4 Works

Data from: Contrasting impacts of precipitation on Mediterranean birds and butterflies

Sergi Herrando, Nicolas Titeux, Lluís Brotons, Marc Anton, Andreu Ubach, Dani Villero, Enrique García-Barros, Miguel L. Munguira, Carlos Godinho & Constantí Stefanescu
The climatic preferences of the species determine to a large extent their response to climate change. Temperature preferences have been shown to play a key role in driving trends in animal populations. However, the relative importance of temperature and precipitation preferences is still poorly understood, particularly in systems where ecological processes are strongly constrained by the amount and timing of rainfall. In this study, we estimated the role played by temperature and precipitation preferences in...

Data from: Randomized phase 2 study of FcRn antagonist efgartigimod in generalized myasthenia gravis

James F. Howard, Vera Bril, Ted M. Burns, Renato Mantegazza, Malgorzata Bilinska, Andrzej Szczudlik, Said Beydoun, Francisco Javier Rodriguez De Rivera Garrido, Fredrik Piehl, Mariarosa Rottoli, Philip Van Damme, Tuan Vu, Amelia Evoli, Miriam Freimer, Tahseen Mozaffar, E. Sally Ward, Torsten Dreier, Peter Ulrichts, Katrien Verschueren, Antonio Guglietta, Hans De Haard, Nicolas Leupin & Jan J. G. M. Verschuuren
Objective: To investigate safety and explore efficacy of efgartigimod (ARGX-113), an anti-neonatal Fc receptor immunoglobulin G1 Fc fragment, in patients with generalized myasthenia gravis (gMG) with a history of anti-acetylcholine receptor (AChR) autoantibodies, who were on stable standard-of-care myasthenia gravis (MG) treatment. Methods: A phase 2, exploratory, randomized, double-blind, placebo-controlled, 15-center study is described. Eligible patients were randomly assigned (1:1) to receive 4 doses over a 3-week period of either 10 mg/kg IV efgartigimod or...

Data from: Reprogramming the antigen specificity of B cells using genome-editing technologies

James E. Voss, Alicia Gonzalez-Martin, Raiees Andrabi, Roberta P. Fuller, Ben Murrell, Laura E. McCoy, Katelyn Porter, Deli Huang, Wenjuan Li, Devin Sok, Khoa Le, Bryan Briney, Morgan Chateau, Geoffrey Rogers, Lars Hangartner, Ann J. Feeney, David Nemazee, Paula Cannon & Dennis R. Burton
We have developed a method to introduce novel paratopes into the human antibody repertoire by modifying the immunoglobulin (Ig) genes of mature B cells directly using genome editing technologies. We used CRISPR-Cas9 in a homology directed repair strategy, to replace the heavy chain (HC) variable region in B cell lines with that from an HIV broadly neutralizing antibody, PG9. Our strategy is designed to function in cells that have undergone VDJ recombination using any combination...

Data from: Time to monitor livestock carcasses for biodiversity conservation and public health

Patricia Mateo-Tomás, Pedro P. Olea & José Vicente López‐Bao
Law enforcement and integration of environmental issues into other policies able to affect species and ecosystems are cornerstones for the effective protection of biodiversity. We illustrate the necessity of monitoring and improving such enforcement and integration through the example of the European sanitary policies for managing livestock carcasses after the “mad cow disease” outbreak while supporting scavengers’ conservation. Continuous updates of EU sanitary regulations for reconciling scavenger conservation and public health have led to actions...

Registration Year

  • 2019
    4

Resource Types

  • Dataset
    4

Affiliations

  • Autonomous University of Madrid
    4
  • University of Southern California
    2
  • University of Oviedo
    1
  • The Ohio State University
    1
  • University of North Carolina
    1
  • University of Virginia
    1
  • University of California, San Diego
    1
  • Texas A&M University
    1
  • German Center for Integrative Biodiversity Research
    1
  • Leiden University
    1