15 Works

A genome-wide association study of total child psychiatric problems scores: summary statistics

Alexander Neumann, Ilja M. Nolte, Irene Pappa, Tarunveer S. Ahluwalia, Erik Pettersson, Alina Rodriguez, Andrew J.O. Whitehouse, Catharina van Beijsterveldt, Beben Benyamin, Anke Hammerschlag, Quinta Helmer, Ville Karhunen, Eva Krapohl, Yi Lu, Peter van der Most, Teemu Palviainen, Beate St. Pourcain, Ilkka Seppälä, Anna Suarez, Natalia Vilor-Tejedor, Carla M. T. Tiesler, Carol Wang, Amanda Wills, Ang Zhou, Silvia Alemany … & Henning Tiemeier
Summary statistics for EAGLE GWAS on total child psychiatric problems scores.
Data is provided in R binary format and can be loaded within R with load("total_child_psychiatric_GWAS.Rdata").
snp: SNP RS ID effect_allele: Effect allele other_allele: Other allele beta: Change in total psychiatric problem score in SD per number of effect allele se: Standard Error p: p-value n: Sample Size
For more information, see PLOS ONE publication:
Neumann A, Nolte IM, [...], Hartman...

Health-related quality of life in patients with lower limb amputation – an assessment of the measurement properties of EQ-5D-3L and EQ-5D-5L using data from the Swedish Amputation and Prosthetics Registry

Olivia Ernstsson, Kerstin Hagberg, Mathieu F. Janssen, Gouke J. Bonsel, Seher Korkmaz, Niklas Zethraeus & Emelie Heintz
To assess the measurement properties of EQ-5D-3L and EQ-5D-5L in patients with a major lower limb amputation (LLA). This was a retrospective register-based study using data from the Swedish Amputation and Prosthetics Registry (SwedeAmp). Patients with a six-months follow-up (including either EQ-5D-3L or EQ-5D-5L) after a major unilateral LLA were included. The measurement properties of EQ-5D-3L and EQ-5D-5L were compared in terms of feasibility, response patterns, informativity, and convergent and known-group validity. The sample included...

Sleep disturbance and intrusive memories after presenting to the emergency department following a traumatic motor vehicle accident: an exploratory analysis

Annemarie I. Luik, Lalitha Iyadurai, Isabel Gebhardt & Emily A. Holmes
Background: Sleep disturbances are common after traumatic events and have been hypothesized to be a risk factor in the development of psychopathology such as that associated with posttraumatic stress disorder (PTSD). Objective: To assess the association between intrusive memories, a core clinical feature of PTSD, and self-reported sleep disturbance shortly after experiencing or witnessing a motor vehicle accident, and whether a brief behavioural intervention (trauma reminder cue and Tetris gameplay) reduced sleep disturbance post-trauma. Method:...

Likelihood ratio test for genetic association study with case–control data under Probit model

Zhen Sheng, Yukun Liu, Pengfei Li & Jing Qin
Probit and Logit models are the most popular for binary disease statusing in genetic association studies. They are equally used and nearly exchangeable in the analysis of prospectively collected data. However, no strong inferences were made based on Probit models for the retrospectively collected case–control data, especially in the presence of random effects. This paper systematically investigates the performance of Probit mixed-effects models for case–control data. We find that the retrospective likelihood has a closed-form,...

Effectiveness of animal-assisted interventions for children and adults with post-traumatic stress disorder symptoms: a systematic review and meta-analysis

Karin Hediger, Julia Wagner, Pascale Künzi, Anna Haefeli, Felicitas Theis, Carmina Grob, Elena Pauli & Heike Gerger
Background: Animal-assisted interventions (AAI) are increasingly applied for people with post-traumatic stress disorder (PTSD) symptoms albeit its effectiveness is unclear.Objectives: To examine the effectiveness of AAI for treating PTSD symptoms.Method: We searched 11 major electronic databases for studies reporting quantitative data on effects of AAI for children and adults with PTSD symptoms. Of 22ʹ211 records identified, we included 41 studies with 1111 participants in the systematic review comprising eight controlled studies with 469 participants in...

