1,350 Works

Cholesterol efflux regulator ABCA1 exerts protective role against high shear stress-induced injury of HBMECs via regulating PI3K/Akt/eNOS signaling

Zhe Li, Jia-Nan Li, Qiang Li, Chun Liu, Lin-Hua Zhou, Qi Zhang & Yi Xu
Abstract Background In brain, microvascular endothelial cells are exposed to various forces, including shear stress (SS). However, little is known about the effects of high shear stress (HSS) on human brain microvascular endothelial cells (HBMECs) and the underlying mechanism. The cholesterol efflux regulator ATP-binding cassette subfamily A member 1 (ABCA1) has been demonstrated to exert protective effect on HBMECs. However, whether ABCA1 is involved in the mechanism underneath the effect of HSS on HBMECs remains...

Additional file 1 of Cholesterol efflux regulator ABCA1 exerts protective role against high shear stress-induced injury of HBMECs via regulating PI3K/Akt/eNOS signaling

Zhe Li, Jia-Nan Li, Qiang Li, Chun Liu, Lin-Hua Zhou, Qi Zhang & Yi Xu
Additional file 1: Figure S1. Full-length blots/gels of ABCA1, MMP9, AQP4, CYP46, and beta-actin are presented. Figure S2. Full-length blots/gels of phospho-PI3K, PI3K, AKT, phospho-AKT, eNOS, phospho-eNOS and beta-actin are presented. Figure S3. Full-length blots/gels of ABCA1 and beta-actin are presented. Figure S4. Full-length blots/gels of MMP9, AQP4, CYP46 and β-actin are presented. Figure S5. Full-length blots/gels of phospho-PI3K, PI3K, AKT, phospho-AKT, eNOS, phospho-eNOS and β-actin are presented.

Additional file 1 of Characteristics of population structure, antimicrobial resistance, virulence factors, and morphology of methicillin-resistant Macrococcus caseolyticus in global clades

Yu Zhang, Shengyi Min, Yuxuan Sun, Jiaquan Ye, Zhemin Zhou & Heng Li
Additional file 1: Supply Table 1. Isolation and identification of nine M. caseolyticus isolates from this study by fIDBAC ( http://fbac.dmicrobe.cn ). Supply Table 2. Description of the genomes used in this study. A total of 85 global strains were downloaded from GenBank including 34 sets of filtered SRA genomes and 51 already assemblies. Supply Table 3. Description of the 24 antimicrobial resistance genes used in this study. Supply Table 4. Multi-locus sequence typing (MLST)...

Additional file 1 of Characteristics of population structure, antimicrobial resistance, virulence factors, and morphology of methicillin-resistant Macrococcus caseolyticus in global clades

Yu Zhang, Shengyi Min, Yuxuan Sun, Jiaquan Ye, Zhemin Zhou & Heng Li
Additional file 1: Supply Table 1. Isolation and identification of nine M. caseolyticus isolates from this study by fIDBAC ( http://fbac.dmicrobe.cn ). Supply Table 2. Description of the genomes used in this study. A total of 85 global strains were downloaded from GenBank including 34 sets of filtered SRA genomes and 51 already assemblies. Supply Table 3. Description of the 24 antimicrobial resistance genes used in this study. Supply Table 4. Multi-locus sequence typing (MLST)...

Supplementary document for Realization of all-optical higher-order spatial differentiators based on cascaded operations - 6107218.pdf

Hailu Luo, yichang Shou, Yan Wang, Lili Miao & Shizhen Chen
The PB phase metasurface differential operation theory and design details

Clinical application of autophagy proteins as prognostic biomarkers in colorectal cancer: a meta-analysis Supplementary tables 1-3

Dongqing Hu, Yanming Huo, Ye Xue, Haixia Feng, Wei Sun, Huiqi Wang, Jing Wu & Xiaoyan Wang
Clinical application of autophagy proteins as prognostic biomarkers in colorectal cancer: a meta-analysis Supplementary tables 1-3

Additional file 2 of Characteristics of oral microbiome of healthcare workers in different clinical scenarios: a cross-sectional analysis

Zhixia Zhang, Wenyi Yu, Guangyao Li, Yukun He, Zhiming Shi, Jing Wu, Xinqian Ma, Yu Zhu, Lili Zhao, Siqin Liu, Yue Wei, Jianbo Xue, Shuming Guo & Zhancheng Gao
Additional File 2: Supplementary Figure

