8 Works

Data from: Using routinely collected laboratory data to identify high rifampicin-resistant tuberculosis burden communities in the Western Cape Province, South Africa: a retrospective spatiotemporal analysis

Avery I. McIntosh, Helen E. Jenkins, Laura F. White, Marinus Barnard, Dana Thompson, Tania Dolby, John Simpson, Elizabeth M. Streicher, Mary B. Kleinman, Elizabeth J. Ragan, Paul D. Van Helden, Megan B. Murray, Robin M. Warren & Karen R. Jacobson
Background: South Africa has the highest tuberculosis incidence globally (781/100,000), with an estimated 4.3% of cases being rifampicin resistant (RR). Control and elimination strategies will require detailed spatial information to understand where drug-resistant tuberculosis exists and why it persists in those communities. We demonstrate a method to enable drug-resistant tuberculosis monitoring by identifying high-burden communities in the Western Cape Province using routinely collected laboratory data. Methods and findings: We retrospectively identified cases of microbiologically confirmed...

Additional file 1 of Methods for handling missing data in serially sampled sputum specimens for mycobacterial culture conversion calculation

Samantha Malatesta, Isabelle R. Weir, Sarah E. Weber, Tara C. Bouton, Tara Carney, Danie Theron, Bronwyn Myers, C. Robert Horsburgh, Robin M. Warren, Karen R. Jacobson & Laura F. White
Additional file 1.

Additional file 1 of Methods for handling missing data in serially sampled sputum specimens for mycobacterial culture conversion calculation

Samantha Malatesta, Isabelle R. Weir, Sarah E. Weber, Tara C. Bouton, Tara Carney, Danie Theron, Bronwyn Myers, C. Robert Horsburgh, Robin M. Warren, Karen R. Jacobson & Laura F. White
Additional file 1.

Additional file 2 of Methods for handling missing data in serially sampled sputum specimens for mycobacterial culture conversion calculation

Samantha Malatesta, Isabelle R. Weir, Sarah E. Weber, Tara C. Bouton, Tara Carney, Danie Theron, Bronwyn Myers, C. Robert Horsburgh, Robin M. Warren, Karen R. Jacobson & Laura F. White
Additional file 2.

Methods for handling missing data in serially sampled sputum specimens for mycobacterial culture conversion calculation

Samantha Malatesta, Isabelle R. Weir, Sarah E. Weber, Tara C. Bouton, Tara Carney, Danie Theron, Bronwyn Myers, C. Robert Horsburgh, Robin M. Warren, Karen R. Jacobson & Laura F. White
Abstract Background The occurrence and timing of mycobacterial culture conversion is used as a proxy for tuberculosis treatment response. When researchers serially sample sputum during tuberculosis studies, contamination or missed visits leads to missing data points. Traditionally, this is managed by ignoring missing data or simple carry-forward techniques. Statistically advanced multiple imputation methods potentially decrease bias and retain sample size and statistical power. Methods We analyzed data from 261 participants who provided weekly sputa for...

Data from: Two-year impact of community-based health screening and parenting groups on child development in Zambia: follow-up to a cluster-randomized controlled trial

Peter C. Rockers, Arianna Zanolini, Bowen Banda, Mwaba Moono Chipili, Robert C. Hughes, Davidson H. Hamer & G√ľnther Fink
Background: Early childhood interventions have potential to offset the negative impact of early adversity. We evaluated the impact of a community-based parenting group intervention on child development in Zambia. Methods and Findings: We conducted a non-masked cluster-randomized controlled trial in Southern Province, Zambia. Thirty clusters of villages were matched based on population density and distance from the nearest health center, and randomly assigned to intervention (15 clusters, 268 caregiver-child dyads) or control (15 clusters, 258...

Additional file 2 of Methods for handling missing data in serially sampled sputum specimens for mycobacterial culture conversion calculation

Samantha Malatesta, Isabelle R. Weir, Sarah E. Weber, Tara C. Bouton, Tara Carney, Danie Theron, Bronwyn Myers, C. Robert Horsburgh, Robin M. Warren, Karen R. Jacobson & Laura F. White
Additional file 2.

Methods for handling missing data in serially sampled sputum specimens for mycobacterial culture conversion calculation

Samantha Malatesta, Isabelle R. Weir, Sarah E. Weber, Tara C. Bouton, Tara Carney, Danie Theron, Bronwyn Myers, C. Robert Horsburgh, Robin M. Warren, Karen R. Jacobson & Laura F. White
Abstract Background The occurrence and timing of mycobacterial culture conversion is used as a proxy for tuberculosis treatment response. When researchers serially sample sputum during tuberculosis studies, contamination or missed visits leads to missing data points. Traditionally, this is managed by ignoring missing data or simple carry-forward techniques. Statistically advanced multiple imputation methods potentially decrease bias and retain sample size and statistical power. Methods We analyzed data from 261 participants who provided weekly sputa for...

Registration Year

  • 2022
    6
  • 2018
    2

Resource Types

  • Text
    4
  • Collection
    2
  • Dataset
    2

Affiliations

  • Boston Medical Center
    8
  • Boston University
    8
  • Stellenbosch University
    7
  • Groote Schuur Hospital
    6
  • Curtin University
    6
  • University of Cape Town
    6
  • Harvard University
    6
  • South African Medical Research Council
    6
  • National Health Laboratory Service
    1
  • University of Basel
    1