823 Works

Tanshinone increases Hemopexin expression in lung cells and macrophages to protect against cigarette smoke-induced COPD and enhance antiviral responses

Ning Yang, Liang Zhang, Dongdong Tian, Ping Wang, Kai Men, Yiliang Ge & Cailian Zhang
Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory disease, while respiratory infections can elicit exacerbations in COPD patients to mediate increased mortality. Administration of Tanshinones (TS) derivatives has been demonstrated to protect against cigarette smoking (CS) and lipopolysaccharide (LPS)-induced COPD progression. However, the underlying molecular mechanisms and the roles of TS in mitigating the severity of viral-mediated exacerbations of COPD have not been elucidated. Here, we found that TS treatments significantly attenuated lung function...

The perception of people with chronic kidney disease towards exercise and physical activity: a literature review

Jing Zhang & Paul Bennett
The perception of people with chronic kidney disease towards exercise and physical activity: a literature review

DNA repair in lung cancer: a large-scale quantitative analysis for polymorphisms in DNA repairing pathway genes and lung cancer susceptibility

Zexi Liao, Minhan Yi, Jiaxin Li & Yuan Zhang
The results of associations between single nucleotide polymorphisms (SNPs) of genes in DNA repairing pathway and lung cancer (LC) risk are inconsistent. We applied allele, dominant and recessive models to explore the risk of researched variants to LC in total LC and subgroups by ethnicity or LC subtypes with a cutoff point of p < 0.05. A total of 76,935 cases and 88,649 controls from 192 articles were included. Among the analyzed 40 variants from...

Deciphering the lncRNA and mRNA profiles of Min pig backfat after acute cold stress

Dongjie Zhang, Wentao Wang, Zhongqiu Li, Liang Wang & Di Liu
Cold stress can promote fat metabolism and reduce fat deposition. The present study compared differentially expressed (DE) lncRNAs and mRNAs in the subcutaneous back fat of Min pigs subjected to 24 h acute cold stress. Transcriptome sequencing was used to identify DE lncRNAs and mRNAs. A lncRNA mRNA co expression network was constructed using the confirmed lncRNAs. GO and KEGG analyses were performed to investigate the biological processes involved in the response to acute cold...

Comprehensive comparative analysis and expression profiles and effects on physiological response of DEAD-box RNA helicase genes in Lumnitzera littorea (Jack) Voigt under cold stress

LuLu Hao, Ying Zhang, Ying Li, Linxia Bai, Danfei Yue, Huiyu Zhang & Chunfang Zheng
The DEAD-box family has been shown to play an important role in a variety of abiotic stresses, but little is known in studies of mangrove plants. Here, the effects of cold stress on various physiological changes and the role of the DEAD-box RNA helicase family in response to cold stress were determined. First, we identified 73 DEAD-box RNA helicase family members in L. littorea. Second, the evolutionary relationships between the DEAD family in L. littorea...

Supply-side drivers of phosphorus emissions from phosphorus supply chains in China

Jing Zhang, Qiumeng Zhong, Yadong Yu, Jetashree, Xuechun Yang, Cuiyang Feng, Hui Li & Sai Liang
Human activities interfere with natural Phosphorus (P) cycles by introducing increased levels of P emissions to air, land, and water. A supply-side analysis of P supply chains and associated P emissions can provide insights into underlying economic activities and transitions responsible for human-induced P emissions. Taking the mainland China as the case, this study constructs time-series physical input-output tables to describe P supply chains during 1949–2012. Subsequently, it identifies critical products and influencing factors of...

Additional file 2 of Clinical and prognostic analysis of 42 children with malignant rhabdoid tumor of the kidney: a 7-year retrospective multi-center study

Chenghao Zhanghuang, Zhaoxia Zhang, Li Zeng, Bing Yan, Haoyu Tang, Jinkui Wang, Xing Liu, Guanghui Wei & Dawei He
Supplementary Material 2

Left ventricular non-compaction cardiomyopathy associated with the PRKAG2 mutation

Jing Zhang, Xiu Han, Qun Lu, Yunfei Feng, Aiqun Ma & Tingzhong Wang
Abstract Left ventricular non-compaction cardiomyopathy (LVNC) is one of the most common inherited cardiovascular diseases. The genetic backgrounds of most LVNC patients are not fully understood. We collected clinical data, family histories, and blood samples and performed genetic analysis using next-generation sequencing (NGS) from a Chinese family of 15 subjects. Clinically LVNC affected subjects showed marked cardiac phenotype heterogeneity. We found that these subjects with LVNC carried a missense heterozygous genetic mutation c.905G>A (p.R302Q) in...

Additional file 1 of Early coagulopathy after pediatric out-of-hospital cardiac arrest: secondary analysis of a randomized clinical trial

Dawei Zhou, Tong Li, Yi Lv, Dijia Wang, Rongli Zhang, Qing Lin, Chao Wang, Dong Zhao, Shuyang Fei & Wei He
Additional file 1: Supplemental Table 1. Comparison of baseline characteristics between survivors and non-survivors. Supplemental Figure 1. Kaplan-Meier plots for cumulative 1-year survival according to early coagulopathy. The difference was statistically significant according to the log-rank test (P <0.001).

