7 Works

Data from: Control of proline accumulation under drought via a novel pathway comprising the histone methylase CAU1 and the transcription factor ANAC055

Yanlei Fu, Hailing Ma, Siying Chen, Tianyu Gu & Jiming Gong
Proline plays a crucial role in the drought stress response in plants. However, there are still gaps in our knowledge about the molecular mechanisms that regulate proline metabolism under drought stress. Here, we report that the histone methylase encoded by CAU1, which is genetically upstream of P5CS1 (encoding the proline biosynthetic enzyme Δ1-pyrroline-5-carboxylate synthetase 1), plays a crucial role in proline-mediated drought tolerance. We determined that the transcript level of CAU1 decreased while that of...

Data from: The transcription factor Pou3f1 promotes neural fate commitment via activation of neural lineage genes and inhibition of external signaling pathways

Qingqing Zhu, Lu Song, Guangdun Peng, Na Sun, Jun Chen, Ting Zhang, Nengyin Sheng, Wei Tang, Cheng Qian, Yunbo Qiao, Ke Tang, Jing-Dong Han, Jinsong Li, Naihe Jing & Jing-Dong Jackie Han
The neural fate commitment of pluripotent stem cells requires the repression of extrinsic inhibitory signals and the activation of intrinsic positive transcription factors. However, how these two events are integrated to ensure appropriate neural conversion remains unclear. Here, we showed that Pou3f1 is essential for the neural differentiation of mouse embryonic stem cells (ESCs), specifically during the transition from epiblast stem cells (EpiSCs) to neural progenitor cells (NPCs). Chimeric analysis showed that Pou3f1 knockdown leads...

Data from: Species diversity can be overestimated by a fixed empirical threshold: insights from DNA barcoding of the genus Cletus (Hemiptera: Coreidae) and the meta-analysis of COI data from previous phylogeographical studies

Hai-Guang Zhang, Min-Hua Lv, Wen-Bo Yi, Wei-Bing Zhu, We-Jun Bu & Wen-Jun Bu
The use of genetic distances to identify species within the framework of DNA barcoding has to some extent improved the development of biodiversity studies. However, using a fixed empirical threshold to delimit species may lead to overestimating species diversity. In this study, we use a new data set of COI sequences for 366 specimens within the genus of Cletus as well as conduct an analysis on the same genetic data for collected morphologically defined species...

Data from: Genome patterns of selection and introgression of haplotypes in natural populations of the house mouse (Mus musculus)

Fabian Staubach, Anna Lorenc, Philipp W. Messer, Kun Tang, Dmitri A. Petrov & Diethard Tautz
General parameters of selection, such as the frequency and strength of positive selection in natural populations or the role of introgression are still insufficiently understood. The house mouse (Mus musculus) is a particularly well-suited model system to approach such questions, since it has a defined history of splits into subspecies and populations and extensive genome information is available. We have used high-density single nucleotide polymorphism (SNP) typing arrays to assess genomic patterns of positive selection...

Data from: Whole-genome sequencing of 128 camels across Asia reveals origin and migration of domestic Bactrian camels

Zhen Wang, Liang Ming, Liyun Yuan, Li Yi, Yixue Li &
The domestic Bactrian camels were treated as one of the principal means of locomotion between the eastern and western cultures in history. However, whether they originated from East Asia or Central Asia remains elusive. To address this question, we performed whole-genome sequencing of 128 camels across Asia. The extant wild and domestic Bactrian camels showed remarkable genetic divergence since they were split from dromedaries. The wild Bactrian camels also contributed little to the ancestry of...

Data from: Forward genetic screening for regulators involved in cholesterol synthesis using validation-based insertional mutagenesis

Wei Jiang, Jing-Jie Tang, Hong-Hua Miao, Yu-Xiu Qu, Jie Qin, Jie Xu, Jinbo Yang, Bo-Liang Li & Bao-Liang Song
Somatic cell genetics is a powerful approach for unraveling the regulatory mechanism of cholesterol metabolism. However, it is difficult to identify the mutant gene(s) due to cells are usually mutagenized chemically or physically. To identify important genes controlling cholesterol biosynthesis, an unbiased forward genetics approach named validation-based insertional mutagenesis (VBIM) system was used to isolate and characterize the 25-hydroxycholesterol (25-HC)-resistant and SR-12813-resisitant mutants. Here we report that five mutant cell lines were isolated. Among which,...

Stochastic cell-cycle entry and cell-state-dependent fate outputs of injury-reactivated tectal radial glia in zebrafish

Shuguang Yu & Jie He
Gliosis defined as reactive changes of resident glia is the primary response of the central nervous system (CNS) to trauma. The proliferation and fate controls of injury-reactivated glia are essential but remain largely unexplored. In zebrafish optic tectum, we found that stab injury drove a subset of radial glia (RG) into the cell cycle, and surprisingly, proliferative RG responding to sequential injuries of the same site were distinct but overlapping, which was in agreement with...

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