997 Works

Additional file 1 of Early coagulopathy after pediatric out-of-hospital cardiac arrest: secondary analysis of a randomized clinical trial

Dawei Zhou, Tong Li, Yi Lv, Dijia Wang, Rongli Zhang, Qing Lin, Chao Wang, Dong Zhao, Shuyang Fei & Wei He
Additional file 1: Supplemental Table 1. Comparison of baseline characteristics between survivors and non-survivors. Supplemental Figure 1. Kaplan-Meier plots for cumulative 1-year survival according to early coagulopathy. The difference was statistically significant according to the log-rank test (P <0.001).

Estimating disability-adjusted life years for breast cancer and the impact of screening in female populations in China, 2015–2030: an exploratory prevalence-based analysis applying local weights

Xin-Xin Yan, Juan Zhu, Yan-Jie Li, Meng-Di Cao, Xin Wang, Hong Wang, Cheng-Cheng Liu, Jing Wang, Yang Li & Ju-Fang Shi
Abstract Background Most cancer disability-adjusted life year (DALY) studies worldwide have used broad, generic disability weights (DWs); however, differences exist among populations and types of cancers. Using breast cancer as example, this study aimed to estimate the population-level DALYs in females in China and the impact of screening as well as applying local DWs. Methods Using multisource data, a prevalence-based model was constructed. (1) Overall years lived with disability (YLDs) were estimated by using numbers...

Additional file 2 of Estimating disability-adjusted life years for breast cancer and the impact of screening in female populations in China, 2015–2030: an exploratory prevalence-based analysis applying local weights

Xin-Xin Yan, Juan Zhu, Yan-Jie Li, Meng-Di Cao, Xin Wang, Hong Wang, Cheng-Cheng Liu, Jing Wang, Yang Li & Ju-Fang Shi
Additional file 2: Clinical stage-specific disability weights and distribution of breast cancer in females in China.

Additional file 1 of TPM1 mediates inflammation downstream of TREM2 via the PKA/CREB signaling pathway

Rong Li, Jing Zhang, Qiong Wang, Meng Cheng & Bin Lin
Additional file 1: Figure S1. Validation of TPM1 overexpression or knockdown in BV2 cells after transfection with TPM1 plasmid or siTPM1. A mRNA level of TPM1 in BV2 cells after TPM1 plasmid transfection. Data are presented as mean ± SEM and analyzed by unpaired two-tailed Student’s t test or by one-way ANOVA with Tukey’s multiple comparison test (control plasmid vs. TPM1 plasmid, **p < 0.01). Three independent experiments were performed. B, C Western blot analysis...

Additional file 2 of TPM1 mediates inflammation downstream of TREM2 via the PKA/CREB signaling pathway

Rong Li, Jing Zhang, Qiong Wang, Meng Cheng & Bin Lin
Additional file 2: Figure S2. TPM1 knockdown reduces inflammation via the PKA/CREB pathway in BV2 cells. A–F qPCR analysis of TPM1, TNF-α, IL-1β, IL-6, COX-2 and iNOS in BV2 cells following treatments with LPS and siTPM1-1, siTPM1-2, or siCTR. Data are presented as mean ± SEM and analyzed by one-way ANOVA with Tukey’s multiple comparison test (compared to LPS + siCTR or control, *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.001;...

Additional file 3 of TPM1 mediates inflammation downstream of TREM2 via the PKA/CREB signaling pathway

Rong Li, Jing Zhang, Qiong Wang, Meng Cheng & Bin Lin
Additional file 3: Figure S3. TPM1 knockdown reduces LPS-induced inflammation and function decline in C57BL/6J mice. A, B mRNA level of TPM1 (A) and IL-10 (B) in C57BL/6 J mouse retinas after treatments with LPS and siCTR or siTPM1-1. Data are presented as mean ± SEM and analyzed by one-way ANOVA with Tukey’s multiple comparison test (compared to LPS + siCTR or LPS + siTPM1-1, *p < 0.05, **p < 0.01). n = 4 or...

