2 Works

Data from: Population transcriptomes reveal synergistic responses of DNA polymorphism and RNA expression to extreme environments on the Qinghai–Tibetan Plateau in a predatory bird

Shengkai Pan, Tongzuo Zhang, Zhengqin Rong, Li Hu, Zhongru Gu, Qi Wu, Shanshan Dong, Qiong Liu, Zhenzhen Lin, Lucia Deutschova, Xin-Hai Li, Andrew Dixon, Michael W. Bruford, Xiangjiang Zhan & Xinhai Li
Low oxygen and temperature pose key physiological challenges for endotherms living on the Qinghai–Tibetan Plateau (QTP). Molecular adaptations to high-altitude living have been detected in the genomes of Tibetans, their domesticated animals and a few wild species, but the contribution of transcriptional variation to altitudinal adaptation remains to be determined. Here we studied a top QTP predator, the saker falcon, and analysed how the transcriptome has become modified to cope with the stresses of hypoxia...

Data from: Early antiretroviral therapy and potent second-line drugs could decrease HIV incidence of drug resistance

Mingwang Shen, Yanni Xiao, Libin Rong, Lauren Ancel Meyers, Steve E. Bellan & Steven E. Bellan
Early initiation of antiretroviral therapy (ART) reduces the risk of drug-sensitive HIV transmission but may increase the transmission of drug-resistant HIV. We used a mathematical model to estimate the long-term population-level benefits of ART and determine the scenarios under which earlier ART (treatment at 1 year post-infection, on average) could decrease simultaneously both total and drug-resistant HIV incidence (new infections). We constructed an infection-age-structured mathematical model that tracked the transmission rates over the course of...

Registration Year

  • 2017
    2

Resource Types

  • Dataset
    2

Affiliations

  • Xi'an Jiaotong University
    2
  • The University of Texas at Austin
    1
  • University of Georgia
    1
  • Oakland University
    1
  • Beijing Normal University
    1
  • Chinese Academy of Sciences
    1
  • Raptor Protection of Slovakia
    1
  • Cardiff University
    1
  • Zoological Society of London
    1
  • University of Chinese Academy of Sciences
    1