3,432 Works

Data from: Phosphorescence monitoring of hypoxic microenvironment in solid-tumors to evaluate chemotherapeutic effects using the hypoxia-sensitive iridium (III) coordination compound

Yun Zeng, Yang Liu, Jin Shang, Jingwen Ma, Rong Wang, Lei Deng, Youmin Guo, Fan Zhong, Mingfeng Bai, Shaojuan Zhang & Daocheng Wu
Objectives: To utilize phosphorescence to monitor hypoxic microenvironment in solid-tumors and investigate cancer chemotherapeutic effects in vivo. Methods: A hypoxia-sensitive probe named BTP was used to monitor hypoxic microenvironment in solid-tumors. The low-dose metronomic treatment with cisplatin was used in anti-angiogenetic chemotherapeutic programs. The phosphorescence properties of BTP were detected by a spectrofluorometer. BTP cytotoxicity utilized cell necrosis and apoptosis, which were evaluated by trypan blue dye exclusion and Hoechst33342 plus propidium iodide assays. Tumor-bearing...

The use of TLR2 modified BMSCs for enhanced bone regeneration in the inflammatory micro-environment

Qin Zhou, Xiaoyu Gu, Jiachen Dong, Chao Zhu, Zhen Cai, Dongmei He, Chi Yang, Ling Xu & Jiawei Zheng
The repair of periodontal bone tissue defects in patients with periodontitis is one of the major challenges for dentists. Stem cell-based bone regeneration has been considered as a promising strategy to restore the lost periodontal bone tissue. However, the local inflammatory environment of periodontal tissue affects stem cell-based periodontal bone regeneration. Toll-like receptor 2 (TLR2), a member of the TLR family, plays an important role in regulating immunoreaction. Previous studies have shown that the activation...

The use of TLR2 modified BMSCs for enhanced bone regeneration in the inflammatory micro-environment

Qin Zhou, Xiaoyu Gu, Jiachen Dong, Chao Zhu, Zhen Cai, Dongmei He, Chi Yang, Ling Xu & Jiawei Zheng
The repair of periodontal bone tissue defects in patients with periodontitis is one of the major challenges for dentists. Stem cell-based bone regeneration has been considered as a promising strategy to restore the lost periodontal bone tissue. However, the local inflammatory environment of periodontal tissue affects stem cell-based periodontal bone regeneration. Toll-like receptor 2 (TLR2), a member of the TLR family, plays an important role in regulating immunoreaction. Previous studies have shown that the activation...

Genetic compensation by epob in pronephros development in epoa mutant zebrafish

Jianqing She, Yue Wu, Bowen Lou, Elisabeth Lodd, Alina Klems, Felix Schmoehl, Zuyi Yuan, Ferdinand Le Noble & Jens Kroll
Zebrafish erythropoietin a (epoa) is a well characterized regulator of red blood cell formation. Recent morpholino mediated knockdown data have also identified epoa being essential for physiological pronephros development in zebrafish, which is driven by blocking apoptosis in developing kidneys. Yet, zebrafish mutants for epoa have not been described so far. In order to compare a transient knockdown vs. permanent knockout for epoa in zebrafish on pronephros development, we used CRISPR/Cas9 technology to generate epoa...

Circular RNA ZFR accelerates non-small cell lung cancer progression by acting as a miR-101-3p sponge to enhance CUL4B expression

Haifeng Zhang, Xiaolong Wang, Baoli Hu, Feng Zhang, Haitao Wei & Li Li
Non-small-cell lung carcinoma (NSCLC) is the most common type of lung cancer. Circular RNA ZFR (circZFR) is an identified circular RNA (circRNA) that is correlated with cancer progression. However, the role of circZFR in NSCLC remains unknown. In the present study, we aimed to investigate the function of circZFR in NSCLC and the underlying mechanism. The expression patterns of circZFR were determined using qRT-PCR in NSCLC samples and cell lines. The subcellular distribution of circZFR...

