Long non-coding RNA (lncRNA) PMS2L2 has been reported to participate in endotoxin-induced inflammatory responses. As these types of responses can promote osteoarthritis (OA), it was of interest to ascertain if PMS2L2 may be involved in OA. To explore any potential participation of PMS2L2 in OA, synovial fluid was extracted from both OA patients and healthy controls (n = 62 each) and PMS2L2 expression of each sample determined by RT-qPCR. In addition, as miR-34a has a...

Lepidoptera is a highly diverse, predominantly herbivorous insect order, with species transported to outside their native range largely facilitated by the global trade of plants and plant-based goods. Analogous to island disharmony, we examine invasion disharmony, where species filtering during invasions increases systematic compositional differences between native and non-native species assemblages, and test whether some families are more successful at establishing in non-native regions than others. We compared numbers of non-native, unintentionally introduced Lepidoptera species...

Additional file 1. Table S1: Plant species and library information.

Supplementary Material 1

Supplementary Material 2

Additional file 10: Figure S3. The co-expression levels of S. mansoni proteins identified.

Additional file 7: Figure S2. The representative MS/MS of supporting peptides of S. mansoni protein identification.

Additional file 2: Fig. S1. Multicollinearity analysis for Hb, ALT and ALB.

Additional file 2: Table S2: Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways analysis of the STEAP3-related genes.

Additional file 1. Section S1: The specific process of Focal liver lesion puncture biopsy procedure. Section S2: Image archiving and scanning parameters of CT and MRI. Table S1: FLLs with TIV images characteristics. Except where indicated, data are numbers of nodules or TIV cases and numbers in parentheses are percentages. * datas are Mean ± SD. / means NA. AP: Arterial phase; APHE: Arterial phase hyperenhancement; CEUS: Contrast-enhanced ultrasound; FLLs: Focal liver lesions; HCC: Hepatocellular...

Additional file 1: Figure S1. Verification of PpKO gene structure using the alignment results of reads obtained from the transcriptome of peach flowers, stems, fruits and pits. Figure S2. Sequence alignment of GA20ox from Arabidopsis and peach. The LPWKET motif are underlined. Figure S3. The phylogenetic trees of CPS (A), KS (B), KO (C), KAO (D) and GA3ox (E). The amino acid sequences were downloaded from Phytozome database and the Gene ID are listed after...

Additional file 1: Table S1. The codes for dependent and independent variables included in multivariable logistic regression models. Table S2. Characteristics of Global Youth Tobacco Surveys among adolescents aged 12-16 years in 138 countries/territories in 2010-2019. Table S3. Prevalence of current smokeless tobacco use among adolescents aged 12-16 years in 138 countries by sex, age group, and country/territory, 2010-2019. Table S4. Trends in the prevalence of current smokeless tobacco use among adolescents aged 12-16 years...

Abstract Background Smokeless tobacco use is popular in some regions worldwide, but it receives less attention compared to cigarette smoking. We aimed to estimate the recent prevalence of, and trends in, smokeless tobacco use and to examine its associated factors among adolescents aged 12–16 years in 138 countries/territories (hereafter “countries”) from 1999 to 2019. Methods Data from the Global Youth Tobacco Survey conducted in 138 countries in 2010–2019 and the National Youth Tobacco Survey conducted...

Fig. S1. Myelopoiesis in Tg(drl:hoxa9;hsp70:meis1) embryos receiving one time of HS induction or daily HS induction. Embryos were assayed by WISH for mpx at 5 dpf. HS, heat-shock; NS, no statistical significance. ;Fig. S2. A subgroup of Tg(drl:hoxa9;hsp70:meis1) adult fish develops AML-like phenotypes after one time HS in the embryos. Tg(drl:hoxa9;hsp70:meis1) embryos were HS induced at 24 hpf once and grown to adulthood. (A) May-Grünwald/Giemsa staining of the whole kidney marrow blood cells and peripheral...

