126 Works

Landscape of tissue-specific RNA Editome provides insight into co-regulated and altered gene expression in pigs (Sus-scrofa)

A.ADETULA ET AL. Abiola Adetula, Xinhao Fan, Yongsheng Zhang, Yilong Yao, Junyu Yan, Muya Chen, Yijie Tang, Yuwen Liu, Guoqiang Yi, Kui Li & Zhonglin Tang
RNA editing generates genetic diversity in mammals by altering amino acid sequences, miRNA targeting site sequences, influencing the stability of targeted RNAs, and causing changes in gene expression. However, the extent to which RNA editing affect gene expression via modifying miRNA binding site remains unexplored. Here, we first profiled the dynamic A-to-I RNA editome across tissues of Duroc and Luchuan pigs. The RNA editing events at the miRNA binding sites were generated. The biological function...

Kinesin family member 3C (KIF3C) is a novel non-small cell lung cancer (NSCLC) oncogene whose expression is modulated by microRNA-150-5p (miR-150-5p) and microRNA-186-3p (miR-186-3p)

Haiwang Liu, Ran Liu, Meiling Hao, Xing Zhao & Chunhui Li
This study is aimed at investigating the biological function of kinesin family member 3 C (KIF3C) in non-small cell lung cancer (NSCLC) progression and its upstream regulatory mechanism. Quantitative real-time PCR, Western blot and immunohistochemistry were adopted to examine microRNA-150-5p (miR-150-5p), microRNA-186-3p (miR-186-3p) and kinesin family member 3 C (KIF3C) expression levels. NSCLC cell proliferation, migration, and invasion were detected through cell counting kit-8 (CCK-8) assay, EdU assay, and Transwell assay. The metastasis of NSCLC...

Increased production of 8-oxo-7,8-dihydroguanine in human urine, a novel biomarker of osteoporosis

Qian Liu, Zhen Liu, Chen-Chen Wang, Xin Gao, Chuan-Bao Li, Meng Wang, Qiang Wang & Jian-Ping Cai
Osteoporosis is a worldwide disease that seriously affects the quality of life and survival rate of the elderly. The detection of bone biomarkers will provide supplementary information on bone mineral density, contributing to the accurate diagnosis of osteoporosis and better health care for prevention. This study aimed to investigate the efficacy of oxidative stress markers—8-oxo-7,8-dihydroguanine (8-oxoGsn) and 8-oxo-7,8-dihydro-2′-deoxyguanosine (8-oxodGsn) in the assessment of osteoporosis. We conducted a cross-sectional study among menopausal women with a mean...

Additional file 1 of Implantation of adipose-derived mesenchymal stem cell sheets promotes axonal regeneration and restores bladder function after spinal cord injury

Jiasheng Chen, Lin Wang, Meng Liu, Guo Gao, Weixin Zhao, Qiang Fu & Ying Wang
Additional file 1: Table S1. Primers used for PCR analysis.

Additional file 7 of Genome-wide identification and characterization of lncRNAs in sunflower endosperm

Shuai Yu, Zhichao Zhang, Jing Li, Yanbin Zhu, Yanzhe Yin, Xiaoyu Zhang, Yuxin Dai, Ao Zhang, Cong Li, Yanshu Zhu, Jinjuan Fan, Yanye Ruan & Xiaomei Dong
Additional file 7: Fig. S4. DNA methylation profiles of protein-coding genes (PCgenes) in sunflower endosperm from SY1.

Additional file 1 of Bacterial communities in co-cultured fish intestines and rice field soil irrigated with aquaculture wastewater

Weibing Guan, Kui Li & Kejun Li
Additional file 1: Figure S1. Location of sampling sites.

Additional file 12 of Genome-wide identification and characterization of lncRNAs in sunflower endosperm

Shuai Yu, Zhichao Zhang, Jing Li, Yanbin Zhu, Yanzhe Yin, Xiaoyu Zhang, Yuxin Dai, Ao Zhang, Cong Li, Yanshu Zhu, Jinjuan Fan, Yanye Ruan & Xiaomei Dong
Additional file 12: Table S7. GO Gene Ontology analysis of co-expressed protein-coding genes with lncRNAs of allelic bias toward cultivated lines for oil.

