Purpose: Understanding the mechanism of brain functional alterations in rectal cancer (RC) patients is of great significance to improve the prognosis and quality of life of patients. Additionally, the influence of chemotherapy on brain function in RC patients is still unclear. In this study, we aimed to investigate the alterations of brain functional network dynamics in RC patients and explore the effects of chemotherapy on temporal dynamics of dynamic functional connectivity (DFC). Methods: The group...

Table S1: SIMS analytical results of detrital zircons. Table S2: LA–ICP–MS analytical results of detrital zircons

Additional file 1: Figure S1. Study design. Figure S2. Tumor response of patients in the dose-escalation and dose-expansion phase. Figure S3. Percentage change from baseline in target lesion tumour burden over time in patients with select tumors at the recommended dose (30 mg/kg q3w). Figure S4. Receiver operating characteristic curve analysis of pSmad2 level in tumor cells for ORR per RECIST v1.1. Table S1. Pharmacokinetic parameters following a single infusion. Table S2. Summary of treatment-related...

Additional file 1: Table S1. Characteristics of patients with PVRL and PCNSL with vitreoretinal involvement.

Additional file 2: Table S2. Diagnostic test results of vitreoretinal lymphoma patients.

Additional file 12 Table S11. Genome-wide detection and functional annotation of selective sweep regions in the upland GJ rice.

Additional file 15 Table S14. KEGG annotation of selective sweep regions in the upland GJ rice.

Additional file 18 Table S17. Ratio of RPKM within the 200-kb selective sweep region on chromosome 11.

Additional file 1 Table S1. Information about samples used in this study.

Additional file 1 Table S1. Information about samples used in this study.

Additional file 20 Table S19. Genome-wide detection of highly differentiated loci between IR-XI and UP-XI.

Additional file 20 Table S19. Genome-wide detection of highly differentiated loci between IR-XI and UP-XI.

Additional file 4: Figure S4. PRR34-AS1 enhances THLE-3 cell malignant phenotypes via elevating the expression of Rab27a. A–F Rescue experiments were carried on in THLE-3 cells transfected with NC, PRR34-AS1, PRR34-AS1 + sh/Rab27a#a to assess cell proliferative, migratory and invasive as well as EMT phenotypes. N = 3. Scale bar = 50 µm. **P < 0.01.

Abstract Background Exosomes are deemed to be an important tool of intercellular communicators in cancer cells. Our study investigated the role of PRR34 long non-coding RNA antisense RNA 1 (PRR34-AS1) in regulating exosome secretion in hepatocellular carcinoma (HCC) cells. Methods Quantitative real-time polymerase chain reaction (RT-qPCR) analyzed the expression of PRR34-AS1. We assessed the function of PRR34-AS1 on the biological changes of THLE-3 cells and HCC cells. The downstream interaction between RNAS was assessed by...

Additional file 3: Table S2. Differentially upregulated genes in DBS group at 22 h compared with 4 h following oviposition.

Supplementary Material 1: DNA Methylation Alternation in Stanford-A Acute Aortic Dissection

Main Dataset;Subsidiary Data matrix 2;Subsidiary Data matrix 3;Subsidiary Data matrix 4

Supplemental material, sj-docx-1-tar-10.1177_17534666221138001 for Predictors of early response to balloon pulmonary angioplasty in patients with inoperable chronic thromboembolic pulmonary hypertension by Xin Li, Yi Zhang, Qi Jin, Qin Luo, Qing Zhao, Tao Yang, Qixian Zeng, Lu Yan, Anqi Duan, Zhihua Huang, Meixi Hu, Changming Xiong, Zhihui Zhao and Zhihong Liu in Therapeutic Advances in Respiratory Disease

Abstract Xingnaojing (XNJ) injection was used to treat pneumonia and stroke in clinic in China, but with poor patient compliance. Xingnaojing nanoemulsion for intranasal delivery was developed to improve it. This article tried to evaluate the mucosal irritation of Xingnaojing nanoemulsion and investigate cellular uptake mechanism of its encapsulated lipophilic drugs. The toad palate model and rat nasal mucosa model were used to study the nasal ciliotoxicity and nasal mucosal irritation of nanoemulsion to evaluate...

Abstract Xingnaojing (XNJ) injection was used to treat pneumonia and stroke in clinic in China, but with poor patient compliance. Xingnaojing nanoemulsion for intranasal delivery was developed to improve it. This article tried to evaluate the mucosal irritation of Xingnaojing nanoemulsion and investigate cellular uptake mechanism of its encapsulated lipophilic drugs. The toad palate model and rat nasal mucosa model were used to study the nasal ciliotoxicity and nasal mucosal irritation of nanoemulsion to evaluate...

Silicon bowtie structure based all-nonmetal metamaterial (ANM) terahertz device has been developed, which has comparable efficiency to that of their metallic counterparts, and better compatibility with modern semiconductor fabrication processes. Moreover, with the same structure but highly tunable ANM is successfully fabricated through integrating with a flexible substrate, it demonstrates large tunability over a wide frequency range. Such a device can be used in terahertz systems for numerous applications, and potentially be a promising substitute...

Additional file 2 Table S2. Summary of Annotation for genomic variation.

Additional file 4 Table S3. Genetic divergence (FST) among distinct rice ecotypes populations and wild rice.

Additional file 6 Table S5. Variation types between each ecotype and its immediate ancestral progenitor.

Additional file 6 Table S5. Variation types between each ecotype and its immediate ancestral progenitor.