11 Works

The effect of geriatric comanagement (gc) in geriatric trauma patients treated in a level 1 trauma setting: a comparison of data before and after the implementation of a certified geriatric trauma center

Sascha Halvachizadeh
Introduction: Improvements in life expectancy imply that an increase of geriatric trauma patients occurs. These patients require special attention due to their multiple comorbidity issues. The aim of this study was to assess the impact of the implementation of geriatric comanagement (GC) on the allocation and clinical outcome of geriatric trauma patients. Methods: This observational cohort study aims to compare the demographic development and the clinical outcome in geriatric trauma patients (aged 70 years and...

Data from: Implementation of new standard operating procedures for geriatric trauma patients with multiple injuries: a single level I trauma centre study

Lorenz Peterer, Christian Ossendorf, Kai Oliver Jensen, Georg Osterhoff, Ladislav Mica, Burkhardt Seifert, Clément ML Werner, Hans-Peter Simmen, Hans-Christoph Pape & Kai Sprengel
Background The demographic changes towards ageing of the populations in developed countries impose a challenge to trauma centres, as geriatric trauma patients require specific diagnostic and therapeutic procedures. This study investigated whether the integration of new standard operating procedures (SOPs) for the resuscitation room (ER) has an impact on the clinical course in geriatric patients. The new SOPs were designed for severely injured adult trauma patients, based on the Advanced Trauma Life Support (ATLS) and...

Data from: Increasing cognitive load attenuates right arm swing in healthy human walking

Tim Killeen, Christopher S. Easthope, Linard Filli, Lilla Lőrincz, Miriam Schrafl-Altermatt, Peter Brugger, Michael Linnebank, Armin Curt, Björn Zörner & Marc Bolliger
Human arm swing looks and feels highly automated, yet it is increasingly apparent that higher centres, including the cortex, are involved in many aspects of locomotor control. The addition of a cognitive task increases arm swing asymmetry during walking, but the characteristics and mechanism of this asymmetry are unclear. We hypothesized that this effect is lateralized and a Stroop word-colour naming task—primarily involving left hemisphere structures—would reduce right arm swing only. We recorded gait in...

Data from: Protein synthesis inhibition in the peri-infarct cortex slows motor recovery in rats

Maximilian Schubring-Giese, Susan Leemburg, Andreas Rüdiger Luft & Jonas Aurel Hosp
Neuroplasticity and reorganization of brain motor networks are thought to enable recovery of motor function after ischemic stroke. Especially in the cortex surrounding the ischemic scar (i.e., peri-infarct cortex), evidence for lasting reorganization has been found at the level of neurons and networks. This reorganization depends on expression of specific genes and subsequent protein synthesis. To test the functional relevance of the peri-infarct cortex for recovery we assessed the effect of protein synthesis inhibition within...

Data from: How to detect a polytrauma patient at risk of complications: a validation and database analysis of four published scales

Sascha Halvachizadeh
Introduction Early accurate assessment of the clinical status of severely injured patients is crucial for guiding the surgical treatment strategy. Several scales are available to differentiate between risk categories. They vary between expert recommendations and scores developed on the basis of patient data (level II). We compared four established scoring systems in regard to their predictive abilities for early (e.g., hemorrhage-induced mortality) versus late (Multiple Organ Failure (MOF), sepsis, late death) in-hospital complications. Methods A...

Data from: Ten-year survival trends of neovascular age-related macular degeneration at first presentation

Cristina Arpa, Hagar Khalid, Shruti Chandra, Siegfried Wagner, Katrin Fasler, Livia Faes, Pakinee Pooprasert, Reena Chopra, Gabriella Moraes, Konstantinos Balaskas, Pearse Keane, Sobha Sivaprasad & Dun Jack Fu
Background: To describe 10-year trends in visual outcomes, anatomical outcomes, and treatment burden of patients receiving anti-vascular endothelial growth factor (VEGF) therapy for neovascular age-related macular degeneration (nAMD). Methods: Retrospective cohort study of treatment-naïve, first-affected eyes with nAMD started on ranibizumab before January 1, 2009. The primary outcome was time to best-corrected visual acuity (BCVA) falling ≤ 35 Early Treatment Diabetic Retinopathy Study (ETDRS) letters after initiating anti-VEGF therapy. Secondary outcomes included time to BCVA...

