823 Works

FMO3 deficiency of duck leads to decreased lipid deposition and increased antibacterial activity

Xingzheng Li, Jianlou Song, Xuefeng Shi, Mingyi Huang, Lei Liu, Guoqiang Yi, Ning Yang, Guiyun Xu & Jiangxia Zheng
Abstract Background Most duck eggs possess a fishy odor, indicating that ducks generally exhibit impaired trimethylamine (TMA) metabolism. TMA accumulation is responsible for this unpleasant odor, and TMA metabolism plays an essential role in trimethylaminuria (TMAU), also known as fish odor syndrome. In this study, we focused on the unusual TMA metabolism mechanism in ducks, and further explored the unclear reasons leading to the debilitating TMA metabolism. Methods To achieve this, transcriptome, proteome, and metagenome...

Additional file 1 of Characteristics of lymphocyte subset alterations in COVID-19 patients with different levels of disease severity

Wei Dai, Aifang Zhong, Qinghua Qiao, Jian Wu, Weiwei Li, Qiuyue Wu, Hongjian Zhou, Shijie Qin, Weijun Jiang, Jing Zhang & Xinyi Xia
Additional file 1. Figure S1 Representative flow cytometry dot plots showing the gating strategy for B lymphocyte subsets. Figure S2 Representative flow cytometry dot plots showing the gating strategy for T lymphocyte subsets. Figure S3 Representative flow cytometry dot plots showing the gating strategy for basic cell subsets. Figure S4 Representative flow cytometry dot plots showing the gating strategy for Treg lymphocyte subsets.

Additional file 23 of Evolution of different rice ecotypes and genetic basis of flooding adaptability in Deepwater rice by GWAS

Xueqiang Wang, Yan Zhao, Conghui Jiang, Libing Wang, Lei Chen, Fengmei Li, Yanhong Zhang, Yinghua Pan & Tianzhen Zhang
Additional file 23 Table S22. The cloned genes for deepwater and heat map of the ratio of RPKM.

Additional file 24 of Evolution of different rice ecotypes and genetic basis of flooding adaptability in Deepwater rice by GWAS

Xueqiang Wang, Yan Zhao, Conghui Jiang, Libing Wang, Lei Chen, Fengmei Li, Yanhong Zhang, Yinghua Pan & Tianzhen Zhang
Additional file 24 Table S23. Haplotype analysis of the candidate genes for deepwater QTLs.

Additional file 3 of Evolution of different rice ecotypes and genetic basis of flooding adaptability in Deepwater rice by GWAS

Xueqiang Wang, Yan Zhao, Conghui Jiang, Libing Wang, Lei Chen, Fengmei Li, Yanhong Zhang, Yinghua Pan & Tianzhen Zhang
Additional file 3 Fig. S1 PCA plot of the first two eigenvectors (a) and two and three eigenvectors (b) of rice accessions. Additional file 2. Fig. S2 Maximum-likelihood tree of rice assuming 0 to 3 migration edges. Additional file 2. Fig. S3 Corresponding residual of rice assuming 0 to 10 migration edges. Additional file 2. Fig. S4 Genome-wide detection of positive selection in different rice ecotypes. Additional file 2. Fig. S5 Selective sweep regions identified...

Cancer-associated fibroblast-derived gene signatures predict radiotherapeutic survival in prostate cancer patients

Ran Zhang & Feng Liu
Abstract Background Cancer-associated fibroblasts (CAFs) play multiple roles in regulating tumor metastasis and treatment response. Current clinical indicators are insufficient to accurately assess disease risk and radiotherapy response, emphasizing the urgent need for additional molecular prognostic markers. Methods In order to investigate CAF-related genes associated with radiotherapy and construct prognostic CAF-related gene signatures for prostate cancer, we firstly established a radio-resistant prostate CAF cell subline (referred to as CAFR) from Mus-CAF (referred to as CAF)...

Additional file 1 of Circ_0003570 Suppresses the progression of hepatocellular carcinoma through miR-182-5p/STARD13 regulatory axis

Xu Zhang, Wenwen Chen, Dan Guo, Yarui Li, Yan Zhao, Mudan Ren, Guifang Lu, Xinlan Lu & Shuixiang He
Additional file 1: Figure S1. The vector map of (A) wt-circ_0003570-luc, (B) mut-circ_0003570-luc; (C) wt-STARD13-luc, and (D) mut-STARD13-luc. Figure S2. Knockdown of circ_0003570 promotes proliferation, migration and invasion of MHCC-97L cells in vitro. (A) MTT assays and (B) colony formation assays showing that downregulation of circ_0003570 promoted the proliferation of MHCC-97L cells, *P < 0.05. (C) Transwell assays showed circ_0003570 knockdown reduced the migration and invasion of MHCC-97L cells. *P < 0.05. (D) Representative images...

