79 Works

Inefficient integration during multiple facial processing in pre-morbid and early phases of psychosis

TianHong Zhang, YingYu Yang, LiHua Xu, XiaoChen Tang, YeGang Hu, Xin Xiong, YanYan Wei, HuiRu Cui, YingYing Tang, HaiChun Liu, Tao Chen, Zhi Liu, Li Hui, ChunBo Li, XiaoLi Guo & JiJun Wang
We used eye-tracking to evaluate multiple facial context processing and event-related potential (ERP) to evaluate multiple facial recognition in individuals at clinical high risk (CHR) for psychosis. In total, 173 subjects (83 CHRs and 90 healthy controls [HCs]) were included and their emotion perception performances were accessed. A total of 40 CHRs and 40 well-matched HCs completed an eye-tracking task where they viewed pictures depicting a person in the foreground, presented as context-free, context-compatible, and...

Observational study to characterize treatment-resistant depression in Germany, France and the United Kingdom: analysis of real-world data collected through a survey of healthcare professionals

Lucinda S. Orsini, Shane J. O'Connor, Marco T. Mohwinckel, Lindsey Marwood, Ankit S. Pahwa, Matti N. Bryder, Xinzhe Dong & Steven P. Levine
Objective: This study describes treatment patterns, productivity, healthcare resource utilisation and previous episodes of depression for patients with treatment-resistant depression (TRD). Methods: In this cross-sectional study, a quantitative survey was administered to 225 healthcare providers (HCPs) distributed evenly across Germany, France and the United Kingdom (UK) from July to August 2021. Each HCP was asked to answer based on medical records of five patients with TRD, defined as patients failing to respond to two or...

Talaromyces marneffei activates the AIM2-caspase-1/-4-GSDMD axis to induce pyroptosis in hepatocytes

Gang Wang, Wudi Wei, Zhongsheng Jiang, Junjun Jiang, Jing Han, Hong Zhang, Jiaguang Hu, Peng Zhang, Xu Li, Tao Chen, Jinhao He, Zhen Li, Jingzhen Lai, Hao Liang, Chuanyi Ning & Li Ye
Talaromyces marneffei tends to induce systemic infection in immunocompromised individuals, which is one of the causes of the high mortality. The underlying molecular mechanisms of T.marneffei-induced abnormal liver function are still poorly understood. In this study, we found that T.marneffei-infected patients could develop abnormal liver function, evidenced by reduced albumin and increased levels of aspartate aminotransferase (AST) and AST/alanine aminotransferase (ALT). T. marneffei-infected mice exhibited similar characteristics. In vitro investigations showed that T.marneffei induced the...

Additional file 4 of PCSK9 promotes the progression and metastasis of colon cancer cells through regulation of EMT and PI3K/AKT signaling in tumor cells and phenotypic polarization of macrophages

Lu Wang, Shuangshuang Li, Huanhua Luo, Qi Lu & Shuwen Yu
Additional file 4: Supplemental Table S4. Primers used for qRT- PCR

PCSK9 promotes the progression and metastasis of colon cancer cells through regulation of EMT and PI3K/AKT signaling in tumor cells and phenotypic polarization of macrophages

Lu Wang, Shuangshuang Li, Huanhua Luo, Qi Lu & Shuwen Yu
Abstract Background Proprotein convertase subtilisin/kexin type 9 (PCSK9) is the ninth member of the proprotein convertase family that regulates lipoprotein homeostasis and altered PCSK9 expression was reportedly associated with tumor development and progression. This study assessed PCSK9 expression and functions in human colon cancer and then explored the underlying molecular events. Methods Colon cancer tissues were utilized for analysis of PCSK9 expression for association with clinicopathological factors from patients by immunohistochemistry assay. Manipulation of PCSK9...

