2 Works

10-year comparative follow up of familial versus multifactorial chylomicronemia syndromes

Manon Belhassen, Eric Van Ganse, Maeva Nolin, Marjorie Bérard, Hanane Bada, Eric Bruckert, Michel Krempf, Vinciane Rebours, René Valéro & Philippe Moulin
The relative incidence of acute pancreatitis, ischemic cardiovascular disease and diabetes in hyperchylomicronemic patients exhibiting familial chylomicronemia syndrome (FCS), or multifactorial chylomicronemia syndrome (MCS), is unknown. The objective was to study the occurrence of these events in FCS and MCS patients compared with the general population. Twenty-nine FCS and 124 MCS patients, with genetic diagnosis, in four lipid clinics were matched with 413 controls. Individual hospital data linked to the national claims database were collected...

Effects of high and low-efficacy therapy in secondary progressive multiple sclerosis

Izanne Roos, Emmanuelle Leray, Romain Casey, Dana Horakova, Eva Havrdova, Guillermo Izquierdo, Sara Eichau, Francesco Patti, Gilles Edan, Marc Debouverie, Jean Pelletier, Serkan Ozakbas, Maria Pia Amato, Pierre Clavelou, Pierre Grammond, Cavit Boz, Katherine Buzzard, Olga Skibina, Jonathan Ciron, Oliver Gerlach, Francois Grand'Maison, Jeannette Lechner-Scott, Charles Malpas, Helmut Butzkueven, Sandra Vukusic … & Tomas Kalincik
Objective: To compare the clinical effectiveness of high- and low-efficacy treatments in patients with recently active and inactive secondary progressive multiple sclerosis (SPMS) after accounting for therapeutic lag. Methods: Patients treated with high- (natalizumab, alemtuzumab, mitoxantrone, ocrelizumab, rituximab, cladribine, fingolimod) or low-efficacy (interferon β, glatiramer acetate, teriflunomide) therapies after SPMS onset were selected from MSBase and OFSEP, two large observational cohorts. Therapeutic lag was estimated for each patient based on their demographic and clinical characteristics....

Registration Year

  • 2021
    2

Resource Types

  • Dataset
    2

Affiliations

  • Hospices Civils de Lyon
    2
  • Marseille Public University Hospital System
    1
  • Dokuz Eylül University
    1
  • University of Newcastle Australia
    1
  • University of Rennes 1
    1
  • Hospital Universitario Virgen Macarena
    1
  • Centre Hospitalier Universitaire de Toulouse
    1
  • University of Clermont Auvergne
    1
  • University of Melbourne
    1
  • University of Lyon System
    1