125 Works

Nalbuphine: a candidate for treatment of women overwhelmed with sudden, intense labor pain?

Seraina Schoppmann, Deborah Spiess, Daniel Müller, Andrea Burch, Roland Zimmermann & Ana Paula Simões-Wüst
On very rare occasions, women are overwhelmed with sudden, intense labor pain in the context of ultra-rapid late second stage of labor, especially when the head is crowning. The consequences may comprise serious pelvic floor damage for the mother and hypoxia for the fetus. Drugs like nalbuphine for immediate maternal analgesia and sedation would be helpful. This mixed opioid agonist–antagonist, that was used in obstetric anesthesia in the 1980s, acts quickly while side effects for...

Closed-loop auditory stimulation method to modulate sleep slow waves and motor learning performance in rats

Carlos Gonçalves Moreira & Daniela Noain
Slow waves and cognitive output have been modulated in humans by phase-targeted auditory stimulation. However, to advance its technical development and further our understanding, implementation of the method in animal models is indispensable. Here, we report the successful employment of slow waves’ phase-targeted closed-loop auditory stimulation (CLAS) in rats. To validate this new tool both conceptually and functionally, we tested the effects of up- and down‑phase CLAS on proportions and spectral characteristics of sleep, and...

Colorectal cancer incidences in Lynch syndrome: a comparison of results from the prospective lynch syndrome database and the international mismatch repair consortium

Pål Møller, Toni Seppälä, James G. Dowty, Saskia Haupt, Mev Dominguez-Valentin, Lone Sunde, Inge Bernstein, Christoph Engel, Stefan Aretz, Maartje Nielsen, Gabriel Capella, Dafydd Gareth Evans, John Burn, Elke Holinski-Feder, Lucio Bertario, Bernardo Bonanni, Annika Lindblom, Zohar Levi, Finlay Macrae, Ingrid Winship, John-Paul Plazzer, Rolf Sijmons, Luigi Laghi, Adriana Della Valle, Karl Heinimann … & Mark A. Jenkins
Abstract Objective To compare colorectal cancer (CRC) incidences in carriers of pathogenic variants of the MMR genes in the PLSD and IMRC cohorts, of which only the former included mandatory colonoscopy surveillance for all participants. Methods CRC incidences were calculated in an intervention group comprising a cohort of confirmed carriers of pathogenic or likely pathogenic variants in mismatch repair genes (path_MMR) followed prospectively by the Prospective Lynch Syndrome Database (PLSD). All had colonoscopy surveillance, with...

Smartphone-RCCT: an online repository of randomized controlled clinical trials of smartphone applications for chronic conditions

Jürgen Barth, Jiani Wang, Jesus Lopez-Alcalde, Christoph Kramm, Daniel Pach, Noelia Álvarez-Díaz, Eulàlia Grifol-Clar & Claudia M. Witt
Abstract Background Chronic health conditions have a big impact on disability, morbidity, and mortality worldwide. Smartphone health applications (apps) can improve the health of patients with chronic conditions and enhance the quality and efficiency of healthcare. The number of randomized controlled trials (RCTs) of smartphone health apps is increasing, but a collection of the available evidence into a single database is still missing. The purpose of this study is to describe Smartphone-RCCT, which is an...

Additional file 1 of Whole blood methylome-derived features to discriminate endocrine hypertension

Roberta Armignacco, Parminder S. Reel, Smarti Reel, Anne Jouinot, Amandine Septier, Cassandra Gaspar, Karine Perlemoine, Casper K. Larsen, Lucas Bouys, Leah Braun, Anna Riester, Matthias Kroiss, Fidéline Bonnet-Serrano, Laurence Amar, Anne Blanchard, Anne-Paule Gimenez-Roqueplo, Aleksander Prejbisz, Andrzej Januszewicz, Piotr Dobrowolski, Eleanor Davies, Scott M. MacKenzie, Gian Paolo Rossi, Livia Lenzini, Filippo Ceccato, Carla Scaroni … & Guillaume Assié
Additional file 1: Fig. S1. Components of variation in the whole methylome dataset. a) Scree plot representing the percentage of explained variability by the first five principal components of PCA performed on the whole dataset (n=731,635 CpG sites, n=255 samples). b) Singular value decomposition (SVD) plot assessing the correlation between the first five significant components of variation in the dataset and other biological factors of interest (Hypertension type –PHT, CS, PA, PPGL-, age, sex, cell...

