38 Works

Parasites, niche modification and the host microbiome: A field survey of multiple parasites

Kayleigh R. O'Keeffe, Fletcher W. Halliday, Corbin D. Jones, Ignazio Carbone & Charles E. Mitchell
Parasites can affect and be affected by the host's microbiome, with consequences for host susceptibility, parasite transmission, and host and parasite fitness. Yet, two aspects of the relationship between parasite infection and host microbiota remain little understood: the nature of the relationship under field conditions, and how the relationship varies among parasites. To overcome these limitations, we performed a field survey of the within-leaf fungal community in a tall fescue population. We investigated how diversity...

Human thymidylate synthase NMR relaxation data

Jeffrey Bonin, Andrew Lee & Paul Sapienza
Table of intensities of NMR signals of human thymidylate synthase in multiple bound forms from several NMR relaxation experiments. Bound forms studied include apo, dUMP (substrate) bound, TMP (product) bound, as well as apo and dUMP bound N-terminal truncation. Experiments include methyl 13C MQ and SQ CPMG, CHD2 methyl 13C CEST, CHD2 methyl 2H R2, solvent PRE, backbone amide RDC, and 15N relaxation. Details of the data collection can be found in the associated publication.

Coastal squeeze on temperate reefs: long-term shifts in salinity, water quality, and oyster-associated communities

Maxwell Tice-Lewis, Y. Stacy Zhang, S. Gray Redding, Niels L. Lindquist, Claire M. Fieseler, Quentin A. Walker, Antonio B. Rodriguez & F. Joel Fodrie
Foundation species such as mangroves, saltmarshes, kelps, seagrasses, and oysters thrive within suitable environmental envelopes as narrow ribbons along the land-sea margin. Therefore, these habitat-forming species and resident fauna are sensitive to modified environmental gradients. For oysters, many estuaries impacted by sea-level rise, channelization, and municipal infrastructure are experiencing saltwater intrusion and water-quality degradation that may alter reef distributions, functions, and services. To explore decadal-scale oyster-reef community patterns across a temperate estuary in response to...

Post-ACL reconstruction surgery rehabilitation dataset using isokinetic dynamometer and wearable IMUs

Robert Gutierrez, Joe Hart & Mehdi Boukhechba
Rehabilitation post-ACL reconstruction surgery is a lengthy process that involves a variety of exercises, with the goal of achieving leg symmetry. Testing for leg symmetry generally involves a series of tests, which may include walking gait analysis, isokinetic dynamometry, and single leg hop, if able. Isokinetic dynamometry readings have proven useful in understanding leg symmetry by providing a reading of muscle torque during a specific motion. However, the use of surface electromyography (sEMG) may provide...

Climate change alters sexual signaling in a desert-adapted frog

Gina Calabrese & Karin Pfennig
Climate change is altering species’ habitats, phenology, and behavior. Although sexual behaviors impact population persistence and fitness, climate change’s effects on sexual signals are understudied. Climate change can directly alter temperature-dependent sexual signals, cause changes in body size or condition that affect signal production, or alter the selective landscape of sexual signals. We tested whether temperature-dependent mating calls of Mexican spadefoot toads (Spea multiplicata) had changed in concert with climate in the Southwestern U.S.A. across...

Latinos in Sampson County, North Carolina : an action-oriented community diagnosis

Rebecca Cashman, Katie Cravens, Amy Hobbie, Tanya Montoya, Serene Myers & Sarah O'Brien
The following document is a detailed report of an Action Oriented Community Diagnosis (AOCD) conducted by a team of six students from the University of North Carolina Chapel Hill, School of Public Health, Department of Health Behavior and Health Educations in collaboration with the Sampson County Health Department. The AOCD was conducted in order to understand the cultural, social, economic, and health experiences of Latinos living in or accessing services in Sampson County. Throughout the...

Spanish-speaking community of Asheboro, Randolph County, North Carolina : an action oriented community diagnosis : findings and recommendations for future action

Kelley De Leeuw, Carrie Fesperman, Mariana Garrettson, Matthew Griffith, Heather Hart & Ann Krier
Asheboro, a small textile-manufacturing city in the southern Piedmont region of North Carolina, is considered a desirable place to live by most of its adult residents. However, the small city has been struggling to keep up with rapid population growth due in part to an influx of Latino immigrants. From 1990 to 2000 the Asheboro Latino population increased by well over 2,000%. This rapid growth has put a strain on social services in the region,...

