Crisis Resolution Teams (CRT) for rapid assessment and short-term treatment of mental health problems have increasingly been implemented internationally over the last decades. Among the Nordic countries, the CRT model has been particularly influential in Norway, where ‘Ambulante akutteam (AAT)’ is a widespread psychiatric emergency service for adult patients. However, the clinical practice of these teams varies significantly. To aid further development of the service and guide future research efforts, we carried out a scoping...

Abstract Background Digitalization of health care has opened up for new ways to involve and engage patients. With this, increased attention has been put on digital patient portals. There exists some research on patient portals for adolescent patients in general and for adults in mental health care. However, no studies on patient portals for adolescents in mental health care have been identified in a recent review. The aim was therefore to explore the views on...

Additional File 5: Figure S5. Supporting data to Fig. 4. Verification of knockdown in INA-6 cells. A-C Knockdown of SMAD1, SMAD5, and SMAD4 after use of SMAD1/5 and SMAD4 siRNAs. D, E. Knockdown after use of ALK2 (ACVR1) and ALK3 (BMPR1A) siRNAs. F. Knockdown of BMPR2 in INA-6 shBMPR2 cells.

Additional file 2: Figure S2. Supporting data to Fig. 2. Relative amount of FKBP gene transcripts in 66 human myeloma cell lines.

Additional File 3: Figure S3. Supporting data to Fig. 2. Potentiation of BMP6 activity with FKBP-binding compounds.

Additional File 4: Figure S4. Supporting data to Fig. 3. Expression levels of ALK2 (ACVR1), ALK3 (BMPR1A), and ALK6 (BMPR1B) in (A) INA-6, (B) KARPAS-417, (C) KATO-III, and (D) DOHH-2 using RT-qPCR and the comparative Ct method with GAPDH as housekeeping gene.

Additional File 4: Figure S4. Supporting data to Fig. 3. Expression levels of ALK2 (ACVR1), ALK3 (BMPR1A), and ALK6 (BMPR1B) in (A) INA-6, (B) KARPAS-417, (C) KATO-III, and (D) DOHH-2 using RT-qPCR and the comparative Ct method with GAPDH as housekeeping gene.

Additional file 3.

Abstract Background Insomnia is common in the general population and is a risk factor for ill-health, which highlights the importance of treating insomnia effectively and cost-efficiently. Cognitive-behavioural therapy for insomnia (CBT-I) is recommended as first-line treatment due to its long-term effectiveness and few side-effects, but its availability is limited. The aim of this pragmatic, multicentre randomized controlled trial is to investigate the effectiveness of group-delivered CBT-I in primary care compared to a waiting-list control group....

Abstract Background Patients with moderate and severe traumatic brain injury (TBI) are admitted to general hospitals (GHs) without neurosurgical services, but few studies have addressed the management of these patients. This study aimed to describe these patients, the rate of and reasons for managing patients entirely at the GH, and differences between patients managed entirely at the GH (GH group) and patients transferred to the regional trauma centre (RTC group). We specifically examined the characteristics...

Additional file 19: Table S11. Significant female-specific multi-ancestry meta-analysis results.

Additional file 19: Table S11. Significant female-specific multi-ancestry meta-analysis results.

Additional file 16: Figure S8. PheWAS meta-analysis results for the trans-ethnic nonHDL-C PGS in UK Biobank and MVP.

Additional file 29: Table S19. Comparison of sex-stratified effect sizes in the UK Biobank for BMI, waist hip ratio adjusted for BMI, alcohol use, and smoking status.

Additional file 31: Supplementary Note. Supplementary Note and Cohort Acknowledgments.

Additional file 1. Supplementary Fig. 1. Graphical display of birth year, age distribution and follow up period for the three cohorts. Cohort 1 is marked in yellow, cohort 2 in orange and cohort 3 in blue. Age according to birth year and year of follow up is listed in the background. Supplementary Fig. 2. Incidence rates according to age, years of birth and proliferative marker status. Blue lines: women born before 1929. Red lines: Women...

Abstract Background Long-term breast cancer incidence trends according to proliferation status are poorly described. We studied time-trends in breast cancer incidence, using mitotic count and Ki-67 as markers of proliferation. Methods Among 83,298 Norwegian women followed for breast cancer occurrence 1961–2012, 2995 incident breast cancers were diagnosed. Ki-67 was assessed using immunohistochemistry on tissue microarrays and mitoses were counted on whole sections. We compared incidence rates according to proliferation status among women born 1886–1928 and...

Additional file 8: Table S6. Association of lipid index variants with CAD, T2D and NAFLD.

Additional file 24: Figure S9. Comparison of effect size estimates between males and females for index variants showing a significant difference in effect size between sexes.

Abstract Background Sexual assault and rape are the traumatic life events with the highest probability for posttraumatic stress disorder (PTSD), which can have devastating consequences for those afflicted by the condition. Studies indicate that modified prolonged exposure (mPE) therapy may be effective in preventing the development of PTSD in recently traumatized individuals, and especially for people who have experienced sexual assault. If a brief, manualized early intervention can prevent or reduce post-traumatic symptoms in women...

Additional file 1: Table S1. Characteristics of contributing cohorts (as provided by each participating cohort).

Additional file 5: Table S4. Hypermethylation in myelination program but hypomethylation in regulators of OPC specification in PM gliomas.

Additional file 4: Table S3. Pearson correlation coefficient between PM glioma cells and cell populations in murine oligodendrocyte lineage.

Most cancer patients with solid tumors who succumb to their illness die of metastatic disease. While early detection and improved treatment have led to reduced mortality, even for those with metastatic cancer, some patients still respond poorly to treatment. Understanding the mechanisms of metastasis is important to improve prognostication, to stratify patients for treatment, and to identify new targets for therapy. We have shown previously that expression of nephronectin (NPNT) is correlated with metastatic propensity...

The aim of the present study was to investigate the psychometric validity of the Modular Assessment of Risk for Imminent Suicide (MARIS) questionnaire in relation to recent suicidal ideation and behavior among a sample of patients admitted to an acute psychiatric inpatient department in Norway. The MARIS was completed within the first 24 h after admission by 338 patients and their clinicians. Information on recent suicidal ideation and behavior was extracted from patients’ medical charts....