2 Works

Data from: Optimal lineage principle for age-structured populations

Yuichi Wakamoto, Alexander Y Grosberg & Edo Kussell
We present a formulation of branching and aging processes that allows distributions along lineages to be studied within populations, and provides a new interpretation of classical results in the theory of aging. We establish a variational principle for the stable age distribution along lineages. Using this optimal lineage principle, we show that the response of a population’s growth rate to age-specific changes in mortality and fecundity – a key quantity which was first calculated by...

Data from: The W100 pocket on HIV-1 gp120 penetrated by b12 is not a target for other CD4bs monoclonal antibodies

Maria J. Duenas-Decamp, Olivia J. O'Connell, Davide Corti, Susan Zolla-Pazner & Paul R. Clapham
BACKGROUND: The conserved CD4 binding site (CD4bs) on HIV-1 gp120 is a major target for vaccines. It is a priority to determine sites and structures within the CD4bs that are important for inclusion in vaccines. We studied a gp120 pocket penetrated by W100 of the potent CD4bs monoclonal antibody (mab), b12. We compared HIV-1 envelopes and corresponding mutants that carried blocked W100 pockets to evaluate whether other CD4bs mabs target this site. FINDINGS: All CD4bs...

Registration Year

  • 2011
    2

Resource Types

  • Dataset
    2

Affiliations

  • New York University
    2
  • Penn Center for AIDS Research
    1
  • University of Tokyo
    1