The Hispanic/Latino community in the Fox Ridge Manor Apartments, Wake County, North Carolina : an action-oriented community diagnosis : findings and next steps of action

Carolyn Gray, Tasseli McKay, Kisha Merchant, Amanda Phillips-Martinez & Kristin Schaible
During the 2002-2003 academic year, five students from the University of North Carolina’s School of Public Health conducted a community diagnosis for Hispanic/Latino residents of Fox Ridge Manor, an apartment complex in Southeast Raleigh. The AOCD process is used to help understand the many sides of a community, including its norms, values, culture, power structure, history, and patterns of communication (Eng and Blanchard, 1991). The goal is to develop an insider’s view and understanding of...

Asymmetry of thermal sensitivity and the thermal risk of climate change

Lauren Buckley, Raymond Huey & Joel Kingsolver
Aim. Understanding and predicting the biological consequences of climate change requires considering the thermal sensitivity of organisms relative to environmental temperatures. One common approach involves “thermal safety margins” (TSMs), which are generally estimated as the temperature differential between the highest temperature an organism can tolerate (CTmax) and the mean or maximum environmental temperature it experiences. Yet, organisms face thermal stress and performance loss at body temperatures below their CTmax, and the steepness of that loss...

Fruits of Nandina domestica are (Sometimes) Cyanogenic and (Sometimes) Hazardous to Birds

Scott Zona
A 12-month survey of cyanogenesis in the fruits and leaves of Nandina domestica (Berberidaceae) revealed that the leaves are strongly cyanogenic throughout the year, as measured by the Feigl-Anger test. Fruits vary in their cyanogenic potential depending on the degree of ripeness and clone. Green fruits are strongly and rapidly cyanogenic, but most ripe fruits are weakly and slowly cyanogenic. Some fruits tested negative for cyanide. Fruits tend to become less cyanogenic the longer they...

Volatile social environments can favour investments in quality over quantity of social relationships

Thomas G. Aubier & Hanna Kokko
Cooperation does not occur in a vacuum: interactions develop over time in social groups that undergo demographic changes. Intuition suggests that stable social environments favour developing few but strong reciprocal relationships (a 'focused' strategy), while volatile social environments favour the opposite: more but weaker social relationships (a 'diversifying' strategy). We model reciprocal investments under a quality-quantity tradeoff for social relationships. We find that volatility, counterintuitively, can favour a focused strategy. This result becomes explicable through...

Can disease resistance evolve independently at different ages? Genetic variation in age-dependent resistance to disease in three wild plant species

Emily Bruns, Michael Hood, Janis Antonovics, Indigo Ballister, Sarah Troy & Jae Hoon Cho
1. Juveniles are typically less resistant (more susceptible) to infectious disease than adults, and this difference in susceptibility can help fuel the spread of pathogens in age-structured populations. However evolutionary explanations for this variation in resistance across age remain to be tested. 2. One hypothesis is that natural selection has optimized resistance to peak at ages where disease exposure is greatest. A central assumption of this hypothesis is that hosts have the capacity to evolve...

sj-pptx-1-tag-10.1177_17562848221124029 – Supplemental material for ‘FLARE’ of tumor marker in advanced gastric cancer treated with first-line systemic therapy

Fangyuan Zhang, Menglan Zhai, Jinru Yang, Lei Zhao, Zhenyu Lin, Jing Wang, Tao Zhang & Dandan Yu
Supplemental material, sj-pptx-1-tag-10.1177_17562848221124029 for ‘FLARE’ of tumor marker in advanced gastric cancer treated with first-line systemic therapy by Fangyuan Zhang, Menglan Zhai, Jinru Yang, Lei Zhao, Zhenyu Lin, Jing Wang, Tao Zhang and Dandan Yu in Therapeutic Advances in Gastroenterology

Aventureras y ‘medio putas’ en la narrativa breve del último José Revueltas

Oswaldo Estrada
pp. 131-143. Taking into account the novel El apando (1969) and the last short stories that Revueltas gathered in Material de los sueños (1974), this essay analyzes how the Mexican writer manipulates the profile of the prostitute, in order to create female characters that destabilize inherited models. Thanks to a set of unusual turns, innovative descriptions, and unexpected transgressions, the prostitutes that we find in Revueltas’s last compositions show alternative ways of being a woman....

