2 Works

Data from: Insight in genome-wide association of metabolite quantitative traits by exome sequence analyses

Ayşe Demirkan, Peter Henneman, Aswin Verhoeven, Harish Dharuri, Najaf Amin, Jan Bert Van Klinken, Lennart C. Karssen, Boukje De Vries, Axel Meissner, Sibel Göraler, Arn M. J. M. Van Den Maagdenberg, André M. Deelder, , Cornelia M. Van Duijn & Ko Willems Van Dijk
Metabolite quantitative traits carry great promise for epidemiological studies, and their genetic background has been addressed using Genome-Wide Association Studies (GWAS). Thus far, the role of less common variants has not been exhaustively studied. Here, we set out a GWAS for metabolite quantitative traits in serum, followed by exome sequence analysis to zoom in on putative causal variants in the associated genes. 1H Nuclear Magnetic Resonance (1H-NMR) spectroscopy experiments yielded successful quantification of 42 unique...

Data from: High bandwidth synaptic communication and frequency tracking in human neocortex

Guilherme Testa-Silva, Matthijs B. Verhoog, Daniele Linaro, Christiaan P. J. De Kock, Johannes C. Baayen, Rhiannon M. Meredith, Chris I. De Zeeuw, Michele Giugliano & Huibert D. Mansvelder
Neuronal firing, synaptic transmission, and its plasticity form the building blocks for processing and storage of information in the brain. It is unknown whether adult human synapses are more efficient in transferring information between neurons than rodent synapses. To test this, we recorded from connected pairs of pyramidal neurons in acute brain slices of adult human and mouse temporal cortex and probed the dynamical properties of use-dependent plasticity. We found that human synaptic connections were...

Registration Year

  • 2014
    2

Resource Types

  • Dataset
    2

Affiliations

  • Erasmus University Medical Center
    2
  • University of Antwerp
    1
  • VU University Amsterdam
    1
  • VU University Medical Center
    1
  • Netherlands Institute for Neuroscience
    1
  • University of Sheffield
    1
  • Leiden University Medical Center
    1