444 Works

Angiopoietin-like protein 8, molecular cloning and regulating lipid accumulation in goat intramuscular preadipocytes

Wei Huang, Yaqiu Lin, Hua Xiang, Jiangjiang Zhu & Yong Wang
This study aimed to clone the full-length open reading frame (ORF) of goat ANGPTL8 gene sequence, reveal its molecular and expression characteristics, and explore its effect on the differentiation of goat intramuscular preadipocytes. The full-length ORF sequence of goat ANGPTL8 gene was cloned by RT-PCR technology, and bioinformatics analysis was performed by related biological software. RT-qPCR was used to detect the expression of ANGPTL8 mRNA in goat tissues. Further use of RNA interference to study...

The effect of amiloride in decreasing albuminuria in patients with diabetic kidney diseases: a prospective, crossover, open-label study

Ruizhao Li, Zhiyong Xie, Li Zhang, Ying Huang, Jianchao Ma, Wei Dong, Zhilian Li, Yuanhan Chen, Huaban Liang, Yanhua Wu, Xingchen Zhao, Wenjian Wang, Zhiming Ye, Shuangxin Liu, Wei Shi & Xinling Liang
Diabetic kidney diseases (DKD) were the leading cause of End-stage renal diseases worldwide. Albuminuria was a target for treatment in DKD and decreasing albuminuria was particularly important for improving its prognosis. However, there is still a lack of specific treatment for DKD. We conducted a prospective, crossover, open-label study to investigate the effect of amiloride in patients with DKD. Safety and efficacy were assessed by monitoring urine protein creatinine ratio(uPCR), urinary albumin creatinine ratio (uACR),...

Risk factors for mortality in patients undergoing peritoneal dialysis: a systematic review and meta-analysis

Jialing Zhang, Xiangxue Lu, Han Li & Shixiang Wang
Inconsistent investigations of the risk factors for all-cause mortality in patients undergoing peritoneal dialysis (PD) were reported. The present meta-analysis aimed to assess the impact of some clinical characteristics on the risk of mortality in PD patients. PubMed and Embase were systematically searched for studies evaluating the risk factors for all-cause mortality in PD patients. Hazard ratio (HR) and 95% confidence interval (CI) were derived using a random-effect or fixed-effect model considering the heterogeneity across...

The feasibility of one-stage flexible ureteroscopy lithotripsy in solitary kidney patients with 1–3 cm renal stones and risk factors of renal function changes

Yang Pan, Han Chen, Hualin Chen, Xiaoxiang Jin, Yunxiao Zhu & Gang Chen
To compare perioperative outcomes and long-term renal function changes between prior stenting (PS) and not prior stenting (NPS) before flexible ureteroscopy lithotripsy (f-URS) for solitary kidney patients. Solitary kidney patients with 10–30 mm renal stones were enrolled in this historical control study. Perioperative parameters and complications were compared. Stone-free was defined as the absence of any residual stones on a CT scan. Renal function changes were evaluated by estimated glomerular filtration rate (eGFR) and adjusted...

Risk factors for mortality in hemodialysis patients with COVID-19: a systematic review and meta-analysis

Fengping Wang, Guangyu Ao, Yushu Wang, Fuqiang Liu, Mulong Bao, Ming Gao, Shulu Zhou & Xin Qi
New evidence from studies on risk factors for mortality in hemodialysis (HD) patients with COVID-19 became available. We aimed to review the clinical risk factors for fatal outcomes in these patients. We performed meta-analysis using the PubMed, EMBASE, and Cochrane databases. A fixed- or random-effects model was used for calculating heterogeneity. We used contour-enhanced funnel plot and Egger’s tests to assess potential publication bias. Twenty-one studies were included. The proportion of males was lower in...

Spatiotemporal specificity of correlated DNA methylation and gene expression pairs across different human tissues and stages of brain development

Kangli Wang, Rujia Dai, Yan Xia, Jianghua Tian, Chuan Jiao, Tatiana Mikhailova, Chunling Zhang, Chao Chen & Chunyu Liu
DNA methylation (DNAm) that occurs on promoter regions is primarily considered to repress gene expression. Previous studies indicated that DNAm could also show positive correlations with gene expression. Both DNAm and gene expression profiles are known to be tissue- and development-specific. This study aims to investigate how DNAm and gene expression are coordinated across different human tissues and developmental stages, as well as the biological significance of such correlations. By analyzing 2,239 samples with both...

