Biologists recognize the Caribbean archipelago as a biodiversity hotspot and employ it for their research as a “natural laboratory”, but do not always appreciate that these ecosystems are in fact palimpsests shaped by multiple human cultures over millennia. We discuss two case studies of the Caribbean’s fragmented natural history collections, the effects of differing legislation and governance by the region’s multiple nation states. We use digital natural history specimen data from GBIF to demonstrate how...
Introduction Mobile health (mHealth) applications may improve timely access to health services and improve patient-provider communication, but the upfront costs of implementation may be prohibitive, especially in resource-limited settings. Methods We measured the costs of developing and implementing an mHealth-facilitated, home-based strategy for tuberculosis (TB) contact investigation (CI) in Kampala, Uganda, between February 2014 and July 2017. We compared routine implementation involving community health workers (CHWs) screening and referring household contacts to clinics for TB...
Surprisingly, despite its immediate relevance to metacognition and theory of mind, little research has focused on quantifying pretense accuracy, relative to non-pretense behaviour. In previous experiments, we examined the ability to both produce and detect pretense behaviour using the game “Battleship” — normally played by searching for ships hidden behind cells in a grid. Here, we test the generalizability of our findings to a game where players reveal a hidden word by guessing letters (“Hangman”).
Data from: Benchmarking ultra-high molecular weight DNA preservation methods for long-read and long-range sequencingHollis Dahn, Jacquelyn Mountcastle, Jennifer Balacco, Sylke Winkler, Iliana Bista, Anthony Schmitt, Olga Vinnere Pettersson, Giulio Formenti, Karen Oliver, Michelle Smith, Wenhua Tan, Anne Kraus, Stephen Mac, Lisa Komoroske, Tanya Lama, Andrew Crawford, Robert Murphy, Samara Brown, Alan Scott, Phillip Morin, Erich Jarvis & Olivier Fedrigo
Studies in vertebrate genomics require sampling from a broad range of tissue types, taxa, and localities. Recent advancements in long-read and long-range genome sequencing have made it possible to produce high-quality chromosome-level genome assemblies for almost any organism. However, adequate tissue preservation for the requisite ultra-high molecular weight DNA (uHMW DNA) remains a major challenge. Here we present a comparative study of preservation methods for field and laboratory tissue sampling, across vertebrate classes and different...
Senescent preosteoclast secretome promotes metabolic syndrome-associated osteoarthritis through COX2-PGE2Weiping Su
Metabolic syndrome–associated osteoarthritis (MetS-OA) is a distinct osteoarthritis phenotype defined by the coexistence of MetS or its individual components. Despite the high prevalence of MetS-OA, its pathogenic mechanisms are unclear. Here, we report that humans and mice with MetS are more likely to develop osteoarthritis-related subchondral bone alterations than those without MetS. MetS-OA mice exhibited a rapid increase in joint subchondral bone plate and trabecular thickness before articular cartilage degeneration. Subchondral preosteoclasts undergo senescence at...
PTEN is a phosphatidylinositol-3,4,5-triphosphate (PIP3) phospholipid phosphatase that is commonly mutated or silenced in cancer. PTEN's catalytic activity, cellular membrane localization, and stability are orchestrated by a cluster of C-terminal phosphorylation events on Ser380, Thr382, Thr383, and Ser385, but the molecular details of this multifaceted regulation have remained uncertain. Here we use a combination of protein semisynthesis, biochemical analysis, NMR, X-ray crystallography, and computational simulations on human PTEN and its sea squirt homolog VSP to...
Are the Subjective Effects of Psychedelics Necessary for Their Enduring Therapeutic Effects? A conversation with David E. Olson and David B. Yaden hosted by George FejerDavid E. Olson, David B. Yaden & Fejer George
ALIUS recently invited Dr. David E. Olson and Dr. David B. Yaden to discuss whether or not the subjective effects of psychedelics are necessary for their enduring therapeutic benefit in an interactive online discussion. The aim of this discussion is to examine their most recent back-to-back publication wherein Yaden & Griffiths (2021) emphasized the subjective effects of psychedelics, such as mystical experiences, in relation to their long-lasting therapeutic effects, whereas Olson (2021) emphasized that there...
Johns Hopkins University10
University of Massachusetts Amherst1
Antiquities, Monuments and Museum Corporation1
The University of Texas at Austin1
Arima Genomics (United States)1
University of Minnesota1
Simon Fraser University1
University of Oregon1
Dana-Farber Cancer Institute1