4 Works

Data from: Genomic diversity and differentiation of a managed island wild boar population

Laura Iacolina, Massimo Scandura, Daniel J. Goedbloed, Panoraia Alexandri, Richard P. M. A. Crooijmans, Greger Larson, Alan Archibald, Marco Apollonio, Lawrence B. Schook, Martien A. Groenen & Hendrik-Jan Megens
The evolution of island populations in natural systems is driven by local adaptation and genetic drift. However, evolutionary pathways may be altered by humans in several ways. The wild boar (WB) (Sus scrofa) is an iconic game species occurring in several islands, where it has been strongly managed since prehistoric times. We examined genomic diversity at 49 803 single-nucleotide polymorphisms in 99 Sardinian WBs and compared them with 196 wild specimens from mainland Europe and...

Data from: Health trajectories reveal the dynamic contributions of host genetic resistance and tolerance to infection outcome

Graham Lough, Ilias Kyriazakis, Andreas Lengeling, Silke Bergmann & Andrea B. Doeschl-Wilson
Resistance and tolerance are two alternative strategies hosts can adopt to survive infections. Both strategies may be genetically controlled. To date, the relative contribution of resistance and tolerance to infection outcome is poorly understood. A bioluminescent Listeria monocytogenes (Lm) infection challenge model on four genetically diverse mouse strains was used to study the genetic determination and dynamic contributions of host resistance and tolerance to listeriosis, a serious food-borne infectious disease in humans. Conventional statistical analyses...

Data from: Regional heritability mapping method helps explain missing heritability of blood lipid traits in isolated populations

Masoud Shirali, Ricardo Pong-Wong, Pau Navarro, Sara Knott, Caroline Hayward, Veronique Vitart, Igor Rudan, Harry Campbell, Nicholas Hastie, Alan Wright & Christopher Haley
Single single-nucleotide polymorphism (SNP) genome-wide association studies (SSGWAS) may fail to identify loci with modest effects on a trait. The recently developed regional heritability mapping (RHM) method can potentially identify such loci. In this study, RHM was compared with the SSGWAS for blood lipid traits (high-density lipoprotein (HDL), low-density lipoprotein (LDL), plasma concentrations of total cholesterol (TC) and triglycerides (TG)). Data comprised 2246 adults from isolated populations genotyped using ~300 000 SNP arrays. The results...

Data from: Mapping and validation of a major QTL affecting resistance to pancreas disease (salmonid alphavirus) in Atlantic salmon (Salmo salar)

Serap Gonen, Matthew Baranski, Ingunn Thorland, Ashie Norris, Harald Grove, Petter Arnesen, Håvard Bakke, Sigbjørn Lien, Stephen C. Bishop & Ross D. Houston
Pancreas disease (PD), caused by a salmonid alphavirus (SAV), has a large negative economic and animal welfare impact on Atlantic salmon aquaculture. Evidence for genetic variation in host resistance to this disease has been reported, suggesting that selective breeding may potentially form an important component of disease control. The aim of this study was to explore the genetic architecture of resistance to PD, using survival data collected from two unrelated populations of Atlantic salmon; one...

Registration Year

  • 2015
    4

Resource Types

  • Dataset
    4

Affiliations

  • Roslin Institute
    4
  • University of Split
    1
  • University of Sassari
    1
  • Newcastle University
    1
  • University of Edinburgh
    1
  • Durham University
    1
  • Marine Harvest (Norway)
    1
  • Nofima
    1
  • University of Veterinary Medicine
    1
  • University of Illinois at Urbana Champaign
    1