2,830 Works

Simultaneous retrieval of land surface temperature and emissivity from the FengYun-4A advanced geosynchronous radiation imager

Weihan Liu, Jiancheng Shi, Shunlin Liang, Shugui Zhou & Jie Cheng
This paper extends a new temperature and emissivity separation (TES) algorithm for retrieving land surface temperature and emissivity (LST and LSE) to the Advanced Geosynchronous Radiation Imager (AGRI) onboard Fengyun-4A, China’s newest geostationary meteorological satellite. The extended TES algorithm was named the AGRI TES algorithm. The AGRI TES algorithm employs a modified water vapor scaling (WVS) method and a recalibrated empirical function over vegetated surfaces. In situ validation and cross-validation are utilized to investigate the...

miR-669a-5p promotes adipogenic differentiation and induces browning in preadipocytes

Xiaoqiong Tan, Tingting Zhu, Linqiang Zhang, Lin Fu, Ying Hu, Huiqin Li, Chengbin Li, Jingjing Zhang, Bin Liang & Jing Liu
Obesity is a major global health issue that contributes to the occurrence of metabolic disorders. Based on this fact, understanding the underlying mechanisms and to uncover promising therapeutic approaches for obesity have attracted intense investigation. Brown adipose tissue (BAT) can help burns excess calories. Therefore, promoting White adipose tissue (WAT) browning and BAT activation is an attractive strategy for obesity treatment. MicroRNAs (miRNAs) are small, non-coding RNAs, which are involved in regulation of adipogenic processes...

Foxhead box D1 promotes the partial epithelial-to-mesenchymal transition of laryngeal squamous cell carcinoma cells via transcriptionally activating the expression of zinc finger protein 532

Liang Fan, Jinxiu Wang, Pingping Deng, Yuanyuan Wang, Aiping Zhang, Mengsheng Yang & Gang Zeng
The presence of cervical lymph node metastases has been considered as the most important adverse prognostic factor for patients with laryngeal squamous cell carcinoma (LSCC). However, the underlying mechanisms remain to be fully revealed. In this study, we explored the expression profile of Foxhead box D1 (FOXD1), its association with epithelial-to-mesenchymal transition (EMT), and its downstream targets in LSCC. Bioinformatic analysis was performed based on the LSCC subset of The Cancer Genome Atlas-Head and Neck...

Foxhead box D1 promotes the partial epithelial-to-mesenchymal transition of laryngeal squamous cell carcinoma cells via transcriptionally activating the expression of zinc finger protein 532

Liang Fan, Jinxiu Wang, Pingping Deng, Yuanyuan Wang, Aiping Zhang, Mengsheng Yang & Gang Zeng
The presence of cervical lymph node metastases has been considered as the most important adverse prognostic factor for patients with laryngeal squamous cell carcinoma (LSCC). However, the underlying mechanisms remain to be fully revealed. In this study, we explored the expression profile of Foxhead box D1 (FOXD1), its association with epithelial-to-mesenchymal transition (EMT), and its downstream targets in LSCC. Bioinformatic analysis was performed based on the LSCC subset of The Cancer Genome Atlas-Head and Neck...

MYB proto-oncogene like 2 promotes hepatocellular carcinoma growth and glycolysis via binding to the Optic atrophy 3 promoter and activating its expression

Miao Liu, Qiang Du, Gang Mao, Ning Dai & Fan Zhang
Optic atrophy 3 (OPA3) is an integral protein of the mitochondrial outer membrane. The current study explored the expression of OPA3 in hepatocellular carcinoma (HCC), its association with the prognosis and its involvement in HCC cell proliferation and aerobic glycolysis. In addition, the transcription factors that activate its expression were screened and validated. Gene expression data in normal liver and liver cancer were acquired from the Genotype-Tissue Expression Project (GTEx) and The Cancer Genome Atlas...

MYB proto-oncogene like 2 promotes hepatocellular carcinoma growth and glycolysis via binding to the Optic atrophy 3 promoter and activating its expression

Miao Liu, Qiang Du, Gang Mao, Ning Dai & Fan Zhang
Optic atrophy 3 (OPA3) is an integral protein of the mitochondrial outer membrane. The current study explored the expression of OPA3 in hepatocellular carcinoma (HCC), its association with the prognosis and its involvement in HCC cell proliferation and aerobic glycolysis. In addition, the transcription factors that activate its expression were screened and validated. Gene expression data in normal liver and liver cancer were acquired from the Genotype-Tissue Expression Project (GTEx) and The Cancer Genome Atlas...