Transcutaneous electrical acupoint stimulation for high-normal blood pressure: study protocol for a randomized controlled pilot trial

Yu Wang, Guang-Xia Shi, Zhong-Xue Tian, Jun-Hong Liu, You-Sheng Qi, Jian-Feng Tu, Jing-Wen Yang, Li-Qiong Wang & Cun-Zhi Liu
Abstract Background High-normal blood pressure (BP) is associated with increased all-cause, cardiovascular mortality and frequently progresses to hypertension. Transcutaneous electrical acupoint stimulation (TEAS) might be a non-pharmaceutical therapy option to control BP. This trial aims to determine the effectiveness and safety of TEAS combined with lifestyle modification for high-normal BP. Methods/design This prospective, randomized, and parallel clinical trial will be conducted in a community service center in China. Sixty participants with high-normal BP will be...

Cessation of collisional tectonism and rapid crustal uplift recorded by 430–420 Ma igneous rocks in the South Kunlun belt, northwest China

Jing Chen, Bing-Zhang Wang, Fu-Cheng Yu, Jie Han & Wu-Fu Li
The Wanbaogou granitic plutons are exposed along with coeval volcanic rocks, and provide an opportunity to investigate Silurian tectonism in the South Kunlun belt, northwest China. This study presents new whole-rock geochemical, and zircon U–Pb geochronological and Lu–Hf isotope data for Silurian intrusive rocks of the Wanbaogou area. We analysed four samples: a porphyritic monzogranite and dioritic dike from the Wanbaogou pluton and a granodiorite and monzogranite from the Wudaogou pluton. Zircon U–Pb dating yielded...

Early Cretaceous rapid exhumation processes in the southern Great Xing’an Range, NE China: implications for extensional geodynamics

Wen Chen, Wen Zhang, Shuangfeng Zhao, Jingbo Sun, Ze Shen, Qiuyi Du & Zhi Li
The Mesozoic-Cenozoic geological evolution of the southern Great Xing’an Range (GXR) has long been controversial since it is located in the superposed region of different tectonic regimes and involves complex interactions. Here, we present low-temperature thermochronological data from granitoids emplaced in multiple magmatic stages to delineate the tectono-thermal history and further understand the geodynamic process. Most zircon and apatite (U-Th)/He ages, within error, indicate Early Cretaceous: the zircon average (U-Th)/He ages range from 146.7 ±...

Using a WeChat mini-program-based lactation consultant intervention to increase the consumption of mother’s own milk by preterm infants in the neonatal intensive care unit: a study protocol for a cluster randomized controlled trial

Jie Huo, Xinping Wu, Chuanli Gu, Zhangbin Yu, Jun Zhang, Xiaohui Chen, Jingai Zhu, Feng Liu, Beibei Liu, Qianqian Li & Shuping Han
Abstract Background The benefits of mother’s own milk (MOM) for preterm infants have been widely recognized. Many studies have shown that the rate of breastfeeding of premature infants remains very low. Although many studies use measures to promote breastfeeding, few high-quality cluster randomized controlled studies have evaluated the effectiveness of these measures. WeChat is an instant messaging software for smart terminals, and WeChat mini-programs have been widely used to promote health and self-management in China....

Additional file 2 of Using a WeChat mini-program-based lactation consultant intervention to increase the consumption of mother’s own milk by preterm infants in the neonatal intensive care unit: a study protocol for a cluster randomized controlled trial

Jie Huo, Xinping Wu, Chuanli Gu, Zhangbin Yu, Jun Zhang, Xiaohui Chen, Jingai Zhu, Feng Liu, Beibei Liu, Qianqian Li & Shuping Han
Additional file 2.

Additional file 2 of Effect of traditional Chinese medicine formula Guilu Xian on in vitro fertilization and embryo transfer outcome in older women with low prognosis: study protocol for a prospective, multicenter, randomized double-blind study

Yingjie Ma, Xianling Cao, Jingyan Song, Dandan Gao, Xinlei Wang, Li Li & Zhengao Sun
Additional file 2. Schedule of the study process

Effect of traditional Chinese medicine formula Guilu Xian on in vitro fertilization and embryo transfer outcome in older women with low prognosis: study protocol for a prospective, multicenter, randomized double-blind study

Yingjie Ma, Xianling Cao, Jingyan Song, Dandan Gao, Xinlei Wang, Li Li & Zhengao Sun
Abstract Introduction In recent years, the prevalence of infertility has significantly increased and has become a global reproductive health problem. The female ovarian reserves have been shown to decrease progressively with an increase in age. Besides, the rate of embryo implantation and clinical pregnancy also decreases. Traditional Chinese medicine has been widely applied in assisted reproductive technology. It is reported to have a significant influence on improving the quality of oocytes, improving endometrial receptivity, increasing...

