823 Works

Additional file 1 of Consumption of coffee and tea with all-cause and cause-specific mortality: a prospective cohort study

Yanchun Chen, Yuan Zhang, Mengnan Zhang, Hongxi Yang & Yaogang Wang
Additional file 1: Table S1. Diet component definitions used in the UK Biobank study. Table S2. Multivariable HRs and 95% CIs of combined effect of coffee and tea consumption on total and cause-specific mortality. Table S3. Multivariable HRs and 95% CIs of separate and combined effect of coffee and tea consumption on total and cause-specific mortality by sex. Table S4. Multivariable HRs and 95% CIs of separate and combined effect of coffee and tea consumption...

Consumption of coffee and tea with all-cause and cause-specific mortality: a prospective cohort study

Yanchun Chen, Yuan Zhang, Mengnan Zhang, Hongxi Yang & Yaogang Wang
Abstract Background Previous studies suggested that moderate coffee and tea consumption are associated with lower risk of mortality. However, the association between the combination of coffee and tea consumption with the risk of mortality remains unclear. This study aimed to evaluate the separate and combined associations of coffee and tea consumption with all-cause and cause-specific mortality. Methods This prospective cohort study included 498,158 participants (37–73 years) from the UK Biobank between 2006 and 2010. Coffee...

Additional file 1 of Global, regional, national burden and gender disparity of cataract: findings from the global burden of disease study 2019

Rui Fang, Yang-Fan Yu, En-Jie Li, Ning-Xin Lv, Zhao-Chuan Liu, Hong-Gang Zhou & Xu-Dong Song
Additional file 1: Figure S1-3.

Additional file 1 of Exploring the pharmacological mechanism of Shengjing capsule on male infertility by a network pharmacology approach

Ming Wang, Qi Wang, Hui Jiang, Yongqiang Du & Xiansheng Zhang
Additional file 1:

Additional file 11 of FMO3 deficiency of duck leads to decreased lipid deposition and increased antibacterial activity

Xingzheng Li, Jianlou Song, Xuefeng Shi, Mingyi Huang, Lei Liu, Guoqiang Yi, Ning Yang, Guiyun Xu & Jiangxia Zheng
Additional file 11: Table S4. Taxa associated with TMA metabolism using the Mann-Whitney U-test.

Additional file 1 of FMO3 deficiency of duck leads to decreased lipid deposition and increased antibacterial activity

Xingzheng Li, Jianlou Song, Xuefeng Shi, Mingyi Huang, Lei Liu, Guoqiang Yi, Ning Yang, Guiyun Xu & Jiangxia Zheng
Additional file 1: Fig. S1. TMT10-plex proteomic data processing and protein interaction networks. A Characteristics of the detected peptides. The left panel represents the distribution of peptide length, and the right panel represents the distribution of missed cleavages. B Number of peptides in each sample. C Normalized data distribution before and after normalization. D Protein interaction network of differentially expressed proteins in eight modules.

Additional file 2 of FMO3 deficiency of duck leads to decreased lipid deposition and increased antibacterial activity

Xingzheng Li, Jianlou Song, Xuefeng Shi, Mingyi Huang, Lei Liu, Guoqiang Yi, Ning Yang, Guiyun Xu & Jiangxia Zheng
Additional file 2: Fig. S2. Data processing for weighted correlation network analysis (WGCNA) and Gene ontology enrichment categories for transcripts in the most significantly correlated module #7EC563. A Analysis of network topology for 1-20 soft-thresholding powers. B Clustering dendrogram of transcripts, with dissimilarity based on the topological overlap, and assigned merged and original module colors. C Gene ontology enrichment categories for transcripts in the most significantly correlated module #7EC563.

Additional file 3 of FMO3 deficiency of duck leads to decreased lipid deposition and increased antibacterial activity

Xingzheng Li, Jianlou Song, Xuefeng Shi, Mingyi Huang, Lei Liu, Guoqiang Yi, Ning Yang, Guiyun Xu & Jiangxia Zheng
Additional file 3: Fig. S3. Differentially expressed transcripts were not enriched in any molecular function annotations. A MA plot of the quantified transcripts, and Venn diagram displaying differentially expressed transcripts. B Heatmap of hierarchical clustering based on the differentially expressed transcripts. C Gene ontology enrichment categories of the differentially expressed transcripts.

Additional file 5 of FMO3 deficiency of duck leads to decreased lipid deposition and increased antibacterial activity

Xingzheng Li, Jianlou Song, Xuefeng Shi, Mingyi Huang, Lei Liu, Guoqiang Yi, Ning Yang, Guiyun Xu & Jiangxia Zheng
Additional file 5: Fig. S5. Bacteria in the duck cecum exhibited similar patterns in the CL and TH groups. A Rarefaction curve of the number of observed operational taxonomic units (OTUs) from 16S rRNA sequence data. B Histogram showing the distribution of the phyla. C Principal coordinates analysis (PCoA) with phylogeny-based (UniFrac) weighted distances of bacterial communities present in the duck cecum.