Additional file 2 of DLC1 deficiency at diagnosis predicts poor prognosis in acute myeloid leukemia

Xueqian Li, Jiaqian Qi, Xiaofei Song, Xiaoyan Xu, Tingting Pan, Hong Wang, Jingyi Yang & Yue Han
Additional file 2: Figure S2. A Venn diagram shows the overlap of 22 optimal hub genes between GEO differential genes and WGCNA grey gene set.

Additional file 3 of DLC1 deficiency at diagnosis predicts poor prognosis in acute myeloid leukemia

Xueqian Li, Jiaqian Qi, Xiaofei Song, Xiaoyan Xu, Tingting Pan, Hong Wang, Jingyi Yang & Yue Han
Additional file 3: Figure S3. Identification of candidate hub genes to predict prognosis for AML patients. A. Partial likelihood deviance for different numbers of variables revealed by the LASSO regression model. Red dots represent the partial likelihood deviance values. Gray lines represent the partial likelihood deviance ± standard error. B. Fourteen candidate genes with minimum lambda values were obtained by LASSO regression with tenfold cross-validation. C. Candidate genes were filtrated from SVM-RFE algorithms. D. Five...

Additional file 6 of DLC1 deficiency at diagnosis predicts poor prognosis in acute myeloid leukemia

Xueqian Li, Jiaqian Qi, Xiaofei Song, Xiaoyan Xu, Tingting Pan, Hong Wang, Jingyi Yang & Yue Han
Additional file 6: Table S1. Clinical characteristics of 48 AML patients. Table S2. Basic information for the included GEO databases.

DLC1 deficiency at diagnosis predicts poor prognosis in acute myeloid leukemia

Xueqian Li, Jiaqian Qi, Xiaofei Song, Xiaoyan Xu, Tingting Pan, Hong Wang, Jingyi Yang & Yue Han
Abstract Acute myeloid leukemia (AML) is a complex, heterogeneous malignant hematologic disease. Although multiple prognostic-related genes gave been explored in previous studies, there are still many genes whose prognostic value remains unclear. In this study, a total of 1532 AML patients from three GEO databases were included, five genes with potential prognostic value (DLC1, NF1B, DENND5B, TANC2 and ELAVL4) were screened by weighted gene co-expression network analysis (WGCNA), least absolute shrinkage and selection operator (LASSO)...

Additional file 5 of Biallelic mutations of TTC12 and TTC21B were identified in Chinese patients with multisystem ciliopathy syndromes

Weicheng Chen, Feifei Wang, Weijia Zeng, Xinyan Zhang, Libing Shen, Yuan Zhang & Xiangyu Zhou
Additional file 5: Supplementary Methods

DLC1 deficiency at diagnosis predicts poor prognosis in acute myeloid leukemia

Xueqian Li, Jiaqian Qi, Xiaofei Song, Xiaoyan Xu, Tingting Pan, Hong Wang, Jingyi Yang & Yue Han
Abstract Acute myeloid leukemia (AML) is a complex, heterogeneous malignant hematologic disease. Although multiple prognostic-related genes gave been explored in previous studies, there are still many genes whose prognostic value remains unclear. In this study, a total of 1532 AML patients from three GEO databases were included, five genes with potential prognostic value (DLC1, NF1B, DENND5B, TANC2 and ELAVL4) were screened by weighted gene co-expression network analysis (WGCNA), least absolute shrinkage and selection operator (LASSO)...

Omicron infections profile and vaccination status among 1881 liver transplant recipients: a multi-centre retrospective cohort

Ensi Ma, Jingwen Ai, Yi Zhang, Jianming Zheng, Xiaogang Gao, Junming Xu, Hao Yin, Zhiren Fu, Hao Xing, Li Li, Liying Sun, Heyu Huang, Quanbao Zhang, Linlin Xu, Yanting Jin, Rui Chen, Guoyue Lv, Zhijun Zhu, Wenhong Zhang & Zhengxin Wang
A wave of Omicron infections rapidly emerged in China in 2022, but large-scale data concerning the safety profile of vaccines and Coronavirus disease 2019 (COVID-19) infection features in liver transplant (LT) recipients have not been collected. Therefore, the aim of this study was to assess the protectiveness and safety profile of the inactivated vaccines in LT patients against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant infections. A multi-centre retrospective study was conducted in...

Additional file 8 of TPM1 mediates inflammation downstream of TREM2 via the PKA/CREB signaling pathway

Rong Li, Jing Zhang, Qiong Wang, Meng Cheng & Bin Lin
Additional file 8: Figure S8. Validation of TPM1 and TREM2 in BV2 cells after transfection with control plasmid, TPM1 plasmid, or TPM1 and Trem2 plasmids. A mRNA level of TPM1 in BV2 cells after transfection with control plasmid, TPM1 plasmid, or TPM1 and Trem2 plasmids. Data are presented as mean ± SEM and analyzed by one-way ANOVA with Tukey’s multiple comparison test (compared to TPM1 plasmid, **p < 0.01). Five independent experiments were performed. B–D...