Additional file 11 of Genome-wide identification and characterization of lncRNAs in sunflower endosperm

Shuai Yu, Zhichao Zhang, Jing Li, Yanbin Zhu, Yanzhe Yin, Xiaoyu Zhang, Yuxin Dai, Ao Zhang, Cong Li, Yanshu Zhu, Jinjuan Fan, Yanye Ruan & Xiaomei Dong
Additional file 11: Table S6. GO Gene Ontology analysis of co-expressed protein-coding genes with lncRNAs of allelic bias toward cultivated lines for edible fruit.

Additional file 2 of Bacterial communities in co-cultured fish intestines and rice field soil irrigated with aquaculture wastewater

Weibing Guan, Kui Li & Kejun Li
Additional file 2: Figure S2. Community heatmap showing the top 50 genera.

Additional file 3 of Bacterial communities in co-cultured fish intestines and rice field soil irrigated with aquaculture wastewater

Weibing Guan, Kui Li & Kejun Li
Additional file 3: Figure S3. Venn diagrams showing the number of shared bacterial genera by soil and intestinal bacterial communities in each carp species.

Bacterial communities in co-cultured fish intestines and rice field soil irrigated with aquaculture wastewater

Weibing Guan, Kui Li & Kejun Li
Abstract In some regions, integrated rice-fish farms have been developed to balance the needs of aquaculture wastewater discharge and rice field irrigation. In this type of aqua-agriculture system, soil is irrigated with aquaculture wastewater, and intestinal bacteria in cultured fish species likely impact soil bacteria through irrigation. However, little is known about the relationship between soil bacteria and intestinal bacteria in some carp species commonly co-cultured in some Asian regions. Therefore, we co-cultured five carp...

Giant enhancement of acoustic and fluorescence emission from an off-axis reflective femtosecond laser filamentation system

Shishi Tao, Bofu Xie, Jiayun Xue, Zhi Zhang, Zhang Nan, Lanjun Guo, Lie Lin, Pengfei Qi, Xing Zhao & Weiwei Liu
Femtosecond laser filamentation propagating tens of meters to several kilometers with high intensity in the atmosphere has been demonstrated as a powerful tool for remote sensing. In contrast to the refractive systems, the reflective optical systems possess a variety of advantages including broad bandwidth, large aperture, light weight and low energy loss. However, astigmatic aberration is inevitably introduced by off-axis reflective mirrors. It can greatly affect the filament quality, which is critical for exciting and...

Supplementary document for Significant performance enhancement of UV-Vis self-powered CsPbBr₃ quantum dots photodetectors induced by ligand modification and P3HT embedding - 5987985.pdf

Meng Wang, Dehai Liang, Wen Ma, Qionghua Mo, Zhigang Zang, Qingkai Qian & wensi cai
The experiment and results.

Significant performance enhancement of UV-Vis self-powered CsPbBr3 quantum dot-based photodetectors induced by ligand modification and P3HT embedding

Meng Wang, Dehai Liang, Wen Ma, Qionghua Mo, Zhigang Zang, Qingkai Qian & wensi cai
In this work, we report a novel strategy in improving the performance of UV-Vis self-powered CsPbBr₃ quantum dots (QDs) photodetectors (PDs) by ligand modification and P3HT embedding. Compared with those based on pure QDs, modified PDs show a shorten of response time by nearly 10 times, and an increase of maximum responsivity and specific detectivity for nearly 45 and 97 times, respectively. Such PDs also show a high stability with 90% of the initial photocurrent...

