67 Works

Data from: Abortion legislation, maternal healthcare, fertility, female literacy, sanitation, violence against women, and maternal deaths: a natural experiment in 32 Mexican states

Elard Koch, Monique Chireau, Fernando Pliego, Joseph Stanford, Sebastián Haddad, Byron Calhoun, Paula Aracena, Miguel Bravo, Sebastián Gatica & John Thorp
Objective: To test whether there is an association between abortion legislation and maternal mortality outcomes after controlling for other factors thought to influence maternal health. Design: Population-based natural experiment. Setting and data sources: Official maternal mortality data from 32 federal states of Mexico between 2002 and 2011. Main outcomes: Maternal mortality ratio (MMR), MMR with any abortive outcome (MMRAO) and induced abortion mortality ratio (iAMR). Independent variables: Abortion legislation grouped as less (n=18) or more...

Data from: Geographical barriers and climate influence demographic history in narrowleaf cottonwoods

Luke M. Evans, Gerard J. Allan, Stephen P. DiFazio, Gancho T. Slavov, Jason A. Wilder, Kevin D. Floate, Stewart B. Rood & Thomas G. Whitham
Studies of genetic variation can clarify the role of geography and spatio-temporal variation of climate in shaping demography, particularly in temperate zone tree species with large latitudinal ranges. Here, we examined genetic variation in narrowleaf cottonwood, Populus angustifolia, a dominant riparian tree. Using multi-locus surveys of polymorphism in 363 individuals across the species’ 1800 km latitudinal range, we found that, first, P. angustifolia has stronger neutral genetic structure than many forest trees (simple sequence repeat...

Nexus-formatted text file of ISSR band presence/absence for 75 loci in Corallorhiza bentleyi

Craig Barrett
Mycoheterotrophic plants derive most or all carbon and nutrients from fungal partners and represent poorly understood components of forest biodiversity. Many are rare or endangered yet can be ecological indicators of forest ecosystem function due to their often highly specific fungal host requirements. One such species is the IUCN red-listed (‘vulnerable’), fully mycoheterotrophic orchid, Corallorhiza bentleyi. This recently described species is among the rarest plants in Appalachia, known from five counties in Virginia and West...

Data from: Causes and consequences of large clonal assemblies in a poplar hybrid zone

David Macaya-Sanz, Myriam Heuertz, Dorothea Lindtke, Giovanni G. Vendramin, Christian Lexer & Santiago C. Gonzalez-Martinez
Asexual reproduction is a common and fundamental mode of reproduction in plants. Although persistence in adverse conditions underlies most known cases of clonal dominance, proximal genetic drivers remain unclear, in particular for populations dominated by a few large clones. In this study, we studied a clonal population of the riparian tree Populus alba in the Douro river basin (northwestern Iberian Peninsula) where it hybridizes with Populus tremula, a species that grows in highly contrasted ecological...

Data from: Age, growth and fall diet of channel catfish in Cheat Lake, West Virginia

Corbin Hilling, Stuart Welsh, Dustin Smith, Corbin D. Hilling & Stuart A. Welsh
Acidification has historically impaired Cheat Lake's fish community, but recent mitigation efforts within the Cheat River watershed have improved water quality and species richness. Presently, channel catfish Ictalurus punctatus are abundant and attain desirable sizes for anglers. We evaluated the age, growth and fall diet of the population. A sample of 155 channel catfish was collected from Cheat Lake from 5 August to 4 December 2014, a subsample of which was aged (n = 148)...

