102 Works

Distinct population code for movement kinematics and changes of ongoing movements in human subthalamic nucleus

Dennis London, Arash Fazl, Kalman Katlowitz, Marisol Soula, Michael Pourfar, Alon Mogilner & Roozbeh Kiani
The subthalamic nucleus (STN) is theorized to globally suppress movement through connections with downstream basal ganglia structures. Current theories are supported by increased STN activity when subjects withhold an uninitiated action plan, but a critical test of these theories requires studying STN responses when an ongoing action is replaced with an alternative. We perform this test in subjects with Parkinson’s disease using an extended reaching task where the movement trajectory changes mid-action. We show that...

Cortical encoding of melodic expectations in human temporal cortex

Giovanni Di Liberto, Claire Pelofi, Roberta Bianco, Prachi Patel, Ashesh D Mehta, Jose L Herrero, Alain De Cheveigné, Shihab A Shamme & Nima Mesgarani
Humans engagement in music rests on underlying elements such as the listeners’ cultural background and interest in music. These factors modulate how listeners anticipate musical events, a process inducing instantaneous neural responses as the music confronts these expectations. Measuring such neural correlates would represent a direct window into high-level brain processing. Here we recorded cortical signals as participants listened to Bach melodies. We assessed the relative contributions of acoustic versus melodic components of the music...

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