Origin of the volcanic rocks in Dianzhong Formation, central Lhasa Terrane, Tibet: implication for the genesis of syn-collisional magmatism and Neo-Tethyan slab roll-back

Yutong Zhang, Feng Huang, Jifeng Xu, Yunchuan Zeng, Baodi Wang, Mingda Lv, Le Zhang, Mingjian Li, Zhao Zhang, Ye Tian, Qian Liu & Liying Zhang
The origin and formation of the continental collision-related magmas remain elusive. The volcanic rocks erupted during India-Asia continental collision offer an ideal opportunity to explore their genesis and geodynamic process. Here, we report new zircon U-Pb dating results and Hf isotope, whole-rock element and Sr-Nd isotope data of volcanic rocks in Linzhou Basin, central Lhasa Terrane, southern Tibet. These volcanic rocks are mainly comprised of andesites and belong to Dianzhong Formation. The timing of their...

RTN4/Nogo-A-S1PR2 negatively regulates angiogenesis and secondary neural repair through enhancing vascular autophagy in the thalamus after cerebral cortical infarction

Peiyi Xiao, Jinmin Gu, Wei Xu, Xingyang Niu, Jian Zhang, Jingjing Li, Yicong Chen, Zhong Pei, Jinsheng Zeng & Shihui Xing
Cerebral infarction induces angiogenesis in the thalamus and influences functional recovery. The mechanisms underlying angiogenesis remain unclear. This study aimed to investigate the role of RTN4/Nogo-A in mediating macroautophagy/autophagy and angiogenesis in the thalamus following middle cerebral artery occlusion (MCAO). We assessed secondary neuronal damage, angiogenesis, vascular autophagy, RTN4 and S1PR2 signaling in the thalamus. The effects of RTN4-S1PR2 on vascular autophagy and angiogenesis were evaluated using lentiviral and pharmacological approaches. The results showed that...

Two new terpenoids with anti-inflammatory activity from the fruits of Arenga pinnata (Wurmb) Merr.

Jia-Tong Wu, Adnan Mohammed Algradi, Yan Liu, Jin-Hai Huo, Xiao-Mao Li, Bing-You Yang & Wei-Ming Wang
Two new terpenoids (1 and 2), arenterpenoid D (1) and pinnasesquiterpene A (2), along with 16 phenylpropanoids (3–18) and 8 known terpenoids (19–26) were isolated from 70% EtOH extract of the Arenga pinnata (Wurmb) Merr. fruits. Their structures were elucidated by spectroscopic methods including HR-ESI-MS, 1D, and 2D NMR. The absolute configuration of arenterpenoid D (1) was defined by X-ray crystallographic analysis. Furthermore, we evaluated the anti-inflammatory activity of all compounds, and outcomes showed that...

Two new terpenoids with anti-inflammatory activity from the fruits of Arenga pinnata (Wurmb) Merr.

Jia-Tong Wu, Adnan Mohammed Algradi, Yan Liu, Jin-Hai Huo, Xiao-Mao Li, Bing-You Yang & Wei-Ming Wang
Two new terpenoids (1 and 2), arenterpenoid D (1) and pinnasesquiterpene A (2), along with 16 phenylpropanoids (3–18) and 8 known terpenoids (19–26) were isolated from 70% EtOH extract of the Arenga pinnata (Wurmb) Merr. fruits. Their structures were elucidated by spectroscopic methods including HR-ESI-MS, 1D, and 2D NMR. The absolute configuration of arenterpenoid D (1) was defined by X-ray crystallographic analysis. Furthermore, we evaluated the anti-inflammatory activity of all compounds, and outcomes showed that...

Protein disulfide isomerases (PDIs) negatively regulate ebolavirus structural glycoprotein expression in the endoplasmic reticulum (ER) via the autophagy-lysosomal pathway

Bin Wang, Jing Zhang, Xin Liu, Qingqing Chai, Xiaoran Lu, Xiaoyu Yao, Zhichang Yang, Liangliang Sun, Silas F. Johnson, Richard C Schwartz & Yong-Hui Zheng
Zaire ebolavirus (EBOV) causes a severe hemorrhagic fever in humans and non-human primates with high morbidity and mortality. EBOV infection is dependent on its structural glycoprotein (GP), but high levels of GP expression also trigger cell rounding, detachment, and downregulation of many surface molecules that is thought to contribute to its high pathogenicity. Thus, EBOV has evolved an RNA editing mechanism to reduce its GP expression and increase its fitness. We now report that the...

Comprehensive bioinformatics analysis reveals the hub genes and pathways associated with multiple myeloma

Shengli Zhao, Xiaoyi Mo, Zhenxing Wen, Lijuan Ren, Zhipeng Chen, Wei Lin, Qi Wang, Shaoxiong Min & Bailing Chen
While the prognosis of multiple myeloma (MM) has significantly improved over the last decade because of new treatment options, it remains incurable. Aetiological explanations and biological targets based on genomics may provide additional help for rational disease intervention. Three microarray datasets associated with MM were downloaded from the Gene Expression Omnibus (GEO) database. GSE125364 and GSE39754 were used as the training set, and GSE13591 was used as the verification set. The differentially expressed genes (DEGs)...

