3 Works

Data from: Fetal genome profiling at 5 weeks of gestation after noninvasive isolation of trophoblast cells from the endocervical canal

Chandni V. Jain, Leena Kadam, Marie Van Dijk, Hamid-Reza Kohan-Ghad, Brian A. Kilburn, Craig Hartman, Vicki Mazzorana, Allerdien Visser, Michael Hertz, Alan D. Bolnick, Rani Fritz, D. Randall Armant & Sascha Drewlo
Single-gene mutations account for more than 6000 diseases, 10% of all pediatric hospital admissions, and 20% of infant deaths. Down syndrome and other aneuploidies occur in more than 0.2% of births worldwide and are on the rise because of advanced reproductive age. Birth defects of genetic origin can be diagnosed in utero after invasive extraction of fetal tissues. Noninvasive testing with circulating cell-free fetal DNA is limited by a low fetal DNA fraction. Both modalities...

Data from: Impacts of dispersal on rapid adaptation and dynamic stability of Daphnia in fluctuating environments

Christopher F. Steiner, Richard D. Stockwell, Monica Tadros, Laith Shaman, Komal Patel & Laila Khraizat
Prior ecological research has shown that spatial processes can enhance the temporal stability of populations in fluctuating environments. Less explored is the effect of dispersal on rapid adaptation and its concomitant impact on population dynamics. For asexually reproducing populations, theory predicts that dispersal in fluctuating environments can facilitate asynchrony among clones and enhance stability by reducing temporal variability of total population abundance. This effect is predicted when clones exhibit heritable variation in environmental optima and...

Data from: Regulation of HBEGF by micro-RNA for survival of developing human trophoblast cells

Chandni V. Jain, Philip Jessmon, Brian A. Kilburn, Meritxell Jodar, Edward Sendler, Stephen A. Krawetz & D. Randall Armant
Introduction: The growth factor HBEGF is upregulated post-transcriptionally in the low O2 environment of the human placenta during the first 10 weeks of pregnancy. We have examined the possible roles of HBEGF turnover and micro-RNA (miRNA) in its regulation by O2 in human first trimester trophoblast. Methods: HTR-8/SVneo trophoblast cells were cultured at 2% or 20% O2. The cells were transfected with a dual luciferase reporter construct (psiCHECK-2) containing no insert (control), the HBEGF 3’...

Registration Year

  • 2016

Resource Types

  • Dataset


  • Wayne State University
  • VU University Medical Center
  • National Institute of Child Health and Human Development