Additional file 2 of Whole blood methylome-derived features to discriminate endocrine hypertension

Roberta Armignacco, Parminder S. Reel, Smarti Reel, Anne Jouinot, Amandine Septier, Cassandra Gaspar, Karine Perlemoine, Casper K. Larsen, Lucas Bouys, Leah Braun, Anna Riester, Matthias Kroiss, Fidéline Bonnet-Serrano, Laurence Amar, Anne Blanchard, Anne-Paule Gimenez-Roqueplo, Aleksander Prejbisz, Andrzej Januszewicz, Piotr Dobrowolski, Eleanor Davies, Scott M. MacKenzie, Gian Paolo Rossi, Livia Lenzini, Filippo Ceccato, Carla Scaroni … & Guillaume Assié
Additional file 2: Table S1. Differentially methylated CpG sites in endocrine hypertension.

Additional file 1 of Smartphone-RCCT: an online repository of randomized controlled clinical trials of smartphone applications for chronic conditions

Jürgen Barth, Jiani Wang, Jesus Lopez-Alcalde, Christoph Kramm, Daniel Pach, Noelia Álvarez-Díaz, Eulàlia Grifol-Clar & Claudia M. Witt
Additional file 1. Chronic health conditions

Hybrid Kronecker Product Decomposition and Approximation

Chencheng Cai, Rong Chen & Han Xiao
Discovering underlying low dimensional structure of a high-dimensional matrix is traditionally done through low rank matrix approximations in the form of a sum of rank-one matrices. In this article, we propose a new approach. We assume a high-dimensional matrix can be approximated by a sum of a small number of Kronecker products of matrices with potentially different configurations, named as a hybrid Kronecker outer Product Approximation (hKoPA). It provides an extremely flexible way of dimension...

Hybrid Kronecker Product Decomposition and Approximation

Chencheng Cai, Rong Chen & Han Xiao
Discovering underlying low dimensional structure of a high-dimensional matrix is traditionally done through low rank matrix approximations in the form of a sum of rank-one matrices. In this article, we propose a new approach. We assume a high-dimensional matrix can be approximated by a sum of a small number of Kronecker products of matrices with potentially different configurations, named as a hybrid Kronecker outer Product Approximation (hKoPA). It provides an extremely flexible way of dimension...

Speed of cooling after cardiac arrest in relation to the intervention effect: a sub-study from the TTM2-trial

Rupert F. G. Simpson, Josef Dankiewicz, Grigoris V. Karamasis, Paolo Pelosi, Matthias Haenggi, Paul J. Young, Janus Christian Jakobsen, Jonathan Bannard-Smith, Pedro D. Wendel-Garcia, Fabio Silvio Taccone, Per Nordberg, Matt P. Wise, Anders M. Grejs, Gisela Lilja, Roy Bjørkholt Olsen, Alain Cariou, Jean Baptiste Lascarrou, Manoj Saxena, Jan Hovdenes, Matthew Thomas, Hans Friberg, John R. Davies, Niklas Nielsen & Thomas R. Keeble
Abstract Background Targeted temperature management (TTM) is recommended following cardiac arrest; however, time to target temperature varies in clinical practice. We hypothesised the effects of a target temperature of 33 °C when compared to normothermia would differ based on average time to hypothermia and those patients achieving hypothermia fastest would have more favorable outcomes. Methods In this post-hoc analysis of the TTM-2 trial, patients after out of hospital cardiac arrest were randomized to targeted hypothermia...