Effectiveness of animal-assisted interventions for children and adults with post-traumatic stress disorder symptoms: a systematic review and meta-analysis

Karin Hediger, Julia Wagner, Pascale Künzi, Anna Haefeli, Felicitas Theis, Carmina Grob, Elena Pauli & Heike Gerger
Background: Animal-assisted interventions (AAI) are increasingly applied for people with post-traumatic stress disorder (PTSD) symptoms albeit its effectiveness is unclear.Objectives: To examine the effectiveness of AAI for treating PTSD symptoms.Method: We searched 11 major electronic databases for studies reporting quantitative data on effects of AAI for children and adults with PTSD symptoms. Of 22ʹ211 records identified, we included 41 studies with 1111 participants in the systematic review comprising eight controlled studies with 469 participants in...

Supplemental Materials Eikelboom et al. Neuropsychiatric and cognitive symptoms across the Alzheimer's disease clinical spectrum

Willem Eikelboom, Esther Van Den Berg, Ellen Singleton, Sara Baart, Michiel Coesmans, Annebet Leeuwis, Charlotte Teunissen, Bart Van Berckel, Yolande Pijnenburg, Philip Scheltens, Wiesje Van Der Flier, Rik Ossenkoppele & Janne Papma
The objective of this study was to investigate the prevalence and trajectories of neuropsychiatric symptoms (NPS) in relation to cognitive functioning in a cohort of amyloid-β positive individuals across the Alzheimer’s disease (AD) clinical spectrum. In this single-center observational study, we included all individuals who visited the Alzheimer Center Amsterdam and had 1) a clinical diagnosis of subjective cognitive decline (SCD), mild cognitive impairment (MCI), or probable AD dementia, and 2) were amyloid-β positive (A+)....

The first historical description of chronic subdural hematoma: A tale of inaccurate interpretation, inaccurate quoting and inaccurate requoting

Ruben Dammers, Dana C. Holl, Brenda Kapiteijn & Erwin J. O. Kompanje
Most historical articles have named Johann Jacob Wepfer as the first author to describe a case of chronic subdural hematoma (CSDH). However, the question arises whether these cases truly describe CSDH. Two other names that appear in literature as the first authors to describe a case of CSDH are Thomas Willis and Giovanni Battista Morgagni. In our attempt to find the first description of a CSDH, we studied the original cases described by Willis, Wepfer,...

Experimental and field investigations of exposure, replication and transmission of SARS-CoV-2 in pigs in the Netherlands

Reina S. Sikkema, Tijs Tobias, Nadia Oreshkova, Erwin de Bruin, Nisreen Okba, Felicity Chandler, Marcel M. Hulst, Jordi Rodon, Manon Houben, Kees van Maanen, Hans Bultman, Marina Meester, Nora M. Gerhards, Martijn Bouwknegt, Bert Urlings, Bart Haagmans, Jan Kluytmans, Corine H. GeurtsvanKessel, Wim H.M. van der Poel, Marion P.G. Koopmans & Arjan Stegeman
In order to assess the risk of SARS-CoV-2 infection, transmission and reservoir development in swine, we combined results of an experimental and two observational studies. First, intranasal and intratracheal challenge of eight pigs did not result in infection, based on clinical signs and PCR on swab and lung tissue samples. Two serum samples returned a low positive result in virus neutralization, in line with findings in other infection experiments in pigs. Next, a retrospective observational...

Experimental and field investigations of exposure, replication and transmission of SARS-CoV-2 in pigs in the Netherlands

Reina S. Sikkema, Tijs Tobias, Nadia Oreshkova, Erwin de Bruin, Nisreen Okba, Felicity Chandler, Marcel M. Hulst, Jordi Rodon, Manon Houben, Kees van Maanen, Hans Bultman, Marina Meester, Nora M. Gerhards, Martijn Bouwknegt, Bert Urlings, Bart Haagmans, Jan Kluytmans, Corine H. Geurtsvan Kessel, Wim H.M. van der Poel, Marion P.G. Koopmans & Arjan Stegeman
Experimental and field investigations of exposure, replication and transmission of SARS-CoV-2 in pigs in the Netherlands

A genome-wide association study of total child psychiatric problems scores: summary statistics