Association between exercise and risk of cardiovascular diseases in patients with non-cystic fibrosis bronchiectasis

Hayoung Choi, Sang Hyuk Kim, Kyungdo Han, Tai Sun Park, Dong Won Park, Ji-Yong Moon, Sang-Heon Kim, Tae-Hyung Kim, Jang Won Sohn, Ho Joo Yoon & Hyun Lee
Abstract Background: Although cardiovascular comorbidities negatively impact survival in patients with bronchiectasis, there is limited evidence to recommend exercise in this population. We aimed to evaluate whether exercise habit changes are related to reduced cardiovascular disease risk and explore an optimal exercise amount. Methods: This study identified 165,842 patients with newly diagnosed bronchiectasis during 2010–2016 who underwent two health examinations and were followed up until December 2020. The exposure was the change in weekly habits...

PrEP-related stigma and PrEP use among gay, bisexual and other men who have sex with men in Ontario and British Columbia, Canada

Oscar Javier Pico-Espinosa, Mark Hull, Paul MacPherson, Daniel Grace, Mark Gaspar, Nathan Lachowsky, Saira Mohammed, James Demers, Marshall Kilduff, Robinson Truong & Darrell H. S. Tan
Abstract Background We aimed to explore the association between PrEP-related stereotypes and perceived disapproval (hereafter PrEP-related stigma), and PrEP use. Methods We used data from a cross-sectional online survey among adult gay, bisexual, other men who have sex with men in Ontario and British Columbia, Canada. Participants were recruited 2019–2020 in-person from sexual health clinics and outreach programs, and online through dating mobile applications and websites. We used logistic regression models to explore the relationship...

Additional file 2 of PCSK9 promotes the progression and metastasis of colon cancer cells through regulation of EMT and PI3K/AKT signaling in tumor cells and phenotypic polarization of macrophages

Lu Wang, Shuangshuang Li, Huanhua Luo, Qi Lu & Shuwen Yu
Additional file 2: Supplemental Table S2. ThesiRNA sequences of NC and siPCSK9

Additional file 3 of B7-H3 targeted CAR-T cells show highly efficient anti-tumor function against osteosarcoma both in vitro and in vivo

Qian Zhang, Zhiqiang Zhang, Guodi Liu, Dehua Li, Zhangjie Gu, Linsong Zhang, Yingjiao Pan, Xingbing Cui, Lu Wang, Guoping Liu, Xiaoli Tian & Ziming Zhang
Additional file 3: Supplemental Figure 3. Negative and lowgrades of B7-H3 expression in the pathological sections of 60 cases ofosteosarcoma.

Additional file 1 of B7-H3 targeted CAR-T cells show highly efficient anti-tumor function against osteosarcoma both in vitro and in vivo

Qian Zhang, Zhiqiang Zhang, Guodi Liu, Dehua Li, Zhangjie Gu, Linsong Zhang, Yingjiao Pan, Xingbing Cui, Lu Wang, Guoping Liu, Xiaoli Tian & Ziming Zhang
Additional file 1: Supplemental Figure 1. The cytotoxicity of B7-H3CAR-T cells against solid tumor cell lines was analyzed by RTCA assay. The redarrow represents the time point of effector cell addition.

New polyacetylenes from Bidens procera

Jinli Tian, Shaohua Yu, Lu Wang, Degang Kong, Wei Zhao, Zhenhua Tian & Honglei Zhou
A phytochemical investigation of Bidens procera L.C.Xu ex X.W.Zheng afforded two novel polyacetylenes, tridecane-2E-monoene-4,6,8-triyntylen-1,13-diol-12-O-β-glucoside (1) and tetradecane-2E,8E-diene-4,6-diyne-1,14-diol-13-O-β-glucoside (2), together with ten known compounds (3 − 12). Their chemical structures were elucidated by NMR and MS spectrums as well as the comparison of the published data. Furthermore, the chemotaxonomy of the yielded compounds was also discussed.