Significant performance enhancement of UV-Vis self-powered CsPbBr3 quantum dot-based photodetectors induced by ligand modification and P3HT embedding

Meng Wang, Dehai Liang, Wen Ma, Qionghua Mo, Zhigang Zang, Qingkai Qian & wensi cai
In this work, we report a novel strategy in improving the performance of UV-Vis self-powered CsPbBr₃ quantum dots (QDs) photodetectors (PDs) by ligand modification and P3HT embedding. Compared with those based on pure QDs, modified PDs show a shorten of response time by nearly 10 times, and an increase of maximum responsivity and specific detectivity for nearly 45 and 97 times, respectively. Such PDs also show a high stability with 90% of the initial photocurrent...

Dementia risk prediction in individuals with mild cognitive impairment: a comparison of Cox regression and machine learning models

Meng Wang, Matthew Greenberg, Nils D. Forkert, Thierry Chekouo, Gabriel Afriyie, Zahinoor Ismail, Eric E. Smith & Tolulope T. Sajobi
Abstract Background Cox proportional hazards regression models and machine learning models are widely used for predicting the risk of dementia. Existing comparisons of these models have mostly been based on empirical datasets and have yielded mixed results. This study examines the accuracy of various machine learning and of the Cox regression models for predicting time-to-event outcomes using Monte Carlo simulation in people with mild cognitive impairment (MCI). Methods The predictive accuracy of nine time-to-event regression...

CCK regulates osteogenic differentiation through TNFα/NF-κB in peri-implantitis

LongHang Chou, YaTing Chang, KaiWen Lan, Meng Liu, YuKun Lu, XiaoLei Li, PeiRu Li & Yue Xu
ObjectivePeri-implantitis is characterized by peri-implant mucositis and alveolar bone resorption. This study investigated cholecystokinin (CCK) expression and the mechanism underlying its involvement in peri-implantitis.MethodsmRNA sequencing was performed using the Gene Expression Omnibus database GSE106090. Human bone marrow mesenchymal stem cells (hBMSCs) were pretreated with various concentrations of CCK (0, 10, 30, or 100 nM) for 1 hour before induction in osteogenic differentiation medium for 2 weeks. Alkaline phosphatase (ALP) activity was determined, and the cells...

Additional file 1 of Genome-wide screening for differentially methylated long noncoding RNAs identifies LIFR-AS1 as an epigenetically regulated lncRNA that inhibits the progression of colorectal cancer

Peng Song, Ying Li, Feng Wang, Lingxiao Pu, Linsen Bao, Hengfei Gao, Chuandong Zhu, Meng Wang & Liang Tao
Additional file 1: Figure S1. Pie chart shows the number of differentially expressed lncRNAs in each category.

The effect of a single escalating dose of long-acting recombinant human follicle-stimulating hormone Fc fusion protein (KN015) on healthy, pituitary-suppressed women: first-in-human and randomized study on its pharmacokinetics, pharmacodynamics, and tolerability

Hong Zhang, Yanyan Fan, Lei Gao, Boguang Wang, Ting Xu, Min Wu, Jingrui Liu, Xiaoxue Zhu, Xiaojiao Li, Hong Chen, Cuiyun Li, Meng Wang, Chengjiao Liu, Yanhong Mao, Mingtang Yang & Yanhua Ding
KN015 is a long-acting, recombinant human follicle-stimulating hormone Fc fusion protein that induces follicle development. This first-in-human study evaluated the effect of KN015 on healthy, pituitary-suppressed women and examined its pharmacokinetics, pharmacodynamics, and tolerability. This phase I study was a double-blind, randomized, and placebo-controlled design with a single ascending dose (20, 40, and 60 μg, respectively). After subcutaneous administration of a single dose, the maximum serum KN015 concentrations reached 1.57, 2.78, and 3.62 ng/mL, respectively,...