Alexander Neumann, Ilja M. Nolte, Irene Pappa, Tarunveer S. Ahluwalia, Erik Pettersson, Alina Rodriguez, Andrew J.O. Whitehouse, Catharina van Beijsterveldt, Beben Benyamin, Anke Hammerschlag, Quinta Helmer, Ville Karhunen, Eva Krapohl, Yi Lu, Peter van der Most, Teemu Palviainen, Beate St. Pourcain, Ilkka Seppälä, Anna Suarez, Natalia Vilor-Tejedor, Carla M. T. Tiesler, Carol Wang, Amanda Wills, Ang Zhou, Silvia Alemany … & Henning Tiemeier
Summary statistics for EAGLE GWAS on total child psychiatric problems scores.
Data is provided in R binary format and can be loaded within R with load("total_child_psychiatric_GWAS.Rdata").
snp: SNP RS ID effect_allele: Effect allele other_allele: Other allele beta: Change in total psychiatric problem score in SD per number of effect allele se: Standard Error p: p-value n: Sample Size
For more information, see PLOS ONE publication:
Neumann A, Nolte IM, [...], Hartman...

Experimental and field investigations of exposure, replication and transmission of SARS-CoV-2 in pigs in the Netherlands

Reina S. Sikkema, Tijs Tobias, Nadia Oreshkova, Erwin de Bruin, Nisreen Okba, Felicity Chandler, Marcel M. Hulst, Jordi Rodon, Manon Houben, Kees van Maanen, Hans Bultman, Marina Meester, Nora M. Gerhards, Martijn Bouwknegt, Bert Urlings, Bart Haagmans, Jan Kluytmans, Corine H. GeurtsvanKessel, Wim H.M. van der Poel, Marion P.G. Koopmans & Arjan Stegeman
In order to assess the risk of SARS-CoV-2 infection, transmission and reservoir development in swine, we combined results of an experimental and two observational studies. First, intranasal and intratracheal challenge of eight pigs did not result in infection, based on clinical signs and PCR on swab and lung tissue samples. Two serum samples returned a low positive result in virus neutralization, in line with findings in other infection experiments in pigs. Next, a retrospective observational...

Health-related quality of life in patients with lower limb amputation – an assessment of the measurement properties of EQ-5D-3L and EQ-5D-5L using data from the Swedish Amputation and Prosthetics Registry

Olivia Ernstsson, Kerstin Hagberg, Mathieu F. Janssen, Gouke J. Bonsel, Seher Korkmaz, Niklas Zethraeus & Emelie Heintz
To assess the measurement properties of EQ-5D-3L and EQ-5D-5L in patients with a major lower limb amputation (LLA). This was a retrospective register-based study using data from the Swedish Amputation and Prosthetics Registry (SwedeAmp). Patients with a six-months follow-up (including either EQ-5D-3L or EQ-5D-5L) after a major unilateral LLA were included. The measurement properties of EQ-5D-3L and EQ-5D-5L were compared in terms of feasibility, response patterns, informativity, and convergent and known-group validity. The sample included...

The first historical description of chronic subdural hematoma: A tale of inaccurate interpretation, inaccurate quoting and inaccurate requoting

Ruben Dammers, Dana C. Holl, Brenda Kapiteijn & Erwin J. O. Kompanje
Most historical articles have named Johann Jacob Wepfer as the first author to describe a case of chronic subdural hematoma (CSDH). However, the question arises whether these cases truly describe CSDH. Two other names that appear in literature as the first authors to describe a case of CSDH are Thomas Willis and Giovanni Battista Morgagni. In our attempt to find the first description of a CSDH, we studied the original cases described by Willis, Wepfer,...

Likelihood ratio test for genetic association study with case–control data under Probit model

Zhen Sheng, Yukun Liu, Pengfei Li & Jing Qin
Probit and Logit models are the most popular for binary disease statusing in genetic association studies. They are equally used and nearly exchangeable in the analysis of prospectively collected data. However, no strong inferences were made based on Probit models for the retrospectively collected case–control data, especially in the presence of random effects. This paper systematically investigates the performance of Probit mixed-effects models for case–control data. We find that the retrospective likelihood has a closed-form,...

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