This is the data and analysis code underlying the paper "Addressing people’s current and future states in a reinforcement learning algorithm for persuading to quit smoking and to be physically active" by Nele Albers, Mark A. Neerincx, and Willem-Paul Brinkman. This paper proposes a Reinforcement Learning (RL)-algorithm for persuading people in the context of a virtual coach for quitting smoking and becoming more physically active. Study The paper is based on a longitudinal study on...

A new continuous flow synthetic method for preparing indole and its derivatives are successfully developed to overcome the disadvantages of traditional batch methods, such as low conversion rates, long reaction times, and amplification effects. The method represents a sustainable and efficient preparation of indole and its derivatives without the need for additional catalysts. By investigating the effects of the reaction temperature, the solvent, the equivalence ratio, and the residence time, high conversion rates and excellent...

TNO Applied Geosciences (1); TNO Advisory Group for Economic Affairs (2); TNO Geomodelling (3); TNO Geo Data and IT (4); TNO Monitoring and Control Services (5); TNO Data Science (6)

The Netherlands is subject to anthropogenic and natural subsidence with rates which are an order of magnitude higher than sea-level rise. Because one-third of the Netherlands lies below mean sea level, subsidence may threaten the country’s subsistence with major socio-economic consequences. Subsidence is a...

In diesem Bericht werden die bestehenden nationalen 3D-Modelle in Niedersachsen und den Niederlanden miteinander in einem „Inventory Report“ verglichen, um die Harmonisierungskriterien für das neue NLS3D abzuleiten.

Peritoneal dialysis (PD)-associated peritonitis is a serious complication observed in peritoneal dialysis patients. Herein, we investigated the clinical characteristics and treatment outcomes of PD peritonitis in patients with different PD durations. All peritonitis episodes from January 2007 to December 2020 at Peking University People’s hospital PD center were retrospectively analyzed and divided into the long-dialysis duration (≥60 months, LDD) and short-dialysis duration (<60 months, SDD) groups. Clinical characteristics and outcomes were compared between these groups....

Additional file 1. Supplementary Tables and Figures

Prioritizing the risk posed by thousands of chemicals potentially present in the environment requires exposure, toxicity, and toxicokinetic (TK) data, which are often unavailable. Relatively high throughput, in vitro TK (HTTK) assays and in vitro-to-in vivo extrapolation (IVIVE) methods have been developed to predict TK, but most of the in vivo TK data available to benchmark these methods are from pharmaceuticals. Here we report on new, in vivo rat TK experiments for 26 non-pharmaceutical chemicals...

Dieser Bericht dokumentiert die Arbeiten entlang der niedersächsischen-niederländischen Grenze im Arbeitspaket 1 in 3DGEO-EU. Neben der Harmonisierung bestehender 3D-Modelle werden die aus NLS3D abgeleiteten känozoischen Verbreitungs- und Mächtigkeitskarten beschrieben. Das NLS3D-Modell und die weiteren harmonisierten 3D-Modelle des Projektes 3DGEO-EU zeigen, dass geowissenschaftliche Fragestellungen zur Nutzung des tieferen Untergrundes in Grenzregionen, welche bisher nur auf nationaler Ebene beantwortet werden konnten, nun auch grenzüberschreitend diskutiert werden können. Der Harmonisierungsprozess zeigt aber auch die Herausforderungen bei transnationalen 3D-Modellierungsprojekten...

Objectives: To adapt and translate the Edinburgh Cognitive and behavioural amyotrophic lateral sclerosis screen (ECAS); to generate preliminary normative data for three language groups in South Africa (SA); to assess the convergent validity of the ECAS in SA samples. Methods: The ECAS was linguistically and culturally adapted for Afrikaans-, isiXhosa-, and English-speaking SA adults (n = 108, 100, and 53, respectively). Each language group was stratified by age and educational level. Cutoff scores for cognitive...

This deliverable summarizes the activities related to the development of predictive models to simulate the impact of fluid flow hydrodynamics and chemical composition uncertainties on the production behavior of geothermal assets. Specifically, in this report, the mineral precipitation behavior of the geothermal fluid was studied as both uncertainties in the fluid composition and the interaction between the fluid flow hydrodynamics and mineral precipitation can impact the deposition of the scaling. A workflow was developed to...

Abstract Epithelial-to-mesenchymal transition (EMT) is a critical underpinning process for cancer progression, recurrence and resistance to drug treatment. Identification of new regulators of EMT could lead to the development of effective therapies to improve the outcome of advanced cancers. In the current study we discovered, using a variety of in vitro and in vivo approaches, that RAB4A function is essential for EMT and related manifestation of stemness and invasive properties. Consistently, RAB4A suppression abolished the...