Human thymidylate synthase ITC data

Jeffrey Bonin, Andrew Lee & Paul Sapienza
This dataset includes isothermal titration calorimetry measurements of human thymidylate synthase (hTS) binding its product deoxythymidine monophosphate (TMP) and an N-terminal trunction of hTS binding its substrate deoxyuridine monophosphate (dUMP). These measurements include heats produced at various enzyme and ligand concentrations. Analysis of these data provide binding free energies, enthalpies, and entropies for these binding events. We find that in contrast to hTS binding its substrate dUMP, which we have previously shown to have positive...

Climatic niche conservatism in a clade of disease vectors (Diptera: Phlebotominae)

Emmanuel R. R. D'Agostino, Rafael Jose Vivero Gomez, Luis Romero, Eduar Bejarano, Allen Hurlbert, Aaron A. Comeault & Daniel Matute
Sandflies of the family Psychodidae show notable diversity in both disease vector status and climatic niche. Psychodid species’ ranges can be solely tropical, confined to the temperate zones, or span both. We obtained observation site data, and associated climate data, for 223 psychodid species to understand which aspects of climate most closely predict distribution. Temperature and seasonality are strong determinants of species occurrence within the clade. We built a mitochondrial DNA phylogeny of Psychodidae, and...

‘FLARE’ of tumor marker in advanced gastric cancer treated with first-line systemic therapy

Fangyuan Zhang, Menglan Zhai, Jinru Yang, Lei Zhao, Zhenyu Lin, Jing Wang, Tao Zhang & Dandan Yu
Background:Transient tumor marker elevations caused by chemotherapy were defined as ‘Flare’ and have been demonstrated in some solid tumors. In clinical practice, we observed that some patients were accompanied by elevated tumor markers during treatment, but subsequent imaging proved that the treatment they received was effective.Objectives:We aimed to study the Flare and the prognosis in advanced gastric cancer.Design:This is an observational retrospective study. A total of 167 patients were enrolled in this study. Carcinoembryonic antigen...

sj-pptx-1-tag-10.1177_17562848221124029 – Supplemental material for ‘FLARE’ of tumor marker in advanced gastric cancer treated with first-line systemic therapy

Fangyuan Zhang, Menglan Zhai, Jinru Yang, Lei Zhao, Zhenyu Lin, Jing Wang, Tao Zhang & Dandan Yu
Supplemental material, sj-pptx-1-tag-10.1177_17562848221124029 for ‘FLARE’ of tumor marker in advanced gastric cancer treated with first-line systemic therapy by Fangyuan Zhang, Menglan Zhai, Jinru Yang, Lei Zhao, Zhenyu Lin, Jing Wang, Tao Zhang and Dandan Yu in Therapeutic Advances in Gastroenterology

sj-pptx-2-tag-10.1177_17562848221124029 – Supplemental material for ‘FLARE’ of tumor marker in advanced gastric cancer treated with first-line systemic therapy

Fangyuan Zhang, Menglan Zhai, Jinru Yang, Lei Zhao, Zhenyu Lin, Jing Wang, Tao Zhang & Dandan Yu
Supplemental material, sj-pptx-2-tag-10.1177_17562848221124029 for ‘FLARE’ of tumor marker in advanced gastric cancer treated with first-line systemic therapy by Fangyuan Zhang, Menglan Zhai, Jinru Yang, Lei Zhao, Zhenyu Lin, Jing Wang, Tao Zhang and Dandan Yu in Therapeutic Advances in Gastroenterology

A Framework for Estimating the Bounds of Contingency Tables: Application to an Open Clinical Research Service

Patrick L. Schmitt, Karamarie Fecho, Perry Haaland, Ashok Krishnamurthy, Bo Lan, Priya Sharma, Meghamala Sinha & Hao Xu

Climate-driven thermal opportunities and risks for leaf miners in aspen canopies

H. Arthur Woods, Geoffrey Legault, Joel Kingsolver, Sylvain Pincebourde, Alisha Shah & Beau Larkin
In tree canopies, incoming solar radiation interacts with leaves and branches to generate temperature differences within and among leaves, presenting thermal opportunities and risks for leaf-dwelling ectotherms. Although leaf biophysics and insect thermal ecology are well understood, few studies have examined them together in single systems. We examined temperature variability in aspen canopies, Populus tremuloides, and its consequences for a common herbivore, the leaf-mining caterpillar Phyllocnistis populiella. We shaded leaves in the field and measured...