Additional file 1 of Spatial metabolomics on liver cirrhosis to hepatocellular carcinoma progression

Michelle Junyi He, Wenjun Pu, Xi Wang, Xiaoni Zhong, Dong Zhao, Zhipeng Zeng, Wanxia Cai, Jiayi Liu, Jianrong Huang, Donge Tang & Yong Dai
Additional file 1: Figure S1. Total metabolite distributions in the HC, LC and HCC tissue samples. a HE and MSI diagrams of HC, LC and HCC whole samples under the negative ionization mode. b PLS-DA comparison of AFADESI-MSI data under the negative ionization mode. c, d Alterations of metabolites detected by AFADESI-MSI method in the HC, LC and HCC samples based on positive (c) and negative (d) ionization modes. e, f K-means diagrams of the...

Additional file 2 of The landscape of hervRNAs transcribed from human endogenous retroviruses across human body sites

Jianqi She, Minghao Du, Zhanzhan Xu, Yueqi Jin, Yu Li, Daoning Zhang, Changyu Tao, Jian Chen, Jiadong Wang & Ence Yang
Additional file 2: Table S1-S15. Supplementary tables.

Additional file 3 of The landscape of hervRNAs transcribed from human endogenous retroviruses across human body sites

Jianqi She, Minghao Du, Zhanzhan Xu, Yueqi Jin, Yu Li, Daoning Zhang, Changyu Tao, Jian Chen, Jiadong Wang & Ence Yang
Additional file 3. Peer review history.

Additional file 1 of A study protocol for a randomized controlled trial to assess the efficacy of Baduanjin exercise on older adults with sarcopenia in China

Shengnan Yue, Jing Zhang, Jiaxin Li, Yanwei Hao, Shaofeng Wang, Tianyu Liu, Wen Zhong, Chongli Chen, Fei Wang & Bin Li
Additional file 1. SPIRIT checklist

The palynology of the Permian succession in the CSDP-2 Well, South Yellow Sea, China

Xing-Kai Ji, Xing-Wei Guo, Ning Yang, Jiří Bek, Ting Nie, Hui-Nan Lu & Hong-He Xu
The fully cored CSDP-2 Well, drilled in the central uplift region of the South Yellow Sea, China, provides indispensable and very significant research opportunities to understand the evolution of life, paleoclimate, paleogeography, and tectonics during the Permian in the South Yellow Sea area of the Yangtze paleoblock. We here analyze 118 samples from 893.7 to 1798.8 m depth of the CSDP-2 borehole core and recognize three Permian palynological assemblages, Laevigatosporites minimus – Florinites florini (MF)...

Additional file 1 of Comprehensive virome analysis of the viral spectrum in paediatric patients diagnosed with Mycoplasma pneumoniae pneumonia

Qiong Guo, Lili Li, Chao Wang, Yiman Huang, Fenlian Ma, Shanshan Cong, Jingjing Tan, Lihong Yao, Aijun Chen & Lishu Zheng
Additional file 1. The tables of the filtering parameters setting using Prinseq-lite software, primers and probes used to detect co-infection respiratory viruses, type analysis of common virus-related sequence viral in MP positive and MP negative (TTV has been removed). Table S1: The filtering parameters setting using Prinseq-lite software. Table S2: Primers and probes used to detect co-infection respiratory viruses. Table S3: Type analysis of common virus-related sequence viral in MP positive and MP negative (TTV...

Comprehensive virome analysis of the viral spectrum in paediatric patients diagnosed with Mycoplasma pneumoniae pneumonia

Qiong Guo, Lili Li, Chao Wang, Yiman Huang, Fenlian Ma, Shanshan Cong, Jingjing Tan, Lihong Yao, Aijun Chen & Lishu Zheng
Abstract Background Among hospitalized children suffering from community-acquired pneumonia, Mycoplasma pneumoniae (MP) is one of the most common pathogens. MP often exists as a co-infection with bacteria or viruses, which can exacerbate the clinical symptoms. We investigated the pathogen spectrum in MP-positive and MP-negative samples from hospitalized children with respiratory tract infections in Beijing, China. Method This study included 1038 samples of nasopharyngeal aspirates obtained between April, 2017 and March, 2018 from hospitalized children under...

VDAC1 balances mitophagy and apoptosis in leafhopper upon arbovirus infection

Qian Chen, Dongsheng Jia, Jiping Ren, Yu Cheng, Haibo Wu, Shude Guo & Taiyun Wei
Mitophagy is a form of autophagy that selectively removes damaged mitochondria and attenuates mitochondrial-dependent apoptosis during viral infection, but how arboviruses balance mitophagy and apoptosis to facilitate persistent viral infection in insect vectors without causing evident fitness cost remains elusive. Here, we identified mitochondrial VDAC1 (voltage-dependent anion channel 1) that could be hijacked by nonstructural protein Pns11 of rice gall dwarf virus (RGDV), a plant nonenveloped double-stranded RNA virus, to synergistically activate pro-viral extensive mitophagy...