Foliar nutrient diagnosis norms for litchi (Litchi chinensis Sonn. cv. Feizixiao) in South China

Donglin Luo, Wei Wang, Cuihua Bai, Luwei Zhu, Huan Li, Changmin Zhou, Quanmin Qiu & Lixian Yao
Foliar nutrient diagnosis is a potent tool for nutrient management in crops. Litchi (Litchi chinensis Sonn.) plantation in China dominates the worldwide litchi cultivation, and Feizixiao is the most widely cultivated species in China. Herein, 538 leaf samples were collected at fruit swelling stage and the terminal shoot maturing stage during 2016–2017, and the fruit yields of all the sampled trees were recorded. The suitability of four nutrient diagnosis methods including critical value approach (CVA),...

The effects of ground cover management on fruit yield and quality: a meta-analysis

Linfa Fang, Xiaojun Shi, Yong Zhang, Yehua Yang, Xueliang Zhang, Xiaozhong Wang & Yuting Zhang
An important management strategy for the development of sustainable agriculture in orchards is the management of ground cover. However, there is a knowledge gap regarding the effects of ground cover on fruit yield and quality. We performed a meta-analysis of 580 observations collected from 116 peer-reviewed field studies, to assess the effects of ground cover on fruit yield and quality indicators. Overall, ground cover significantly increased fruit yield, soluble solid content, sugar content, and vitamin...

Supplemental Material, sj-pdf-1-teu-10.1177_13548166211021175 - Effects of tourism development on economic growth: An empirical study of China based on both static and dynamic spatial Durbin models

Honghong Liu, Ye Xiao, Bin Wang & Dianting Wu
Supplemental Material, sj-pdf-1-teu-10.1177_13548166211021175 for Effects of tourism development on economic growth: An empirical study of China based on both static and dynamic spatial Durbin models by Honghong Liu, Ye Xiao, Bin Wang and Dianting Wu in Tourism Economics

Supplemental Material, sj-pdf-1-teu-10.1177_13548166211021175 - Effects of tourism development on economic growth: An empirical study of China based on both static and dynamic spatial Durbin models

Honghong Liu, Ye Xiao, Bin Wang & Dianting Wu
Supplemental Material, sj-pdf-1-teu-10.1177_13548166211021175 for Effects of tourism development on economic growth: An empirical study of China based on both static and dynamic spatial Durbin models by Honghong Liu, Ye Xiao, Bin Wang and Dianting Wu in Tourism Economics

Inference on Nadarajah–Haghighi distribution with constant stress partially accelerated life tests under progressive type-II censoring

Sanku Dey, Liang Wang & Mazen Nassar
This paper presents methods of estimation of the parameters and acceleration factor for Nadarajah–Haghighi distribution based on constant-stress partially accelerated life tests. Based on progressive Type-II censoring, Maximum likelihood and Bayes estimates of the model parameters and acceleration factor are established, respectively. In addition, approximate confidence interval are constructed via asymptotic variance and covariance matrix, and Bayesian credible intervals are obtained based on importance sampling procedure. For comparison purpose, alternative bootstrap confidence intervals for unknown...

Self-assembled polymeric nanocarrier-mediated co-delivery of metformin and doxorubicin for melanoma therapy

Mingming Song, Wentao Xia, Zixuan Tao, Bin Zhu, Wenxiang Zhang, Chang Liu & Siyu Chen
Malignant melanoma is a life-threatening form of skin cancer with a low response rate to single-agent chemotherapy. Although combined therapies of metformin (MET) and doxorubicin (DOX) are effective in treating a variety of cancers, including breast cancer, their different physicochemical properties and administration routines reduce the effective co-accumulation of both drugs in tumors. Nanoparticles (NPs) have been demonstrated to potentially improve drug delivery efficiency in cancer therapy of, for example, liver and lung cancers. Hence,...

Topically applied liposome-in-hydrogels for systematically targeted tumor photothermal therapy

Gang Chen, Aftab Ullah, Gang Xu, Zhou Xu, Fei Wang, Tianqing Liu, Yi Su, Tangjie Zhang & Kaikai Wang
Transdermal drug delivery for local or systemic therapy provides a potential anticancer modality with a high patient compliance. However, the drug delivery efficiency across the skin is highly challenging due to the physiological barriers, which limit the desired therapeutic effects. In this study, we prepared liposome-in-hydrogels containing a tumor targeting photosensitizer IR780 (IR780/lipo/gels) for tumor photothermal therapy (PTT). The formulation effectively delivered IR780 to subcutaneous tumor and deep metastatic sites, while the hydrogels were applied...