Supplementary document for Electrically induced adiabatic frequency conversion in an integrated lithium niobate ring resonator - 6087966.pdf

Xiaotong He, Luis Cortes Herrera, Kwadwo Opong-Mensah, Yi Zhang, Meiting Song, Govind Agrawal & Jaime Cardenas
Detailed discussion and supplemental data

Electrically induced adiabatic frequency conversion in an integrated lithium niobate ring resonator

Xiaotong He, Luis Cortes Herrera, Kwadwo Opong-Mensah, Yi Zhang, Meiting Song, Govind Agrawal & Jaime Cardenas
Changing the frequency of light outside the laser cavity is essential for fields that require precise frequencies such as optical communication, ultracold molecules and single photon sources. Frequency conversion is usually accomplished by nonlinear wave mixing. However, integrating a system with the required high-power optical pump onto a photonic chip is challenging. To achieve on-chip optical frequency conversion, we electrically tune a lithium niobate ring resonator to induce adiabatic frequency conversion. In this work, frequency...

lipidomics raw data for CaV2.3

Xia Yao, Yan Wang, Zhifei Wang, Xiao Fan, Di Wu, Jian Huang, Alexander Mueller, Sarah Gao, Miaohui Hu, Carol V. Robinson, Yong Yu, Shuai Gao & Nieng Yan
ZIP archive containing raw LC-MS data of CaV2.3

Supplemental Material - Responses of sedimentary proxy indicators to lake-level fluctuations on the central Tibetan Plateau since the last deglaciation

Kan Yuan, Zhe Sun, Can-Ge Li, Kejia Ji, Xiaohuan Hou, Mingda Wang & Juzhi Hou
Supplemental Material for Responses of sedimentary proxy indicators to lake-level fluctuations on the central Tibetan Plateau since the last deglaciation by Kan Yuan, Zhe Sun, Can-Ge Li, Kejia Ji, Xiaohuan Hou, Mingda Wang and Juzhi Hou in Progress in Physical Geography: Earth and Environment

Responses of sedimentary proxy indicators to lake-level fluctuations on the central Tibetan Plateau since the last deglaciation

Kan Yuan, Zhe Sun, Can-Ge Li, Kejia Ji, Xiaohuan Hou, Mingda Wang & Juzhi Hou
Lake sediments are valuable archives to investigate past changes in climate and environment on various timescales. Closed-basin lakes can be regarded as precipitation gauges, which are ideal for studying past climate changes. However, the climatic implications of various sedimentary proxy indicators from closed-basin lakes are often confounded by lake-level fluctuations, which are affected by lake watershed processes, besides climate change. Here, we present records of multi-proxy indicators since the last deglaciation at Lake Cuoe, on...

Additional file 17 of Lipidomics combined with transcriptomic and mass spectrometry imaging analysis of the Asiatic toad (Bufo gargarizans) during metamorphosis and bufadienolide accumulation

Bo Sun, Shan Jiang, Mingli Li, Yan Zhang, Yanyan Zhou, Xiaolu Wei, Hongjie Wang, Nan Si, Baolin Bian & Haiyu Zhao
Additional file 17: Fig. S10. Identification of organs in DESI-MSI sections. (A–C) Frozen sections selected for DESI-MSI; (D–F) DESI-MSI at a specific mass-to-charge ratio that presents a clear org an position. (a–c) Microscope images of the corresponding parts of A to C. A, D and a representative of the left sagittal sections (sagittal section A); B, E, and b represent the mid-sagittal sections (sagittal section B); C, F, and c represent the horizontal sections (horizontal...