Data from: Agreements between industry and academia on publication rights: a retrospective study of protocols and publications of randomized clinical trials

Benjamin Kasenda, Erik Von Elm, John J. You, Anette Blümle, Yuki Tomonaga, Ramon Saccilotto, Alain Amstutz, Theresa Bengough, Joerg J. Meerpohl, Mihaela Stegert, Kelechi K. Olu, Kari A. O. Tikkinen, Ignacio Neumann, Alonso Carrasco-Labra, Markus Faulhaber, Sohail M. Mulla, Dominik Mertz, Elie A. Akl, Dirk Bassler, Jason W. Busse, Ignacio Ferreira-González, Francois Lamontagne, Alain Nordmann, Viktoria Gloy, Heike Raatz … & Matthias Briel
Background: Little is known about publication agreements between industry and academic investigators in trial protocols and the consistency of these agreements with corresponding statements in publications. We aimed to investigate (i) the existence and types of publication agreements in trial protocols, (ii) the completeness and consistency of the reporting of these agreements in subsequent publications, and (iii) the frequency of co-authorship by industry employees. Methods and Findings: We used a retrospective cohort of randomized clinical...

The Dimensions of Consciousness: From perceptual illusions to psychedelics. An interview of Olivia Carter by Katrin H. Preller.

Olivia Carter & Katrin, H. Preller
In this interview, the psychologist and neuroscientist Olivia Carter (University of Melbourne, Australia) explains how she became interested in the field of consciousness. We discuss how her work on visual perception has led her to study the effect of psychedelics and how this has inspired a multidimensional model of consciousness. We discuss the potential contents of “higher” states of consciousness and argue that the existence of those is an unresolved question. We finish the exchange...

Data from: Assessment of polytraumatized patients according to the Berlin Definition: Does the addition of physiological data really improve interobserver reliability?

Carina Eva Maria Pothmann, Stephen Baumann, Kai Oliver Jensen, Ladislav Mica, Georg Osterhoff, Hans Peter Simmen & Kai Sprengel
Background Several new definitions for categorizing the severely injured as the Berlin Definition have been developed. Here, severely injured patients are selected by additive physiological parameters and by the general Abbreviated Injury Scale (AIS)-based assessment. However, all definitions should conform to an AIS severity coding applied by an expert. We examined the dependence of individual coding on defining injury severity in general and in identifying polytrauma according to several definitions. A precise definition of polytrauma...

Resuscitative endovascular balloon occlusion of the aorta (REBOA) minimal dataset

Sascha Halvachizadeh
Introduction Resuscitative endovascular balloon occlusion of the aorta (REBOA) may be used in severely injured patients with uncontrollable bleeding. However, zone dependent effects of REBOA are rarely described. We compared the short-term zone- and organ-specific microcirculatory changes in abdominal organs and the extremity during occlusion of the aorta in a standardized porcine model. Methods Male pigs were placed under general anesthesia, for median laparotomy to expose intra-abdominal organs. REBOA placement occurred in Zone 1 (from...

Data from: Substance P signalling in primary motor cortex facilitates motor learning in rats

Benjamin Hertler, Jonas Aurel Hosp, Manuel Buitrago Blanco & Andreas Rüdiger Luft
Among the genes that are up-regulated in response to a reaching training in rats, Tachykinin 1 (Tac1) - a gene that encodes the neuropeptide Substance P (Sub P) - shows an especially strong expression. Using Real-Time RT-PCR, a detailed time-course of Tac1 expression could be defined: a significant peak occurs 7 hours after training ended at the first and second training session, whereas no up-regulation could be detected at a later time-point (sixth training session)....

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