VEGFR2 Trafficking by KIF13B Is a Novel Therapeutic Target for Wet Age-Related Macular Degeneration

Stephen B Waters, Christopher Zhou, Tara Nguyen, Ruth Zelkha, Hyun Lee, Andrius Kazlauskas, Mark Rosenblatt, Asrar Malik & Kaori Yamada
Purpose: Vascular endothelial growth factor (VEGF) and its receptor VEGFR2 are promising therapeutic targets for wet age-related macular degeneration (AMD). As a topically applicable option, we developed the peptide KAI to selectively interfere with VEGFR2 trafficking to the cell surface where it receives VEGF. This study sought to determine the efficacy of KAI in the mouse model of choroidal neovascularization (CNV). Methods: The specificity of KAI was tested by surface plasmon resonance. The drug delivery...

Mining and characterization of the PKS–NRPS hybrid for epicoccamide A: a mannosylated tetramate derivative from Epicoccum sp. CPCC 400996

Tao Zhang, Guowei Cai, Xiaoting Rong, Jingwen Xu, Bingya Jiang, Hao Wang, Xinxin Li, Lu Wang, Ran Zhang, Wenni He & Liyan Yu
Abstract Background Genomic analysis indicated that the genomes of ascomycetes might carry dozens of biosynthetic gene clusters (BGCs), yet many clusters have remained enigmatic. The ascomycete genus Epicoccum, belonging to the family Didymellaceae, is ubiquitous that colonizes different types of substrates and is associated with phyllosphere or decaying vegetation. Species of this genus are prolific producers of bioactive substances. The epicoccamides, as biosynthetically distinct mannosylated tetramate, were first isolated in 2003 from Epicoccum sp. In...

Data from: Loss of GD1-positive Lactobacillus correlates with inflammation in human lungs with COPD

Marc A. Sze, Soraya Utokaparch, W. Mark Elliott, James C. Hogg & Richard G. Hegele
Objectives: The present study assesses the relationship between contents of GD1 (glycerol dehydratase)-positive Lactobacillus, presence of Lactobacillus and the inflammatory response measured in host lung tissue in mild to moderate chronic obstructive pulmonary disease (COPD). We hypothesise that there will be a loss of GD1 producing Lactobacillus with increasing severity of COPD and that GD1 has anti-inflammatory properties. Setting: Secondary care, 1 participating centre in Vancouver, British Columbia, Canada. Participants: 74 individuals who donated non-cancerous...

Stochastic Tree Search for Estimating Optimal Dynamic Treatment Regimes

Yilun Sun & Lu Wang
A dynamic treatment regime (DTR) is a sequence of decision rules that adapt to the time-varying states of an individual. Black-box learning methods have shown great potential in predicting the optimal treatments; however, the resulting DTRs lack interpretability, which is of paramount importance for medical experts to understand and implement. We present a stochastic tree-based reinforcement learning (ST-RL) method for estimating optimal DTRs in a multistage multitreatment setting with data from either randomized trials or...

Inefficient integration during multiple facial processing in pre-morbid and early phases of psychosis

TianHong Zhang, YingYu Yang, LiHua Xu, XiaoChen Tang, YeGang Hu, Xin Xiong, YanYan Wei, HuiRu Cui, YingYing Tang, HaiChun Liu, Tao Chen, Zhi Liu, Li Hui, ChunBo Li, XiaoLi Guo & JiJun Wang
We used eye-tracking to evaluate multiple facial context processing and event-related potential (ERP) to evaluate multiple facial recognition in individuals at clinical high risk (CHR) for psychosis. In total, 173 subjects (83 CHRs and 90 healthy controls [HCs]) were included and their emotion perception performances were accessed. A total of 40 CHRs and 40 well-matched HCs completed an eye-tracking task where they viewed pictures depicting a person in the foreground, presented as context-free, context-compatible, and...

Dual-imaging-mode smart hydrogel information platform for illumination-independent covert decryption and read

Junjie Wei, Long Li, Rui Li, Qingquan Liu, Zejun Yan & Tao Chen
Smart hydrogel with color responsiveness is envisioned as one of the most promising materials for advanced information encryption and decryption platform, but the illumination-dependent way of decrypting and reading information leads to the worrying of concealment in some particular scenarios. Herein, we proposed a smart hydrogel information platform with dual imaging modes by utilizing the accompanying behaviors in transparency change and heat releasing after crystallization of supercooled solution. For this smart hydrogel information platform, the...

