3 Works

The effect of amiloride in decreasing albuminuria in patients with diabetic kidney diseases: a prospective, crossover, open-label study

Ruizhao Li, Zhiyong Xie, Li Zhang, Ying Huang, Jianchao Ma, Wei Dong, Zhilian Li, Yuanhan Chen, Huaban Liang, Yanhua Wu, Xingchen Zhao, Wenjian Wang, Zhiming Ye, Shuangxin Liu, Wei Shi & Xinling Liang
Diabetic kidney diseases (DKD) were the leading cause of End-stage renal diseases worldwide. Albuminuria was a target for treatment in DKD and decreasing albuminuria was particularly important for improving its prognosis. However, there is still a lack of specific treatment for DKD. We conducted a prospective, crossover, open-label study to investigate the effect of amiloride in patients with DKD. Safety and efficacy were assessed by monitoring urine protein creatinine ratio(uPCR), urinary albumin creatinine ratio (uACR),...

Antibody features towards VAR2CSA and CSA binding infected erythrocytes in a cohort of pregnant women from PNG

Elizabeth Aitken, Amaya Ortega-Pajares, Agersew Alemu, Wina Hasang, Saber Dini, Holger Unger, Maria Ome-Kaius, Morten Nielsen, Ali Salanti, Joe Smith, Stephen Kent, P Mark Hogarth, Bruce Wines, Julie Simpson, Timon Damelang, Amy Chung & Stephen Rogerson
Plasmodium falciparum causes placental malaria, which results in adverse outcomes for mother and child. P. falciparum infected erythrocytes that express the parasite protein VAR2CSA on their surface can bind to placental chondroitin sulfate-A. It has been hypothesized that naturally acquired antibodies towards VAR2CSA protect against placental infection, but it has proven difficult to use measures of antibody to identify individuals protected from disease. We used a systems serology approach to identify naturally acquired antibody features...

The effect of amiloride in decreasing albuminuria in patients with diabetic kidney diseases: a prospective, crossover, open-label study

Ruizhao Li, Zhiyong Xie, Li Zhang, Ying Huang, Jianchao Ma, Wei Dong, Zhilian Li, Yuanhan Chen, Huaban Liang, Yanhua Wu, Xingchen Zhao, Wenjian Wang, Zhiming Ye, Shuangxin Liu, Wei Shi & Xinling Liang
Diabetic kidney diseases (DKD) were the leading cause of End-stage renal diseases worldwide. Albuminuria was a target for treatment in DKD and decreasing albuminuria was particularly important for improving its prognosis. However, there is still a lack of specific treatment for DKD. We conducted a prospective, crossover, open-label study to investigate the effect of amiloride in patients with DKD. Safety and efficacy were assessed by monitoring urine protein creatinine ratio(uPCR), urinary albumin creatinine ratio (uACR),...

Registration Year

  • 2021
    3

Resource Types

  • Image
    2
  • Dataset
    1

Affiliations

  • Walter and Eliza Hall Institute of Medical Research
    3
  • University of Melbourne
    3
  • Hebei Normal University
    2
  • Sun Yat-sen University
    2
  • West China Hospital of Sichuan University
    2
  • Zhejiang University
    2
  • Southwest Medical University
    2
  • Longgang Central Hospital
    2
  • Jilin University
    2
  • Huazhong University of Science and Technology
    2