Data from: Isotopic evidence for oligotrophication of terrestrial ecosystems

Joseph M. Craine, Andrew J. Elmore, Lixin Wang, Julieta Aranibar, Marijn Bauters, Pascal Boeckx, Brooke E. Crowley, Melissa A. Dawes, Sylvain Delzon, Alex Fajardo, Yunting Fang, Lei Fujiyoshi, Alan Gray, Rossella Guerrieri, Michael J. Gundale, David J. Hawke, Peter Hietz, Mathieu Jonard, Elizabeth Kearsley, Tanaka Kenzo, Mikhail Makarov, Sara Marañón-Jiménez, Terrence P. McGlynn, Brenden E. McNeil, Stella G. Mosher … & Katarzyna Zmudczyńska-Skarbek
Human societies depend on an Earth System that operates within a constrained range of nutrient availability, yet the recent trajectory of terrestrial nitrogen (N) availability is uncertain. Examining patterns of foliar N concentrations ([N]) and isotope ratios (15N) from more than 42,000 samples acquired over 37 years, here we show that foliar [N] declined by 8% and foliar 15N declined by 0.8 – 1.9 ‰. Examining patterns across different climate spaces, foliar 15N declined across...

Data from: Mammal communities are larger and more diverse in moderately developed areas

Arielle Waldstein Parsons, Tavis Forrester, Megan C. Baker-Whatton, William J. McShea, Christopher T. Rota, Stephanie G. Schuttler, Joshua J. Millspaugh & Roland Kays
Developed areas are thought to have low species diversity, low animal abundance, few native predators, and thus low resilience and ecological function. Working with citizen scientist volunteers to survey mammals at 1427 sites across two development gradients (wild-rural-exurban-suburban-urban) and four plot types (large forests, small forest fragments, open areas and residential yards) in the eastern US, we show that developed areas actually had significantly higher or statistically similar mammalian occupancy, relative abundance, richness and diversity...

Data from: Landscape of tumor mutation load, mismatch repair deficiency, and PD-L1 expression in a large patient cohort of gastrointestinal cancers

Mohamed E. Salem, Alberto Puccini, Axel Grothey, Derek Raghavan, Richard M. Goldberg, Joanne Xiu, W. Michael Korn, Benjamin A. Weinberg, Jimmy J. Hwang, Anthony F. Shields, John L. Marshall, Philip A. Philip & Heinz-Josef Lenz
Purpose: The efficacy of immunotherapy varies widely among different gastrointestinal cancers. Response to immune checkpoint inhibitors is shown to correlate with tumor mutation load (TML), mismatch repair deficiency status (dMMR), and programmed cell death-ligand 1 (PD-L1) expression. Herein, we attempt to quantify TML, dMMR, and PD-L1 expression and determine their interrelationship in gastrointestinal cancers. Experimental Design: A total of 4125 tumors from 14 different gastrointestinal cancer sites were studied. Next-generation sequencing was performed on genomic...

Data from: Oral anticoagulation in patients with chronic kidney disease: a systematic review and meta-analysis

Konark Malhotra, Muhammad Fawad Ishfaq, Nitin Goyal, Aristeidis H. Katsanos, John Parissis, Anne W Alexandrov, Andrei V. Alexandrov & Georgios Tsivgoulis
Objective: Data regarding the efficacy and safety of warfarin and Non-Vitamin K Antagonist Oral Anticoagulant (NOAC) among patients with chronic kidney disease (CKD) remain scarce. Methods: Systematic review and meta-analysis of studies involving CKD patients treated on OACs was conducted to evaluate following outcomes: ischemic stroke, intracerebral hemorrhage (ICH), combined ischemic and hemorrhagic stroke (strokecombined), stroke or systemic embolism, mortality, and major bleeding events. CKD was defined based on creatinine clearance (CrCl) ranging from mild...

Leveraging Electronic Health Records Data for Enhanced Colorectal Cancer Screening Efforts

Adam D. Baus, Lauren E. Wright, Stephenie Kennedy-Rea, Mary E. Conn, Susan Eason, Dannell Boatman, Cecil Pollard, Andrea Calkins & Divya Gadde
Introduction: Colorectal cancer is the third most common type of cancer in the United States for men and women combined. While the current threat of disease nationally is significant, the majority of colorectal cancer cases and deaths could be prevented through established screening tests and guidelines. Within the Appalachian region and West Virginia in particular, colorectal cancer is a significant public health problem. A more systematic, comprehensive approach to preventing and controlling cancer is essential....