HOXA9 and MEIS1 are co-expressed in over 50% of acute myeloid leukaemia (AML) and play essential roles in leukemogenesis, but the mechanisms involved are poorly understood. Diverse animal models offer valuable tools to recapitulate different aspects of AML and link in vitro studies to clinical trials. We generated a double transgenic zebrafish that enables hoxa9 overexpression in blood cells under the draculin (drl) regulatory element and an inducible expression of meis1 through a heat shock...

Abstract Background Biological age (BA) has been recognized as a more accurate indicator of aging than chronological age (CA). However, the current limitations include: insufficient attention to the incompleteness of medical data for constructing BA; Lack of machine learning-based BA (ML-BA) on the Chinese population; Neglect of the influence of model overfitting degree on the stability of the association results. Methods and results Based on the medical examination data of the Chinese population (45–90 years),...

A large and ever-growing literature implicates male facial width-to-height ratio (bizygomatic width divided by facial height) as a secondary sexual trait linked to numerous physical and psychological perceptions. However, this research is based entirely on the premise that bizygomatic width is sexually dimorphic, which recent research has called into question. Unfortunately, statisticians for the last 125 years have noted that morphological ratio measurements may engender spurious correlations and biased effect-size estimates. In the current study,...

Additional file 1: Supplemental file 1. Study information sheet for patients.

Additional file 1: Supplementary results. Fig. S1. Flow chartof inclusion/exclusion of participants in this study. Fig. S2. Cumulative incidence of overall early-onset kidneydiseases later in life among children by age of diagnosis of type 1 diabetesmellitus (0-5, 6-12, and 13-17 years). Fig. S3. Cumulative incidence of overall early-onset kidney diseases later inlife among children by age of diagnosis of type 2 diabetes mellitus (0-5, 6-12,and 13-17 years). Table S1. International Classification of Diseases codes for...

Effective restoration planning tools are needed to mitigate global carbon and biodiversity crises. Published spatial assessments of restoration potential are often at large scales or coarse resolutions inappropriate for local action. Using a Tanzanian case study, we introduce a systematic approach to inform landscape restoration planning, estimating spatial variation in cost-effectiveness, based on restoration method, logistics, biomass modelling and uncertainty mapping. We found potential for biomass recovery across 77.7% of a 53,000 km2 region, but...

Purpose There is limited treatment for lung squamous cell carcinoma (LUSC), so there is an urgent need to find new antitumor drugs. Materials and Methods We downloaded datasets from the Gene Expression Omnibus (GEO) and the Cancer Genome Atlas databases. We used GEO2R and the “limma” package to screen differentially expressed genes. We used the Cytoscape software to screen out hub genes. We screened herbs that act on hub genes on the Chinese medicine website....

Abstract Background The relationship between vascular endothelial growth factor (VEGF) and the risk of venous thromboembolism (VTE) has always been one of the concerns in the medical field. However, the causal inferences from published observational studies on this issue may be affected by confounders or reverse causality. We performed a two-sample bidirectional Mendelian randomization (MR) to infer the associations between VEGF and VTE. Methods Summary statistics from genome-wide association studies (GWAS) for VEGF and VTE...

Additional file 2: Fig. S1. Evolutionary inference of nutrition types for Neottieae. Numbers in bold near branches indicate the node number, as referred to Fig. 3. Large pie charts show the relative probabilities of alternative ancestral states obtained by BayesTraits. Fig. S2. Ancestral range reconstruction for Neottieae using BioGeoBEARS under the statistical DEC model. Numbers in bold near branches indicate the node number, as referred to Fig. 3. Large pie charts show the relative probabilities...

The annual dynamics of winter wheat yield in Henan, China from 2018 to 2021 are provided, with the resolution of 20m and GeoTiff format.

Additional file 1: Supplementary Fig. S1. PGA with highly complex structure under SEM. Supplementary Fig. S2. Two other crosslinking methods. Supplementary Fig. S3. The detailed process of fabricating DCDS suture with standardization. Supplementary Fig. S4. The tensile strength of double-layers swim bladder with and without crosslinking.