Bone morphogenetic protein 10 alleviates doxorubicin-induced cardiac injury via signal transducer and activator of transcription 3 signaling pathway

Peng An, Di Fan, Zhen Guo, Fang-Yuan Liu, Chen-Fei Li, Dan Yang, Ming-Yu Wang, Zheng Yang & Qi-Zhu Tang
Doxorubicin (DOX) has limited antitumor applications owing to its association with life-threatening cardiac injury. Oxidative damage and cardiac apoptosis are crucial in DOX-induced cardiac injury. Bone morphogenetic protein 10 (BMP10) is predominantly distributed in the heart and acts as a cardioprotective factor that preserves cardiac function. However, the role of BMP10 in DOX-induced cardiac injury has not yet been explored. The current study aimed to examine the function and mechanism of action of BMP10 in...

Circ_0057452 sponges miR-7-5p to promote keloid progression through upregulating GAB1

Mengying Zhu, Yonglin Li, Linbo Liu & Xiaomei Zhai
Increasing evidence has shown that circular RNAs (circRNAs) play critical roles in various diseases, including keloid. The purpose of this study was to investigate the role of circ_0057452 and related action mechanisms during the development of keloid. The expression levels of circ_0057452, microRNA-7-5p (miR-7-5p) and GRB2 associated binding protein 1 (GAB1) mRNA were determined by quantitative real-time PCR (qRT-PCR). Cell proliferation was evaluated using methylthiazolyldiphenyl-tetrazolium bromide (MTT) and 5-Ethynyl-2’-deoxyuridine (Edu) assays. Flow cytometry analysis was...

Cost-effectiveness analysis of donafenib versus lenvatinib for first-line treatment of unresectable or metastatic hepatocellular carcinoma

Rui Meng, Xueke Zhang, Ting Zhou, Mengjie Luo & Yijin Qiu
Donafenib and lenvatinib are approved by China National Medical Products Administration and recommended as first-line treatment of Metastatic Hepatocellular Carcinoma (HCC). The aim of this study was to assess the cost-effectiveness of donafenib compared with lenvatinib for first-line treatment of advanced HCC in China. A partitioned survival model consisting with three health states was developed to simulate lifetime development of advanced HCC from China healthcare payer’s perspective. The lifetime costs, quality-adjusted life-years (QALYs), life-years (LYs),...

Quantifying the relationship between biofilm reduction and thermal tissue damage on metal implants exposed to alternating magnetic fields

Bibin Prasad, Sumbul Shaikh, Reshu Saini, Qi Wang, Serena Zadoo, Varun Sadaphal, David E. Greenberg & Rajiv Chopra
Metal implant infections are a devastating problem due to the formation of biofilm which impairs the effectiveness of antibiotics and leads to surgical replacement as definitive treatment. Biofilm on metal implants can be reduced using heat generated by alternating magnetic fields (AMF). In this study, the relationship between implant surface biofilm reduction and surrounding tissue thermal damage during AMF exposure is investigated through numerical simulations. Mathematical models of biofilm reduction with heat were created based...

Middle Permian magmatism in the Tangjia-Sumdo region, Tibet: evidence for intra-oceanic subduction

Bin Wang, Chao-Ming Xie, Carlos A. Spier, Yong-Sheng Dong, Yun-Peng Yu, Yu-Hang Song, Meng-Long Duan & Chris Yakymchuk
The late Paleozoic tectonic evolution of the Lhasa terrane and subduction of Sumdo Paleo-Tethys ocean remains controversial due to limited data and variable Permian magmatism in central and southern Lhasa. We report new zircon U–Pb ages and Hf-isotope ratios as well as whole-rock major element, trace element, and Sr–Nd isotope data from middle Permian (266 ~ 257 Ma) arc-related magmatism, including high-Mg quartz diorite and trondhjemite in the Tangjia-Sumdo area. The quartz diorite has high...

Polysaccharides from Laminaria japonica protect memory abilities and neurogenesis in mice after cranial irradiation through ameliorating neuroinflammation and collagen IV degradation

Siqin Zhang, Shaoyong Chen, Pian Ao, Rong Cai, Wenqi Liu & Li Wei
Radiation-induced brain injury (RIBI) is one of the most common long-term complications for patients with malignant brain tumors after radiotherapy. At present, there is no effective treatment for RIBI. Recent studies have also confirmed that polysaccharides from laminaria japonica (LJP) display potential neuroprotective function. However, its mechanisms of neuroprotection remain unclear. In this study, we aimed to explore the effect and underlying mechanism of LJP on neurogenesis in radiation-induced brain injury mice. SPF two-month-old male...

