3 Works

Data from: Exploitation of interspecific diversity for monocot crop improvement

Julie King, Ian Armstead, John Harper, Luke Ramsay, John Snape, Robbie Waugh, Caron James, Ann Thomas, Dagmara Gasior, Rhys Kelly, Luned Roberts, Perry Gustafson, Ian King & L Ramsey
In many cultivated crop species there is limited genetic variation available for the development of new higher yielding varieties adapted to climate change and sustainable farming practises. The distant relatives of crop species provide a vast and largely untapped reservoir of genetic variation for a wide range of agronomically important traits that can be exploited by breeders for crop improvement. In this paper, in what we believe to be the largest introgression programme undertaken in...

Data from: Macroparasites at peripheral sites of infection are major and dynamic modifiers of systemic anti-microbial pattern recognition responses

Ida M. Friberg, Susan Little, Catriona Ralli, Ann Lowe, Amy Hall, Joseph A. Jackson & Jan E. Bradley
Immune defences and the maintenance of immunological homeostasis in the face of pathogenic and commensal microbial exposures are channelled by innate anti-microbial pattern recognition receptors (PRRs) such as toll-like receptors (TLRs). Whilst PRR-mediated response programmes are the result of long-term host-pathogen or host-commensal co-evolutionary dynamics involving microbes, an additional possibility is that macroparasitic co-infections may be a significant modifier of such interactions. We demonstrate experimentally that macroparasites (the model gastrointestinal nematode, Heligmosomoides) at peripheral sites...

Data from: Maintaining functional major histocompatibility complex diversity under inbreeding: the case of a selfing vertebrate

A. Ellison, J. Allainguillaume, S. Girdwood, J. Pachebat, K. M. Peat, P. Wright, Sofia Consuegra Del Olmo & S. Consuegra
Major histocompatibility complex (MHC) genes encode proteins that present pathogen-derived antigens to T-cells, initiating the adaptive immune response in vertebrates. Although populations with low MHC diversity tend to be more susceptible to pathogens, some bottlenecked populations persist and even increase in numbers despite low MHC diversity. Thus, the relative importance of MHC diversity versus genome-wide variability for the long-term viability of populations after bottlenecks and/or under high inbreeding is controversial. We tested the hypothesis that...

Registration Year

  • 2012

Resource Types

  • Dataset


  • Aberystwyth University
  • University of Nottingham
  • University of Guelph
  • University of the West of England
  • University of Missouri
  • James Hutton Institute
  • Institute of Biological, Environmental and Rural Sciences
  • John Innes Centre