Screening for novel risk factors related to high myopia using machine learning

Ruiheng Zhang, Li Dong, Qiong Yang, Wenda Zhou, Haotian Wu, Yifan Li, Heyan Li & Wenbin Wei
Abstract Background High myopia-related complications have become a major cause of irreversible vision loss. Evaluating the association between potential factors and high myopia can provide insights into pathophysiologic mechanisms and further intervention targets for myopia progression. Method Participants aged 12–25 years from National Health and Nutrition Examination Survey 2001–2006 were selected for the analysis. Myopia was defined as spherical equivalent (sum of spherical error and half of the cylindrical error) of any eyes ≤-0.5 diopters....

Additional file 6 of TPM1 mediates inflammation downstream of TREM2 via the PKA/CREB signaling pathway

Rong Li, Jing Zhang, Qiong Wang, Meng Cheng & Bin Lin
Additional file 6: Figure S6. TPM1 knockdown elicits inflammation-related transcriptomic alterations in the WT retina. A, B DEGs associated with the phagosome formation pathway (A) and neuroinflammation signaling pathway (B) in WT mice after treatments with LPS and siTPM1-1 or siCTR.

Additional file 5 of Genetic diversity in the transmission-blocking vaccine candidate Plasmodium vivax gametocyte protein Pvs230 from the China–Myanmar border area and central Myanmar

Xin Zhao, Yubing Hu, Yan Zhao, Lin Wang, Zifang Wu, Myat Thu Soe, Myat Phone Kyaw, Liwang Cui, Xiaotong Zhu & Yaming Cao
Additional file 5: Figure S2. Median-joining network of Pv230 among eight geographically diverse populations. Haplotypes composed of nucleotide polymorphism in ICP of Pv230 with a frequency > 1 were used to create a median-joining network. Each node represents one haplotype, node size indicates haplotype frequency, and node color corresponds to the country of origin. Line length is proportional to genetic distance.

Additional file 3 of Genetic diversity in the transmission-blocking vaccine candidate Plasmodium vivax gametocyte protein Pvs230 from the China–Myanmar border area and central Myanmar

Xin Zhao, Yubing Hu, Yan Zhao, Lin Wang, Zifang Wu, Myat Thu Soe, Myat Phone Kyaw, Liwang Cui, Xiaotong Zhu & Yaming Cao
Additional file 3: Table S3. Codon-based tests for selection on Pvs230 in China–Myanmar border and Myanmar isolates.

A general method for calculating power for GEE analysis of complete and incomplete stepped wedge cluster randomized trials

Ying Zhang, John S Preisser, Elizabeth L Turner, Paul J Rathouz, Mark Toles & Fan Li
Stepped wedge designs have uni-directional crossovers at randomly assigned time points (steps) where clusters switch from control to intervention condition. Incomplete stepped wedge designs are increasingly used in cluster randomized trials of health care interventions and have periods without data collection due to logistical, resource and patient-centered considerations. The development of sample size formulae for stepped wedge trials has primarily focused on complete designs and continuous responses. Addressing this gap, a general, fast, non-simulation based...

Additional file 4 of Functional analysis revealed the involvement of ZmABCB15 in resistance to rice black-streaked dwarf virus infection

Runqing Yue, Qi Sun, Jianguo Ding, Wenlan Li, Wencai Li, Meng Zhao, Shouping Lu, Tingru Zeng, Hua Zhang, Suxian Zhao, Shuanggui Tie & Zhaodong Meng
Additional file 4: Table S3. The primer sequences for the qRT-PCR.

Functional analysis revealed the involvement of ZmABCB15 in resistance to rice black-streaked dwarf virus infection

Runqing Yue, Qi Sun, Jianguo Ding, Wenlan Li, Wencai Li, Meng Zhao, Shouping Lu, Tingru Zeng, Hua Zhang, Suxian Zhao, Shuanggui Tie & Zhaodong Meng
Abstract Background Maize rough dwarf disease (MRDD), caused by rice black-streaked dwarf virus (RBSDV) belonging to the Fijivirus genus, seriously threatens maize production worldwide. Three susceptible varieties (Ye478, Zheng 58, and Zhengdan 958) and two resistant varieties (P138 and Chang7–2) were used in our study. Results A set of ATP-binding cassette subfamily B (ABCB) transporter genes were screened to evaluate their possible involvements in RBSDV resistance. In the present study, ZmABCB15, an ABCB transporter family...