Circular RNA ZFR accelerates non-small cell lung cancer progression by acting as a miR-101-3p sponge to enhance CUL4B expression

Haifeng Zhang, Xiaolong Wang, Baoli Hu, Feng Zhang, Haitao Wei & Li Li
Non-small-cell lung carcinoma (NSCLC) is the most common type of lung cancer. Circular RNA ZFR (circZFR) is an identified circular RNA (circRNA) that is correlated with cancer progression. However, the role of circZFR in NSCLC remains unknown. In the present study, we aimed to investigate the function of circZFR in NSCLC and the underlying mechanism. The expression patterns of circZFR were determined using qRT-PCR in NSCLC samples and cell lines. The subcellular distribution of circZFR...

Mice deficient in UXT exhibit retinitis pigmentosa-like features via aberrant autophagy activation

Mingyu Pan, Yue Yin, Xinxia Wang, Quanyi Wang, Lele Zhang, Haiyang Hu & Chen Wang
UXT (ubiquitously expressed prefoldin like chaperone), a small chaperone-like protein, is widely expressed in diverse human and mouse tissues and is more abundant in retina and kidney. However, the functional characterization of UXT at tissue level was largely unknown. Here, we reported that mice deficient in UXT exhibited salient features of retinal degenerative disease, similar to retinitis pigmentosa. Conditional knockout (CKO) of Uxt led to retinal degeneration and pigmentation in mice retina along with significant...

Additional file 3 of The effectiveness of case management for cancer patients: an umbrella review

Nina Wang, Jia Chen, Wenjun Chen, Zhengkun Shi, Huaping Yang, Peng Liu, Xiao Wei, Xiangling Dong, Chen Wang, Ling Mao & Xianhong Li
Additional file 3.

Additional file 1 of Early coagulopathy after pediatric out-of-hospital cardiac arrest: secondary analysis of a randomized clinical trial

Dawei Zhou, Tong Li, Yi Lv, Dijia Wang, Rongli Zhang, Qing Lin, Chao Wang, Dong Zhao, Shuyang Fei & Wei He
Additional file 1: Supplemental Table 1. Comparison of baseline characteristics between survivors and non-survivors. Supplemental Figure 1. Kaplan-Meier plots for cumulative 1-year survival according to early coagulopathy. The difference was statistically significant according to the log-rank test (P <0.001).

Additional file 4 of Genome-wide identification, new classification, expression analysis and screening of drought & heat resistance related candidates in the RING zinc finger gene family of bread wheat (Triticum aestivum L.)

Yongliang Li, Pai Qin, Aolong Sun, Wenjun Xiao, Fenglin Chen, Yang He, Keyao Yu, You Li, Meng Zhang & Xinhong Guo
Additional file 4: Table S1. Detailed information of all 138 TaRING zinc finger genes identified in tomato genome.

Additional file 5 of Genome-wide identification, new classification, expression analysis and screening of drought & heat resistance related candidates in the RING zinc finger gene family of bread wheat (Triticum aestivum L.)

Yongliang Li, Pai Qin, Aolong Sun, Wenjun Xiao, Fenglin Chen, Yang He, Keyao Yu, You Li, Meng Zhang & Xinhong Guo
Additional file 5: Table S2. One-to-one orthologous relationships among T.aestivum and T.aestivum, A.thaliana, A. tauschii, B. distachyon, H. vulgare, rice, S.italica and Zea mays, respectively.

Additional file 1 of Short-term effects of tropical cyclones on the incidence of dengue: a time-series study in Guangzhou, China

Chuanxi Li, Zhe Zhao, Yu Yan, Qiyong Liu, Qi Zhao & Wei Ma
Additional file 1: Table S1. The detail information of tropical cyclones during the study period. Table S2. The lag and cumulative effects of tropical storm and typhoon on dengue incidence among subgroups. Figure. S1. The lag effects of tropical cyclones on dengue incidence when changing the meteorological factors in the model. Figure. S2. The lag effects of tropical cyclones on dengue incidence when changing the df (2–5) for WAT, WCP, WARH, and time. Figure. S3....