Tumor-targeted Gd-doped mesoporous Fe3O4 nanoparticles for T1/T2 MR imaging guided synergistic cancer therapy

Shaohui Zheng, Shang Jin, Min Jiao, Wenjun Wang, Xiaoyu Zhou, Jie Xu, Yong Wang, Peipei Dou, Zhen Jin, Changyu Wu, Jingjing Li, Xinting Ge & Kai Xu
In this study, a novel intelligent nanoplatform to integrate multiple imaging and therapeutic functions for targeted cancer theranostics. The nanoplatform, DOX@Gd-MFe3O4 NPs, was constructed Gd-doped mesoporous Fe3O4 nanoparticles following with the doxorubicin (DOX) loading in the mesopores of the NPs. The DOX@Gd-MFe3O4 NPs exhibited good properties in colloidal dispersity, photothermal conversion, NIR triggered drug release, and high T1/T2 relaxicity rate (r1=9.64 mM−1s−1, r2= 177.71 mM−1s−1). Benefiting from the high MR contrast, DOX@Gd-MFe3O4 NPs enabled simultaneous...

Silmitasertib-induced macropinocytosis promoting DDP intracellular uptake to enhance cell apoptosis in oral squamous cell carcinoma

Shaojuan Song, Xin Xia, Jiajia Qi, Xiaopei Hu, Qian Chen, Jiang Liu, Ning Ji & Hang Zhao
Cisplatin (DDP) is a first-line chemotherapeutic drug applied for the treatment of oral squamous cell carcinoma (OSCC). The anticancer activity of DDP is tightly linked to its intracellular uptake. It is unwise to increase the DDP intake by increasing the dose or shortening the dosing interval because of the severe systemic toxicity (nephrotoxicity, ototoxicity and neurotoxicity) in DDP application. The main uptake pathways of DDP include passive diffusion and active transporter transport. Therefore, finding additional...

The synergistic antitumor activity of 3-(2-nitrophenyl) propionic acid-paclitaxel nanoparticles (NPPA-PTX NPs) and anti-PD-L1 antibody inducing immunogenic cell death

Xiao-Chuan Duan, Li-Yuan Peng, Xin Yao, Mei-Qi Xu, Hui Li, Shuai-Qiang Zhang, Zhuo-Yue Li, Jing-Ru Wang, Zhen-Han Feng, Guang-Xue Wang, Ai Liao, Ying Chen & Xuan Zhang
Cancer immunotherapy is a strategy that is moving to the frontier of cancer treatment in the current decade. In this study, we show evidence that 3-(2-nitrophenyl) propionic acid-paclitaxel nanoparticles (NPPA-PTX NPs), act as immunogenic cell death (ICD) inducers, stimulating an antitumor response which results in synergistic antitumor activity by combining anti-PD-L1 antibody (aPD-L1) in vivo. To investigate the antitumor immunity induced by NPPA-PTX NPs, the expression of both ICD marker calreticulin (CRT) and high mobility...

Folic acid-modified ROS-responsive nanoparticles encapsulating luteolin for targeted breast cancer treatment

Yu Wang, Qianmei Wang, Wei Feng, Qian Yuan, Xiaowei Qi, Sheng Chen, Pu Yao, Qing Dai, Peiyuan Xia, Dinglin Zhang & Fengjun Sun
Luteolin (Lut) is a natural flavonoid polyphenolic compound with multiple pharmacological activities, such as anti-oxidant, anti-inflammatory, and anti-tumor effects. However, the poor aqueous solubility and low bioactivity of Lut restrict its clinical translation. Herein, we developed a reactive oxygen species (ROS)-responsive nanoplatforms to improve the bioactivity of Lut. Folic acid (FA) was employed to decorate the nanoparticles (NPs) to enhance its targeting ability. The size of Lut-loaded ROS-responsive nanoparticles (Lut/Oxi-αCD NPs) and FA-modified Lut/Oxi-αCD NPs...

Ages and tectonic attributes of Late Palaeozoic stratigraphic units in the Tarbagatay, West Junggar (NW China): revisited

Yan Xu, Ang Li, Wen Liao & Bao-Fu Han
As the youngest single age of detrital zircons is used as the maximum depositional age, the ages and tectonic attributes of the Late Palaeozoic stratigraphic units in the Tarbagatay area, West Junggar, NW China, become very confusing. An improved statistical approach indicates that 5, 6 and 7 concordant zircons are required for the maximum depositional age at 95% confidence level when the quantity of total concordant zircon in a sample does not exceed 50, 140...

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  • Fudan University
    444
  • Chinese Academy of Medical Sciences & Peking Union Medical College
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  • Zhejiang University
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  • Chinese Academy of Sciences
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