Additional file 2 of Lipidomics combined with transcriptomic and mass spectrometry imaging analysis of the Asiatic toad (Bufo gargarizans) during metamorphosis and bufadienolide accumulation

Bo Sun, Shan Jiang, Mingli Li, Yan Zhang, Yanyan Zhou, Xiaolu Wei, Hongjie Wang, Nan Si, Baolin Bian & Haiyu Zhao
Additional file 2: Table S2. Differential lipids in four stages.

sj-docx-1-tam-10.1177_17588359221138380 – Supplemental material for An open label, safety study of Asian patients with advanced non-small-cell lung cancer receiving second-line nivolumab monotherapy (CheckMate 870)

Shun Lu, Ying Cheng, Jianying Zhou, Mengzhao Wang, Jun Zhao, Baocheng Wang, Gongyan Chen, Jifeng Feng, Zhiyong Ma, Lin Wu, Changli Wang, Kewei Ma, Shucai Zhang, Jun Liang, Yong Song, Jie Wang, Yi-Long Wu, Ang Li, Yizhi Huang & Jianhua Chang
Supplemental material, sj-docx-1-tam-10.1177_17588359221138380 for An open label, safety study of Asian patients with advanced non-small-cell lung cancer receiving second-line nivolumab monotherapy (CheckMate 870) by Shun Lu, Ying Cheng, Jianying Zhou, Mengzhao Wang, Jun Zhao, Baocheng Wang, Gongyan Chen, Jifeng Feng, Zhiyong Ma, Lin Wu, Changli Wang, Kewei Ma, Shucai Zhang, Jun Liang, Yong Song, Jie Wang, Yi-Long Wu, Ang Li, Yizhi Huang and Jianhua Chang in Therapeutic Advances in Medical Oncology

An open label, safety study of Asian patients with advanced non-small-cell lung cancer receiving second-line nivolumab monotherapy (CheckMate 870)

Shun Lu, Ying Cheng, Jianying Zhou, Mengzhao Wang, Jun Zhao, Baocheng Wang, Gongyan Chen, Jifeng Feng, Zhiyong Ma, Lin Wu, Changli Wang, Kewei Ma, Shucai Zhang, Jun Liang, Yong Song, Jie Wang, Yi-Long Wu, Ang Li, Yizhi Huang & Jianhua Chang
Background:Nivolumab has been approved in China as second-line treatment for advanced non-small-cell lung cancer (NSCLC) via weight-based infusion, based on the CheckMate 078 study. We investigated the safety and efficacy of 240 mg flat-dose nivolumab in patients with advanced NSCLC, including those with hepatitis B virus (HBV) and epidermal growth factor receptor (EGFR) mutation/ALK receptor tyrosine kinase (ALK) translocation due to high prevalence in China.Methods:CheckMate 870 was a single-arm, open-label, phase IIIb trial in Asian...

Association between susceptibility value and cerebral blood flow in the bilateral putamen in patients undergoing hemodialysis

Hao Wang, Lijun Song, Mingan Li, Zhenghan Yang & Zhen-Chang Wang
Hemodialysis (HD) is the most regularly applied replacement therapy for end-stage renal disease, but it may result in brain injuries. The correlation between cerebral blood flow (CBF) alteration and iron deposition has not been investigated in patients undergoing HD. Ferritin level may be a dominant factor in CBF and iron deposition change. We hypothesize that ferritin level might be the key mediator between iron deposition and CBF alteration. The correlation in the putamen was estimated...

Circular polarization detector based on polarization holography

Yuanying Zhang, Qi Zhang, xiaochuan jiang, Zheng Shujun, Jinhong Li, Xianmiao Xu, Yang Yi, Zhiyun Huang & Xiaodi Tan
We propose and experimentally demonstrate the generation of a circular polarization detector based on planar polarization holography. The detector is designed by constructing the interference field according to the null reconstruction effect (NRE). We create the multiplexed holograms which feature the combination of two sets of hologram patterns and operate with opposite circular polarization beams. In a few seconds, the exposure operation allows the polarization multiplexed holograms element to be generated, with functionality equivalent to...

Additional file 1 of A nomogram for predicting cancer-specific survival for elderly patients with gallbladder cancer

Chong Wen, Jie Tang, Tao Wang & Hao Luo
Additional file 1: Figure S1. Histological type of gallbladder carcinoma in all patients. The vast majority of patients were adenocarcinoma, followed by squamous cell carcinoma, endocrine carcinoma, and some unknown epithelial tumors.

