91 Works

sj-pdf-1-jfi-10.1177_0192513X211042843 – Supplemental Material for Interparental Conflict and Chinese Children’s Social Development

Fengjiao Xu, Xinyi Chen, Haiyan Xing & Hongmei Wang
Supplemental Material, sj-pdf-1-jfi-10.1177_0192513X211042843 for Interparental Conflict and Chinese Children’s Social Development by Fengjiao Xu, Xinyi Chen, Haiyan Xing and Hongmei Wang in Journal of Family Issues

Using crowdsourcing to understand patients attitudes toward a clinical trial for retinitis pigmentosa requiring 4 years of participation

Xiangrong Kong, Cory Dorfman, Susie Trotochaud, Fahd Naufal, Carl A. Latkin & Peter A. Campochiaro
Clinical trials for retinitis pigmentosa (RP) likely require long follow-ups because of the slow progression of RP. Understanding patients’ attitudes toward participation in a long trial and their acceptability of strategies aimed at promoting retention/compliance is important for assessing feasibility and resource needs and optimizing trial design. A crowdsourcing survey to adult RP patients was administered on social media in 2020 July-November. Patient enthusiasm level of study participation, acceptability of attending clinic visits every 4–5...

Improved household living standards can restore dry tropical forests

Ruth DeFries, Meghna Agarwala, Sandra Baquie, Pooja Choksi, Sarika Khanwilkar, Pinki Mondal, Harini Nagendra & Johannes Uperlainen.
Despite multiple approaches over the last several decades to harmonize conservation and development goals in the tropics, forest-depende­­­­­­nt households remain the poorest in the world. Durable housing and alternatives to fuelwood for cooking are critical needs to reduce multi-dimensional poverty. These improvements also potentially reduce pressure on forests and alleviate forest degradation. We test this possibility in dry tropical forests of the Central Indian Highlands where tribal and other marginalized populations rely on forests for...

Reliability and validity of the Korean version of the Functional Status Score for the ICU after translation and cross-cultural adaptation

Jong Geol, Gee Young Suh, Yu Hui Won, Won Hyuk Chang, Stephanie Hiser, Dale M. Needham & Chi Ryang Chung
The Functional Status Score for the Intensive Care Unit (FSS-ICU) evaluates the physical function of ICU patients. The objective of the study was to translate and cross-culturally adapt the FSS-ICU into Korean and assess its reliability and validity. An expert committee supervised the forward and backward translation process and the final translated version. Experienced physiotherapists assessed patients (n= 31) from a medical ICU using the Korean version of FSS-ICU. Intra-class correlation coefficients (ICCs) and Bland–Altman’s...

MicroRNA-146b-3p regulates the dysfunction of vascular smooth muscle cells via repressing phosphoinositide-3 kinase catalytic subunit gamma

Xijing Zhuang, Feng Gao, Lei Shi, Wei Liu, Wenjun Wang, Xuezhi He & Yang Gao
MicroRNAs are crucial regulators in the phenotype switch of vascular smooth muscle cells (VSMCs). Nonetheless, the role of miR-146b-3p in VSMCs remains unclear. In the present study, platelet-derived growth factor-BB (PDGF-BB) at different concentrations was employed to stimulate VSMCs for different times, to establish the model of VSMC dysfunction. The relative expression of miR-146b-3p was quantified by quantitative real-time polymerase chain reaction (qRT-PCR). The proliferation of VSMCs was measured by BrdU assay. Flow cytometry analysis...

Multi-omics landscape of circadian rhythm pathway alterations in Glioma

Chang Zhang, Jiahui Xu, Lijun Chen & Xiaojie Lin
Circadian rhythm pathway was demonstrated pathological functions in glioma on single-gene level. We aim to depict the multi-omics landscape of circadian rhythm pathway alteration in glioma using bioinformatic analyses. Multi-omics data were obtained from “cBioPortal” database. Comparisons were done regarding clinical parameters, differential-expressed genes and functional annotations. A pathway index was generated using the expression data from TCGA and GTEx to quantify the general alteration level of the pathway with clinical association of circadian rhythm...

Multi-omics landscape of circadian rhythm pathway alterations in Glioma

Chang Zhang, Jiahui Xu, Lijun Chen & Xiaojie Lin
Circadian rhythm pathway was demonstrated pathological functions in glioma on single-gene level. We aim to depict the multi-omics landscape of circadian rhythm pathway alteration in glioma using bioinformatic analyses. Multi-omics data were obtained from “cBioPortal” database. Comparisons were done regarding clinical parameters, differential-expressed genes and functional annotations. A pathway index was generated using the expression data from TCGA and GTEx to quantify the general alteration level of the pathway with clinical association of circadian rhythm...

