Two new halogenated metabolites, laurenhalogens A (1) and B (2), along with four known ones (3–6), were isolated from the red alga Laurencia sp. The structures of 1 and 2 were determined by the means of UV, IR, MS, NMR and X-ray diffraction analysis. In addition, the antibacterial activities of 1–6 were also evaluated.

Currently, human papillomavirus (HPV) vaccines are in short supply, so the development of HPV vaccines has a broad market prospect. The 3-, 9-, and 15-valent HPV vaccines developed by ourselves all contain HPV58-derived antigen components. It is important to detect HPV 58 during vaccine production. Here, we introduced a development process of HPV58 type-specific antibodies and a detection kit. Briefly, HPV58 L1-Virus Like Particles (VLPs) were used as antigens to immunize mice, followed by extraction...

Additional file 1. .

Additional file 1. Table S1: Plant species and library information.

Limestone mainly consisting of CaCO3 is one of the most abundant carbonates on Earth's surface. The sound velocities of limestone at high pressure were determined at room temperature using ultrasonic interferometry in a multi-anvil apparatus. Softening and discontinuities in compressional (P) and shear (S) wave velocities have been observed at around 1.45 GPa due to the phase transition of CaCO3-I to CaCO3-II, and the coexistence of CaCO3-IIIb and CaCO3-III stay up to ∼5 GPa. Limestone...

Additional file 4. The 23 genes differentially expressed in both the transcriptome and methylation sequencing for MM cells transfected with sh-HNRNPA2B1-8226 and the control sh-NC-8226.

Four-dimensional (4-D) imaging of embryonic heart is valuable for the study of in vivo cardiac morphology and function during development. Optical coherence tomography (OCT) is a non-invasive imaging modality with high spatial resolution suitable for early embryonic heart imaging. However, most commonly used OCT systems cannot provide direct 4-D imaging due to acquisition speed limitations. We proposed a retrospective gating 4-D reconstruction method based on spectral domain OCT. A special circuit was designed to measure...

Abstract Background The SARS-CoV-2 containment strategy has been successful in mainland China prior to the emergence of Omicron. However, in the era of highly transmissible variants, whether it is possible for China to sustain a local containment policy and under what conditions China could transition away from it are of paramount importance at the current stage of the pandemic. Methods We developed a spatially structured, fully stochastic, individual-based SARS-CoV-2 transmission model to evaluate the feasibility...

Additional file 23 Table S22. The cloned genes for deepwater and heat map of the ratio of RPKM.

Additional file 24 Table S23. Haplotype analysis of the candidate genes for deepwater QTLs.

Additional file 3 Fig. S1 PCA plot of the first two eigenvectors (a) and two and three eigenvectors (b) of rice accessions. Additional file 2. Fig. S2 Maximum-likelihood tree of rice assuming 0 to 3 migration edges. Additional file 2. Fig. S3 Corresponding residual of rice assuming 0 to 10 migration edges. Additional file 2. Fig. S4 Genome-wide detection of positive selection in different rice ecotypes. Additional file 2. Fig. S5 Selective sweep regions identified...

Additional file 9 Table S8. Genome-wide detection of positive selection in upland GJ rice.

Additional file 5: Table S2. The details of questionnaire.

BackgroundTo determine the populations who suitable for surgical treatment in elderly patients (age ≥ 75 y) with IA stage.MethodsThe clinical data of NSCLC patients diagnosed from 2010 to 2015 were collected from the SEER database and divided into surgery group (SG) and no-surgery groups (NSG). The confounders were balanced and differences in survival were compared between groups using PSM (Propensity score matching, PSM). Cox regression analysis was used to screen the independent factors that affect...

Research Data for Healthy adults with Streptococcus pneumoniae meningitis and Streptococcus pneumoniae subdural abscess: two case reports and a literature review by Fanxin Kong, Liling Li, Daxue Zhang, Baorong Lian, Xudong Liu, Shuqun Ren, Yu Zhang, Liming Cao in Journal of International Medical Research

Investigation on the chemical components of Valeriana jatamansi Jones (Caprifoliaceae), a new lignan with pyran-ring, dipsalignan G (1), along with eight known compounds (2–9) were isolated. Their structures were elucidated by extensive analysis of 1D, 2D NMR and HR-ESI-MS spectroscopic data. Additionally, possible biosynthetic pathway of 1 was proposed. Finally, biological evaluation results showed that 8 had significant scavenging ability to ABTS and DPPH free radicals, with IC50 values of 1.35 ± 0.01 and 2.94...

Abstract Background Multiple myeloma (MM) is a malignancy of plasma cells that remains incurable. Toll-like receptor 4 (TLR4) acts as a stress-responsive signal, protecting mitochondria during proteasome inhibitor (PI) exposure, maintaining mitochondrial metabolism and increasing drug resistance in MM. However, the mechanism of TLR4 regulation remains elusive. Aims The purpose of this study was to investigate the methylation pattern of multiple myeloma and its effect on the expression of HNRNPA2B1 and downstream targets. Methods The...

Supplemental material, sj-docx-1-tva-10.1177_15248380221129596 for The Association Between Child Abuse and Aggressive Behavior: A Three-Level Meta-Analysis by Guangming Ran, Qiongzhi Zhang, Qi Zhang, Jun Li and Jing Chen in Trauma, Violence, & Abuse

Additional file 1.

Additional file 5: Figure S5. Genes in central carbon metabolism pathway of YAP high expression group on KEGG graph rendered by pathview. Gene expression levels are indicated as significantly higher (red), unchanged (gray), or lower (green).

Abstract Background Workload of healthcare providers may affect the quality of healthcare. Practical evidences have indicated that healthcare providers are differentially associated with workload due to their different education and training background. Clinical pharmacists are an indispensable part of medical teams. Under the precondition that clinical pharmacists in China generally undertake uneven clinical pharmacy workload, the relationship of workload and clinical pharmacists’ different education backgrounds remains unclear. This study aimed to assess the association between...

Additional file 8: Fig. S1. Cumulative lipids composition.

Additional file 2: Table S1. Detected gene levels upon methionine restriction in livers of HCC mouce models.

Abstract Background Exploiting cancer metabolism during nutrient availability holds immense potential for the clinical and therapeutic benefits of hepatocellular carcinoma (HCC) patients. Dietary methionine is a metabolic dependence of cancer development, but how the signal transduction integrates methionine status to achieve the physiological demand of cancer cells remains unknown. Methods Low or high levels of dietary methionine was fed to mouse models with patient-derived xenograft or diethyl-nitrosamine induced liver cancer. RNA sequence and metabolomics were...

Cascaded operations play an important role in traditional electronic computing systems for the realization of advanced strategies. Here, we introduce the idea of cascaded operations into all-optical spatial analog computing. The single function of the first-order operation is difficult to meet the requirements of practical applications in image recognition. The all-optical second-order spatial differentiators are implemented by cascading two first-order differential operation units, and the image edge detection of amplitude and phase objects are demonstrated....