Transmissible gastroenteritis virus (TGEV) infection causes acute enteritis in swine of all ages, and especially in suckling piglets. Small intestinal inflammation is considered a central event in the pathogenesis of TGEV infections, and nuclear factor-kappa B (NF-κB) is a key transcription factor in the inflammatory response. However, it is unclear whether NF-κB is crucial for inducing inflammation during a TGEV infection. Our results show that NF-κB was activated in swine testicular (ST) cells and intestinal...

Few mental health assessment tools are available for people with hearing loss (HL) in China. The Acceptance and Action Questionnaire-Adult Hearing Loss (AAQ-AHL) has been specifically designed to assess psychological inflexibility in adults with HL and may help assess mental health status promptly for targeted psychological interventions. The study aimed to investigate the cross-cultural validity and reliability of the Chinese version of the AAQ-AHL to assess its applicability to teenagers and adults with HL in...

Sanitary landfills and uncontrolled dumpsites are plastic wastes (PWs) reservoirs containing ∼60% of all the plastics ever made, amounting to 5,000 × 106 tons as of 2017. The distribution, long-term behavior, and release of macro- and microplastics (MPs) from disposal sites are critical to global plastics pollution, but are poorly understood and lack systematic assessments. We review comprehensively the available knowledge in the three aspects herein. The spatial and temporal distribution of PW in 616...

Long non-coding RNA (lncRNA) ZFAS1 (zinc finger antisense 1) was demonstrated to play critical roles in various cancer progression. However, the functions of ZFAS in cervical cancers (CC) are unclear. Human CC cell lines were used for in vitro experiments. RT-qPCR (Real Time Quantitative PCR) was performed to detect the expression of ZFAS1, microRNA-190a-3p (miR-190a-3p) and Kruppel-like factor 6 (KLF6). Cell proliferation, invasion and migration assays were used to investigate biological behaviors of CC cells...

Additional file 1: Figure S1. qPCR analysis of knockdown efficiency. A-L AML12 cells were transfected with siRNA against genes of interest and relative expression of Rab33b (A), Nfs (B), Rab9 (C), Vps18 (D), Rab22a (E), Rab35 (F), Rab24 (G), Vps39 (H), Rab14 (I), Rab4 (J), Rab11a (K) and Tfeb (L). Gapdh served as an internal reference gene. Data are expressed as mean $$\pm$$ ± SEM of three independent experiments. * p < 0.05 by t-test....

Additional file 1: Figure S1. qPCR analysis of knockdown efficiency. A-L AML12 cells were transfected with siRNA against genes of interest and relative expression of Rab33b (A), Nfs (B), Rab9 (C), Vps18 (D), Rab22a (E), Rab35 (F), Rab24 (G), Vps39 (H), Rab14 (I), Rab4 (J), Rab11a (K) and Tfeb (L). Gapdh served as an internal reference gene. Data are expressed as mean $$\pm$$ ± SEM of three independent experiments. * p < 0.05 by t-test....

Additional file 1: Fig. S1. Study population flow chart. Fig. S2. The mean (95% CI) of TyG index was 8.56 (8.52, 8.59). Fig. S3. The mean (95% CI) of SBP was 118.64 (117.89, 119.39) mmHg. Fig. S4. The correlation analysis between TyG index and SBP. Table S1. The correlation between TyG index and SBP was analyzed by Pearson correlation test. Table S2. Results of univariate Cox regression analysis. Table S3. ROC curve analysis determined optimal...

Ulcerative colitis (UC) is the most prevalent form of chronic inflammatory bowel disease, the etiology of which is poorly understood. This study investigated the role of miR-151-5p on UC and explored the role of brain-derived neurotrophic factor (BDNF) in a UC mouse model and cell model. A UC mouse model was engineered by dextran sulfate sodium (DSS) induction. Primary mouse intestinal epithelial cells (IECs) were isolated. Colitis mice were intraperitoneally injected with miR-151-5p antagomir and...