Genome-wide analysis and characterization of GRAS family in switchgrass

Xiaoqin Wang, Guixia Li, Yajing Sun, Zhongyu qin & Pengcheng Feng
Panicum virgatum, a model plant of cellulosic ethanol conversion, not only has high large biomass and strong adaptability to soil, but also grows well in marginal soil and has the advantage of improving saline-alkali soil. GRAS transcription factor gene family play important roles in individual environment adaption, and these vital functions has been proved in several plants, however, the research of GRAS in the development of switchgrass (Panicum virgatum) were limited. A comprehensive study was...

MicroRNA-146a-5p enhances T helper 17 cell differentiation via decreasing a disintegrin and metalloprotease 17 level in primary sjögren’s syndrome

Xiaoyan Wang, Shaojun Xin, Youqing Wang, Duo Ju, Quan Wu, Ye Qiu, Xuemin Niu, Wei Liu, Jianyou Li & Pengtian Ji
In clinical practice, we found that microRNA (miR)-146a-5p is significantly up-regulated in peripheral blood mononuclear cells (PBMCs) of primary sjögren’s syndrome (pSS) patients. In vitro experiments confirmed that miR-146a-5p promotes T helper 17 (Th17) cell differentiation, but the specific mechanism is still unknown. To solve this problem, 20 pSS patients and 20 healthy subjects were enrolled in this study and PBMCs were isolated from their blood. The expression of the membrane IL-23 R (mIL-23 R)...

Deep neural networks easily learn unnatural infixation and reduplication patterns

Coleman Haley & Colin Wilson

Lexical strata and phonotactic perplexity minimization

Eric R. Rosen

Multiple cropping alone does not improve year-round food security among smallholders in rural India

Pinki Mondal, Ruth DeFries, Jessica Clark, Nicole Flowerhill, , Aurélie Harou, Shauna Downs & Jessica Fanzo
Achieving and maintaining food and nutrition security is an important Sustainable Development Goal (SDG), especially in countries with largely vulnerable population with high occurrence of hunger and malnutrition. By studying a small-scale agricultural system in India, we aim to understand the current state of dietary diversity and food insecurity among the farmer communities. The study landscape has witnessed a steady rise in multiple cropping along with irrigation over the last two decades. Whether this multiple...

Adaptation without specialization early in a host shift: fecundity data

Rafael Rodriguez, Thomas Wood, Frank Stearns, Robert Snyder, Kelley Tilmon, Michael Cast, Randy Hunt & Reginald Cocroft
Students of speciation debate the role of performance trade-offs across different environments early in speciation. We tested for early performance trade-offs with a host shift experiment using a member of the Enchenopa binotata species complex of treehoppers (Hemiptera: Membracidae). In this clade of plant-feeding insects, different species live on different host plants and exhibit strong behavioral and physiological host specialization. After five generations, the experimental host shifts resulted either in no adaptation or in adaptation...

Serotonin neurons modulate learning rate through uncertainty

Jeremiah Cohen, Cooper Grossman & Bilal Bari
Regulating how fast to learn is critical for flexible behavior. Learning about the consequences of actions should be slow in stable environments, but accelerate when that environment changes. Recognizing stability and detecting change is difficult in environments with noisy relationships between actions and outcomes. Under these conditions, theories propose that uncertainty can be used to modulate learning rates ("meta-learning"). We show that mice behaving in a dynamic foraging task exhibit choice behavior that varied as...

The effect of amiloride in decreasing albuminuria in patients with diabetic kidney diseases: a prospective, crossover, open-label study

Ruizhao Li, Zhiyong Xie, Li Zhang, Ying Huang, Jianchao Ma, Wei Dong, Zhilian Li, Yuanhan Chen, Huaban Liang, Yanhua Wu, Xingchen Zhao, Wenjian Wang, Zhiming Ye, Shuangxin Liu, Wei Shi & Xinling Liang
Diabetic kidney diseases (DKD) were the leading cause of End-stage renal diseases worldwide. Albuminuria was a target for treatment in DKD and decreasing albuminuria was particularly important for improving its prognosis. However, there is still a lack of specific treatment for DKD. We conducted a prospective, crossover, open-label study to investigate the effect of amiloride in patients with DKD. Safety and efficacy were assessed by monitoring urine protein creatinine ratio(uPCR), urinary albumin creatinine ratio (uACR),...

