Nd3+-doped three-level (4F3/2–4I9/2) fiber lasers with wavelengths in the range of 850–950 nm are of considerable interest in applications such as bio-medical imaging and blue and ultraviolet laser generation. Although the design of a suitable fiber geometry has enhanced the laser performance by suppressing the competitive four-level (4F3/2–4I11/2) transition at ~1 µm, efficient operation of Nd3+-doped three-level fiber lasers still remains a challenge. In this study, taking a developed Nd3+-doped silicate glass single-mode fiber as...

We illustrate use of induced pluripotent stem cells (iPSCs) as platforms for investigating cardiomyocyte phenotypes in a human family pedigree exemplified by novel heterozygous RYR2-A1855D and SCN10A-Q1362H variants occurring alone and in combination. The proband, a four-month-old boy, presented with polymorphic ventricular tachycardia. Genetic tests revealed double novel heterozygous RYR2-A1855D and SCN10A-Q1362H variants inherited from his father (F) and mother (M), respectively. His father showed ventricular premature beats; his mother was asymptomatic. Molecular biological characterizations...

BackgroundOur previous studies have shown that the basic helix-loop-helix family member e40 (Bhlhe40) plays a critical role in regulating calcification and senescence of vascular smooth muscle cells induced by high glucose. In this study, we determined the association between serum Bhlhe40 levels and subclinical atherosclerosis in patients with type 2 diabetes mellitus (T2DM).Methods247 patients with T2DM were included in this cross-sectional study between June 2021 and July 2022. The presence of subclinical atherosclerosis was evaluated...

Supplemental material, sj-docx-1-tag-10.1177_17562848231165129 for Neutrophil-to-lymphocyte ratio for predicting postoperative recurrence in Crohn’s disease patients with isolated anastomotic lesions by Rirong Chen, Chao Li, Kang Chao, Yizhe Tie, Jieqi Zheng, Huili Guo, Zhirong Zeng, Li Li, Minhu Chen and Shenghong Zhang in Therapeutic Advances in Gastroenterology

Background:Patients with isolated anastomotic lesions (iAL) are common in postoperative Crohn’s disease (CD) and have heterogeneous prognosis.Objectives:To investigate the prognostic value of neutrophil-to-lymphocyte ratio (NLR) in CD patients with iAL.Design:A bicenter retrospective cohort study.Methods:CD patients who received ileocolonic resection from 2013 and 2020 and had a modified Rutgeerts score of i2a were recruited. NLR was determined within 1 week around the initial endoscopy after ileocolectomy. The primary outcome was clinical recurrence. Kaplan–Meier method and Cox...

Biochar-derived dissolved organic matter (BDOM) plays key roles in soil ecosystem by affecting soil physicochemical and biological properties and supplying nutrients to soil microbes. It can either enhance or suppress the growth of certain soil microorganisms, depending on its composition and content of labile organic compounds. This review aims to discuss and summarize the role of BDOM in modifying soil microbial functioning, microbial community structure, and enzymatic activity. We mainly focus on the role of...

Biochar-derived dissolved organic matter (BDOM) plays key roles in soil ecosystem by affecting soil physicochemical and biological properties and supplying nutrients to soil microbes. It can either enhance or suppress the growth of certain soil microorganisms, depending on its composition and content of labile organic compounds. This review aims to discuss and summarize the role of BDOM in modifying soil microbial functioning, microbial community structure, and enzymatic activity. We mainly focus on the role of...

The oxidation of sulfur dioxide (SO2) to sulfate in the atmosphere is an important concern in regional air quality, global climate change, and human health. While gas-phase and liquid-phase oxidation of SO2 are widely regarded as important sources of sulfate, the contribution of the heterogeneous oxidation process on particle surfaces is controversial. Recently, this heterogeneous chemistry has been considered to be an important mechanism that is missing in current models to explain sulfate concentrations observed...

A new naphthoquinone derivative (1) together with twenty-three known compounds (2–24), were isolated from the aerial parts of Rubia cordifolia L. Their structures were elucidated on the basis of NMR and HR-ESIMS data. Compounds 1–13 were assessed for their inhibitory effects on NO production in LPS-stimulated RAW 264.7 macrophage cells. Compounds 2-6 exhibited significant inhibitory activities with IC50 values of 21.37, 13.81, 24.56, 20.32, and 30.08 μmol·L−1, respectively.

We selected 43 grassland sites along a 1,500-km latitudinal gradient (c. 27°N to 39°N) and a 2,698-m elevational gradient (1,886 m to 4,584 m) on the Qinghai-Tibetan Plateau. We calculated the overall herbivory percentage (ranging from 0% to 100%) for each plant species by first multiplying the number of leaves in each damage class by the median removal value for that class (i.e., 0%, 2.5%, 7.5%, 15.0%, 35.0%, or 75.0%). Obtained values were then summed...

ABSTRACT Introduction: The objectives of this study were to investigate the main treatment strategies and long-term follow-up results of aortic dissection surgery after open-heart surgery (ADSOHS) and to analyze the risk factors that cause ADSOHS. Methods: One hundred thirty-seven patients with ADSOHS hospitalized in our hospital from January 2009 to December 2018 were selected as the research object. Long-term follow-up results, complications, mortality, and changes of cardiac function before and after operation were used to...