Speed of cooling after cardiac arrest in relation to the intervention effect: a sub-study from the TTM2-trial

Rupert F. G. Simpson, Josef Dankiewicz, Grigoris V. Karamasis, Paolo Pelosi, Matthias Haenggi, Paul J. Young, Janus Christian Jakobsen, Jonathan Bannard-Smith, Pedro D. Wendel-Garcia, Fabio Silvio Taccone, Per Nordberg, Matt P. Wise, Anders M. Grejs, Gisela Lilja, Roy Bjørkholt Olsen, Alain Cariou, Jean Baptiste Lascarrou, Manoj Saxena, Jan Hovdenes, Matthew Thomas, Hans Friberg, John R. Davies, Niklas Nielsen & Thomas R. Keeble
Abstract Background Targeted temperature management (TTM) is recommended following cardiac arrest; however, time to target temperature varies in clinical practice. We hypothesised the effects of a target temperature of 33 °C when compared to normothermia would differ based on average time to hypothermia and those patients achieving hypothermia fastest would have more favorable outcomes. Methods In this post-hoc analysis of the TTM-2 trial, patients after out of hospital cardiac arrest were randomized to targeted hypothermia...

Additional file 1 of Speed of cooling after cardiac arrest in relation to the intervention effect: a sub-study from the TTM2-trial

Rupert F. G. Simpson, Josef Dankiewicz, Grigoris V. Karamasis, Paolo Pelosi, Matthias Haenggi, Paul J. Young, Janus Christian Jakobsen, Jonathan Bannard-Smith, Pedro D. Wendel-Garcia, Fabio Silvio Taccone, Per Nordberg, Matt P. Wise, Anders M. Grejs, Gisela Lilja, Roy Bjørkholt Olsen, Alain Cariou, Jean Baptiste Lascarrou, Manoj Saxena, Jan Hovdenes, Matthew Thomas, Hans Friberg, John R. Davies, Niklas Nielsen & Thomas R. Keeble
Additional file 1: Fig. 1. Predicted probability of death across the 6 hypothermia groups as compared to the normothermia groups at the corresponding sites. Patients in group 1, with the lowest average temperature at 4 hours had a higher probability of death.

Mapping the availability of translated versions of posttraumatic stress disorder screening questionnaires for adults: A scoping review

Joel Hoffman, Ziv Ben-Zion, Adrián Arévalo, Or Duek, Talya Greene, Brian J. Hall, Ilan Harpaz-Rotem, Belinda Liddell, Cosima Locher, Naser Morina, Angela Nickerson, Monique C. Pfaltz, Matthis Schick, Ulrich Schnyder, Soraya Seedat, Fatlinda Shatri, Hao Fong Sit, Roland von Känel & Tobias R. Spiller
Background: The most used questionnaires for PTSD screening in adults were developed in English. Although many of these questionnaires were translated into other languages, the procedures used to translate them and to evaluate their reliability and validity have not been consistently documented. This comprehensive scoping review aimed to compile the currently available translated and evaluated questionnaires used for PTSD screening, and highlight important gaps in the literature. Objective: This review aimed to map the availability...

Additional file 1 of Hand hygiene improvement of individual healthcare workers: results of the multicentre PROHIBIT study

Tjallie van der Kooi, Hugo Sax, Hajo Grundmann, Didier Pittet, Sabine de Greeff, Jaap van Dissel, Lauren Clack, Albert W. Wu, Judith Davitt, Sofia Kostourou, Alison Maguinness, Anna Michalik, Viorica Nedelcu, Márta Patyi, Janja Perme Hajdinjak, Milena Prosen, David Tellez, Éva Varga, Fani Veini, Mirosław Ziętkiewicz & Walter Zingg
Additional file 1: Table S1. Association between hand hygiene and activity index during baseline and intervention; Table S2. Overall (i.e. for all HCWs) hand hygiene compliance per hospital, during baseline and the intervention period; Figure S1. Boxplot (median, quartiles and ranges) of individual HH compliance both during baseline and intervention period; Figure S2. Boxplot (median, quartiles and ranges) of hand hygiene increase (in percentage points) in the group of improving HCWs; Figure S3. Variability within...