Clinical outcomes, quality of life, and costs evaluation of peritoneal dialysis management models in Shanghai Songjiang District: a multi-center and prospective cohort study

Xiaoyan Ma, Min Tao, Yan Hu, Lunxian Tang, Jiasun Lu, Yingfeng Shi, Hui Chen, Si Chen, Yi Wang, Binbin Cui, Lin Du, Weiwei Liang, Guansen Huang, Xun Zhou, Andong Qiu, Shougang Zhuang, Xiujuan Zang & Na Liu
Background: The new Family-Community-Hospital (FCH) three-level comprehensive management aimed to improve the efficiency and scale of peritoneal dialysis (PD) to meet the increased population of end-stage renal disease (ESRD). Our study focused on the clinical outcomes, quality of life, and costs evaluation of this model in a multi-center and prospective cohort study. Methods: A total of 190 ESRD patients who commenced PD at Shanghai Songjiang District were enrolled. According to different PD management models, patients...

Dynamics in perioperative neutrophil-to-lymphocyte*platelet ratio as a predictor of early acute kidney injury following cardiovascular surgery

Yang Li, Zhouping Zou, Yunlu Zhang, Bowen Zhu, Yichun Ning, Bo Shen, Chunsheng Wang, Zhe Luo, Jiarui Xu & Xiaoqiang Ding
In this study, we applied a composite index of neutrophil-lymphocyte * platelet ratio (NLPR), and explore the significance of the dynamics of perioperative NLPR in predicting cardiac surgery-associated acute kidney injury (CSA-AKI). During July 1st and December 31th 2019, participants were prospectively derived from the ‘Zhongshan Cardiovascular Surgery Cohort’. NLPR was determined using neutrophil counts, lymphocyte and platelet count at the two-time points. Dose-response relationship analyses were applied to delineate the non-linear odds ratio (OR)...

Cataract Surgery Numbers in U.S. Ophthalmology Residency Programs: An ACGME Case Log Analysis

Brittany C. Tsou, Hursuong Vongsachang, Boonkit Purt, Divya Srikumaran, Grant A. Justin & Fasika A. Woreta
To describe and assess the cataract experience of ophthalmology residents throughout the United States (U.S.). Cataract procedures logged by graduating ophthalmology residents nationwide and published by the Accreditation Council for Graduate Medical Education (ACGME) from 2009 to 2020 were analyzed using linear regression on log-transformed response variables with robust variance. As primary surgeon, average numbers logged for phacoemulsification increased yearly by an average of 4.1% prior to 2019 and then decreased by 22.1% in 2019...

Transcriptional dynamics of transposable elements when converting fibroblast cells of Macaca mulatta to neuroepithelial stem cells

Dahai Liu, Li Liu, Kui Duan, Junqiang Guo, Shipeng Li, Zhigang Zhao, Xiaotuo Zhang, Nan Zhou & Yun Zheng
Abstract Background Transposable elements (TE) account for more than 50% of human genome. It has been reported that some types of TEs are dynamically regulated in the reprogramming of human cell lines. However, it is largely unknown whether some TEs in Macaca mulatta are also regulated during the reprogramming of cell lines of monkey. Results Here, we systematically examined the transcriptional activities of TEs during the conversion of Macaca mulatta fibroblast cells to neuroepithelial stem...

sj-pdf-1-jfi-10.1177_0192513X211042843 – Supplemental Material for Interparental Conflict and Chinese Children’s Social Development

Fengjiao Xu, Xinyi Chen, Haiyan Xing & Hongmei Wang
Supplemental Material, sj-pdf-1-jfi-10.1177_0192513X211042843 for Interparental Conflict and Chinese Children’s Social Development by Fengjiao Xu, Xinyi Chen, Haiyan Xing and Hongmei Wang in Journal of Family Issues

Stakeholders’ Perceptions of a School-Based Eye Care Programme in Baltimore, MD

Alyssa M. Kretz, Hursuong Vongsachang, David S. Friedman, Jonathan Callan, Madison Wahl, M. Rani Mukherjee, Amanda Neitzel & Megan E. Collins
To explore stakeholders’ perceptions of a school-based vision programme (SBVP). We conducted 20 focus groups with 105 parents and teachers at schools in Baltimore, MD, that participated in a SBVP. Facilitators used a semi-structured interview guide to discuss participants’ perceptions of the SBVP. Focus groups were audio-recorded, transcribed, and coded using inductive thematic analysis. Participant perceptions fell into three categories: benefits of school-based eye care, limitations of school-based eye care, and observation of impact. The...

