sofya Laskina, Nisha Thapa, Darlan C. Minussi, Nicholas Navin, Charles Swanton, Peter Van Loo, Kerstin Haase, Maxime Tarabichi & Roland F. Schwarz
Additional file 2. Peer review history.

A Randomized Trial of Autologous Chondrocyte Implantation Versus Alternative Forms of Surgical Cartilage Management in Patients With a Failed Primary Treatment for Chondral or Osteochondral Defects in the Knee

Martyn Snow, Lee Middleton, Samir Mehta, Andrew Roberts, Richard Grey, James Richardson, Jan Herman Kuiper, Anthony Smith, Steve White, Simon Roberts, David Griffiths, Aslam Mohammed, Kirti Moholkar, Tanweer Ashraf, Marcus Green, James Hutchinson, Tony Bhullar, Sanjeev Chitnis, Andrew Shaw, Louw van Niekerk, Anthony Hui, Jon Olav Drogset, Gunnar Knutsen, Mike McNicholas, Mark Bowditch … & Shaun O’Brien
Background:There are limited randomized controlled trials with long-term outcomes comparing autologous chondrocyte implantation (ACI) versus alternative forms of surgical cartilage management within the knee.Purpose:To determine at 5 years after surgery whether ACI was superior to alternative forms of cartilage management in patients after a failed previous treatment for chondral or osteochondral defects in the knee.Study Design:Randomized controlled trial; Level of evidence, 1.Methods:In total, 390 participants were randomly assigned to receive either ACI or alternative management....

sj-docx-1-ajs-10.1177_03635465221141907 – Supplemental material for A Randomized Trial of Autologous Chondrocyte Implantation Versus Alternative Forms of Surgical Cartilage Management in Patients With a Failed Primary Treatment for Chondral or Osteochondral Defects in the Knee

Martyn Snow, Lee Middleton, Samir Mehta, Andrew Roberts, Richard Grey, James Richardson, Jan Herman Kuiper, Anthony Smith, Steve White, Simon Roberts, David Griffiths, Aslam Mohammed, Kirti Moholkar, Tanweer Ashraf, Marcus Green, James Hutchinson, Tony Bhullar, Sanjeev Chitnis, Andrew Shaw, Louw van Niekerk, Anthony Hui, Jon Olav Drogset, Gunnar Knutsen, Mike McNicholas, Mark Bowditch … & Shaun O’Brien
Supplemental material, sj-docx-1-ajs-10.1177_03635465221141907 for A Randomized Trial of Autologous Chondrocyte Implantation Versus Alternative Forms of Surgical Cartilage Management in Patients With a Failed Primary Treatment for Chondral or Osteochondral Defects in the Knee by Martyn Snow, Lee Middleton, Samir Mehta, Andrew Roberts, Richard Grey, James Richardson, Jan Herman Kuiper, Anthony Smith, Steve White, Simon Roberts, David Griffiths, Aslam Mohammed, Kirti Moholkar, Tanweer Ashraf, Marcus Green, James Hutchinson, Tony Bhullar, Sanjeev Chitnis, Andrew Shaw, Louw van...

sj-docx-1-msj-10.1177_13524585221124043 – Supplemental material for The mSteps pilot study: Analysis of the distance walked using a novel smartphone application in multiple sclerosis

Sarah Alexander, Marie Braisher, Carmen Tur & Jeremy Chataway
Supplemental material, sj-docx-1-msj-10.1177_13524585221124043 for The mSteps pilot study: Analysis of the distance walked using a novel smartphone application in multiple sclerosis by Sarah Alexander, Marie Braisher, Carmen Tur and Jeremy Chataway in Multiple Sclerosis Journal

The mSteps pilot study: Analysis of the distance walked using a novel smartphone application in multiple sclerosis

Sarah Alexander, Marie Braisher, Carmen Tur & Jeremy Chataway
Background:Clinical studies in multiple sclerosis (MS) often require accurate measurement of walking distance. Utilisation of electronic devices could theoretically improve this. Mobile devices have the potential to continuously monitor health by collecting movement data. Popular fitness trackers record steps taken and distance travelled, typically using a fixed-stride length. However, applications using fixed-stride length may be less accurate in those with altered gait patterns. While useful for everyday purposes, medical monitoring requires greater accuracy.Objective:Our aim was...