Detrital zircon U–Pb age constraints on the Meso-Tethys Ocean closure in Southeast Asia

Xiao-Ping Xia, Jing Mo, Meiling Zhou, Chun-Kit Lai, Zexian Cui, Jian Xu & Felix Aidoo
Table S1: SIMS analytical results of detrital zircons

Detrital zircon U–Pb age constraints on the Meso-Tethys Ocean closure in Southeast Asia

Xiao-Ping Xia, Jing Mo, Meiling Zhou, Chun-Kit Lai, Zexian Cui, Jian Xu & Felix Aidoo
The location of the Meso-Tethyan suture in SE Asia is ambiguous due to the strong overprint by the later India–Asia collisional tectonics. For the SE Asian extension of the Meso-Tethyan Bangong–Nujiang Suture (BNS) in Tibet, the two main candidates are the Longling–Ruili Suture (between the Tengchong and Baoshan blocks) and the Myitkyina ophiolite belt. Here, we present new detrital zircon U–Pb ages from high grade metasedimentary rocks of the Gaoligong Group, which is considered to...

Electromagnetic induction for reinforced concrete bursting: principles, simulations, experiments, and applications

Min Wang, Zhan Wang, Zhaojun Chen, Xiaopeng Wang & Ruichan Lv
Reinforced concrete structures are widely used in the field of architecture. With the rapid development of highway construction all over the world, the structure of some buildings has various problems and needs to be demolished. However, various traditional dismantling methods are either time-consuming and labor-intensive, or cause pollution and have certain safety hazards. In this research, Comsol simulation and experimental verification on various schemes of electromagnetic heating blasting reinforced concrete were carried out. Also, the...

Correction of Mild-to-Moderate Sunken Upper Eyelids of Asians with Stromal Vascular Fraction Gel

Adis journals on behalf of, Feixue Ding, Yirui Shen, Lin Lu, Di Sun, Xusong Luo, Xiao Liang, Jun Yang & Rui Jin
The above video represents the opinions of the authors. For a full list of declarations, including funding and author disclosure statements, and copyright information, please see the full text online. (see “read the peer-reviewed publication” opposite).

The Mechanical Properties of Jute/PLA Composites Combining Nano Polymerized Styrene Butadiene Rubber Modified by Coupling Agents

Xueyang Song, Ting Zou, Yan Zhang, Yuanyuan Li & Ping Wang
The jute/polylactic acid (PLA) composite material has been widely concerned in the field of composite materials because of its green, degradable and renewable properties, but its low mechanical properties limit the application field. In order to improve the mechanical properties of jute/PLA composites, styrene butadiene rubber (SBR) particles modified by different silane coupling agents were introduced into PLA matrix, and jute/PLA composites were prepared by solution casting and molding method. The changes in the mechanical...

Additional file 2 of Genes related to allergen exposure in allergic rhinitis: a gene-chip-based study in a mouse model

Min Wang, Ying Li, Jun Yang, Xiangdong Wang & Luo Zhang
Additional file 2: Table S2. Differentially expressed genes.

Additional file 7 of FMO3 deficiency of duck leads to decreased lipid deposition and increased antibacterial activity

Xingzheng Li, Jianlou Song, Xuefeng Shi, Mingyi Huang, Lei Liu, Guoqiang Yi, Ning Yang, Guiyun Xu & Jiangxia Zheng
Additional file 7: Fig. S7. Only a few proteins and transcripts have potential impacts on TMA production. A Ranked abundance plot of proteins and transcripts in duck livers. The top 10 most abundant proteins accounted for 12.7% of the total proteins, and the top 10 most abundant transcripts covered 33.8% of all transcripts in this tissue. B Changes in protein and transcript abundances. The upper-right panel shows the proportion of significantly altered proteins and transcripts.

Additional file 9 of FMO3 deficiency of duck leads to decreased lipid deposition and increased antibacterial activity

Xingzheng Li, Jianlou Song, Xuefeng Shi, Mingyi Huang, Lei Liu, Guoqiang Yi, Ning Yang, Guiyun Xu & Jiangxia Zheng
Additional file 9: Table S2. Differently expressed protein applying TMT10plex.

Registration Year

  • 2022
    823

Resource Types

  • Text
    309
  • Dataset
    224
  • Collection
    182
  • Image
    100
  • Audiovisual
    4
  • Other
    4

Affiliations

  • Beijing Tongren Hospital
    823
  • Zhejiang University
    555
  • Capital Medical University
    527
  • Chinese Academy of Medical Sciences & Peking Union Medical College
    492
  • Anhui Medical University
    478
  • Fudan University
    462
  • Sun Yat-sen University
    454
  • University of Chinese Academy of Sciences
    439
  • Chinese Academy of Sciences
    430
  • Shanghai Jiao Tong University
    409