Additional file 1 of VoiceS: voice quality after transoral CO2 laser surgery versus single vocal cord irradiation for unilateral stage 0 and I glottic larynx cancer—a randomized phase III trial

Philipp Reinhardt, Roland Giger, Eberhard Seifert, Mohamed Shelan, Elena Riggenbach, Dario Terribilini, Andreas Joosten, Daniel H. Schanne, Daniel M. Aebersold, Peter Manser, Matthias S. Dettmer, Christian Simon, Esat M. Ozsahin, Raphaël Moeckli, Andreas Limacher, Francesca Caparrotti, Deepa Nair, Jean Bourhis, Martina A. Broglie, Abrahim Al-Mamgani & Olgun Elicin
Additional file 1. Full study protocol

The A to I editing landscape in melanoma and its relation to clinical outcome

Austeja Amweg, Marina Tusup, Phil Cheng, Ernesto Picardi, Reinhard Dummer, Mitchell P Levesque, Lars E French, Emmanuella Guenova, Severin Läuchli, Thomas Kundig, Mark Mellett & Steve Pascolo
RNA editing refers to non-transient RNA modifications that occur after transcription and prior to translation by the ribosomes. RNA editing is more widespread in cancer cells than in non-transformed cells and is associated with tumorigenesis of various cancer tissues. However, RNA editing can also generate neo-antigens that expose tumour cells to host immunosurveillance. Global RNA editing in melanoma and its relevance to clinical outcome currently remain poorly characterized. The present study compared RNA editing as...

Additional file 2 of Development and validation of a prognostic model for the early identification of COVID-19 patients at risk of developing common long COVID symptoms

Manja Deforth, Caroline E. Gebhard, Susan Bengs, Philipp K. Buehler, Reto A. Schuepbach, Annelies S. Zinkernagel, Silvio D. Brugger, Claudio T. Acevedo, Dimitri Patriki, Benedikt Wiggli, Raphael Twerenbold, Gabriela M. Kuster, Hans Pargger, Joerg C. Schefold, Thibaud Spinetti, Pedro D. Wendel-Garcia, Daniel A. Hofmaenner, Bianca Gysi, Martin Siegemund, Georg Heinze, Vera Regitz-Zagrosek, Catherine Gebhard & Ulrike Held
Additional file 2. Partial plots for continuous candidate predictors of the global logistic generalized additive model. The y-axis contains the REST outcome on the log-odds scale $$(ln(\frac{\hat{y}}{1-\hat{y}}))$$ ( l n ( y ^ 1 - y ^ ) ) , with the patient's predicted probability $$\hat{y}$$ y ^ of developing REST symptoms.

Additional file 3 of Practice of oxygen use in anesthesiology – a survey of the European Society of Anaesthesiology and Intensive Care

Martin Scharffenberg, Thomas Weiss, Jakob Wittenstein, Katharina Krenn, Magdalena Fleming, Peter Biro, Stefan De Hert, Jan F. A. Hendrickx, Daniela Ionescu & Marcelo Gama de Abreu
Additional file 3: Supplementary Table 2. Post-surgical oxygen management by geographical regions.

Impact of GTF2H1 and RAD54L2 polymorphisms on the risk of lung cancer in the Chinese Han population

Tingting Geng, Miao Li, Rong Chen, Shuangyu Yang, Guoquan Jin, Tinabo Jin & Fulin Chen
Abstract Background Repair pathway genes play an important role in the development of lung cancer. The study aimed to assess the correlation between single nucleotide polymorphisms (SNPs) in DNA repair gene (GTF2H1 and RAD54L2) and the risk of lung cancer. Methods Five SNPs in GTF2H1 and four SNPs in RAD54L2 in 506 patients with lung cancer and 510 age-and gender-matched healthy controls were genotyped via the Agena MassARRAY platform. The influence of GTF2H1 and RAD54L2...

Impact of GTF2H1 and RAD54L2 polymorphisms on the risk of lung cancer in the Chinese Han population

Tingting Geng, Miao Li, Rong Chen, Shuangyu Yang, Guoquan Jin, Tinabo Jin & Fulin Chen
Abstract Background Repair pathway genes play an important role in the development of lung cancer. The study aimed to assess the correlation between single nucleotide polymorphisms (SNPs) in DNA repair gene (GTF2H1 and RAD54L2) and the risk of lung cancer. Methods Five SNPs in GTF2H1 and four SNPs in RAD54L2 in 506 patients with lung cancer and 510 age-and gender-matched healthy controls were genotyped via the Agena MassARRAY platform. The influence of GTF2H1 and RAD54L2...