Additional file 1 of Identification of a flavonoid C-glycosyltransferase from fern species Stenoloma chusanum and the application in synthesizing flavonoid C-glycosides in Escherichia coli

Rong Ni, Xin-Yan Liu, Jiao-Zhen Zhang, Jie Fu, Hui Tan, Ting-Ting Zhu, Jing Zhang, Hai-Long Wang, Hong-Xiang Lou & Ai-Xia Cheng
Additional file 1: Fig. S1. The possible biosynthetic pathways for C-glycosylflavones. F2H: flavanone 2-hydroxylase; FNS: flavone synthase; CGT: C-glycosyltransferase. Fig. S2. SDS-PAGE analysis of recombinant proteins. M: Weight marker, Lane 1: pET32a, Lane 2: ScGT1, Lane 3: ScGT2, Lane 4: ScGT3, Lane 5: ScGT4, Lane 6: ScCGT1-H26A, Lane 7: ScCGT1-L143T, Lane 8: ScCGT1-P164T, Lane 9: ScCGT1-L301G, Lane 10: ScCGT1-D141I/P142D, Lane 11: ScCGT1-4T (S108D/H109P/V110F/L111F). Fig. S3. Sugar donor selectivity of ScCGT1. A. HPLC chromatograms of the...

Additional file 1 of Application of exome sequencing for prenatal diagnosis of fetal structural anomalies: clinical experience and lessons learned from a cohort of 1618 fetuses

Fang Fu, Ru Li, Qiuxia Yu, Dan Wang, Qiong Deng, Lushan Li, Tingying Lei, Guilan Chen, Zhiqiang Nie, Xin Yang, Jin Han, Min Pan, Li Zhen, Yongling Zhang, Xiangyi Jing, Fucheng Li, Fatao Li, Lina Zhang, Cuixing Yi, Yingsi Li, Yan Lu, Hang Zhou, Ken Cheng, Jian Li, Lina Xiang … & Can Liao
Additional file 1. Analysis and interpretation process of fetal ES data.

Short night-time sleep duration is associated with thyroid nodules: A community-based survey from Guangzhou, China

Yuerong Yan, Xiaoyi Wang, Hongshi Wu, Caixia Chen, Xiaohui Li, Rongxue Yang, Feng Li, Li Yan, Muchao Mu & Mingtong Xu
Sleep plays a critical role in maintaining human health. This study aimed to explore the association between sleep status and thyroid nodules. A total of 2414 individuals aged 18 or older with euthyroidism were enrolled in this community-based survey. Sleep status was self-reported. Thyroid ultrasonography was performed to measure nodules. Multiple logistic analyses were applied to adjust for confounding factors. The percentages of thyroid nodules among individuals who slept <5 hours, 5–8 hours, and >8...

DNA methylation alternation in Stanford- A acute aortic dissection

Yufei Chen, Xu Xu, Zhaoran Chen, Bi Huang, Xiaojian Wang & Xiaohan Fan
Abstract Background Acute aortic dissection (AAD) is a life-threatening cardiovascular disease. Recent studies have shown that DNA methylation may be associated with the pathological mechanism of AAD, but the panorama of DNA methylation needs to be explored. Methods DNA methylation patterns were screened using Infinium Human Methylation 450 K BeadChip in the aortic tissues from 4 patients with Stanford-A AAD and 4 controls. Gene enrichment was analyzed by Kyoto Encyclopedia of Genes and Genomes (KEGG)...

Additional file 3 of PRR34-AS1 promotes exosome secretion of VEGF and TGF-β via recruiting DDX3X to stabilize Rab27a mRNA in hepatocellular carcinoma

Zhilei Zhang, Ye Zhou, Yuming Jia, Chao Wang, Meng Zhang & Zhuo Xu
Additional file 3: Figure S3. Transfection efficiency of Rab27a in HCC cells. A Rab27a levels in HCC cells was detected by RT-qPCR and western bot analyses after Rab27a silencing. N = 3. **P < 0.01.

Additional file 4 of PRR34-AS1 promotes exosome secretion of VEGF and TGF-β via recruiting DDX3X to stabilize Rab27a mRNA in hepatocellular carcinoma

Zhilei Zhang, Ye Zhou, Yuming Jia, Chao Wang, Meng Zhang & Zhuo Xu
Additional file 4: Figure S4. PRR34-AS1 enhances THLE-3 cell malignant phenotypes via elevating the expression of Rab27a. A–F Rescue experiments were carried on in THLE-3 cells transfected with NC, PRR34-AS1, PRR34-AS1 + sh/Rab27a#a to assess cell proliferative, migratory and invasive as well as EMT phenotypes. N = 3. Scale bar = 50 µm. **P < 0.01.