A new continuous flow synthetic method for preparing indole and its derivatives are successfully developed to overcome the disadvantages of traditional batch methods, such as low conversion rates, long reaction times, and amplification effects. The method represents a sustainable and efficient preparation of indole and its derivatives without the need for additional catalysts. By investigating the effects of the reaction temperature, the solvent, the equivalence ratio, and the residence time, high conversion rates and excellent...

Supplemental material, sj-docx-1-chl-10.1177_17475198221150384 for Fischer indole synthesis in DMSO/AcOH/H2O under continuous flow conditions by Mei Wang, Shenghu Yan, Yue Zhang and Shunlin Gu in Journal of Chemical Research

Background: Desktop virtual environments (VEs) are increasingly deployed to study the effects of environmental qualities and interventions on human behavior and safety related concerns in built environments. For these applications it is essential that users appraise the affective qualities of the VE similar to those of its real world counterpart. Previous studies have shown that factors like simulated lighting, sound and dynamic elements all contribute to the affective appraisal of a desktop VE. Since ambient...

Department of Earth Sciences, Universiteit Utrecht

The ultimate aim of field courses should be to enable students to work autonomously in the field. Student- and problem-centered approaches to learning in the field afford students much autonomy, but unlike in the more traditional show-and-tell approach, independent projects have so far required that students spend a significant amount of time working in the field without access to supervision. Unless students are competent enough to experience...

Impact assessments for sonar operations typically use received sound levels to predict behavioural disturbance in marine mammals. However, there are indications that cetaceans may learn to associate exposures from distant sound sources with lower perceived risk. To investigate the roles of source distance and received level in an area without frequent sonar activity, we conducted multi-scale controlled exposure experiments (n = 3) with 12 northern bottlenose whales near Jan Mayen, Norway. Animals were tagged with...

Objectives: To adapt and translate the Edinburgh Cognitive and behavioural amyotrophic lateral sclerosis screen (ECAS); to generate preliminary normative data for three language groups in South Africa (SA); to assess the convergent validity of the ECAS in SA samples. Methods: The ECAS was linguistically and culturally adapted for Afrikaans-, isiXhosa-, and English-speaking SA adults (n = 108, 100, and 53, respectively). Each language group was stratified by age and educational level. Cutoff scores for cognitive...

Geology does not follow national borders and for many areas of application, it is essential to know the characteristics of the subsurface on both sides of the border. In the area of the North Sea, however, consistent interpretation of the subsurface across borders are rare, as most studies carried out here by the Geological Survey Organizations (GSOs) in charge have remained confined to their national territories. As a consequence, the interpretations are often not aligned...

This is the data and analysis code underlying the paper "Addressing people’s current and future states in a reinforcement learning algorithm for persuading to quit smoking and to be physically active" by Nele Albers, Mark A. Neerincx, and Willem-Paul Brinkman. This paper proposes a Reinforcement Learning (RL)-algorithm for persuading people in the context of a virtual coach for quitting smoking and becoming more physically active. Study The paper is based on a longitudinal study on...

The root extract of Suregada zanzibariensis Baill. afforded six previously described ent-abietane diterpenoids, namely 7-oxo-ent-abieta-5(6),8(14),13(15)-trien-16,12-olide (1), mangiolide (2), 8,14β:11,12α-diepoxy-13(15)-abietane-16,12-olide (3), 7β,11β,12β-trihydroxy-ent–abieta-8(14),13(15)-diene-16,12-olide (4), 8α,14-dihydro-7-oxo-jolkinolide E (5), jolkinolide A (6), together with 3β-sitosterol (7), scopoletin (8) and vanillin (9). Their structures were deduced through 1D and 2D NMR spectroscopic techniques, and HRESIMS, as well as by comparison of the NMR data with those reported in the literature. The crude extract and compounds 1–9 were evaluated for their...

Supplemental material, sj-docx-1-chl-10.1177_17475198221150384 for Fischer indole synthesis in DMSO/AcOH/H2O under continuous flow conditions by Mei Wang, Shenghu Yan, Yue Zhang and Shunlin Gu in Journal of Chemical Research

Peritoneal dialysis (PD)-associated peritonitis is a serious complication observed in peritoneal dialysis patients. Herein, we investigated the clinical characteristics and treatment outcomes of PD peritonitis in patients with different PD durations. All peritonitis episodes from January 2007 to December 2020 at Peking University People’s hospital PD center were retrospectively analyzed and divided into the long-dialysis duration (≥60 months, LDD) and short-dialysis duration (<60 months, SDD) groups. Clinical characteristics and outcomes were compared between these groups....

CO2Care Publications