4 Works

Data from: Molecular dynamic simulations reveal the structural determinants of fatty acid binding to oxy-myoglobin

Sree V. Chintapalli, Gaurav Bhardwaj, Reema Patel, Natasha Shah, Randen L. Patterson, Damian B. Van Rossum, Andriy Anishkin & Sean H. Adams
The mechanism(s) by which fatty acids are sequestered and transported in muscle have not been fully elucidated. A potential key player in this process is the protein myoglobin (Mb). Indeed, there is a catalogue of empirical evidence supporting direct interaction of globins with fatty acid metabolites; however, the binding pocket and regulation of the interaction remains to be established. In this study, we employed a computational strategy to elucidate the structural determinants of fatty acids...

Data from: Psychostimulant-induced testicular toxicity in mice: evidence of cocaine and caffeine effects on the local dopaminergic system

Candela R. González, Betina González, Maria E. Matzkin, Javier A. Muñiz, Jean Lud Cadet, Edgar Garcia-Rill, Francisco J. Urbano, Alfredo D. Vitullo & Veronica Bisagno
Several organ systems can be affected by psychostimulant toxicity. However, there is not sufficient evidence about the impact of psychostimulant intake on testicular physiology and catecholaminergic systems. The aim of the present study was to further explore potential toxic consequences of chronic exposure to cocaine, caffeine, and their combination on testicular physiology. Mice were injected with a 13-day chronic binge regimen of caffeine (3x5mg/kg), cocaine (3×10mg/kg), or combined administration. Mice treated with cocaine alone or...

Mixed ancestry from wild and domestic lineages contributes to the rapid expansion of invasive feral swine

Timothy Smyser, Michael Tabak, Chris Slootmaker, Michael Robeson, Ryan Miller, Mirte Bosse, Hendrik-Jan Megens, Martien Groenen, Samuel Paiva, Danielle Assis De Faria, Harvey Blackburn, Brandon Schmit & Antoinette Piaggio
Invasive alien species are a significant threat to both economic and ecological systems. Identifying processes that give rise to invasive populations is essential for implementing effective control strategies. We conducted an ancestry analysis of invasive feral swine (Sus scrofa, Linnaeus, 1758), a highly destructive ungulate that is widely distributed throughout the contiguous United States, to describe introduction pathways, sources of newly-emergent populations, and processes contributing to an ongoing invasion. Comparisons of high-density single nucleotide polymorphism...

Control of the anterior pituitary cell lineage regulator POU1F1 by the stem cell determinant Musashi

Angus MacNicol, Melody Allensworth, Jewel Banik, Angela Odle, Jordan Bird, Stephanie Byrum, Melanie MacNicol & Gwen Childs
The cytokine leptin regulates energy homeostasis through ubiquitously expressed leptin receptors. Leptin has a number of major signaling targets in the brain, including cells of the anterior pituitary (AP). We have previously reported that mice lacking leptin receptors in AP somatotropes display growth hormone (GH) deficiency, metabolic dysfunction and adult onset obesity. Amongst other targets, leptin signaling promotes increased levels of the pituitary transcription factor POU1F1 (also referred to as Pit1) which, in turn, regulates...

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  • University of Arkansas for Medical Sciences
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