Short-term effects of tropical cyclones on the incidence of dengue: a time-series study in Guangzhou, China

Chuanxi Li, Zhe Zhao, Yu Yan, Qiyong Liu, Qi Zhao & Wei Ma
Abstract Background Limited evidence is available about the association between tropical cyclones and dengue incidence. This study aimed to examine the effects of tropical cyclones on the incidence of dengue and to explore the vulnerable populations in Guangzhou, China. Methods Weekly dengue case data, tropical cyclone and meteorological data during the tropical cyclones season (June to October) from 2015 to 2019 were collected for the study. A quasi-Poisson generalized linear model combined with a distributed...

Three new compounds with their anti-glioma effects from the roots of Arnebia guttata Bunge

Yu-Mei Yan, Lin-Jun Zou, Min-Hui Li, Zhao-Cui Sun, Min Zhang, Xu-Dong Xu & Chun-Hong Zhang
Three new compounds, arneatas A-C (1–3), together with three known compounds (4–6) were isolated from the roots of Arnebia guttata Bunge. The structures were established on the basis of extensive spectroscopic data including NMR and HRESIMS. All the new compounds (1–3) were tested for their cytotoxic activity against two glioma cell lines (U118-MG and U373-MG) in vitro after treatment for 48 h. Compound 1 exhibited moderate cytotoxic activity against U118-MG and U373-MG glioma cell lines,...

Additional file 1 of Development and validation of an extended Cox prognostic model for patients with ER/PR+ and HER2− breast cancer: a retrospective cohort study

Yiqun Xie, Xizhou Li, Ying Wu, Wenting Cui & Yang Liu
Additional file 1: Appendix 1. Clinicopathologic characteristics of 28 deaths.

Additional file 1 of Anatomical distance affects functional connectivity at rest in medicine-free obsessive–compulsive disorder

Dan Lv, Yangpan Ou, Yunhui Chen, Zhenning Ding, Jidong Ma, Chuang Zhan, Ru Yang, Tinghuizi Shang, Guangfeng Zhang, Xiaoyu Bai, Zhenghai Sun, Jian Xiao, Xiaoping Wang, Wenbin Guo & Ping Li
Additional file 1: TableS1 Comparison of GMV volume between two groups.

Additional file 1 of CXCL12/CXCR7/β-arrestin1 biased signal promotes epithelial-to-mesenchymal transition of colorectal cancer by repressing miRNAs through YAP1 nuclear translocation

Mahan Si, Yujia Song, Xiaohui Wang, Dong Wang, Xiaohui Liu, Xianjun Qu, Zhiyu Song & Xinfeng Yu
Additional file 1: Fig. S1. A, B RT-qPCR and Western blot analysis of the expression of CXCR7 at mRNA and protein levels in CRC cells. Fig. S2. Transwell assay was performed in HCT116CXCR7 and SW620CXCR7 cells compared with controls. Migrating cells were quantified. **P < 0.01. ***P < 0.001. Fig. S3. The correlations of CXCR7 (ACKR3) with ZEB1 and SNAI1 were determined in CRC tissues by Gene Expression Profiling Interactive Analysis (GEPIA). Fig. S4. A,...

Additional file 1 of CXCL12/CXCR7/β-arrestin1 biased signal promotes epithelial-to-mesenchymal transition of colorectal cancer by repressing miRNAs through YAP1 nuclear translocation

Mahan Si, Yujia Song, Xiaohui Wang, Dong Wang, Xiaohui Liu, Xianjun Qu, Zhiyu Song & Xinfeng Yu
Additional file 1: Fig. S1. A, B RT-qPCR and Western blot analysis of the expression of CXCR7 at mRNA and protein levels in CRC cells. Fig. S2. Transwell assay was performed in HCT116CXCR7 and SW620CXCR7 cells compared with controls. Migrating cells were quantified. **P < 0.01. ***P < 0.001. Fig. S3. The correlations of CXCR7 (ACKR3) with ZEB1 and SNAI1 were determined in CRC tissues by Gene Expression Profiling Interactive Analysis (GEPIA). Fig. S4. A,...

