4 Works
Data from: Moving in the Anthropocene: global reductions in terrestrial mammalian movements
Marlee A. Tucker, Katrin Böhning-Gaese, William F. Fagan, John M. Fryxell, Bram Van Moorter, Susan C. Alberts, Abdullahi H. Ali, Andrew M. Allen, Nina Attias, Tal Avgar, Hattie Bartlam-Brooks, Buuveibaatar Bayarbaatar, Jerrold L. Belant, Alessandra Bertassoni, Dean Beyer, Laura Bidner, Floris M. Van Beest, Stephen Blake, Niels Blaum, Chloe Bracis, Danielle Brown, P. J. Nico De Bruyn, Francesca Cagnacci, Justin M. Calabrese, Constança Camilo-Alves … & Thomas Mueller
Animal movement is fundamental for ecosystem functioning and species survival, yet the effects of the anthropogenic footprint on animal movements have not been estimated across species. Using a unique GPS-tracking database of 803 individuals across 57 species, we found that movements of mammals in areas with a comparatively high human footprint were on average one-half to one-third the extent of their movements in areas with a low human footprint. We attribute this reduction to behavioral...
IgM cleavage by Streptococcus suis reduces IgM bound to the bacterial surface and is a novel complement evasion mechanism
Viktoria Rungelrath, Christine Weiße, Nicole Schütze, Uwe Müller, Marita Meurer, Manfred Rohde, Jana Seele, Peter Valentin-Weigand, Michael Kirschfink, Andreas Beineke, Wieland Schrödl, René Bergmann & Christoph Georg Baums
Streptococcus suis (S. suis) causes meningitis, arthritis and endocarditis in piglets. The aim of this study was to characterize the IgM degrading enzyme of S. suis (IdeSsuis) and to investigate the role of IgM cleavage in evasion of the classical complement pathway and pathogenesis. Targeted mutagenesis of a cysteine in the putative active center of IdeSsuis abrogated IgM cleavage completely. In contrast to wt rIdeSsuis, point mutated rIdeSsuis_C195S did not reduce complement-mediated hemolysis indicating that...
Data from: Physiological and social consequences of gastrointestinal nematode infection in a nonhuman primate
Nadine Müller-Klein, Michael Heistermann, Christina Strube, Zina M. Morbach, Navina Lilie, Mathias Franz, Oliver Schülke & Julia Ostner
Gastrointestinal nematodes are intensely studied models for host-pathogen interactions in wildlife, yet consequences of infections are not fully understood. Among the potential costs of nematode infection are physiological changes caused by immune system activation, reduction or reallocation of available energy, as well as potential social consequences in terms of decreased social activity or avoidance of infected individuals. We used experimental anthelmintic treatment to investigate effects of strongyle nematode infection in Barbary macaques (Macaca sylvanus), comparing...
IgM cleavage by Streptococcus suis reduces IgM bound to the bacterial surface and is a novel complement evasion mechanism
Viktoria Rungelrath, Christine Weiße, Nicole Schütze, Uwe Müller, Marita Meurer, Manfred Rohde, Jana Seele, Peter Valentin-Weigand, Michael Kirschfink, Andreas Beineke, Wieland Schrödl, René Bergmann & Christoph Georg Baums
Streptococcus suis (S. suis) causes meningitis, arthritis and endocarditis in piglets. The aim of this study was to characterize the IgM degrading enzyme of S. suis (IdeSsuis) and to investigate the role of IgM cleavage in evasion of the classical complement pathway and pathogenesis. Targeted mutagenesis of a cysteine in the putative active center of IdeSsuis abrogated IgM cleavage completely. In contrast to wt rIdeSsuis, point mutated rIdeSsuis_C195S did not reduce complement-mediated hemolysis indicating that...
Affiliations
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University of Veterinary Medicine Hannover, Foundation2
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University of Veterinary Medicine Hanover2
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Helmholtz Centre for Infection Research2
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Leipzig University2
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Max Planck Institute for Ornithology1
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University of Montana1
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Sao Paulo State University1
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University of Pretoria1
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Princeton University1
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Field Museum of Natural History1