Emotional experiences of women who access early pregnancy assessment units: a qualitative investigation

Sergio A. Silverio, Maria Memtsa, Geraldine Barrett, Venetia Goodhart, Judith Stephenson, Davor Jurković & Jennifer A. Hall
Purpose: Early pregnancy complications are common and often result in pregnancy loss, which can be emotionally challenging for women. Research on the emotional experiences of those attending Early Pregnancy Assessment Units [EPAUs] is scarce. This analysis explored the emotions which women spontaneously reported when being interviewed about their experiences of using EPAU services. Materials and methods: Semi-structured telephone interviews were conducted with a purposive sample of 38 women. Using Thematic Framework Analysis, we identified six...

sj-pdf-1-jrs-10.1177_01410768221131897 - Supplemental material for Using national electronic health records for pandemic preparedness: validation of a parsimonious model for predicting excess deaths among those with COVID-19–a data-driven retrospective cohort study

Mehrdad A Mizani, Ashkan Dashtban, Laura Pasea, Alvina G Lai, Johan Thygesen, Chris Tomlinson, Alex Handy, Jil B Mamza, Tamsin Morris, Sara Khalid, Francesco Zaccardi, Mary Joan Macleod, Fatemeh Torabi, Dexter Canoy, Ashley Akbari, Colin Berry, Thomas Bolton, John Nolan, Kamlesh Khunti, Spiros Denaxas, Harry Hemingway, Cathie Sudlow & Amitava Banerjee
Supplemental material, sj-pdf-1-jrs-10.1177_01410768221131897 for Using national electronic health records for pandemic preparedness: validation of a parsimonious model for predicting excess deaths among those with COVID-19–a data-driven retrospective cohort study by Mehrdad A Mizani, Ashkan Dashtban, Laura Pasea, Alvina G Lai, Johan Thygesen, Chris Tomlinson, Alex Handy, Jil B Mamza, Tamsin Morris, Sara Khalid, Francesco Zaccardi, Mary Joan Macleod, Fatemeh Torabi, Dexter Canoy, Ashley Akbari, Colin Berry, Thomas Bolton, John Nolan, Kamlesh Khunti, Spiros Denaxas, Harry...

Using national electronic health records for pandemic preparedness: validation of a parsimonious model for predicting excess deaths among those with COVID-19–a data-driven retrospective cohort study

Mehrdad A Mizani, Ashkan Dashtban, Laura Pasea, Alvina G Lai, Johan Thygesen, Chris Tomlinson, Alex Handy, Jil B Mamza, Tamsin Morris, Sara Khalid, Francesco Zaccardi, Mary Joan Macleod, Fatemeh Torabi, Dexter Canoy, Ashley Akbari, Colin Berry, Thomas Bolton, John Nolan, Kamlesh Khunti, Spiros Denaxas, Harry Hemingway, Cathie Sudlow & Amitava Banerjee
ObjectivesTo use national, pre- and post-pandemic electronic health records (EHR) to develop and validate a scenario-based model incorporating baseline mortality risk, infection rate (IR) and relative risk (RR) of death for prediction of excess deaths.DesignAn EHR-based, retrospective cohort study.SettingLinked EHR in Clinical Practice Research Datalink (CPRD); and linked EHR and COVID-19 data in England provided in NHS Digital Trusted Research Environment (TRE).ParticipantsIn the development (CPRD) and validation (TRE) cohorts, we included 3.8 million and 35.1...

Additional file 1 of MEDICC2: whole-genome doubling aware copy-number phylogenies for cancer evolution

Tom L. Kaufmann, Marina Petkovic, Thomas B. K. Watkins, Emma C. Colliver, Sofya Laskina, Nisha Thapa, Darlan C. Minussi, Nicholas Navin, Charles Swanton, Peter Van Loo, Kerstin Haase, Maxime Tarabichi & Roland F. Schwarz
Additional file 1: Supplementary Figures S1-S23 and Supplementary Tables S1-S3.

Hepatitis B virus: Infection, liver disease, carcinogen or syndemic threat? Remodelling the clinical and public health response

Philippa C Matthews, Tongai Maponga, Indrajit Ghosh, Maud Lemoine, Ponsiano Ocama, Ibrahim Abubakar, Alistair Story & Stuart Flanagan
No description supplied

A Randomized Trial of Autologous Chondrocyte Implantation Versus Alternative Forms of Surgical Cartilage Management in Patients With a Failed Primary Treatment for Chondral or Osteochondral Defects in the Knee

Martyn Snow, Lee Middleton, Samir Mehta, Andrew Roberts, Richard Grey, James Richardson, Jan Herman Kuiper, Anthony Smith, Steve White, Simon Roberts, David Griffiths, Aslam Mohammed, Kirti Moholkar, Tanweer Ashraf, Marcus Green, James Hutchinson, Tony Bhullar, Sanjeev Chitnis, Andrew Shaw, Louw van Niekerk, Anthony Hui, Jon Olav Drogset, Gunnar Knutsen, Mike McNicholas, Mark Bowditch … & Shaun O’Brien
Background:There are limited randomized controlled trials with long-term outcomes comparing autologous chondrocyte implantation (ACI) versus alternative forms of surgical cartilage management within the knee.Purpose:To determine at 5 years after surgery whether ACI was superior to alternative forms of cartilage management in patients after a failed previous treatment for chondral or osteochondral defects in the knee.Study Design:Randomized controlled trial; Level of evidence, 1.Methods:In total, 390 participants were randomly assigned to receive either ACI or alternative management....

Registration Year

  • 2023
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