PRR34-AS1 promotes exosome secretion of VEGF and TGF-β via recruiting DDX3X to stabilize Rab27a mRNA in hepatocellular carcinoma

Zhilei Zhang, Ye Zhou, Yuming Jia, Chao Wang, Meng Zhang & Zhuo Xu
Abstract Background Exosomes are deemed to be an important tool of intercellular communicators in cancer cells. Our study investigated the role of PRR34 long non-coding RNA antisense RNA 1 (PRR34-AS1) in regulating exosome secretion in hepatocellular carcinoma (HCC) cells. Methods Quantitative real-time polymerase chain reaction (RT-qPCR) analyzed the expression of PRR34-AS1. We assessed the function of PRR34-AS1 on the biological changes of THLE-3 cells and HCC cells. The downstream interaction between RNAS was assessed by...

Supplementary document for Engineered second-order nonlinearity in silicon nitride - 6179686.pdf

Yi Zhang, Juniyali Nauriyal, Meiting Song, Xiaotong He, Marissa Granados Báez, Timothy MacDonald & Jaime Cardenas
Revised Supplementary Document

Macrophages in the reticuloendothelial system inhibit early induction stages of mouse apolipoprotein A-II amyloidosis

Hiroki Miyahara, Jian Dai, Ying Li, Xiaoran Cui, Hibiki Takeuchi, Naomi Hachiya, Fuyuki Kametani, Masahide Yazaki, Masayuki Mori & Keiichi Higuchi
Amyloidosis refers to a group of degenerative diseases that are characterized by the deposition of misfolded protein fibrils in various organs. Deposited amyloid may be removed by a phagocyte-dependent innate immune system; however, the precise mechanisms during disease progression remain unclear. We herein investigated the properties of macrophages that contribute to amyloid degradation and disease progression using inducible apolipoprotein A-II amyloidosis model mice. Intravenously injected AApoAII amyloid was efficiently engulfed by reticuloendothelial macrophages in the...

Additional file 1 of Lifestyle behaviors and mental health during the coronavirus disease 2019 pandemic among college students: a web-based study

Yi Zhang, Shuman Tao, Yang Qu, Xingyue Mou, Hong Gan, Panfeng Zhou, Zhuoyan Zhu, Xiaoyan Wu & Fangbiao Tao
Additional file 1: Table S1. List of all the participants. Table S2. The association between health behaviors and mental health among college students. Table S3. Mental health scores stratified by depression, anxiety symptoms. Table S4. The mediation effect of coping style on the relationship between lifestyle health behaviors and mental health symptoms in college students. Table S5. Model characteristics for the conditional process analysis. Table S6. Bootstrapped conditional direct and indirect effects. Fig. S1. The...

Additional file 3 of Genes related to allergen exposure in allergic rhinitis: a gene-chip-based study in a mouse model

Min Wang, Ying Li, Jun Yang, Xiangdong Wang & Luo Zhang
Additional file 3: Table S3. The genes corresponding to the 21 significant pathways.

Supplemental Material, sj-pdf-1-ojs-10.1177_23259671221137051 - A Scientometric Analysis of Studies on Patellar Dislocation

Hong Wang, Zhi Yi, Hongwei Zhan, Yuanjun Teng, Shifeng Zhang, Meng Wu, Bin Geng & Yayi Xia
Supplemental Material, sj-pdf-1-ojs-10.1177_23259671221137051 for A Scientometric Analysis of Studies on Patellar Dislocation by Hong Wang, Zhi Yi, Hongwei Zhan, Yuanjun Teng, Shifeng Zhang, Meng Wu, Bin Geng and Yayi Xia in Orthopaedic Journal of Sports Medicine

Supplemental Material, sj-pdf-1-ojs-10.1177_23259671221137051 - A Scientometric Analysis of Studies on Patellar Dislocation

Hong Wang, Zhi Yi, Hongwei Zhan, Yuanjun Teng, Shifeng Zhang, Meng Wu, Bin Geng & Yayi Xia
Supplemental Material, sj-pdf-1-ojs-10.1177_23259671221137051 for A Scientometric Analysis of Studies on Patellar Dislocation by Hong Wang, Zhi Yi, Hongwei Zhan, Yuanjun Teng, Shifeng Zhang, Meng Wu, Bin Geng and Yayi Xia in Orthopaedic Journal of Sports Medicine