Data from: A search for technosignatures from 14 planetary systems in the Kepler field with the Green Bank Telescope at 1.15–1.73 GHz

Jean-Luc Margot, Adam H. Greenberg, Pavlo Pinchuk, Akshay Shinde, Yashaswi Alladi, Srinivas Prasad MN, M. Oliver Bowman, Callum Fisher, Szilard Gyalay, Willow McKibbin, Brittany Miles, Donald Nguyen, Conor Power, Namrata Ramani, Rashmi Raviprasad, Jesse Santana & Ryan S. Lynch
This dataset describes candidate signal detections obtained at the Green Bank Telescope in 2016 and reprocessed with the 2020 UCLA SETI Group data processing pipeline. Analysis of Kepler mission data suggests that the Milky Way includes billions of Earth-sized planets in the habitable zone of their host stars. Current technology enables the detection of technosignatures emitted from a large fraction of the Galaxy. We describe a search for technosignatures that is sensitive to Arecibo-class transmitters...

Effects of Sleep Duration on Falls in a West Virginia Population-Based study, BRFSS, 2018

R. Constance Wiener & Christopher Waters
Introduction: West Virginia is a state in which most counties are rural, as well as a state with multiple health disparities among its population. The purpose of this study was to determine the association of sleep duration and falls for non-institutionalized West Virginia adults, aged 40 years and above, using the National Sleep Foundation’s definition of “may be appropriate” and “not recommended” sleep durations for specific ages. Methods: Behavior Risk Factor Surveillance System (BRFSS) 2018...

America Contacts Congress: Providing Access to U.S. Congressional Correspondence Data

Danielle Emerling
This is the slide presentation from the 2018 LYRASIS Leaders Summit documenting the West Virginia University Catalyst Fund project - Access to US Congressional Correspondence Data. A recording of the presentation can be found at: https://www.youtube.com/watch?v=IO8h_8WheBs.

Long-term changes in occurrence, relative abundance, and reproductive fitness of bat species in relation to arrival of White-nose Syndrome in West Virginia, USA

Catherine Johnson, Donald Brown, Chris Sanders & Craig Stihler
White-nose syndrome (WNS) is a disease caused by the fungus Pseudogymnoascus destructans which has resulted in the deaths of millions of bats across eastern North America. To date, hibernacula counts have been the predominant means of tracking the spread and impact of this disease on bat populations. However, an understanding of the impacts of WNS on demographic parameters outside the winter season is critical to conservation and recovery of bat populations impacted by this disease....

Appalachia

Lauri Andress & Keri Valentine
As the website Understanding and Dismantling Racism: Crowdsourcing a Pathway Model in Appalachia explains, we are seeking assistance in refining a pathway model that elucidates institutional racism from the unique standpoint of Appalachia. We think that Appalachia has a distinctive cultural toolkit that shapes its orientation on issues. Our goal is to use crowdsourcing to harness this unique Appalachian ethos to refine the Pathway model on Institutional Racism based on comments, edits, questions, and ideas...

Triple Negative Breast Cancer in an Appalachian Region

Gina Sizemore & Toni Marie Rudisill
Introduction: Triple negative breast cancer is an aggressive breast cancer with decreased five-year survival, increased risk for recurrence, and higher risk for metastases. Unlike other breast cancers, it has no targeted treatment and has heterogeneous genetics which make classification and treatment difficult. Purpose: The purpose of our research was to compare triple negative breast cancer to non-triple negative breast cancer to identify key epidemiologic factors that might lead to improved basic science directives for biomarkers,...

Review of: Appalachians for Medicaid Website

Kendra Barker
The Journal of Appalachian Health is committed to reviewing published media that relates to contemporary concepts affecting the health of Appalachia. Access to care and the health disparities we face have a direct effect on our experience of illness. Dr. Kendra Barker reviews the website: Appalachians for Medicaid.

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