2 Works

Data from: Postconvulsive central apnea as a biomarker for sudden unexpected death in epilepsy (SUDEP)

Laura Vilella, Nuria Lacuey, Johnson P. Hampson, M.R. Sandhya Rani, Rup K. Sanju, Daniel Friedman, Maromi Nei, Kingman Strohl, Catherine Scott, Brian K. Gehlbach, Bilal Zony, Norma J. Hupp, Anita Zaremba, Nassim Shafiabadi, Xihue Zhao, Victoria Reick-Mitrisin, Stephan Schuele, Jennifer Ogren, Ronald M. Harper, Beate Diehl, Lisa Bateman, Orrin Devinsky, George B. Richerson, Philippe Ryvlin & Samden D. Lhatoo
Objective: To characterize peri-ictal apnea and post-ictal asystole in generalized convulsive seizures (GCS) of intractable epilepsy. Methods: Prospective, multi-center epilepsy monitoring study of autonomic and breathing biomarkers of SUDEP in patient’s ≥18 years old with intractable epilepsy and monitored GCS. Video EEG, thoraco-abdominal excursions, nasal airflow, capillary oxygen saturation and electrocardiography were analyzed. Results: We studied 148 GCS in 87 patients. Nineteen patients had generalized epilepsy, 65 had focal, one had both and in two,...

Data from: Lasmiditan is an effective acute treatment for migraine A phase 3 randomized study

Bernice Kuca, Stephen D. Silberstein, Linda Wietecha, Paul H. Berg, Gregory Dozier & Richard B. Lipton
Objective: To assess the efficacy and safety of lasmiditan in the acute treatment of migraine. Methods: Adult patients with migraine were randomized (1:1:1) to a double-blind dose of oral lasmiditan 200 mg, lasmiditan 100 mg, or placebo, and were asked to treat their next migraine attack within 4 hours of onset. Over 48 hours following dosing, patients used an electronic diary to record headache pain, and also the presence of nausea, phonophobia, and photophobia, one...

Registration Year

  • 2018
    2

Resource Types

  • Dataset
    2

Affiliations

  • Thomas Jefferson University
    2
  • Northwestern University
    1
  • Columbia University
    1
  • New York University
    1
  • National Institute of Neurological Disorders and Stroke
    1
  • University College London
    1
  • CoLucid Pharmaceuticals (United States)
    1
  • University of Iowa
    1
  • University of California Los Angeles
    1
  • University Hospital of Lausanne
    1