A nomogram for predicting cancer-specific survival for elderly patients with gallbladder cancer

Chong Wen, Jie Tang, Tao Wang & Hao Luo
Abstract Background Gallbladder cancer (GBC) is a highly aggressive malignancy in elderly patients. Our goal is aimed to construct a novel nomogram to predict cancer-specific survival (CSS) in elderly GBC patients. Method We extracted clinicopathological data of elderly GBC patients from the SEER database. We used univariate and multivariate Cox proportional hazard regression analysis to select the independent risk factors of elderly GBC patients. These risk factors were subsequently integrated to construct a predictive nomogram...

A nomogram for predicting cancer-specific survival for elderly patients with gallbladder cancer

Chong Wen, Jie Tang, Tao Wang & Hao Luo
Abstract Background Gallbladder cancer (GBC) is a highly aggressive malignancy in elderly patients. Our goal is aimed to construct a novel nomogram to predict cancer-specific survival (CSS) in elderly GBC patients. Method We extracted clinicopathological data of elderly GBC patients from the SEER database. We used univariate and multivariate Cox proportional hazard regression analysis to select the independent risk factors of elderly GBC patients. These risk factors were subsequently integrated to construct a predictive nomogram...

Additional file 2 of Application of exome sequencing for prenatal diagnosis of fetal structural anomalies: clinical experience and lessons learned from a cohort of 1618 fetuses

Fang Fu, Ru Li, Qiuxia Yu, Dan Wang, Qiong Deng, Lushan Li, Tingying Lei, Guilan Chen, Zhiqiang Nie, Xin Yang, Jin Han, Min Pan, Li Zhen, Yongling Zhang, Xiangyi Jing, Fucheng Li, Fatao Li, Lina Zhang, Cuixing Yi, Yingsi Li, Yan Lu, Hang Zhou, Ken Cheng, Jian Li, Lina Xiang … & Can Liao
Additional file 2: Table S1. Clinical characteristics of the fetal cases. Table S2. Fetuses with diagnostic or VUS results obtained additional new phenotypes during prenatal and/or postnatal period. Table S3. Fetuses with positive diagnostic results detected by ES. Table S4. Diagnostic rates in different malformation subgroups. Table S5. Diagnostic rates in relation to NT measurement range. Table S6. Number of variants analyzed in step 1 and 2- case by case. Table S7. Number of variants...

sj-tif-1-cll-10.1177_09636897221129171 – for Effects of Low-Intensity Pulsed Ultrasound on the Migration and Homing of Human Amnion–Derived Mesenchymal Stem Cells to Ovaries in Rats With Premature Ovarian Insufficiency

Li Ling, Jiying Hou, Yan Wang, Han Shu & Yubin Huang
sj-tif-1-cll-10.1177_09636897221129171 for Effects of Low-Intensity Pulsed Ultrasound on the Migration and Homing of Human Amnion–Derived Mesenchymal Stem Cells to Ovaries in Rats With Premature Ovarian Insufficiency by Li Ling, Jiying Hou, Yan Wang, Han Shu and Yubin Huang in Cell Transplantation

sj-tif-11-cll-10.1177_09636897221129171 – for Effects of Low-Intensity Pulsed Ultrasound on the Migration and Homing of Human Amnion–Derived Mesenchymal Stem Cells to Ovaries in Rats With Premature Ovarian Insufficiency

Li Ling, Jiying Hou, Yan Wang, Han Shu & Yubin Huang
sj-tif-11-cll-10.1177_09636897221129171 for Effects of Low-Intensity Pulsed Ultrasound on the Migration and Homing of Human Amnion–Derived Mesenchymal Stem Cells to Ovaries in Rats With Premature Ovarian Insufficiency by Li Ling, Jiying Hou, Yan Wang, Han Shu and Yubin Huang in Cell Transplantation

sj-tif-2-cll-10.1177_09636897221129171 – for Effects of Low-Intensity Pulsed Ultrasound on the Migration and Homing of Human Amnion–Derived Mesenchymal Stem Cells to Ovaries in Rats With Premature Ovarian Insufficiency

Li Ling, Jiying Hou, Yan Wang, Han Shu & Yubin Huang
sj-tif-2-cll-10.1177_09636897221129171 for Effects of Low-Intensity Pulsed Ultrasound on the Migration and Homing of Human Amnion–Derived Mesenchymal Stem Cells to Ovaries in Rats With Premature Ovarian Insufficiency by Li Ling, Jiying Hou, Yan Wang, Han Shu and Yubin Huang in Cell Transplantation

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