Supplementary document for Ultra-wideband antireflection assisted by continuously varying temporal medium - 6056378.pdf

Yi Zhang, Liang Peng, zhengjie huang, Lixin Ran & Dexin Ye
Configuration of simulation setup

Ultra-wideband antireflection assisted by a continuously varying temporal medium

Yi Zhang, Liang Peng, zhengjie huang, Lixin Ran & Dexin Ye
We demonstrate that reflectionless propagation of electromagnetic waves between two different materials can be achieved by designing an intermediate temporal medium, which can work in an ultra-wide frequency band. Such a temporal medium is designed with consideration of a multi-stage variation of the material’s permittivity in the time domain. The multi-stage temporal permittivity is formed by a cascaded quarter-wave temporal coating, which is an extension of the antireflection temporal coating by Pacheco-Peña et al [[1]...

Additional file 1 of Cancer-associated fibroblast-derived gene signatures predict radiotherapeutic survival in prostate cancer patients

Ran Zhang & Feng Liu
Additional file 1: Figure S1. The clones of the CAF and CAFR group after 0, 4, 8 and 10 Gy irradiation. Representative dishes after colony-forming assay are shown. Figure S2. The senescence and proliferative capacity of CAF and CAFR. (A) Radiation-induced senescence was detected by a β-galactosidase assay. Blue color, β-gal positive cells. Percentage of β-galactosidase positive cells in each group was calculated and showed in bottom. (B) Cell proliferation curve detected by MTT. Figure...

Proteomic analysis implicates that postovulatory aging leads to aberrant gene expression, biosynthesis, RNA metabolism and cell cycle in mouse oocytes

Chuanxin Zhang, Xueqi Dong, Xinyi Yuan, Jinzhu Song, Jiawei Wang, Boyang Liu & Keliang Wu
Abstract Background In mammals, oocytes display compromised quality after experiencing a process of postovulatory aging. However, the mechanisms underlying are not yet fully understood. Here, we portrayed a protein expression profile of fresh and aging metaphase II (MII) mouse oocytes by means of four-dimensional label-free quantification mass spectrometry (4D-LFQ). Results The analysis of 4D-LFQ data illustrated that there were seventy-six differentially expressed proteins (DEPs) between two groups of MII stage oocytes. Fifty-three DEPs were up-regulated...

Additional file 2 of Clinical and prognostic analysis of 42 children with malignant rhabdoid tumor of the kidney: a 7-year retrospective multi-center study

Chenghao Zhanghuang, Zhaoxia Zhang, Li Zeng, Bing Yan, Haoyu Tang, Jinkui Wang, Xing Liu, Guanghui Wei & Dawei He
Supplementary Material 2

Additional file 2 of Microbiota and metabolites alterations in proximal and distal gastric cancer patients

Yan Yang, Daofeng Dai, Wen Jin, Yingying Huang, Yingzi Zhang, Yiran Chen, Wankun Wang, Wu Lin, Xiangliu Chen, Jing Zhang, Haohao Wang, Haibin Zhang & Lisong Teng
Additional file 2: Figure S2. The microbial relative abundance of proximal, distal tumor tissues and matched non-tumor tissues at the genus level. Proximal T,proximal GC tumor tissues; Proximal N,proximal GC non-tumor tissues; Distal T, distal GC tumor tissues; Distal N, distal GC non-tumor tissues.

Magnetically recyclable Cu-BTC@Fe3O4-catalyzed chlorosulfonylation of vinylarenes

Xin Zhang, Liang Wang & Qiaoyong Zhu
A chlorosulfonylation of vinylarenes using magnetic metal–organic framework (MOF) composite Cu-BTC@Fe3O4 (BTC = 1,3,5-benzenetricarboxylate) as the catalyst has been developed. This protocol features easily accessible starting materials, good functional group compatibility and simple recovery of the catalyst. The recovered catalyst could be reused for at least successive five runs with only a slight decrease in its catalytic activity.