Additional file 8 of Biallelic mutations of TTC12 and TTC21B were identified in Chinese patients with multisystem ciliopathy syndromes

Weicheng Chen, Feifei Wang, Weijia Zeng, Xinyan Zhang, Libing Shen, Yuan Zhang & Xiangyu Zhou
Additional file 8: Table S4. Primers used for real-time PCR and cDNA amplification of TTC12

Supplementary material from \"New macronarian from the Middle Jurassic of Chongqing, China: phylogenetic and biogeographic implications for neosauropod dinosaur evolution\"

Hui Dai, Chao Tan, Qingyu Ma, Ning Li, Haidong Yu, Can Xiong, Zhaoying Wei, Ping Wang, Jian Yi, Guangbiao Wei, Hailu You & Xinxin Ren
Macronaria is a clade of gigantic body-sized sauropod dinosaurs widely distributed from the Late Jurassic to the Late Cretaceous globally. However, its origin, early diversification, and dispersal are still controversial. Here, we report a new macronarian Yuzhoulong qurenensis gen. et sp. nov. excavated from the Middle Jurassic (Bathonian) Lower Shaximiao Formation. Yuzhoulong qurenensis bears a unique combination of features, such as two accessory fossae that exist on the posterior surface of dorsal diapophyses of anterior...

Additional file 1 of Bifunctional anti-PD-L1/TGF-βRII agent SHR-1701 in advanced solid tumors: a dose-escalation, dose-expansion, and clinical-expansion phase 1 trial

Dan Liu, Jun Zhou, Yongsheng Wang, Mingjun Li, Haiping Jiang, Yunpeng Liu, Xianli Yin, Minghua Ge, Xiaojun Xiang, Jieer Ying, Jian Huang, Yan-qiao Zhang, Ying Cheng, Zhigang Huang, Xianglin Yuan, Weiqing Han, Dong Yan, Xinshuai Wang, Pan Liu, Linna Wang, Xiaojing Zhang, Suxia Luo, Tianshu Liu & Lin Shen
Additional file 1: Figure S1. Study design. Figure S2. Tumor response of patients in the dose-escalation and dose-expansion phase. Figure S3. Percentage change from baseline in target lesion tumour burden over time in patients with select tumors at the recommended dose (30 mg/kg q3w). Figure S4. Receiver operating characteristic curve analysis of pSmad2 level in tumor cells for ORR per RECIST v1.1. Table S1. Pharmacokinetic parameters following a single infusion. Table S2. Summary of treatment-related...

Bifunctional anti-PD-L1/TGF-βRII agent SHR-1701 in advanced solid tumors: a dose-escalation, dose-expansion, and clinical-expansion phase 1 trial

Dan Liu, Jun Zhou, Yongsheng Wang, Mingjun Li, Haiping Jiang, Yunpeng Liu, Xianli Yin, Minghua Ge, Xiaojun Xiang, Jieer Ying, Jian Huang, Yan-qiao Zhang, Ying Cheng, Zhigang Huang, Xianglin Yuan, Weiqing Han, Dong Yan, Xinshuai Wang, Pan Liu, Linna Wang, Xiaojing Zhang, Suxia Luo, Tianshu Liu & Lin Shen
Abstract Background Dual inhibition of PD-1/PD-L1 and TGF-β pathways is a rational therapeutic strategy for malignancies. SHR-1701 is a new bifunctional fusion protein composed of a monoclonal antibody against PD-L1 fused with the extracellular domain of TGF-β receptor II. This first-in-human trial aimed to assess SHR-1701 in pretreated advanced solid tumors and find the population who could benefit from SHR-1701. Methods This was a dose-escalation, dose-expansion, and clinical-expansion phase 1 study. Dose escalation was initiated...

Seasonal distribution of Cryptosporidium spp., Giardia duodenalis and Enterocytozoon bieneusi in Tibetan sheep in Qinghai, China

Fan Yang, Li Ma, Jing-min Gou, Hui-zhong Yao, Mei Ren, Bing-ke Yang & Qing Lin
Abstract Background Cryptosporidium spp., Giardia duodenalis and Enterocytozoon bieneusi can cause important intestinal diseases in ruminants. However, data on the distribution of these three protozoan pathogens in Tibetan sheep are limited. Methods We collected 761 fecal samples from Tibetan sheep across four seasons in Qinghai Province, China, and screened the samples for Cryptosporidium spp., G. duodenalis and E. bieneusi using PCR-based sequence analysis of the genes encoding 18S ribosomal RNA, triosephosphate isomerase and the internal...

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