Hierarchical assembly and structural regulation of Ti8Ag2 oxo clusters via varying the length of the carbon chains in di-phosphine ligands

Chao Ma, Xiaofeng Yi, Jian Zhang & Lei Zhang
Atomically precise Ag-doped polyoxo-titanium oxo clusters (Ag-PTCs) are beneficial for the investigation on structure-property relationship of silver doped TiO2 materials. Although several Ag-PTC clusters have been reported, their hierarchical assembly into multidimensional structures remains unexplored. In this work, di-phosphine ligands with various carbon chain lengths were exploited to stabilize and induce the hierarchical assembly of Ti8Ag2 oxo clusters. Correspondingly, cis- and trans-isomers of {Ti8Ag2} are generated in the discrete cluster (PTC-337) and two 1D-chains (PTC-338...

Identification of the metabolic remodeling profile in the early-stage of myocardial ischemia and the contributory role of mitochondrion

Jun He, Qian Liu, Jie Wang, Fangjing Xu, Yucheng Fan, Ruhua He, Ru Yan & Li Zhu
Cardiac remodeling is the primary pathological feature of chronic heart failure. Prompt inhibition of remodeling in acute coronary syndrome has been a standard procedure, but the morbidity and mortality are still high. Exploring the characteristics of ischemia in much earlier stages and identifying its biomarkers are essential for introducing novel mechanisms and therapeutic strategies. Metabolic and structural remodeling of mitochondrion is identified to play key roles in ischemic heart disease. The mitochondrial metabolic features in...

Enhancing International Students’ Experience in the UK through the Development of a Higher Education Co-opetition Framework: An Examination into Welsh Universities’ International Collaboration and Student Recruitment Activities

Yi He
Co-opetition is an increasingly popular hybrid corporate strategy, combining cooperative competition and competitive cooperation (Bengtsson and Kock, 2014). It offers organisations five commonly utilised co-opetive models, namely strategic alliance, joint venture, franchising, licensing and co-branding, in which business partners work together to achieve mutual goals, as well as compete in a healthy marketing environment (Leitao et al., 2014). The core of co-opetition, known as the value net framework, provides organisations a guideline to create sustainable...

Enhancing International Students’ Experience in the UK through the Development of a Higher Education Co-opetition Framework: An Examination into Welsh Universities’ International Collaboration and Student Recruitment Activities

Yi He
Co-opetition is an increasingly popular hybrid corporate strategy, combining cooperative competition and competitive cooperation (Bengtsson and Kock, 2014). It offers organisations five commonly utilised co-opetive models, namely strategic alliance, joint venture, franchising, licensing and co-branding, in which business partners work together to achieve mutual goals, as well as compete in a healthy marketing environment (Leitao et al., 2014). The core of co-opetition, known as the value net framework, provides organisations a guideline to create sustainable...

Astragaloside IV attenuate MI-induced myocardial fibrosis and cardiac remodeling by inhibiting ROS/caspase-1/GSDMD signaling pathway

Xiaoqing Zhang, Huiyan Qu, Tao Yang, Qian Liu & Hua Zhou
Astragalus membranaceus is a traditional Chinese medicine and has been widely used in treating cardiovascular diseases (CVDs), such as asthma, edema, and chest tightness. Astragaloside IV (AS-IV), one of the major active components extracted from Astragalus membranaceus, has a series of pharmacological effects, including inhibiting inflammation, regulating energy metabolism, reducing oxidative stress and apoptosis. However, the effect of AS-IV on myocardial infarction (MI) and the underlying molecular mechanism remains unclear. The purpose of our study...

A hexagon-based method for polygon generalization using morphological operators

Lu Wang, Tinghua Ai, Dirk Burghardt, Yilang Shen & Min Yang
Numerous methods based on square rasters have been proposed for polygon generalization. However, these methods ignore the inconsistent distance measurement among neighborhoods of squares, which may result in an imbalanced generalization in different directions. As an alternative raster, a hexagon has consistent connectivity and isotropic neighborhoods. This study proposed a hexagon-based method for polygon generalization using morphological operators. First, we defined three generalization operators: aggregation, elimination, and line simplification, based on hexagonal morphological operations. We...

Exogenous brassinosteroids promotes root growth, enhances stress tolerance, and increases yield in maize

Hao Zhang, Dan Zhao, Ziyan Tang, Ying Zhang, Ke Zhang, Jingao Dong & Fengru Wang
Brassinosteroids (BRs) regulate of maize (Zea mays L.) growth, but the underlying molecular mechanism remains unclear. In this study, we used a multi-disciplinary approach to determine how BRs regulate maize morphology and physiology during development. Treatment with the BRs promoted primary root the elongation and growth during germination, and the early development of lateral roots. BRs treatment during the middle growth stage increased the levels of various stress resistance factors, and enhanced resistance to lodging,...

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