7 Works

Targeting the KRAS α4-α5 allosteric interface inhibits pancreatic cancer tumorigenesis

Imran Khan, Catherine Marelia-Bennet, Julia Lefler, Mariyam Zuberi, Eric Denbaum, Akiko Koide, Dean M. Connor, Ann-Marie Broome, Thierry Pécot, Cynthia Timmers, Michael C. Ostrowski, Shohei Koide & John P. O’Bryan
RAS is the most frequently mutated oncogene in human cancer with nearly ~20% of cancer patients possessing mutations in one of three RAS genes (K, N or HRAS). However, KRAS is mutated in nearly 90% of pancreatic ductal carcinomas (PDAC). Although pharmacological inhibition of RAS has been challenging, KRAS(G12C)-specific inhibitors have recently entered the clinic. While KRAS(G12C) is frequently expressed in lung cancers, it is rare in PDAC. Thus, more broadly efficacious RAS inhibitors are...

Supplement to: Global impact of the COVID-19 pandemic on stroke care and intravenous thrombolysis

Raul Nogueira, Muhammed Qureshi, Mohamad Abdalkader, Sheila Martins, Hiroshi Yamagami, Zhongming Qiu, Ossama Mansour, Anvitha Sathya, Anna Czlonkowska, Georgios Tsivgoulis, Diana Aguiar De Sousa, Jelle Demeestere, Robert Mikulik, Peter Vanacker, James Siegler, Janika Korv, Jose Biller, Conrad Liang, Navdeep Sangha, Alicia Zha, Alexandra Czap, Christine Holmstedt, Tanya Turan, George Ntaios, Konark Malhotra … & Thanh Nguyen
Objective: The objectives of this study were to measure the global impact of the pandemic on the volumes for intravenous thrombolysis (IVT), IVT transfers, and stroke hospitalizations over 4 months at the height of the pandemic (March 1 to June 30, 2020) compared with two control 4-month periods. Methods: We conducted a cross-sectional, observational, retrospective study across 6 continents, 70 countries, and 457 stroke centers. Diagnoses were identified by their ICD-10 codes and/or classifications in...

Data from: Why is inverse symmetry the fundamental architecture of DNA?

Les Hatton & Gregory Warr
A striking global property of genomes observable across all domains of life is their universal inverse symmetry, manifest as equivalent frequencies of inverse complementary sequence motifs on the same strand of duplex DNA, as originally stated in Chargaff’s Second Parity Rule (CPR2) for mononucleotides. Simple mechanistic explanations of CPR2 have proven unsatisfactory. In contrast, we use a conservation principle to explain not only inverse symmetry and its global nature, but also how it breaks down....

Targeting the KRAS α4-α5 allosteric interface inhibits pancreatic cancer tumorigenesis

Imran Khan, Catherine MarElia-Bennet, Julia Lefler, Mariyam Zuberi, Eric Denbaum, Akiko Koide, Dean M. Connor, Ann-Marie Broome, Thierry Pécot, Cynthia Timmers, Michael C. Ostrowski, Shohei Koide & John P. O’Bryan
RAS is the most frequently mutated oncogene in human cancer with nearly ~20% of cancer patients possessing mutations in one of three RAS genes (K, N or HRAS). However, KRAS is mutated in nearly 90% of pancreatic ductal carcinomas (PDAC). Although pharmacological inhibition of RAS has been challenging, KRAS(G12C)-specific inhibitors have recently entered the clinic. While KRAS(G12C) is frequently expressed in lung cancers, it is rare in PDAC. Thus, more broadly efficacious RAS inhibitors are...

Two new amide glycosides with anti-inflammatory activity from the leaves of Streblus ilicifolius (Vidal) Corner

Yan Huang, Xishan Huang, Guobiao Tian, Wenxiu Zhang, Shanshan Su, Xia Xu, Jun Li & Buming Liu
Two new amide glycosides, streblusoamides A (1) and B (2), along with 11 known compounds (3–13) were isolated from the leaves of Streblus ilicifolius. The structures of the isolates were elucidated by spectroscopic methods. All of the isolates were tested for inhibition of NO production in lipopolysaccharide (LPS)-induced RAW 264.7 cells to investigate their anti-inflammatory effects. The results revealed that compounds 1, 5 and 6 moderately inhibited the release of NO production with IC50 values...

Two new amide glycosides with anti-inflammatory activity from the leaves of Streblus ilicifolius (Vidal) Corner

Yan Huang, Xishan Huang, Guobiao Tian, Wenxiu Zhang, Shanshan Su, Xia Xu, Jun Li & Buming Liu
Two new amide glycosides, streblusoamides A (1) and B (2), along with 11 known compounds (3–13) were isolated from the leaves of Streblus ilicifolius. The structures of the isolates were elucidated by spectroscopic methods. All of the isolates were tested for inhibition of NO production in lipopolysaccharide (LPS)-induced RAW 264.7 cells to investigate their anti-inflammatory effects. The results revealed that compounds 1, 5 and 6 moderately inhibited the release of NO production with IC50 values...

Data from: Research and exploratory analysis driven - time-data visualization (read-tv) software

John Del Gaizo, Kenneth Catchpole & Alexander Alekseyenko
read-tv The main paper is about, read-tv, open-source software for longitudinal data visualization. We uploaded sample use case surgical flow disruption data to highlight read-tv's capabilities. We scrubbed the data of protected health information, and uploaded it as a single CSV file. A description of the original data is described below. Data source Surgical workflow disruptions, defined as “deviations from the natural progression of an operation thereby potentially compromising the efficiency or safety of care”,...

Registration Year

  • 2021
    7

Resource Types

  • Dataset
    5
  • Text
    2

Affiliations

  • Medical University of South Carolina
    7
  • Sixth Affiliated Hospital of Sun Yat-sen University
    2
  • Sun Yat-sen University
    2
  • West China Second University Hospital of Sichuan University
    2
  • West China Hospital of Sichuan University
    2
  • Zhejiang University
    2
  • Dalian Polytechnic University
    2
  • Central South University
    2
  • Southwest Medical University
    2
  • Huazhong University of Science and Technology
    2