We investigated the prevalence of work-related musculoskeletal symptoms (WMSs) among medical staff and evaluated the associations of different levels of adverse ergonomic factors with WMSs. A total of 6099 Chinese medical staff were asked to complete a self-reported questionnaire to assess the prevalence and risk factors of WMSs from June 2018 to December 2020. A prevalence rate of 57.5% was observed for WMSs among overall medical staffs, which mainly affected the neck (41.7%) and shoulder...

The formation and distribution of late Mesozoic volcanic rocks in northeast (NE) China remain unclear due to the superimposed influence of the tectonic regimes of the Mongol–Okhotsk Ocean (MOO) and Palaeo-Pacific Ocean (PPO) in Northeast Asia. This study reports the petrogenesis and tectonic settings of Early Cretaceous volcanic rocks from the Erlian Basin (EB) using petrology, geochronology, whole-rock geochemistry, and Sr–Nd–Hf isotopes. The U–Pb data for the magmatic zircons indicate that the volcanic rocks, including...

Diabetic kidney disease (DKD) is a severe complication of type 2 diabetes mellitus (T2DM). However, the pathogenesis of DKD remains unclear, and effective treatment strategies are still lacking. Ginsenoside Rg1 (Rg1) has been reported to improve DKD, but the mechanism is unclear. NADPH oxidase 4 (NOX4) is an essential reactive oxygen species (ROS) source in the kidney. The mitogen-activated protein kinase (MAPK) signaling may exacerbate renal fibrosis. Therefore, we hypothesized that Rg1 might alleviate renal...

Supplemental material, sj-xlt-5-cll-10.1177_09636897231165874 for circSOBP Inhibits Bladder Cancer Proliferation and Metastasis by Regulating the miR-200a-3p/PTEN Axis and Participating in the Immune Response by Yinglang Zhang, Zhi Li, Yu Zhang, Chong Shen, Zhe Zhang, Xiaolei Ren, Changgang Guo, Shaobo Yang, Zejin Wang and Hailong Hu in Cell Transplantation

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The stimulus-responsive smart switching of aggregation-induced emission (AIE) features has attracted considerable attention in 4D information encryption, optical sensors and biological imaging. Nevertheless, for some AIE-inactive triphenylamine (TPA) derivatives, activating the fluorescence channel of TPA remains a challenge based on their intrinsic molecular configuration. Here, we took a new design strategy for opening a new fluorescence channel and enhancing AIE efficiency for (E)-1-(((4-(diphenylamino)phenyl)imino)methyl)naphthalen-2-ol. The turn-on methodology employed is based on pressure induction. Combining ultrafast and...

The stimulus-responsive smart switching of aggregation-induced emission (AIE) features has attracted considerable attention in 4D information encryption, optical sensors and biological imaging. Nevertheless, for some AIE-inactive triphenylamine (TPA) derivatives, activating the fluorescence channel of TPA remains a challenge based on their intrinsic molecular configuration. Here, we took a new design strategy for opening a new fluorescence channel and enhancing AIE efficiency for (E)-1-(((4-(diphenylamino)phenyl)imino)methyl)naphthalen-2-ol. The turn-on methodology employed is based on pressure induction. Combining ultrafast and...

figures and table

supplemental document

Altered retinal neurovascular coupling may contribute to the development and progression of diabetic retinopathy (DR) but remains highly challenging to measure due to limited resolution and field of view of the existing functional hyperemia imaging. Here, we present a novel modality of functional OCT angiography (fOCTA) that allows a 3D imaging of retinal functional hyperemia across the entire vascular tree with single-capillary resolution. In fOCTA, functional hyperemia was evoked by a flicker light stimulation, recorded...

Supplemental Document for Fiber-integrated cantilever-based nanomechanical biosensors as a novel tool for rapid antibiotic susceptibility testing

Supplemental material, sj-docx-1-ine-10.1177_15910199231164840 for Association between basilar artery stenosis features, vertebral artery stenosis and perforator stroke after stenting by Rui Huang, Bo Yang, Feng Gao, Dapeng Mo, Ming Yang, Zhikai Hou, Yifan Liu, Rongrong Cui, Kaijiang Kang, Weibin Gu, Jianfeng He, Xin Lou, Zhongrong Miao and Ning Ma in Interventional Neuroradiology

We investigated the alternatively changing (ac) valley-Hall effect in a graphene/h-BN structure under the modulations of a static electric field $E_0$, magnetic field $B_0$, and light field $E_{A1}$. The proximity to the h-BN film leads to a mass gap and strain-induced pseudopotential for electrons in graphene. Starting from the Boltzmann equation, we derive the ac conductivity tensor $\sigma$, including the orbital magnetic moment, Berry curvature, and anisotropic Berry curvature dipole. It is found that under...

We investigated the alternatively changing (ac) valley-Hall effect in a graphene/h-BN structure under the modulations of a static electric field $E_0$, magnetic field $B_0$, and light field $E_{A1}$. The proximity to the h-BN film leads to a mass gap and strain-induced pseudopotential for electrons in graphene. Starting from the Boltzmann equation, we derive the ac conductivity tensor $\sigma$, including the orbital magnetic moment, Berry curvature, and anisotropic Berry curvature dipole. It is found that under...