Additional file 1 of Microcirculatory alterations in critically ill COVID-19 patients analyzed using artificial intelligence

Matthias Peter Hilty, Emanuele Favaron, Pedro David Wendel Garcia, Yavuz Ahiska, Zuhre Uz, Sakir Akin, Moritz Flick, Sesmu Arbous, Daniel A. Hofmaenner, Bernd Saugel, Henrik Endeman, Reto Andreas Schuepbach & Can Ince
Additional file 1. Supplementary information.

Functional proteomic profiling links deficient DNA clearance with increased mortality in individuals with severe COVID-19 pneumonia

Iker Valle Aramburu, Dennis Hoving, Spyros I Vernardis, Martha CF Tin, Marianna Ioannou, Mia I Temkin, Nathalia M De Vasconcelos, Vadim Demichev, Elisa Theresa Helbig, Lena Lippert, Klaus Stahl, Matthew White, Helena Radbruch, Jana Ihlow, David Horst, Scott T Chiesa, John E Deanfield, Sascha David, Christian Bode, Florian Kurth, Markus Ralser & Venizelos Papayannopoulos
The factors that influence survival during severe infection are unclear. Extracellular chromatin drives pathology, but the mechanisms enabling its accumulation remain elusive. Here, we show that in murine sepsis models, splenocyte death interferes with chromatin clearance through the release of the DNase I inhibitor actin. Actin-mediated inhibition was compensated by upregulation of DNase I or the actin scavenger gelsolin. Splenocyte death and neutrophil extracellular trap (NET) clearance deficiencies were prevalent in individuals with severe COVID-19...

Data from: Protein synthesis inhibition in the peri-infarct cortex slows motor recovery in rats

Maximilian Schubring-Giese, Susan Leemburg, Andreas Rüdiger Luft & Jonas Aurel Hosp
Neuroplasticity and reorganization of brain motor networks are thought to enable recovery of motor function after ischemic stroke. Especially in the cortex surrounding the ischemic scar (i.e., peri-infarct cortex), evidence for lasting reorganization has been found at the level of neurons and networks. This reorganization depends on expression of specific genes and subsequent protein synthesis. To test the functional relevance of the peri-infarct cortex for recovery we assessed the effect of protein synthesis inhibition within...

Data from: How to detect a polytrauma patient at risk of complications: a validation and database analysis of four published scales

Sascha Halvachizadeh
Introduction Early accurate assessment of the clinical status of severely injured patients is crucial for guiding the surgical treatment strategy. Several scales are available to differentiate between risk categories. They vary between expert recommendations and scores developed on the basis of patient data (level II). We compared four established scoring systems in regard to their predictive abilities for early (e.g., hemorrhage-induced mortality) versus late (Multiple Organ Failure (MOF), sepsis, late death) in-hospital complications. Methods A...

Single-arm, open-label, multicenter first in human study to evaluate the safety and performance of Dura Sealant Patch in reducing CSF leakage following elective cranial surgery: The ENCASE trial

Tristan Van Doormaal, Menno Germans, Menno Germans, Mariska Sie, Bart Brouwers, Andrew Carlson, Jan Willem Dankbaar, Jorn Fierstra, Paul Depauw, Pierre Robe & Luca Regli
Objective: The Dural Sealant Patch (DSP) is designed for watertight dural closure after cranial surgery. The goal of this study is to assess, for the first time, safety and performance of the DSP as a means of reducing CSF leakage in patients undergoing elective cranial intradural surgery with a dural closure procedure. Design: First in human, open-label, single-arm, multicenter study with 360 days (12 months) follow up. Setting: Three large tertiary reference neurosurgical centers, 2...

Registration Year

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Affiliations

  • University Hospital of Zurich
    125
  • University Hospital of Bern
    31
  • University of Zurich
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  • Charité - University Medicine Berlin
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  • University of Bern
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  • Hôpital Cochin
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  • University Hospital of Basel
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  • Medical University of Vienna
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