Additional file 1 of Analysis of long non-coding RNA expression profile of bovine monocyte-macrophage infected by Mycobacterium avium subsp. paratuberculosis

Yanhong Bao, Shuiyin Wu, Tianze Yang, Zi Wang, Yiming Wang, Xiuyun Jiang & Hongxia Ma
Additional file 1.

sj-xlsx-1-imr-10.1177_03000605221141312 - Supplemental material for CCK regulates osteogenic differentiation through TNFα/NF-κB in peri-implantitis

LongHang Chou, YaTing Chang, KaiWen Lan, Meng Liu, YuKun Lu, XiaoLei Li, PeiRu Li & Yue Xu
Supplemental material, sj-xlsx-1-imr-10.1177_03000605221141312 for CCK regulates osteogenic differentiation through TNFα/NF-κB in peri-implantitis by LongHang Chou, YaTing Chang, KaiWen Lan, Meng Liu, YuKun Lu, XiaoLei Li, PeiRu Li and Yue Xu in Journal of International Medical Research

Nanomedicines in oral cancer: inspiration comes from extracellular vesicles and biomimetic nanoparticles - Supplementary dataset

Yu-Ting Bai, Xue-Qiong Zhang, Xiao-Jie Chen & Gang Zhou
Oral cancer is a common life-threatening malignancy having high mortality and morbidity rates. During the treatment process, individuals unavoidably experience severe side effects. It is essential to develop safer and more effective strategies. Currently, extracellular vesicles (EVs) and biomimetic nanoparticles are nanomedicines with long-term blood circulation and lower off-target toxicity that orchestrate immune responses and accumulate specifically in tumor sites. EVs create a synergetic effect by encapsulating drugs and collaborating with naturally loaded elements in...

sj-docx-1-jbr-10.1177_07487304221141939 – Supplemental material for Validation of the Self-Rating of Biological Rhythm Disorder for Adolescents (SBRDA) Scale by Dim Light Melatonin Onset in Healthy Young Adults

Yang Xie, Xiaoyan Wu, Xingyue Mou, Meng Wang, Shuman Tao, Yuhui Wan & Fangbiao Tao
Supplemental material, sj-docx-1-jbr-10.1177_07487304221141939 for Validation of the Self-Rating of Biological Rhythm Disorder for Adolescents (SBRDA) Scale by Dim Light Melatonin Onset in Healthy Young Adults by Yang Xie, Xiaoyan Wu, Xingyue Mou, Meng Wang, Shuman Tao, Yuhui Wan and Fangbiao Tao in Journal of Biological Rhythms

Validation of the Self-Rating of Biological Rhythm Disorder for Adolescents (SBRDA) Scale by Dim Light Melatonin Onset in Healthy Young Adults

Yang Xie, Xiaoyan Wu, Xingyue Mou, Meng Wang, Shuman Tao, Yuhui Wan & Fangbiao Tao
Understanding the biological rhythms that influence young adult health is vital because the combination of biological changes and a circadian phase delay lead to young adults being at high risk of circadian misalignment. We have previously established a self-rating of biological rhythm disorder for adolescents (SBRDA). However, we did not externally validate the SBRDA against objective measures of biological rhythms such as dim light melatonin onset (DLMO)—the gold standard of the endogenous circadian phase. The...

Comprehensive analysis of pivotal biomarkers, immune cell infiltration and therapeutic drugs for steroid-induced osteonecrosis of the femoral head

Bo Wang, Song Gong, Wenkai Shao, Lizhi Han, Zilin Li, Zhichao Zhang, Yang Zheng, Fang Ouyang, Yan Ma, Weihua Xu & Yong Feng
Steroid-induced osteonecrosis of the femoral head (SONFH) is a progressive disease that leads to an increased disability rate. This study aimed to ascertain biomarkers, infiltrating immune cells, and therapeutic drugs for SONFH. The gene expression profile of the GSE123568 dataset was downloaded from the Gene Expression Omnibus (GEO) database. The differentially expressed genes (DEGs) were identified using the NetworkAnalyst platform. Functional enrichment, protein-protein interaction network (PPI), and module analyses were performed using Metascape tools. An...

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  • Shanghai Jiao Tong University
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  • First Affiliated Hospital of Zhengzhou University
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