Two episodes of late Neoarchean-early Paleoproterozoic and late Paleoproterozoic garnet-bearing leucogranite, named the Baotou and Jining–Liangcheng garnet-bearing leucogranite are recognized from the Khondalite Belt in the North China Craton. Geochemical studies show that garnet-bearing leucogranite has high Al2O3 content and FeOT/MgO ratio, with a large variation in the CaO content and K2O/Na2O ratio. Additionally, the garnet-bearing leucogranite is enriched in light rare earth elements and large ion lithophile elements and depleted in Nb, Ta, P,...

Additional file 11: Figure S5. Expression of the predicted AI-2 synthases and receptors within a rumen microbial metatranscriptome at the phylum level. (A) The number of bacterial genomes containing AI-2-related genes and the percentage of corresponding genomes that expressed these genes. (B) The number of bacterial genomes containing luxS synthases and the percentage of the corresponding genomes that expressed luxS genes at the phylum level. (C) The number of bacterial genomes containing lsrB receptors and...

Additional file 4.

Abstract The protein Talin1 encoded by the TLN1 gene is a focal adhesion-related protein that binds to various cytoskeletal proteins and plays an important role in cell adhesion and movement. Recent studies have shown that it is overexpressed in prostate cancer, liver cancer, and oral squamous cell carcinoma, and is closely related to tumor progression and metastasis. This study integrated bioinformatics and functional analysis to reveal the prognosis and potential functions of TLN1 in AML....

Additional file 6: Figure S2. Distribution and abundance of AI-2 synthases and receptors based on QS in the rumen bacterial genomes. Numbers indicate the number of bacterial genomes in which the corresponding proteins were found at the genus level. The LuxS synthases, LsrB receptors, and CahR-type receptors were discovered within 88, 27, and 42 genera, respectively.

Additional file 9: Figure S4. The types of the CahR-type receptors. Numbers indicate the number of bacterial genomes in which the corresponding proteins were found. The MCPs and HKs were two dominant AI-2 receptor proteins in rumen bacteria.

Additional file 1: Figure S1. The chemical structure and corresponding mass spectrum of absorbed components in vivo.

Additional file 5: Table S1. Identification of chemical profile of BHGZD in vitro by UFLC-Q-TOF-MS/MS.

Statistical results from this study.

Statistical results from this study.

Supplemental Material for Survival comparison of different histological subtypes of oropharyngeal squamous cell carcinoma: A propensity-matched score analysis based on SEER database by Tao Li, Yi Wang, Xianwang Xiang and Chuanjun Chen in Ear, Nose & Throat Journal

Supplement 1

Additional file 2 .

Replacing traditional refractive lenses with metalenses that have ultrathin and flat architecture could make imaging systems more compact. However, the space between the lens and image is usually the dominating factor in determining the bulkiness, and it cannot be shortened just by using thinner lenses. Here, we propose a pancake metalens that folds the optical path at will using a metacavity consisting of a spin-dependent bifacial metasurface and a mirror. We first verify the asymmetric...

Supplemental Material for Modeling land-use change using partitioned vector cellular automata while considering urban spatial structure by Jing Yang, Xinyu Zhu, Wei Chen, Yizhong Sun and Jie Zhu in Environment and Planning B: Urban Analytics and City Science

Data: Files ending in _current of _future contain hydrological model output, used to caclulate continuity and connectivity metrics. File in map_stats folder contain continuity metric values. blue_fixed.rda and connectivity_wts.csv are used to calculate DCI.
Code: ConnectivityMetrics.R contains code to calculate percent wet length, number of dry fragments, and average length of dry fragments. DCI.R contains code to calculate DCI. change_dryperiodlength.R, change_dryperiods.R, and change_zeroflowdays.R contain code to calculate change in continuity metrics.

Bilateral aid procurement is politicised and strongly favours suppliers from donor countries. Does multilateral development assistance eliminate the procurement bias favouring donor countries because international bureaucrats make procurement decisions? Existing evidence from the World Bank, which delegates procurement responsibilities to aid recipient countries, cannot answer our theoretical question. Using official data from 20 UN organisations during the 2013–2018 period and applying regression and mediation analysis, we find that the procurement of international organisations still favours...