The biogeography of community assembly: latitude and predation drive variation in community trait distribution in a guild of epifaunal crustaceans

Collin Gross, Collin Gross, J Duffy, Kevin Hovel, Melissa Kardish, Pamela Reynolds, Christoffer Boström, Katharyn Boyer, Mathiew Cusson, Johan Eklöf, Aschwin Engelen, Klemens Eriksson, Joel Fodrie, John Griffin, Clara Hereu, Masakazu Hori, A Randall Hughes, Mikhail Ivanov, Pablo Jorgensen, Claudia Kruschel, Kun-Seop Lee, Jonathan Lefcheck, Karen McGlathery, Per-Olav Moksnes, Masahiro Nakaoka … & Jay Stachowicz
While considerable evidence exists of biogeographic patterns in the intensity of species interactions, the influence of these patterns on variation in community structure is less clear. Using a model selection approach on measures of trait dispersion in crustaceans associated with eelgrass (Zostera marina) spanning 30º of latitude in two oceans, we found that dispersion strongly increased with increasing predation and decreasing latitude. Ocean and epiphyte load appeared as secondary predictors; Pacific communities were more overdispersed...

Cyclin F drives proliferation through SCF-dependent degradation of the retinoblastoma-like tumor suppressor p130/RBL2

Wayne Stallaert, Taylor Enrico, Elizaveta Wick, Peter Ngoi, Michael Emanuele, Seth Rubin, Nicholas Brown, Jeremy Purvis, Taylor P Enrico, Elizaveta T Wick, Xianxi Wang, Seth M Rubin, Nicholas G Brown, Jeremy E Purvis & Michael J Emanuele
Cell cycle gene expression programs fuel proliferation and are universally dysregulated in cancer. The retinoblastoma (RB)-family of proteins, RB1, RBL1/p107, and RBL2/p130, coordinately represses cell cycle gene expression, inhibiting proliferation, and suppressing tumorigenesis. Phosphorylation of RB-family proteins by cyclin-dependent kinases is firmly established. Like phosphorylation, ubiquitination is essential to cell cycle control, and numerous proliferative regulators, tumor suppressors, and oncoproteins are ubiquitinated. However, little is known about the role of ubiquitin signaling in controlling RB-family...

CeA Psilocin fiber photometry study: Data and custom code from experiments looking at changes in calcium dynamics in response to an air puff events

Devin Effinger
Psilocybin, and its active metabolite psilocin, have been shown to elicit rapid and long-lasting symptom improvements in a variety of affective psychiatric illnesses. However, the specific mechanisms behind these therapeutic effects remain relatively unknown. The central amygdala (CeA) is a primary output region within the extended amygdala that is heavily dysregulated in affective psychiatric disorders. Here, we utilized fiber photometry to measure changes in CeA reactivity to an aversive air puff stimulus after psilocin administration,...

The Latino community of Carrboro, Orange County, NC : an action-oriented community diagnosis : a participatory assessment of the Latino community of Carrboro

Erica Childs, Stephanie Etienne, Shaina Gross, Kristen Stoimenoff & Nina Yamanis
Carrboro is located adjacent to Chapel Hill, North Carolina and prides itself on being an open and welcoming community. Since 1990 the Latino population of Carrboro has grown 936%, and currently represents 12% of the community. The significant growth of the Latino community of Carrboro has contributed to the town’s diversity and has led to many changes in service delivery. An Action-Oriented Community Diagnosis of the Latino community of Carrboro was conducted by five graduate...

Registration Year

  • 2022

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  • University of North Carolina at Chapel Hill
  • Hainan Medical University
  • Sun Yat-sen University
  • West China Second University Hospital of Sichuan University
  • West China Hospital of Sichuan University
  • Zhejiang University
  • Wuhan University of Science and Technology
  • Central South University
  • Liaoning Shihua University
  • Air Force Medical University