2 Works

Data from: Variation in relapse frequency and the transmission potential of Plasmodium vivax malaria

Michael T. White, George Shirreff, Stephan Karl, Azra C. Ghani & Ivo Mueller
There is substantial variation in the relapse frequency of Plasmodium vivax malaria, with fast relapsing strains in tropical areas, and slow relapsing strains in temperate areas with seasonal transmission. We hypothesise that much of the phenotypic diversity in P. vivax relapses arises from selection of relapse frequency to optimise transmission potential in a given environment, in a process similar to the virulence trade-off hypothesis. We develop mathematical models of P. vivax transmission and calculate the...

Data from: An antibody screen of a Plasmodium vivax antigen library identifies novel merozoite proteins associated with clinical protection

Camila T. Fran├ža, Jessica B. Hostetler, Sumana Sharma, Michael T. White, Enmoore Lin, Benson Kiniboro, Andreea Waltmann, Andrew W. Darcy, Connie S. Li Wai Suen, Peter Siba, Christopher L. King, Julian C. Rayner, Rick M. Fairhurst, Ivo Mueller & Connie S. N. Li Wai Suen
Background. Elimination of Plasmodium vivax malaria would be greatly facilitated by the development of an effective vaccine. A comprehensive and systematic characterization of antibodies to P. vivax antigens in exposed populations is useful in guiding rational vaccine design. Methodology/Principal Findings. In this study, we investigated antibodies to a large library of P. vivax entire ectodomain merozoite proteins in 2 Asia-Pacific populations, analysing the relationship of antibody levels with markers of current and cumulative malaria exposure,...

Registration Year

  • 2016
    2

Resource Types

  • Dataset
    2

Affiliations

  • Walter and Eliza Hall Institute of Medical Research
    2
  • National Institutes of Health
    1
  • University of Melbourne
    1
  • University of Barcelona
    1
  • Wellcome Trust
    1
  • Imperial College London
    1
  • National Institute of Allergy and Infectious Diseases
    1
  • Case Western Reserve University
    1