Abstract Background QL1706 (PSB205) is a single bifunctional MabPair (a novel technical platform) product consisting of two engineered monoclonal antibodies (anti-PD-1 IgG4 and anti-CTLA-4 IgG1), with a shorter elimination half-life (t1/2) for CTLA-4. We report results from a phase I/Ib study of QL1706 in patients with advanced solid tumors who failed standard therapies. Methods In the phase I study, QL1706 was administered intravenously once every 3 weeks at one of five doses ranging from 0.3...

Additional file 1. Supplementary data of first-in-human phase I/Ib study of QL1706 (PSB205) in patients with advanced solid tumors.

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SLC2A3 is an important member of the glucose transporter superfamily. It has been recently suggested that upregulation of SLC2A3 is associated with poor survival and acts as a prognostic marker in a variety of tumors. Unfortunately, the prognostic role of SLC2A3 in head and neck squamous cell carcinoma (HNSC) is less known. In the present study, we analyzed SLC2A3 expression in HNSC and its correlation with prognosis using TCGA and GEO databases. The results showed...

Phytochemical investigation on the plant of Wikstroemia alternifolia led to the isolation of 26 compounds including two new ones, wikstralternifols A and B (1 and 7). Their structures including the absolute configuration were elucidated by spectroscopic data together with analysis of experimental and calculated ECD data. All compounds were isolated from this plant for the first time, and their main structural types were lignans, sesquiterpenoids, and flavonoids. In the sodium nitroprusside-induced rat pheochromocytoma PC-12 cell...

In this contribution, feeding behaviour assays with the three species Paucumara falcata, Dugesia sp. and Girardia sp. were used to investigate the function of the pharynx during feeding and whether absence of feeding behaviour until full regeneration is a widespread phenomenon among planarians from different taxonomic groups. Our results showed that feeding behaviour of decapitated flatworms was inhibited. Intact worms responded only to pork liver pieces, but isolated pharynges were highly responsive to both pork...

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Current unprecedented mpox outbreaks in non-endemic regions represent a global public health concern. Although two live-attenuated vaccinia virus (VACV)-based vaccines have been urgently approved for people at high risk for mpox, a safer and more effective vaccine that can be available for the general public is desperately needed. By utilizing a simplified manufacturing strategy of mixing DNA plasmids before transcription, we developed two multi-antigen mRNA vaccine candidates, which encode four (M1, A29, B6, A35, termed...

Additional file 1. In vitro experiments and subgroup analaysis.

Abstract Background Relapsed or refractory acute myeloid leukemia (R/R AML) has a dismal prognosis. The aim of this study was to investigate the activity and tolerability of venetoclax combined with azacitidine plus homoharringtonine (VAH) regimen for R/R AML. Methods This phase 2 trial was done at ten hospitals in China. Eligible patients were R/R AML (aged 18–65 years) with an Eastern Cooperative Oncology Group performance status of 0–2. Patients received venetoclax (100 mg on day...

Additional file 11: Table S6. Interaction analysis analysis between DEP7 and DEP8 in NIL-F2 population

Abstract Rice panicle architecture is directly associated with grain yield and is also the key target in high-yield rice breeding program. In this study, three BC6F2 segregation populations derived from the crosses between two accessions of Oryza meridionalis and a O. sativa spp. japonica cultivar Dianjingyou 1, were employed to map QTL for panicle architecture. Three QTL, EP4.2, DEP7 and DEP8 were identified and validated using substitution mapping strategy on chromosome 4, 9 and 8,...

Additional file 11: Table S6. Interaction analysis analysis between DEP7 and DEP8 in NIL-F2 population

Additional file 9: Table S4. Interaction analysis between EP4.2 and DEP7 in NIL-F2 population

Additional file 8: Table S3. Mean performance of the plant height and panicle architecture trait of the nine genotypes in NIL-F2 population from the cross between NIL-dep7 and NIL-dep8

Additional file 7: Table S2. Mean performance of the plant height and panicle architecture trait of the nine genotypes in NIL-F2 population from the cross between NIL-ep4.2 and NIL-dep8.

Additional file 4: Figure S4. Correlation coefficient analysis for panicle architecture traits in three BC6F2 populations. a-c Correlation coefficient analysis for panicle architecture traits in populations derived from IL-ep4.2 and DJY1, IL-dep7 and DJY1, IL-dep8 and DJY1, respectively.

Additional file 9: Table S4. Interaction analysis between EP4.2 and DEP7 in NIL-F2 population

Additional file 1. Differentially expressed genes in GSE1009 and GSE30528.

Abstract Background Diabetic kidney disease (DKD) is a major complication of diabetes and the leading cause of end-stage renal disease worldwide. Renal inflammation and infiltration of immune cells contribute to the development and progression of DKD. Thus, the aim of the present study was to identify and validate immune-related biomarkers and analyze potential regulators including transcription factors (TFs), microRNAs (miRNAs), and drugs for DKD. Methods Immune-related genes from the ImmPort database and glomeruli samples from...

Additional file 2: Table S2. The primer sequences used for qRT-PCR.

Additional file 4: Figure S1. CAAs facilitated the malignant behaviors of human breast cancer cells in vitro.

Additional file 5: Uncropped western blot images.