CXCL12/CXCR7/β-arrestin1 biased signal promotes epithelial-to-mesenchymal transition of colorectal cancer by repressing miRNAs through YAP1 nuclear translocation

Mahan Si, Yujia Song, Xiaohui Wang, Dong Wang, Xiaohui Liu, Xianjun Qu, Zhiyu Song & Xinfeng Yu
Abstract Background Chemokine CXC motif receptor 7 (CXCR7) is an atypical G protein-coupled receptor (GPCR) that signals in a biased fashion. CXCL12/CXCR7 biased signal has been reported to play crucial roles in multiple stages of colorectal cancer (CRC). However, the mechanism of CXCL12/CXCR7 biased signal in promoting CRC progression and metastasis remains obscure. Results We demonstrate that CXCR7 activation promotes EMT and upregulates the expression of Vimentin and doublecortin-like kinase 1 (DCLK1) in CRC cells...

Additional file 4 of Using machine learning to identify gene interaction networks associated with breast cancer

Liyuan Liu, Wenli Zhai, Fei Wang, Lixiang Yu, Fei Zhou, Yujuan Xiang, Shuya Huang, Chao Zheng, Zhongshang Yuan, Yong He, Zhigang Yu & Jiadong Ji
Additional file 4: Table S3. Top 10 gene interaction pairs identified by JDINAC after adjusting for BMI and menopause status.

Additional file 5 of Using machine learning to identify gene interaction networks associated with breast cancer

Liyuan Liu, Wenli Zhai, Fei Wang, Lixiang Yu, Fei Zhou, Yujuan Xiang, Shuya Huang, Chao Zheng, Zhongshang Yuan, Yong He, Zhigang Yu & Jiadong Ji
Additional file 5: Table S4. The association of IFI30 polymorphisms with BC adjusted for BMI and menopause status.

Additional file 4 of Deep learning algorithm reveals two prognostic subtypes in patients with gliomas

Jing Tian, Mingzhen Zhu, Zijing Ren, Qiang Zhao, Puqing Wang, Colin K. He, Min Zhang, Xiaochun Peng, Beilei Wu, Rujia Feng & Minglong Fu
Additional file 4: Table S2. Performance of the SVM model on tumor types.

Additional file 5 of Deep learning algorithm reveals two prognostic subtypes in patients with gliomas

Jing Tian, Mingzhen Zhu, Zijing Ren, Qiang Zhao, Puqing Wang, Colin K. He, Min Zhang, Xiaochun Peng, Beilei Wu, Rujia Feng & Minglong Fu
Additional file 5: Table S3. Subtypes identified using alternative approaches.

Additional file 9 of Deep learning algorithm reveals two prognostic subtypes in patients with gliomas

Jing Tian, Mingzhen Zhu, Zijing Ren, Qiang Zhao, Puqing Wang, Colin K. He, Min Zhang, Xiaochun Peng, Beilei Wu, Rujia Feng & Minglong Fu
Additional file 9: Table S6. Clinical information of CGGA RNA-seq dataset.

Additional file 13 of Deep learning algorithm reveals two prognostic subtypes in patients with gliomas

Jing Tian, Mingzhen Zhu, Zijing Ren, Qiang Zhao, Puqing Wang, Colin K. He, Min Zhang, Xiaochun Peng, Beilei Wu, Rujia Feng & Minglong Fu
Additional file 13: Figure S5. Methylation levels of DNA methylation driven genes.

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