Performance of a validated spontaneous preterm delivery predictor in South Asian and Sub-Saharan African women: a nested case control study

Rasheda Khanam, Tracey C. Fleischer, Nansi S. Boghossian, Imran Nisar, Usha Dhingra, Sayedur Rahman, Angela C. Fox, Muhammad Ilyas, Arup Dutta, Nurun Naher, Ashoka D. Polpitiya, Usma Mehmood, Saikat Deb, Aziz Ahmed Choudhury, Md. Bahadur Badsha, Karim Muhammad, Said Mohammed Ali, Salahuddin Ahmed, Durlin E. Hickok, Najeeha Iqbal, Mohammed Hamad Juma, Md. Abdul Quaiyum, J. Jay Boniface, Sachiyo Yoshida, Alexandar Manu … & Abdullah H. Baqui
To address the disproportionate burden of preterm birth (PTB) in low- and middle-income countries, this study aimed to (1) verify the performance of the United States-validated spontaneous PTB (sPTB) predictor, comprised of the IBP4/SHBG protein ratio, in subjects from Bangladesh, Pakistan and Tanzania enrolled in the Alliance for Maternal and Newborn Health Improvement (AMANHI) biorepository study, and (2) discover biomarkers that improve performance of IBP4/SHBG in the AMANHI cohort. The performance of the IBP4/SHBG biomarker...

MicroRNA-146a-5p enhances T helper 17 cell differentiation via decreasing a disintegrin and metalloprotease 17 level in primary sjögren’s syndrome

Xiaoyan Wang, Shaojun Xin, Youqing Wang, Duo Ju, Quan Wu, Ye Qiu, Xuemin Niu, Wei Liu, Jianyou Li & Pengtian Ji
In clinical practice, we found that microRNA (miR)-146a-5p is significantly up-regulated in peripheral blood mononuclear cells (PBMCs) of primary sjögren’s syndrome (pSS) patients. In vitro experiments confirmed that miR-146a-5p promotes T helper 17 (Th17) cell differentiation, but the specific mechanism is still unknown. To solve this problem, 20 pSS patients and 20 healthy subjects were enrolled in this study and PBMCs were isolated from their blood. The expression of the membrane IL-23 R (mIL-23 R)...

Nucleolar protein NOP2 could serve as a potential prognostic predictor for clear cell renal cell carcinoma

Gang Wang, Fangfang Qu, Shouyong Liu, Jincai Zhou & Yi Wang
As an indispensable part for cancer precision medicine, biomarkers and signatures for predicting cancer prognosis and therapeutic benefits were urgently required. The purpose of this study was to investigate the prognostic roles of NOP2 in renal clear cell carcinoma (ccRCC) for overall survival (OS) and its relationships with immunity. NOP2-related gene expression matrix associated with clinical information was obtained from the Cancer Genome Atlas (TCGA) ccRCC dataset and NOP2-related pathways were identified by gene set...

Nucleolar protein NOP2 could serve as a potential prognostic predictor for clear cell renal cell carcinoma

Gang Wang, Fangfang Qu, Shouyong Liu, Jincai Zhou & Yi Wang
As an indispensable part for cancer precision medicine, biomarkers and signatures for predicting cancer prognosis and therapeutic benefits were urgently required. The purpose of this study was to investigate the prognostic roles of NOP2 in renal clear cell carcinoma (ccRCC) for overall survival (OS) and its relationships with immunity. NOP2-related gene expression matrix associated with clinical information was obtained from the Cancer Genome Atlas (TCGA) ccRCC dataset and NOP2-related pathways were identified by gene set...

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  • 2021
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Affiliations

  • Johns Hopkins University
    91
  • Fudan University
    35
  • Sichuan University
    32
  • Chinese Academy of Medical Sciences & Peking Union Medical College
    32
  • Capital Medical University
    31
  • Zhejiang University
    29
  • Huazhong University of Science and Technology
    29
  • Sun Yat-sen University
    26
  • Shanghai Jiao Tong University
    21
  • Southern Medical University
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