Dual-imaging-mode smart hydrogel information platform for illumination-independent covert decryption and read

Junjie Wei, Long Li, Rui Li, Qingquan Liu, Zejun Yan & Tao Chen
Smart hydrogel with color responsiveness is envisioned as one of the most promising materials for advanced information encryption and decryption platform, but the illumination-dependent way of decrypting and reading information leads to the worrying of concealment in some particular scenarios. Herein, we proposed a smart hydrogel information platform with dual imaging modes by utilizing the accompanying behaviors in transparency change and heat releasing after crystallization of supercooled solution. For this smart hydrogel information platform, the...

Degradation of Tetrabromobisphenol S by thermo-activated Persulphate Oxidation: reaction Kinetics, transformation Mechanisms, and brominated By-products

Lu Wang, Yaqun Yu, Guoqiang Liu, Baowei Hu & Junhe Lu
Brominated flame retardants (BFRs) are a group of contaminants of emerging environmental concern. In this study, systematic exploration was carried out to investigate the degradation of tetrabromobisphenol S (TBBPS), a typical emerging BFRs, by thermally activated persulfate (PDS) oxidation. The removal of 5.0 μM TBBPS was 100% after 60 min oxidation treatment under 60°C. Increasing the temperature or initial PDS concentration facilitated the degradation efficiency of TBBPS. The quenching test indicated that TBBPS degradation occurred...

sj-docx-1-joh-10.1177_00207314221134040 - Supplemental material for Is Neoliberalism Killing Us? A Cross Sectional Study of the Impact of Neoliberal Beliefs on Health and Social Wellbeing in the Midst of the COVID-19 Pandemic

Kiffer G. Card & Kirk J. Hepburn
Supplemental material, sj-docx-1-joh-10.1177_00207314221134040 for Is Neoliberalism Killing Us? A Cross Sectional Study of the Impact of Neoliberal Beliefs on Health and Social Wellbeing in the Midst of the COVID-19 Pandemic by Kiffer G. Card and Kirk J. Hepburn in International Journal of Health Services

PCSK9 promotes the progression and metastasis of colon cancer cells through regulation of EMT and PI3K/AKT signaling in tumor cells and phenotypic polarization of macrophages

Lu Wang, Shuangshuang Li, Huanhua Luo, Qi Lu & Shuwen Yu
Abstract Background Proprotein convertase subtilisin/kexin type 9 (PCSK9) is the ninth member of the proprotein convertase family that regulates lipoprotein homeostasis and altered PCSK9 expression was reportedly associated with tumor development and progression. This study assessed PCSK9 expression and functions in human colon cancer and then explored the underlying molecular events. Methods Colon cancer tissues were utilized for analysis of PCSK9 expression for association with clinicopathological factors from patients by immunohistochemistry assay. Manipulation of PCSK9...

Additional file 2 of B7-H3 targeted CAR-T cells show highly efficient anti-tumor function against osteosarcoma both in vitro and in vivo

Qian Zhang, Zhiqiang Zhang, Guodi Liu, Dehua Li, Zhangjie Gu, Linsong Zhang, Yingjiao Pan, Xingbing Cui, Lu Wang, Guoping Liu, Xiaoli Tian & Ziming Zhang
Additional file 2: Supplemental Figure 2. Situation of affectorcells and target cells (HOS, Saos-2, SW1353) displayed by optical microscopy.

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Affiliations

  • St. Paul's Hospital
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  • Chongqing Medical University
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  • Shanghai Jiao Tong University
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  • Chinese PLA General Hospital
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  • Jiangsu Province Hospital
    57
  • Huazhong University of Science and Technology
    55
  • University of Rochester Medical Center
    53
  • Beihang University
    51
  • Inner Mongolia Agricultural University
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  • Chinese Academy of Medical Sciences & Peking Union Medical College
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