Additional file 10 of Identification of crucial genes and metabolites regulating the eggshell brownness in chicken

Jing Yang, Zhiqiong Mao, Xiqiong Wang, Jingjie Zhuang, Sijia Gong, Zhouyang Gao, Guiyun Xu, Ning Yang & Congjiao Sun
Additional file 10: Fig. S2. The location of the next ovulated egg in the oviduct at different time points following oviposition.

Additional file 2 of Identification of crucial genes and metabolites regulating the eggshell brownness in chicken

Jing Yang, Zhiqiong Mao, Xiqiong Wang, Jingjie Zhuang, Sijia Gong, Zhouyang Gao, Guiyun Xu, Ning Yang & Congjiao Sun
Additional file 2: Table S1. Differentially upregulated genes in DBS group at 16 h compared with 4 h following oviposition.

Additional file 3 of Identification of crucial genes and metabolites regulating the eggshell brownness in chicken

Jing Yang, Zhiqiong Mao, Xiqiong Wang, Jingjie Zhuang, Sijia Gong, Zhouyang Gao, Guiyun Xu, Ning Yang & Congjiao Sun
Additional file 3: Table S2. Differentially upregulated genes in DBS group at 22 h compared with 4 h following oviposition.

VDAC1 balances mitophagy and apoptosis in leafhopper upon arbovirus infection

Qian Chen, Dongsheng Jia, Jiping Ren, Yu Cheng, Haibo Wu, Shude Guo & Taiyun Wei
Mitophagy is a form of autophagy that selectively removes damaged mitochondria and attenuates mitochondrial-dependent apoptosis during viral infection, but how arboviruses balance mitophagy and apoptosis to facilitate persistent viral infection in insect vectors without causing evident fitness cost remains elusive. Here, we identified mitochondrial VDAC1 (voltage-dependent anion channel 1) that could be hijacked by nonstructural protein Pns11 of rice gall dwarf virus (RGDV), a plant nonenveloped double-stranded RNA virus, to synergistically activate pro-viral extensive mitophagy...

Additional file 2 of PRR34-AS1 promotes exosome secretion of VEGF and TGF-β via recruiting DDX3X to stabilize Rab27a mRNA in hepatocellular carcinoma

Zhilei Zhang, Ye Zhou, Yuming Jia, Chao Wang, Meng Zhang & Zhuo Xu
Additional file 2: Figure S2. DDX3X positively regulates Rab27a expression in HCC cells. A The cellular distribution of PRR34-AS1 in HCC cells was confirmed by subcellular fractionation assay. N = 3. B, C The mRNA and protein levels of DDX3X and Rab27a were analyzed in HCC cells transfected with sh/DDX3X#a/b. N = 3. **P < 0.01. Data were analyzed via DGP PCR quantification.

Additional file 2 of PRR34-AS1 promotes exosome secretion of VEGF and TGF-β via recruiting DDX3X to stabilize Rab27a mRNA in hepatocellular carcinoma

Zhilei Zhang, Ye Zhou, Yuming Jia, Chao Wang, Meng Zhang & Zhuo Xu
Additional file 2: Figure S2. DDX3X positively regulates Rab27a expression in HCC cells. A The cellular distribution of PRR34-AS1 in HCC cells was confirmed by subcellular fractionation assay. N = 3. B, C The mRNA and protein levels of DDX3X and Rab27a were analyzed in HCC cells transfected with sh/DDX3X#a/b. N = 3. **P < 0.01. Data were analyzed via DGP PCR quantification.

Additional file 3 of PRR34-AS1 promotes exosome secretion of VEGF and TGF-β via recruiting DDX3X to stabilize Rab27a mRNA in hepatocellular carcinoma

Zhilei Zhang, Ye Zhou, Yuming Jia, Chao Wang, Meng Zhang & Zhuo Xu
Additional file 3: Figure S3. Transfection efficiency of Rab27a in HCC cells. A Rab27a levels in HCC cells was detected by RT-qPCR and western bot analyses after Rab27a silencing. N = 3. **P < 0.01.

Seasonal distribution of Cryptosporidium spp., Giardia duodenalis and Enterocytozoon bieneusi in Tibetan sheep in Qinghai, China

Fan Yang, Li Ma, Jing-min Gou, Hui-zhong Yao, Mei Ren, Bing-ke Yang & Qing Lin
Abstract Background Cryptosporidium spp., Giardia duodenalis and Enterocytozoon bieneusi can cause important intestinal diseases in ruminants. However, data on the distribution of these three protozoan pathogens in Tibetan sheep are limited. Methods We collected 761 fecal samples from Tibetan sheep across four seasons in Qinghai Province, China, and screened the samples for Cryptosporidium spp., G. duodenalis and E. bieneusi using PCR-based sequence analysis of the genes encoding 18S ribosomal RNA, triosephosphate isomerase and the internal...

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