Compound glycyrrhiza oral solution alleviates oxidative stress and inflammation by regulating SRC/MAPK pathway in chronic obstructive pulmonary disease

Xiaolin Xu, Mulan Huang, Xiaofeng Duan, Hongyu Liu, Wei Zhang & Dan Li
Patients with chronic obstructive pulmonary disease (COPD) suffer from persistent cough and breathlessness, which can be ameliorated by the Chinese herbal medicine glycyrrhiza. Furthermore, the SRC/MAPK pathway is activated in the process of oxidative stress and inflammation, which afflict COPD progression. Thus, this research aimed at dissecting the mechanism of compound glycyrrhiza oral solution (CGOS) relieving oxidative stress and inflammation in COPD via the SRC/MAPK pathway. After a COPD rat model was established using lipopolysaccharide...

ELK1-Induced upregulation of long non-coding TNK2-AS1 promotes the progression of acute myeloid leukemia by EZH2-mediated epigenetic silencing of CELF2

Dongfang Guo, Airong Zhang, Meifang Suo, Ping Wang & Yile Liang
Acute myeloid leukemia (AML) is the second most common hematological malignancy after lymphoma in the world. Long non-coding RNAs (LncRNAs) have been suggested as key regulators of cancer development and progression in AML. As a member of lncRNA family, the biological role and mechanisms of tyrosine kinase non receptor 2 antisense RNA 1 (TNK2-AS1) in AML is still unclear. The expression of TNK2-AS1 was measured with RT-qPCR in AML cell lines. The changes of the...

DARS-AS1 recruits METTL3/METTL14 to bind and enhance DARS mRNA m6A modification and translation for cytoprotective autophagy in cervical cancer

Miaohua Zhu, Weiwei Shen, Qiming Wang, Xiaoming Zhou, Jiaying Wang, Tingting Wang & Jing Zhang
Cervical cancer (CC) is one of the most prevalent malignancies among females. Cytoprotective autophagy could confer cancer cell tolerance to hypoxic stress, promoting cell survival and adaptation. Aspartyl-tRNA synthetase 1 antisense 1 (DARS-AS1) is an oncogenic long non-coding RNA (lncRNA) in various cancers, but how DARS-AS1 regulates cytoprotective autophagy in hypoxic environment in CC remains unclear. Chromatin immunoprecipitation (ChIP) and luciferase reporter assays were conducted to explore the interaction between hypoxia-inducible factor 1 subunit alpha...

Additional file 9 of Parental genomes segregate into distinct blastomeres during multipolar zygotic divisions leading to mixoploid and chimeric blastocysts

Tine De Coster, Heleen Masset, Olga Tšuiko, Maaike Catteeuw, Yan Zhao, Nicolas Dierckxsens, Ainhoa Larreategui Aparicio, Eftychia Dimitriadou, Sophie Debrock, Karen Peeraer, Marta de Ruijter-Villani, Katrien Smits, Ann Van Soom & Joris Robert Vermeesch
Additional file 9: Figure S9. Genome-wide composition of blastocysts following multipolar zygotic division. Circos plots of six embryos that developed to the blastocyst stage following multipolar zygotic division in which each circle represents the interpreted genome constitution per chromosome (1 - X) of a sampled single cell. The interpreted genome spanning the largest part of the chromosome was chosen as overall interpretation per chromosome, as such, segmental chromosomal errors are not depicted. On the left...

Table S8.xlsx from Transcriptome analysis and mining of genes related to shade tolerance in foxtail millet (Setaria italica (L.) P. Beauv.)

Dan Liu, Yanjiao Cui, Zilong Zhao, Jing Zhang, Suying Li & Zhengli Liu
A stereo interplanting system with foxtail millet beneath chestnut trees is an effective planting method to raise the utilization of land in chestnut orchards, increase yields and improve quality of chestnut nuts. Consequently, exploration of genes involved in shade tolerance response in foxtail millet and breeding shade-tolerant varieties have become urgent issues. In this study, RNA-seq of leaf samples from two shade-tolerant varieties and three shade-intolerant varieties of foxtail millet at the booting stage was...

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